IL-12 promotes drug-induced clearance of Mycobacterium avium infection in mice

Journal of Immunology

Volumn 160, Issue 11, 1998, Pages 5428-5435

  Mark Doherty, T ^a   Sher, Alan ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLARITHROMYCIN; INTERLEUKIN 12; RIFABUTIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DOSE RESPONSE; GENETIC SUSCEPTIBILITY; IMMUNOMODULATION; IMMUNOPOTENTIATION; IMMUNOREGULATION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; MYCOBACTERIUM AVIUM; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CLARITHROMYCIN; CROSSES, GENETIC; DRUG THERAPY, COMBINATION; IMMUNITY, NATURAL; INJECTIONS, INTRAPERITONEAL; INTERFERON TYPE II; INTERLEUKIN-12; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; MYCOBACTERIUM AVIUM; RIFABUTIN; TUBERCULOSIS;

EID: 15144345622     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. D'Souza, S., M. Levin, A. Faith, H. Yssel, B. Bennett, R. A. Lake, I. N. Brown, and J. R. Lamb. 1996. Defective antigen processing associated with familial disseminated mycobacteriosis. Clin. Exp. Immunol. 103:35.
2. Holland, S. M., E. M. Eisenstein, D. B. Kuhns, M. L. Turner, T. A. Fleisher, W. Strober, and J. I. Gallin. 1994. Treatment of refractory disseminated nontuberculous mycobacterial infection with interferon gamma: a preliminary report. N. Engl. J. Med. 330:1348.
3. Hawkins, C. C., J. W. Gold, E. Whimbey, T. E. Kiehn, P. Brannon. R. Cammarata, A. E. Brown, and D. Armstrong. 1986. Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome. Ann. Intern. Med. 105:184.
4. Young, L. S., C. B. Inderlied, O. G. Berlin, and M. S. Gottlieb. 1986. Mycobacterial infections in AIDS patients, with an emphasis on the Mycobacterium avium complex. Rev. Infect. Dis. 8:1024.
5. Shiratsuchi, H., J. L. Johnson, and J. J. Ellner. 1994. Mycobacterium avium: pathogenicity in HIV1 infection. Res. Microbiol. 145:230.
6. Benson, C. A. 1994. Disease due to the Mycobacterium avium complex in patients with AIDS: epidemiology and clinical syndrome. Clin. Infect. Dis. 18: (Suppl. 3):S218.
7. Ellner, J. J., M. J. Goldberger, and D. M. Parenti. 1991. Mycobacterium avium and AIDS: a therapeutic dilemma in rapid evolution. J. Infect. Dis. 163:1326.
8. Baohong, J., L. Nacer, C. Truffot-Pernot, and J. Grosset. 1992. Selection of resistant mutants of Mycobacterium avium in beige mice by clarithromycin monotherapy. Antimicrob. Agents Chemother. 36:2839.
9. Doucet, P. F., P. C. Truffot, J. Grosset, and V. Jarlier. 1995. Acquired resistance in Mycobacterium avium complex strains isolated from AIDS patients and beige mice during treatment with clarithromycin. J. Antimicrob. Chemother. 36:129.
10. Brown, B. A., D. E. Griffith, W. Girard, J. Levin, and R. J. Wallace. 1997. Relationship of adverse events to serum drug levels in patients receiving highdose azithromycin for mycobacterial lung disease. Clin. Infect. Dis. 24:958.
11. Amsden, G. W., C. A. Peloquin, and S. E. Berning. 1997. The role of advanced generation macrolides in the prophylaxis and treatment of Mycobacterium avium complex (MAC) infections. Drugs 54:69.
12. Heifets, L. B. 1996. Clarithromycin against Mycobacterium avium complex infections. Tubercle. Lung Dis. 77:79.
13. Nash, K. A., and C. B. Inderlied. 1996. Rapid detection of mutations associated with macrolide resistance in Mycobacterium avium complex (published erratum appears in Antimicrob. Agents Chemother. 40:2442). Antimicrob. Agents Chemother. 40:1748.
14. Gordin, F., and H. Masur. 1994. Prophylaxis of Mycobacterium avium complex bacteremia in patients with AIDS. Clin. Infect. Dis. 18:5223.
15. Ghebremichael, S., S. B. Svenson, G. Kallenius, and S. E. Hoffner. 1996. Antimycobacterial synergism of clarithromycin and rifabutin. Scand. J. Infect. Dis. 28:387.
16. Kaufmann, S. H. E. 1993. Immunity to intracellular bacteria. Annu. Rev. Immunol. 11:129.
17. Ferreira, P., R. Soares, and C. M. Arala. 1991. Susceptibility to infection with Mycobacterium avium is paradoxically correlated with increased synthesis of specific anti-bacterial antibodies. Int. Immunol. 3:445.
18. Inderlied, C. B., C. A. Kemper, and L. E. Bermudez. 1993. The Mycobacterium avium complex. Clin. Microbiol. Rev. 6:266.
19. Bermudez, L. E. 1994. Potential role of cytokines in disseminated mycobacterial infections. Eur. J. Clin. Microbiol. Infect. Dis. 13:529.
20. Holland, S. M. 1996. Therapy of mycobacterial infections. Res. Immunol. 147: 572.
21. Appelberg, R. 1994. Protective role of interferon gamma, tumor necrosis factor alpha, and interleukin-6 in Mycobacterium tuberculosis and M. avium infections. Immunobiology 191:520.
22. Castro, A. G., R. A. Silva, and R. Appelberg. 1995. Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacteritun avium infections in mice. J. Immunol. 155:2013.
23. Kobayashi, K., T. Kasama, J. Yamazaki, M. Hosaka, T. Katsura, T. Mochizuki, K. Soejima, and R. M. Nakamura. 1995. Protection of mice from Mycobacterium avium infection by recombinant interleukin-12. Antimicrob. Agents Chemother. 39:1369.
24. Doherty, T. M., and A. Sher. 1997. Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection. J. Immunol. 158:4822.
25. Tomioka, H., K. Sato, W. W. Maw, and H. Saito. 1995. The role of tumor necrosis factor, interferon-gamma, transforming growth factor-beta, and nitric oxide in the expression of immunosuppressive functions of splenic macrophages induced by Mycobacterium avium complex infection. J. Leukocyte Biol. 58:704.
26. Tomioka, H., and H. Saito. 1993. Suppressive activity of splenic macrophages induced by transparent and opaque colonial variants of Mycobacterium avium complex against lymphoproliferative response. Microbioi Immunol. 37:477.
27. Appelberg, R., A. G. Castro, J. Pedrosa, R. A. Silva, I. M. Orme, and P. Minoprio. 1994. Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection [Published erratum appears in 7995 Infect. Immun. 63:1145]. Infect. Immun. 62:3962.
28. Hubbard, R. D., C. M. Flory, and F. M. Collins. 1992. T-cell immune responses in Mycobacterium avium-infected mice. Infect. Immun. 60:150.
29. Orme, I. M., S. K. Furney, and A. D. Roberts. 1992. Dissemination of enteric Mycobacterium avium infections in mice rendered immunodeficient by thymectomy and CD4 depletion or by prior infection with murine AIDS retroviruses. Infect. Immun. 60:4747.
30. Frucht, D. M., and S. M. Holland. 1996. Defective monocyte costimulation for IFN-gamma production in familial disseminated Mycobacterium avium complex infection: abnormal IL-12 regulation. J. Immunol. 157:411.
31. Saunders, B. M., Y. Zhan, and C. Cheers. 1995. Endogenous interleukin-12 is involved in resistance of mice to Mycobacterium avium complex infection, infect. Immun. 63:4011.
32. Trinchieri, G., and P. Scott. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions. Res. Immunol. 146:423.
33. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, et al. 1992. Production of natural kiiler cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
34. Scharton-Kersten, T., L. C. Afonso, M. Wysocka, G. Trinchieri, and P. Scott. 1995. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 154:5320.
35. Scharton-Kersten, T. M., T. A. Wynn, E. Y. Denkers, S. Bala, E. Grunvald, S. Heiny, R. T. Gazzinelli, and A. Sher. 1996. In the absence of endogenous IFN-γ. mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J. Immunol. 157:4045.
36. Smith, P. K., R. I. Krohn, G. T. Hermanson, A. K. Mallia, F. H. Gartner, M. D. Provenzano, E. K. Fujimoto, N. M. Goeke, B. J. Olson, and D. C. Klenk. 1985. Measurement of protein using bicinchoninic acid (published erratum appears in Anal. Biochem. 163:279). Anal. Binchem. 150:76.
37. Doherty, T. M., R. A. Seder, and A. Sher. 1996. Induction and regulation of IL-15 expression in murine macrophages. J. Immunol. 156:735.
38. Cherwinski, H. M., J. H. Schumacher, K. D. Brown, and T. R. Mosmann. 1987. Two types of mouse helper T cell clone: further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 166:1229.
39. Magram, J., S. E. Connaughton, R. R. Warner, D. M. Carvajal, C. Y. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 4:471.
40. Magram, J., J. Sfarra, S. Connaughton, D. Faherty, R. Warrier, D. Carvajal, C. Y. Wu, C. Stewart, U. Sarmiento, and M. K. Gately. 1996. IL-12-deficient mice are defective but not devoid of type 1 cytokine responses. Ann. N Y Acad. Sci. 795:60.
41. Tare, N. S., S. Bowen, R. R. Warrier, D. M. Carvajal, W. R. Benjamin, J. H. Riley, T. D. Anderson, and M. K. Gately. 1995. Administration of recombinant interleukin-12 to mice suppresses hematopoiesis in the bone marrow but enhances hematopoiesis in the spleen. J. Interferon Cytokine Res. 15:377.
42. Manetti, R., P. Parronchi, M. G. Giudizi, M. P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 (IL-12)) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199.
43. Tripp, C. S., S. F. Wolf, and E. R. Unanue. 1993. Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90:3725.
44. Cynamon, M. H., S. P. Klemens, and M. A. Grossi. 1994. Comparative activities of azithromycin and clarithromycin against Mycobacterium avium infection in beige mice. Antimicrob. Agents Chemother. 38:1452.
45. Chaisson, R. E., P. Keiser, M. Pierce, W. J. Fessel, J. Ruskin, C. Lahart, C. A. Benson, K. Meek, N. Siepman, and J. C. Craft. 1997. Clarithromycin and ethambutol with or without clofazimine for the treatment of bacteremic Mycobacterium avium complex disease in patients with HIV infection. AIDS 11:311.
46. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:252.
47. Biron, C. A., and R. T. Gazzinelli. 1995. Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr. Opin. Immunol 7:485.
48. Nabors, G. S., L. C. Afonso, J. P. Farrell, and P. Scott. 1995. Switch from a type 2 to a type l T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam. Proc. Natl. Acad. Sci. USA 92:3142.
49. Clemons, K. V., E. Brummer, and D. A. Stevens. 1994. Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis. Antimicrob. Agents Chemother. 38:460.
50. Murray, H. W., J. D. Berman, and S. D. Wright. 1988. Immunochemotherapy for intracellular Leishmania donovani infection: gamma interferon plus pentavalent antimony. J. Infect, Dis. 157:973.
51. Gately, M. K., U. Gubler, M. J. Brunda, R. R. Nadeau, T. D. Anderson, J. M. Lipman, and U. Sarmiento. 1994. Interleukin-12: a cylokine with therapeutic potential in oncology and infectious diseases. Ther. Immunol. 1:187.
52. Jacobsen, S. E. 1995. IL12, a direct stimulator and indirect inhibitor of haematopoiesis. Res. Immunol. 146:506.
53. Taylor, A. P., and H. W. Murray. 1997. Intracellular antimicrobial activity in the absence of interferon-gamma: effect of interleukin-12 in experimental visceral leishmaniasis in interferon-gamma gene-disrupted mice. J. Exp, Med. 185:1231.
54. Lotze, M. T., L. Zitvogel, R. Campbell, P. D. Robbins, E. Elder, C. Haluszczak, D. Martin, T. L. Whiteside, W. J. Storkus, and H. Tahara. 1996. Cytokine gene therapy of cancer using interleukin-12: murine and clinical trials. Ann. NY Acad. Sci. 795:440.
55. Gazzinelli, R. T., S. Hayashi, M. Wysocka, L. Carrera, R. Kuhn, W. Muller, F. Roberge, G. Trinchieri, and A. Sher. 1994. Role of IL-12 in the initiation of cell mediated immunity by Toxoplasma gondii and its regulation by 1L-10 and nitric oxide. J. Eukaryot. Microbiol. 41:9.
56. Zhou, P., M. C. Sieve, J. Bennett, C. K. Kwon, R. P. Tewari, R. T. Gazzinelli, A. Sher, and R. A. Seder. 1995. IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-gamma. J. Immunol. 155:785.
57. Romani, L., A. Mencacci, L. Tonnetti, R. Spaccapelo, E. Cenci, S. Wolf, P. Puccetti, and F. Bistoni. 1994. Interleukin-12 but not interferon-gamma production correlates with induction of T helper type-1 phenotype in murine candidiasis. Eur. J. Immunol. 24:909.