Regulation of the resting potential of rabbit pulmonary artery myocytes by a low threshold, O2-sensing potassium current

British Journal of Pharmacology

Volumn 120, Issue 8, 1997, Pages 1461-1470

  Osipenko, Oleg N ^a   Evans, A Mark ^a,b   Gurney, Alison M ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

4 Aminopyridine; Hypoxia; K channel; K current; Oxygen sensitive K channel; Potassium current; Pulmonary artery; Pulmonary artery myocytes; Quinine

Indexed keywords

4 AMINOPYRIDINE; CHARYBDOTOXIN; DIGITOXIN; GLIBENCLAMIDE; IBERIOTOXIN; OUABAIN; OXYGEN; POTASSIUM ION; QUININE; TETRYLAMMONIUM;

ANIMAL CELL; ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; HYPOXIA; MALE; MEMBRANE STEADY POTENTIAL; MUSCLE CELL; NONHUMAN; OXYGEN TENSION; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; PULMONARY ARTERY; RABBIT;

EID: 0030944919     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701075     Document Type: Article

References (37)

1. ARCHER, S.L., HUANG, J.M.C., REEVE, H.L., HAMPL, V., TOLAROVÁ, S., MICHELAKIS, E, & WEIR, E.K. (1996). Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia. Circ. Res., 78, 431-442.
2. BARNES, P.J. & LIU, S.F. (1995). Regulation of pulmonary vascular tone. Pharmacol. Rev., 47, 87-131.
3. BENHAM, C.D., BOLTON, T.B., LANG, R.J. & TAKEWAKI, T. (1986). Calcium-activated potassium channels in single smooth muscle cells of rabbit jejunum and guinea-pig mesenteric artery. J. Physiol., 371, 45-67.
4. BONNET, P., VANDIER, C., CHELIAKINE, C. & GARNIER, D. (1994). Hypoxia activates a potassium current in isolated smooth muscle cells from the large pulmonary arteries of the rabbit. Exp. Physiol., 79, 597-600.
5. BRAYDEN, J.E. & NELSON, M.T. (1992). Regulation of arterial tone by activation of calcium-dependent potassium channels. Science, 256, 532-535.
6. + channel. Biophys. J., 63, 583-590.
7. CASTEELS, R., KITAMURA, K., KURIYAMA, H. & SUZUKI, H. (1997). The membrane properties of the smooth muscle cells of the rabbit main pulmonary artery. J. Physiol., 271, 41-61.
8. CLAPP, L.H. & GURNEY, A.M. (1991). Outward currents in rabbit pulmonary artery cells dissociated with a new technique. Exp. Physiol., 76, 677-693.
9. CLAPP, L.H. & GURNEY, A.M. (1992). ATP-sensitive potassium channels regulate the resting potential of pulmonary arterial smooth muscle cells. Am. J. Physiol., 262, H916-H920.
10. CORNFIELD, D.N., STEVENS, T., MCMURTY, I.F., ABMAN, S.H. & RODMAN, D.M. (1994). Acute hypoxia causes membrane depolarization and calcium influx fetal pulmonary artery smooth muscle cells. Am. J. Physiol., 266, L469-L475.
11. DEMIREL, E., RUSKO, J., LASKEY, R.E., ADAMS, D.J. & VAN BREEMEN, C. (1994). TEA inhibits ACh-induced EDRF release: Endothelial Ca2+-dependent K+ channels contribute to vascular tone. Am. J. Physiol., 267, H1135-1141.
12. EVANS, A.M., CLAPP, L.H. & GURNEY, A.M. (1994). Augmentation by intracellular ATP of the delayed rectifier current independently of the glibenclamide-sensitive K-current in rabbit arterial myocytes. Br. J. Pharmacol., 111, 972-974.
13. KRP: Characterization and pharmacological separation of a novel potassium current in rabbit pulmonary artery myocytes. Br. J. Pharmacol., 116, 292P.
14. EVANS, A.M., OSIPENKO, O.N. & GURNEY, A.M. (1996). Properties of a novel potassium current that is active at the resting potential in rabbit pulmonary artery smooth muscle cells. J. Physiol., 496, 407-420.
15. HAEUSLER, G. & THORENS, S. (1980). Effects of tetraethylammonium chloride on contractile, membrane and cable properties of rabbit artery muscle. J. Physiol., 303, 203-204.
16. HARA, Y., KITAMURA, K. & KIRIYAMA, H. (1980). Actions of 4-aminopyridine on vascular smooth muscle tissues of the guinea-pig. Br. J. Pharmacol., 68, 99-106.
17. + channel blockers on vascular tone in the perfused rat lung. Am. Rev. Resp. Dis., 144, 884-887.
18. JIN, N., PACKER, C. & RHOADES, R. (1992). Pulmonary arterial hypoxic contraction: signal transduction. Am. J. Physiol., 263, L73-L78.
19. KURIYAMA, H., ITO, Y., SUZUKI, H., KITAMURA, K. & ITOH, T. (1982). Factors modifying contraction-relaxation cycle in vascular smooth muscles. Am. J. Physiol., 243, H641-H662.
20. LEACH, R.M., ROBERTSON, T.P., TWORT, C.H.C. & WARD, J.P.T. (1994). Hypoxic vasoconstriction in rat pulmonary and mesenteric arteries. Am. J. Physiol., 266, L223-L231.
21. MADDEN, J.A., DAWSON, C.A. & HARDER, D.A. (1985). Hypoxia-induced activation in small isolated pulmonary arteries from the cat. J. Appl. Physiol., 59, 113-118.
22. MADDEN, J.A., VADULA, M.S. & KURUP, V.P. (1992). Effects of hypoxia and other vasoactive agents on pulmonary and cerebral artery smooth muscle cells. Am. J. Physiol., 263, L384-L393.
23. MILLER, C., MOCZYDLOWSKI, E., LATORRE, R. & PHILLIPS, M. (1985). Charybdotoxin a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle. Nature, 313, 316-318.
24. MURRAY, T.R., CHEN, L., MARSHALL, B.E. & MACARAK, E.J. (1990). Hypoxic contraction of cultured pulmonary vascular smooth muscle cells. Am. J. Res. Cell. Mol. Biol., 3, 457-465.
25. OKABE, K., KITAMURA, K. & KURIYAMA, H. (1987). Features of a 4-aminopyridine sensitive outward current observed in single smooth muscle cells from the rabbit pulmonary artery. Pflügers Archiv., 409, 561-568.
26. + conductance of isolated rabbit pulmonary artery smooth muscle cells. J. Physiol., 487, 80P.
27. + channels in canine pulmonary artery. Novel mechanism for hypoxia-induced membrane depolarization. Circ. Res., 77, 131-139.
28. POST, J.M., HUME, J.R., ARCHER, S.L. & WEIR, E.K. (1992). Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am. J. Physiol., 262, C882-C890.
29. + efflux from human red blood cells. J. Mem. Biol., 57-63.
30. + current in rat pulmonary artery muscle cells. Am. J. Physiol., 266, H365-H370.
31. SUZUKI, H. & TWAROG, B.M. (1982). Membrane properties of smooth muscle cells in pulmonary arteries of the rat. Am. J. Physiol. 242, H900-H906.
32. 2+ spikes in conduit and resistance myocytes of the rabbit pulmonary artery. J. Physiol., 496.1. 103-109.
33. WADSWORTH, R.M. (1994). Vasoconstrictor and vasodilator effects of hypoxia. Trends. Pharmacol. Sci. 15, 47-53.
34. WEIR, E.K. & ARCHER, S.L. (1995). The mechanisms of acute hypoxic pulmonary vasoconstriction: the tale of two channels. FASEB J. 9, 183-189.
35. i in pulmonary arterial myocytes. Circ. Res., 77, 370-378.
36. YUAN, X.-J., GOLDMAN, W., TOD, M., RUBIN, L. & BLAUSTEIN, M. (1993). Hypoxia reduces potassium currents in cultured rat pulmonary but not messenteric arterial myocytes. Am. J. Physiol., 264, L116-L123.
37. YUAN, X.-J., TOD, M., RUBIN, L. & BLAUSTEIN, M. (1990). Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries. Am. J. Physiol., 259, H281-H289.