Molecular basis of hypoxia-induced pulmonary vasoconstriction: Role of voltage-gated K+ channels

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 281, Issue 1 25-1, 2001, Pages

  Coppock, Elizabeth A ^a   Martens, Jeffrey R ^a   Tamkun, Michael M ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Oxygen sensor; Pulmonary artery; Smooth muscle; Voltage gated potassium channel

Indexed keywords

POTASSIUM CHANNEL; VOLTAGE GATED CHANNEL FORMING PROTEIN;

ARTERY CONSTRICTION; BETA CHAIN; CALCIUM TRANSPORT; HYPOXIA; LUNG VASOCONSTRICTION; MEMBRANE DEPOLARIZATION; MEMBRANE STEADY POTENTIAL; OXYGEN SATURATION; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; REVIEW; VASCULAR SMOOTH MUSCLE;

EID: 0034816783     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.281.1.l1     Document Type: Review

References (117)

1. + channels in pulmonary arterial smooth muscle cells isolated from the rat
2. 2 sensor in rat pulmonary vasculature
3. Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia
4. 2 sensing is preserved in mice lacking the gp 91 phox subunit of NADPH oxidase
5. + channels, Kv1.5 and Kv21, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes
6. 2-sensitive potassium channels in the pulmonary circulation
7. Potassium channels modulate hypoxic pulmonary vasoconstriction
8. Energy state and vasomotor tone in hypoxic pig lungs
9. Oxygen sensing and molecular adaptation to hypoxia
10. A family of putative potassium channel genes in Drosophila
11. Cellular oxygen sensing by mitochondria: Old questions, new insight
12. + channels
13. Heteropolymeric potassium channels expressed in Xenopus oocytes from cloned subunits
14. Potassium channels in the vasculature
15. + channels: Role of the Kv1.2-subunit in mediating the hypoxic response
16. Acute hypoxia causes membrane depolarization and calcium influx in fetal pulmonary artery smooth muscle cells
17. Molecular physiology of cardiac potassium channels
18. Functional effects of 4-aminopyridine (4-AP) on pulmonary and systemic vessels from normoxic control and hypoxic pulmonary hypertensive rats
19. + channel inhibition, calcium signaling, and vasomotor tone in canine pulmonary artery smooth muscle
20. + channels to reactive oxygen species
21. + channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing
22. + channel beta subunit expressed in human heart
23. + current that is active at resting potential in rabbit pulmonary artery smooth muscle cells
24. Resting potentials and potassium currents during development of pulmonary artery smooth muscle cells
25. 2+ channels
26. + channel beta subunit to specifically enhance Kv2.2 (CDRK) expression
27. Differential oxygen sensitivity of calcium channels in rabbit smooth muscle cells of conduit and resistance pulmonary arteries
28. 2 tension Significance for arterial oxygen chemoreception
29. + current modulation in wild-type and oxidase-deficient mice
30. Potassium channel types in arterial chemoreceptor cells and their selective modulation by oxygen
31. 2+ release from intracellular stores is an initial step in hypoxic pulmonary vasoconstriction of rat pulmonary artery resistance vessels
32. Effects of NADPH oxidase inhibitors on hypoxic vasoconstriction in buffer-perfused rabbit lungs
33. + channels, types Kv1.1, 1.2, 1.3, 1.5, and 3. 1, stably expressed in mammalian cell lines
34. Pulmonary circulation in animals and man at high altitude
35. + channel beta subunit
36. + channels
37. 2+-dependent action potentials in small pulmonary arteries of the cat
38. + channel blockers on vascular tone in the perfused rat lung
39. Acute effects of increased intravascular volume and hypoxia on the pulmonary circulation: Assessment with high-resolution CT
40. + channels expressed in the pulmonary vasculature
41. 2+ release in hypoxic vasoconstriction of canine pulmonary artery
42. Ion channels and vascular tone
43. Cloned potassium channels from eukaryotes and prokaryotes
44. Free radical production in hypoxic pulmonary artery smooth muscle cells
45. Immunohistochemical demonstration of four subunits of neutrophil NAD(P)H oxidase in type I cells of carotid body
46. 2)-sensitive chemoreceptor discharge of the rat carotid body
47. + current modulated by PO2 in type I chemoreceptor cells
48. Determination of the subunit stoichiometry of a voltage-activated potassium channel
49. Hypoxia-induced activation in small isolated pulmonary arteries from the cat
50. Effects of hypoxia and other vasoactive agents on pulmonary and cerebral artery smooth muscle cells
51. Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction
52. Oxygen-sensing potassium currents in pulmonary artery
53. BAY K 86 44 potentiates and A23187 inhibits hypoxic vasoconstriction in rat lungs
54. Inhibition of hypoxic pulmonary vasoconstriction by calcium antagonists in isolated rat lungs
55. Acute hypoxic pulmonary vasoconstriction: A model of oxygen sensing
56. A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits
57. + channel beta subunit increases the rate of C-type inactivation from the cytoplasmic side of the channel
58. + channel beta-subunits with alpha-subunits
59. Pulmonary, vascular responses in rats exposed to chronic hypobaric hypoxia at two different altitude levels
60. Physiological roles and properties of potassium channels in arterial smooth muscle
61. Features of 4-aminopyridine sensitive outward current observed in single smooth muscle cells from the rabbit pulmonary artery
62. + currents to the resting potential and tone of rat pulmonary artery smooth muscle
63. 2-sensing potassium current
64. Potential role for kv3.1b channels as oxygen sensors
65. Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila
66. + channel by redox potential in pulmonary and ear arterial smooth muscle cells of the rabbit
67. Redox agents as a link between hypoxia and the responses of ionic channels in rabbit pulmonary vascular smooth muscle
68. + channels by the intracellular redox potential in pulmonary and ear arterial smooth muscle cells of the rabbit
69. + channel in oxygen-sensitive pulmonary artery myocytes
70. 2 sensitivity to kv4.2 but not to Shaker channels
71. + current in chemoreceptor cells
72. + channels in canine pulmonary artery. Novel mechanism for hypoxia-induced membrane depolarization
73. Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction
74. Membrane potential-dependent and -independent vasodilation in small pulmonary arteries from chronically hypoxic rats
75. Ion channels in the pulmonary vasculature
76. + channel activity and tone in rat vascular tissue
77. + channels altered by presence of beta-subunit
78. Inhibitors of oxidative ATP production cause transient vasoconstriction and block subsequent pressor responses in rat lungs
79. Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation
80. + channels cloned from smooth muscle
81. + channels
82. + channels conserved in flies, mice and humans
83. Acute hypoxia increases cytosolic calcium in cultured pulmonary arterial myocytes
84. Mechanism of hypoxic pulmonary vasoconstriction involves ETA receptor-mediated inhibition of KATP channel
85. Perspectives on oxygen sensing
86. Chairman's summary: Mechanisms of oxygen homeostasis, circa 1999
87. HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
88. Effects of hypoxia in porcine pulmonary arterial myocytes: Roles of Kv channel and endothelin-1
89. + channels detected in vivo
90. + currents in pulmonary arterial myocytes
91. + current in rat pulmonary artery muscle cells
92. + channel modulation in arterial smooth muscle
93. Hypoxic pulmonary vasoconstriction: Role of voltage-gated potassium channels
94. Inhibition of hypoxic pulmonary vasoconstriction by diphenyleneiodonium
95. Hypoxic pulmonary hypertension: Acute and chronic
96. Inhibition of hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries by diphenyleneiodonium (DPI)
97. Pulmonary vascular tone is increased by a voltage-dependent calcium channel potentiator
98. + currents and hypoxia in rat pulmonary arterial myocytes
99. 2 release by lung mitochondria and microsomes
100. Functional differences in Kv1.5 currents expressed in mammalian cell lines are due to the presence of endogenous Kv beta 2.1 subunits
101. + channel Kvβ1.3 β-subunit affect voltage-dependent gating
102. Calcium augments hypoxic vasoconstriction in lungs from highaltitude rats
103. Observations on the pulmonary arterial blood pressure in the cat
104. + channel alpha subunits in pulmonary artery smooth muscle cells
105. Mechanisms of hypoxic pulmonary vasoconstriction: Can anyone be right?
106. The role of the endothelium in hypoxic pulmonary vasoconstriction
107. The mechanism of acute hypoxic pulmonary vasoconstriction: The tale of two channels
108. Diphenyleneiodonium inhibits both potassium and calcium currents in isolated pulmonary artery smooth muscle cells
109. Mechanisms of hypoxic vasodilation in ferret pulmonary arteries
110. Oxygen sensing in airway chemoreceptors
111. i in pulmonary arterial myocytes
112. Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes
113. Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries
114. 2+ conductances in pulmonary artery cells
115. + channels in rat pulmonary artery smooth muscle cells
116. + channels in pulmonary arterial smooth muscle cells
117. + current