Structural studies of chemokines that inhibit HIV-1 entry

Antiviral Chemistry and Chemotherapy, Supplement

Volumn 12, Issue 1, 2001, Pages 43-49

  Fernandez, E J ^a   Lolis, E ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

HIV 1; SDF 1 ; Structure; vMIP II

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHEMOKINE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; MACROPHAGE INFLAMMATORY PROTEIN 2; PROTEINASE INHIBITOR; RECEPTOR BLOCKING AGENT; RNA DIRECTED DNA POLYMERASE INHIBITOR; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DRUG BINDING SITE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURFACE PROPERTY; VIRUS CELL INTERACTION; VIRUS INHIBITION;

CHEMOKINES; HIV-1; MEMBRANE FUSION; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

HERPESVIRIDAE; HERPESVIRUS 8; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0034815010     PISSN: 13502816     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (44)

1. Blockade of chemokine activity by a soluble chemokine binding protein from vaccinia virus
2. Homozygous delta 32 deletion of the CCR-5 chemokine receptor gene in an HIV-1-infected patient
3. A new class of membrane-bound chemokine with a CX3C motif
4. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
5. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines
6. In vivo inhibition of CC and CX3C chemokine-induced leukocyte infiltration and attenuation of glomerulonephritis in Wistar-Kyoto (WKY) rats by vMIP-II
7. A hot spot of binding energy in a hormone-receptor interface
8. Structure-activity relationships of chemokines
9. Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities
10. Change in coreceptor use coreceptor use correlates with disease progression in HIV-1-infected individuals
11. Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1
12. Human growth hormone and extracellular domain of its receptor crystal structure of the complex
13. Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 'fusin' coreceptor
14. AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor
15. Current evidence and future directions for targeting HIV entry: Therapeutic and prophylactic strategies
16. The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8
17. HIV-1 entry cofactor functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
18. Comparison of the structure of vMIP-II with eotaxin-1, RANTES, and MCP-3 suggests a unique mechanism for CCR3 activation
19. Scanning mutagenesis of interleukin-8 identifies a cluster of residues required for receptor binding
20. Enveloped viruses: A common mode of membrane fusion?
21. Functional and receptor binding characterization of recombinant murine macrophage inflammatory protein 2: Sequence analysis and mutagenesis identify receptor binding epitopes
22. Lymphotactin: A cytokine that represents a new class of chemokine
23. A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus
24. Divergent patterns of progression to AIDS after infection from the same source: Human immunodeficiency virus type 1 evolution and antiviral responses
25. Dynamics study on the anti-human immunodeficiency virus chemokine viral macrophage-inflammatory protein-II (VMIP-II) reveals a fully monomeric protein
26. Chemokines and chemokine receptors: Biology and clinical relevance in inflammation and AIDS
27. N-terminal peptides of stromal cell-derived factor-1 with CXC chemokine receptor 4 agonist and antagonist activities
28. The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1alpha receptor, confers chemokine selectivity. Evidence for a two-step mechanism for MCP-1 receptor activation
29. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV
30. A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection
31. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
32. Crystal structure of rhodopsin: A G protein-coupled receptor
33. Current approaches to treatment for HIV-1 infection
34. Protein design of an HIV-1 entry inhibitor
35. T-tropic human immunodeficiency virus type 1 (HIV-1)-derived V3 loop peptides directly bind to CXCR-4 and inhibit T-tropic HIV-1 infection
36. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
37. Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPRS/XCR1
38. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist
39. The viral chemokine macrophage inflammatory protein-II is a selective Th2 chemoattractant
40. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
41. Chemokines: Understanding their role in T-lymphocyte biology
42. A novel peptide antagonist of CXCR4 derived from the N-terminus of viral chemokine vMIP-II
43. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development