Nitric oxide in gastrointestinal epithelial cell carcinogenesis: Linking inflammation to oncogenesis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 281, Issue 3 44-3, 2001, Pages

  Jaiswal, M ^a   Larusso, N F ^a   Gores, G J ^a  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

Author keywords

Apoptosis; Cytokines; DNA repair; Oxidative DNA damage; P53

Indexed keywords

DNA; DNA GLYCOSYLTRANSFERASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANGIOGENESIS; APOPTOSIS; DIGESTIVE SYSTEM CANCER; DIGESTIVE SYSTEM INFLAMMATION; DNA DAMAGE; DNA REPAIR; HUMAN; INTESTINE EPITHELIUM; MALIGNANT TRANSFORMATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STOMACH EPITHELIUM;

EID: 0034829648     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2001.281.3.g626     Document Type: Review

References (135)

1. Relationship between p53 mutations and iNOS expression in human colorectal cancer
2. p53 and vascular endothelial growth factor regulate tumor growth of iNOS 2-expressing human carcinoma cells
3. Up-regulation of iNOS expression in cancer-prone p53 knockout mice
4. Function of thioredoxin reductase as a peroxynitrite reductase using selenocysteine or ebselen
5. Macrophage nitric oxide synthase subunits: Purification, characterization and role of prosthetic groups and substrates in regulating their association into dimeric enzyme
6. The yin and yang of nitric oxide: Reflections on physiology and pathophysiology of nitric oxide
7. Modulation of nitric oxide synthase in vivo; N-monomethyl-L-arginine inhibits endotoxin-induced nitrate-nitrite biosynthesis while promoting hepatic damage
8. Gamma radiation-induced apoptosis in human colorectal adenoma and carcinoma cell lines can occur in the absence of wild type p53
9. Nitric oxide (NO): An effector of apoptosis
10. Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary endothelial cells
11. In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventing natural product with anti-inflammatory properties
12. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G to T and A to C substitutions
13. Oligenucleotides as therapeutic agents
14. The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein
15. Clinical biology of nitric oxide
16. Primary sclerosing cholangitis: Liver transplantation or biliary surgery?
17. Stable Mn(II)-porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo
18. Angiogenesis in cancer, vascular rheumatoid and other diseases
19. Nitric oxide-induced p53 accumulation and regulation of iNOS expression by wild-type p 53
20. Relationship between DNA repair and transcription
21. Inhibition of constitutive and inducible nitric oxide synthase: Potential selective inhibition
22. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer
23. Molecular biology of nitric oxide synthase
24. Nitric oxide synthase expression is induced in hepatocytes in vivo during hepatic inflammation
25. Cytokines, endotoxin and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes
26. Mitochondrial nitric oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation
27. Cytokine-induced synthesis of nitrogen oxides in macrophages: A protective host response to Leishmania and other intracellular pathogens
28. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
29. Opposite effects of nitric oxide donors on DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide
30. Pharmacology of hemoglobin therapeutics
31. Mismatch repair proteins and mitotic genome stability
32. Clinical implications of the p53 tumor suppressor gene
33. Liver fluke infection and cholangiocarcinoma: Model of endogenous nitric oxide and extragastric nitrosation in human carcinogenesis
34. The biochemistry of apoptosis
35. L-Arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells
36. Inhibition of nitric oxide synthases as a potential therapeutic target
37. Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: A cancer-prone chronic inflammatory disease
38. NO-mediated inhibition of DNA repair potentiates oxidative DNA damage
39. Cholangiocarcinoma and pro-inflammatory cytokines
40. Inflammatory cytokines induce DNA damage and inhibit repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism
41. Efficient in vitro repair of 7-hydro-8-oxodeoxyguanosine by human cell extracts: Involvement of multiple pathways
42. Anti-apoptotic vs. pro-apoptotic signal transduction: Checkpoints and stop signs along the road to death
43. Role of nitric oxide in tumor growth
44. Oxides, anions and other matters gastrointestinal - 1996 - A perspective
45. Inhibition of viral replication by interferon-gamma induced nitric oxide synthase
46. Nitrotyrosine in esophageal squamous cell carcinoma and relevance to p53 expression
47. Apoptosis in cancer: Cause and cure
48. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression
49. Nitric oxide as a bifunctional regulator of apoptosis
50. Nitric oxide prevents tumor necrosis factor alpha-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through s-nitrosylation of caspase-8
51. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
52. Inducible nitric oxide synthase in human diseases
53. DNA damage-induced mutation: Tolerance via translesion synthesis
54. A discussion of mechanisms of NO genotoxicity: Implication of inhibition of DNA repair proteins
55. Anti-tumor role of base excision repair enzymes upon free radical induced DNA damage
56. Inhibition by nitric oxide of the repair protein O6-methylguanine-DNA methyltransferase
57. Nitric oxide involvement in tumor-induced immunosuppression
58. Quenching of tyrosyl free radical of ribonucleotide reductase by nitric oxide
59. Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation
60. Mammalian DNA ligases
61. Mechanisms of liver disease
62. Endogenous nitric oxide protects against platelet-activating factor-induced bowel injury in the rat
63. Nitric oxide prevents anoxia-induced apoptosis in colonic HT 29 cells
64. Attenuation of intestinal ischemia-reperfusion injury with sodium nitroprusside
65. Inducible nitric oxide synthase expression in chronic viral hepatitis: Evidence for a virus-induced gene upregulation
66. Inducible nitric oxide synthase, nitrotyrosine and apoptosis in Helicobacter pylori gastritis
67. Nitric oxide inhibits Fas-induced apoptosis
68. Nitric oxide synthase: Aspects concerning structure and catalysis
69. Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): In vitro antiproliferative effects of a COX-2 inhibitor
70. Allosteric inhibitors of iNOS characterization discovered via combinatorial chemistry
71. Base excision repair in yeast and mammals
72. Nitric oxide and nitric oxide synthases
73. Role of N-nitroso-compounds (NOC) and nitrosation in etiology of gastric esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposure to NOC
74. Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha
75. Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium
76. Implications of the zinc-finger motif found in the DNA-binding domain of the human XPA protein
77. Nitric oxide. Therapeutic potential of nitric oxide donors and inhibitors
78. Role of nitric oxide synthesis in macrophage antimicrobial activity
79. Regulation of biosynthesis of nitric oxide
80. p53 Tumor suppressor gene therapy for cancer
81. DNA damage and mutation in human cells exposed to nitric oxide in vivo
82. Inflammation, immunoregulation and nitric oxide synthase
83. Induction of nitric oxide synthase and its reactions in cultured human and rat hepatocytes stimulated with cytokines and lipopolysaccharides
84. Chronic infections and inflammatory processes as cancer risk factors: Possible role of nitric oxide in carcinogenesis
85. Cellular responses to nitric oxide: Role of protein S-thiolation/dethiolation
86. Enhanced gastric nitric oxide synthase activity in duodenal ulcer patients
87. Inhibition of mitochondrial electron transport by peroxynitrite
88. Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor
89. p53 Protein overexpression in cholangio-carcinoma arising in primary sclerosing cholangitis
90. The effect of inhibitors of inducible nitric oxide synthase on chronic colitis in the rhesus monkey
91. Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase
92. Nitrite from inflammatory cells - A cancer risk factor in ulcerative colitis?
93. Inhibition of peroxynitrite-mediated inhibition of tyrosine nitration by a novel pyrolopyrimidine antioxidant
94. Cholangiocarcinoma complicating primary sclerosing cholangitis
95. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase
96. Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes
97. DNA excision repair
98. Expression of cyclooxygenase- 2 gene in gastric epithelium
99. Cyclooxygenase-2 expression is increased in the stroma of colon carcinomas from IL-10(-/-)mice
100. Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease
101. Selective pharmacological inhibition of distinct nitric oxide synthase isoforms
102. Sensitivity of protein sulfhydryl repair enzymes to oxidative stress
103. How cells respond to interferons
104. Role of apoptesis in Helicobacter pylori-associated gastric mucosal injury
105. Mercaptoethylguanidine and guanidine inhibitors of nitric oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage
106. DNA damage induced by peroxynitrite: Subsequent biological effects
107. DNA damage by nitric oxide
108. Genomic structure and chromosomal localization of mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage
109. DNA damage and cytotoxicity of nitric oxide
110. Macrophage oxidation of L-arginine to NO, nitrite and nitrate: Tetrahydrobiopterin is required as co-factor
111. Inducible nitric oxide synthase in the liver regulation and function
112. Multiple NF-κB enhances elements regulate cytokine induction in human inducible nitric oxide synthase gene
113. Nitric oxide synthase activity, viability and cyclic cGMP levels in rat colonic epithelial cells: Effect of endotoxin challenge
114. Nitric oxide synthase induction and intestinal epithelial cell viability in rats
115. Antisense oligonucleotide to inducible nitric oxide synthases inhibits nitric oxide synthesis in rat pulmonary artery smooth muscle cells in culture
116. Role of nitric oxide in tumor progression: Lessons from human tumors
117. Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor
118. Caspases: Enemies within
119. Nitric oxide in tumor biology and cancer therapy. 1. Physiological aspects
120. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
121. Helicobacter pylori and gastric carcinogenesis
122. Association of increased immunostaining for iNOS and nitrotyrosine with fibroblast growth factor transformation in pancreatic cancer
123. Nitric oxide mediates activity-dependent synaptic suppression at developing neuromuscular synapses
124. Cholangiocarcinoma in patients with opisthorchiasis
125. Translational regulation via iron-responsive elements by nitric oxide/nitric oxide synthase pathway
126. Direct and indirect effects of nitric oxide in chemical reactions relevant to biology
127. DNA deaminating ability and genotoxicity of nitric oxide and its progenitors
128. The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo
129. Helicobacter pylori infection and urinary excretion of 8-hydroxy-2-deoxyguanine, an oxidative DNA adduct
130. DNA repair in eukaryotes
131. Ubiquitous presence in mammalian cells of enzymatic activity specifically cleaving 8-hydroxyguanine-containing DNA
132. Effect of nitric oxide scavenger carboxy-PTIO on endothelium dependent vasorelaxation of various blood vessels from rabbits
133. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
134. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
135. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis