Redox-dependent binding of CO to heme protein controls P(O2)-sensitive chemoreceptor discharge of the rat carotid body

Respiration Physiology

Volumn 115, Issue 2, 1999, Pages 169-177

  Lahiri, S ^a   Acker, H ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

Chemoreceptor discharge; Ion channels; Rat carotid body; Redox dependent binding

Indexed keywords

CARBON MONOXIDE; HEMOPROTEIN; ION CHANNEL; OXYGEN;

ANIMAL EXPERIMENT; CAROTID BODY; CHEMORECEPTOR; CONFERENCE PAPER; CONTROLLED STUDY; HYPOXIA; NEUROTRANSMITTER RELEASE; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN BINDING; RAT; SENSOR; SIGNAL TRANSDUCTION;

ANIMALS; CARBON MONOXIDE; CAROTID BODY; CHEMORECEPTORS; CYTOCHROMES; HEMEPROTEINS; ION CHANNELS; MODELS, NEUROLOGICAL; NERVE ENDINGS; OXIDATION-REDUCTION; OXYGEN; RATS; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY;

EID: 0033045283     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(99)00014-6     Document Type: Conference Paper

References (42)

1. Acker H. Mechanisms and meaning of cellular oxygen sensing in the organism. Respir. Physiol. 95:1994;1-10.
2. O2 chemoreception. J. Auton. Nerv. Syst. 41:1992;41-52.
3. Acker H., Xue D. Mechanisms of oxygen sensing in the carotid body in comparison to other oxygen sensing cells. NIPS. 10:1995;211-216.
4. 2 sensor. J. Biol. Chem. 273:1998;3320-3326.
5. Bunn H.F., Poyton R.O. Oxygen sensing and molecular adaptation to hypoxia. Physiol.Reviews. 76:1996;839-885.
6. Buerk D.G., Chugh D.K., Osanai S., Mokashi A., Lahiri S. Dopamine increases in cat carotid body during excitation by carbon monoxide: implications for a chromophore theory of chemoreception. J. Autonom. Nerve Syst. 67:1997;130-136.
7. Chance B., Lagallais V., Sorge J., Graham N. A versatile timesharing multichannel spectrophotometer, reflectometer and fluorometer. Anal Biochem. 66:1975;498-514.
8. Chandel N.S., Budinger G.R.S., Choe S.H., Schumacker P.T. Cellular respiration during hypoxia role of cytochrome oxidase as the oxygen sensor in hepatocytes. J. Biol. Chem. 272:1997;18808-18816.
9. Cool R.H., Merten E., Theiss Ch., Acker H. Rac1, and not Rac2, is involved in the regulation of the intracellular hydrogen peroxide level in HepG2 cells. Biochem. J. 332:1998;5-8.
10. O2 sensor protein in the rat carotid body. Biochem. J. 272:1990;743-747.
11. Delpiano M., Acker H. Extracellular pH changes in the superfused cat carotid body during hypoxia and hypercapnia. Brain Res. 342:1985;273-280.
12. 0 in the cat carotid body in vitro. Brain Res. 482:1989;235-246.
13. Donnelly D.F., Kholwadwala D. Hypoxia decreases intracellular calcium in adult rat carotid body glomus cells. J. Neurophysiol. 67:1992;1543-1551.
14. + channels essential for carotid body chemotransduction. Resp. Physiol. 110:1997;211-218.
15. Duchen M.R., Biscoe T.J. Mitochondrial function in type I cells isolated from rabbit arterial chemoreceptors. J. Physiol. Lond. 450:1992;13-31.
16. Ehleben W., Porwol T., Fandrey J., Kummer W., Acker H. Cobalt and desferrioxamine reveal crucial members of the oxygen sensing pathway in HepG2 cells. Kidney Int. 51:1997;483-491.
17. Gonzalez C., Almaraz L., Obeso A., Rigual R. Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol. Rev. 74:1994;829-898.
18. + current and their modulation by hypoxia. J. Physiol. Lond. 501:1997;49-59.
19. Heinrich, U., 1981. Untersuchungen zur quantitativen photometrischen Analyse der Redox-Zustände der Atmungskette in vitro und in vivo am Beispiel des Gehirns. Dissertation, Ruhr Universität Bochum.
20. Kiennecker E.W., Knoche H., Bingmann D. Functional properties of regenerating sinus nerve fibers in the rabbit. Neuroscience. 3:1978;977-988.
21. Katz B. The Release of Neural Transmitter Substances. 1969;Charles C. Thomas, IL, USA.
22. Kummer W., Acker H. Immunohistochemical demonstration of 4 subunits of neutrophil NAD(P)H oxidase in type I cells of carotid body. J. Appl. Physiol. 78:1995;1904-1909.
23. 2 chemoreception: the carotid body model. NIPS. 9:1994;161-165.
24. 2 sensor. Brain Res. 684:1995;194-200.
25. O2 in type I cells in rat carotid body is not a chemosensor. Brain Res. 794:1998;162-165.
26. López-Barneo J., Benot A.R., Urena J. Oxygen sensing and the electrophysiology of arterial chemoreceptor cells. NIPS. 8:1993;191-195.
27. Marshall C., Mamary A.J., Verhoeven A.J., Marshall B.E. Pulmonaryartery NADPH oxidase is activated in hypoxic pulmonary vasoconstriction. Am. J. Respir. Cell Molec. Biol. 15:1996;633-644.
28. McDonald, D.M., 1981. Peripheral chemoreceptors, structure function relationships of the carotid body. In: Regulation of Breathing. Part I. Marcel Dekker, New York, pp. 105-319.
29. Mills E., Jöbsis F.F. Mitochondrial respiratory chain of carotid body and chemoreceptor response to changes in oxygen tension. J. Neurophysiol. 35:1972;405-428.
30. Mitchell R.A., Sinha A.K., McDonald D.M. Chemoreceptive properties of regenerated endings of the carotid sinus nerve. Brain Res. 43:1972;1077-1088.
31. Montoro R.J., Urena J., Fernandezchacon R., Detoldo G.A., Lopez-Barneo J. Oxygen sensing by ion channels and chemotransduction in single glomus cells. J. Gen. Physiol. 107:1996;133-143.
32. 2 chemoreception and mitoc hondrial oxidative phosphorylation. J. Appl. Physiol. 51:1981;438-446.
33. 2 in chemoreception in the cat carotid body. J. Autonom. Nerve Syst. 63:1997;39-45.
34. Peers C. Oxygensensitive ion channels. Trends Pharmacol. Sci. 18:1997;405-408.
35. Porwol T., Ehleben W., Zierold K., Fandrey J., Acker H. The influence of nickel and cobalt on putative members of the oxygensensing pathway of erythropoietinproducing HepG2 cells. Eur. J. Biochem. 256:1998;1623.
36. i, dopamine release and chemosensory discharge from carotid body. Brain Res. 785:1998;228-235.
37. Thelen M., Dewald B., Baggiolini M. Neutrophil signal transduction and activation of the respiratory burst. Physiol. Rev. 73:1993;797-821.
38. + channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lungcarcinoma cell-lines. Proc. Natl. Acad. Sci. USA. 93:1996;13182-13187.
39. 3 of the mitochondrial respiratory chain. FEBS Letts. 351:1994;370-374.
40. + channels by hydrogen peroxide. Biochem. Biophys. Res. Comm. 186:1992;1681-1687.
41. 2 sensing protein (NADPH oxidase) in chemoreceptor cells. Micros. Res. Tech. 37:1997;101-106.
42. Zapata P., Stensaas J., Eyzaguirre C. Axon regeneration following a lesion of the carotid nerve: electrophysiological and ultrastructural observations. Brain Res. 113:1976;235-253.