Functional and receptor binding characterization of recombinant murine macrophage inflammatory protein 2: Sequence analysis and mutagenesis identify receptor binding epitopes

Protein Science

Volumn 6, Issue 8, 1997, Pages 1643-1652

  Jerva, L Fred ^a   Sullivan, Gail ^b   Lolis, Elias ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Chemokine; MIP 2; Mutagenesis; Receptor binding site

Indexed keywords

CHEMOKINE; INTERLEUKIN 8; INTERLEUKIN 8 RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 2;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CIRCULAR DICHROISM; CONTROLLED STUDY; DISSOCIATION CONSTANT; HUMAN; HUMAN CELL; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALIA; MURINAE; PICHIA PASTORIS;

EID: 0030816246     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560060805     Document Type: Article

References (58)

1. Ahuja SK, Lee JC, Murphy PM. 1996. CXC chemokines hind to unique sets of selectivity determinants that can function independently and are broadly distributed on multiple domains of human interleukin-8 receptor B. J Biol Chem 271:225-212.
2. Baron EJ, Proctor RA. 1982. Elicitation of peritoneal polymorphonuclear neutrophils from mice. J Immunol Methods 49:305-313.
3. Bleul C, Farzan M, Choc H, Parolin C, Clark-Lewis I, Sodroski J, Springer T. 1996. The lymphocyte chemoaltractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382:829-833.
4. Bozic CR, Gerard NP, Gerard C. 1996. Receptor binding specificity and pulmonary gene expression of the neutrophil-activating peptide ENA-78. Am J Respir Cell Mol Biol 14:302-308.
5. Bozic CR, Gerard NP, von Uexkull-Guldenband C, Kolakowski LF, Conklyn MJ, Breslow R, Showell HJ, Gerard C. 1994. The murine interleukin-8 type B receptor homologue and its ligands. Expression and biological characterization. J Biol Chem 269:29355-29358
6. Bozic CR, Kolakowski LF Jr, Gerard NP, Garcia-Rodriguez C, von Uexkull-Guldenband C, Conklyn MJ, Breslow R, Showell HJ, Gerard C. 1995. Expression and biologic characterization of the murine chemokine KC. J Immunol 154:6049-6057.
7. Broxmeyer HE, Sherry B, Lu L, Cooper S, Oh KO, Tekamp-Olson P, Kwon BS, Cerami A. 1990. Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells. Blood 76:1110-1116.
8. Cerretti D, Kozlosky C, Bos T, Nelson N, Gearing D, Beckmann M. 1993. Molecular characterization of receptors for human interleukin-8, gro/ melanoma growth-stimulatory activity and neutrophil activating peptide-2. Mol Immunol 30:359-367.
9. Charro IF, Myers SJ, Herman A, Franci C, Connolly AJ, Coughlin SR. 1994. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci USA 97:2752-2756.
10. Chaudhuri A, Zberzezna V, Polyakova J, Pogo AO, Jesselgesser J, Horuk R. 1994. Expression of the Duffy antigen in K562 cells. Evidence that it is the human erythrocyte chemokine receptor. J Biol Chem 269:7835-7838.
11. Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath P, Wu L, Mackay C, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J. 1996. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85:1135-1148.
12. Clackson T, Wells JA. 1995. A hot spot of binding energy in a hormone-receptor interface. Science 267:383-386.
13. Clark-Lewis I, Dewald B, Loetscher M, Moser B. 1994. Structural requirements for interleukin-8 function identified by design of analogs and CXC chemokine hybrids. J Biol Chem 269:16075-16081.
14. Clark-Lewis I, Schumacher C, Baggiolini M, Moser B. 1991. Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. J Biol Chem 266:23128-23134.
15. Clark-Lewis IA, Dewald B, Geiser T, Moser B, Baggiolini M. 1993. Platelet factor 4 binds to interleukin-8 receptors and activates neutrophils when its N-terminus is modified with Glu-Leu-Arg. Proc Natl Acad Sci USA 90:3574-3577.
16. Clore MG, Appella E, Yamada M, Matsushima K, Gronenborn A. 1990. Three dimensional structure of interleukin 8 in solution. Biochemistry 24:1689-1696.
17. Clubb RT, Omichinski JG, Clore GM, Gronenborn AM. 1994. Mapping the binding surface of interleukin-8 complexes with an N-terminal fragment of the type 1 human interleukin-8 receptor. FEBS Lett 338:91-91.
18. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. 1995. Identification of RANTES, MIP-1α and MIP-1β as the major HIV-suppressive factors produced by CD8+ T cells. Science 270:1811-1815.
19. Combadiere C, Ahuja SK, Murphy PM. 1995. Cloning and functional expression of a human eosinophil chemokine receptor. J Biol Chem 270:16491-16494.
20. Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton R, Hill C, Davis C, Peiper S, Schall T, Littman D, Landau N. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661-666.
21. Devereux J, Haeberli P, Smithies O. 1984. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res 12:387-395.
22. Fairbrother WJ, Reilly D, Colby TJ, Hesselgesser J, Horuk R. 1994. The solution structure of melanoma growth stimulating activity. J Mol Biol 242:252-270.
23. Feng L, Xia Y, Yoshimura T, Wilson CB. 1995. Modulation of neutrophil influx in glomerulonephritis in the rat with anti-macrophage inflammatory protein-2 (MIP-2) antibody. J Clin Inv 95:1009-1017.
24. Feng Y, Broder C, Kennedy P, Berger E. 1996. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane. G protein-coupled receptor. Science 272:872-877.
25. Frevert CW, Farone A, Danaee H, Paulauskis JD, Kobzik L. 1995. Functional characterization of rat chemokine macrophage inflammatory protein-2. Inflammation 19:133-142.
26. Gao JL, Murphy PM. 1995. Cloning and differential tissue-specific expression of three mouse β chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 at receptor. J Biol Chem 270:17494-17501.
27. Gayle R, Sleath P, Srinivason S, Birks C, Weerawama K, Ceretti D, Kozlosky C, Nelson N, Bos T, Beckmann M. 1993. Importance of the amino terminus of the interleukin-8 receptor in ligand interactions. J Biol Chem 265:7283-7289.
28. Geiser T, Dewald B, Ehrengruber MU, Clark-Lewis I, Baggiolini M. 1993. The interleukin-8-related chemotactic cytokines gro-α, gro-β, and gro-γ activate neutrophil and basophil leukocytes. J Biol Chem 268:15419-15424.
29. Hammond MEW, Shymala V, Siani MA, Gallegos CA, Feucht PH, Abbott J, Lapointe GR, Moghadam M, Khoja J, Zakel J, Tekamp-Olson P. 1996. Receptor recognition and specificity of interleukin-8 is determined by residues that cluster near a surface-accessible hydrophobic pocket. J Biol Chem 271:8228-8235.
30. Hebert CA, Vitangcol RV, Baker JB. 1991. Scanning mutagenesis of interleukin-8 identifies a cluster of residues required for receptor binding. J Biol Chem 266:18989-18994.
31. Hesselgesser J, Chitnis CE, Miller LH, Yansura DG, Simmons LC, Fairbrother WJ, Kotts C, Wirth C, Gillece-Castro BL, Horuk, R. 1995. A mutant of melanoma growth stimulating activity does not activate neutrophils but blocks erythrocyte invasion by malaria. J Biol Chem 270:11472-11476.
32. Holmes WH, Lee J, Kuang WJ, Rice GC, Wood WI. 1991. Structure and functional expression of a human interleukin-8 receptor. Science 255:1278-1280.
33. Hoogewerf A, Black D, Proudfoot AE, Wells TN, Power CA. 1996. Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4. Biochem Biophys Res Commun 218:331-343.
34. Kasama T, Streiter R, Lukacs N, Lincoln P, Burdick M, Kunkel S. 1995. Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J Clin Inv 95:2868-2876.
35. Lee J, Cacalano G, Camerato T, Koy K, Moore MW, Wood WI. 1995. Chemokine binding and activities mediated by the mouse IL-8 receptor. J Immunol 155:2158-2164.
36. Lee J, Horuk R, Rice G, Bennett G, Camerato T, Wood W. 1992. Characterization of two high affinity human interleukin-8 receptors. J Biol Chem 267:16283-16287.
37. Lodi P, Garrett D, Kuszewski J, Tsang M, Weatherbeen J, Leonard W, Gronenborn A, Clore G. 1994. High-resolution solution structure of the β chemokine hMIP-1β by multidimensional NMR. Science 263:1762-1767.
38. Lolis E, Sweet RM, Cousens LS, Tekamp-Olson P, Sherry B, Cerami A. 1992. Preliminary crystallographic analysis of murine macrophage inflammatory protein 2. J Mol Biol 225:913-915.
39. Lowman HB, Slagle PH, DeForge LE, Wirth CM, Gillece-Castro BL, Bourell JH, Fairbrother WJ. 1996. Exchanging lnterleukin-8 and melanoma growth-stimulating activity receptor binding specificities. J Biol Chem 271:14344-7 14352.
40. Malkowski MG, Wu JY, Lazar JB, Johnson PH, Edwards BFP. 1995. The crystal structure of recombinant human neutrophil-activating peptide-2 (M6I) at 1.9 Å resolution. J Biol Chem 270:7088-7087.
41. Moser B, Schumacher C, von Tscharner V, Clark-Lewis I, Baggiolini M. 1991. Neutrophil-activating peptide 2 and gro/melanoma growth-stimulatory activity interact with neutrophil-activating peptide 1/interleukin 8 receptors on human neutrophils. J Biol Chem 266:10666-10671.
42. Munson P, Rodbard D. 1980. LIGAND: A versatile computerized approach for characterization of ligand-binding sites. Anal Biochem 107:220-239.
43. Murphy B, Tiffany HL. 1991. Cloning of complementary DNA encoding a functional interleukin-8 receptor. Science 253:1280-1283.
44. Murphy PM. 1994. The molecular biology of leukocyte chemoattractant receptors. Annu Rev Immunol 12:593-633.
45. Neote K, DiGregorio D, Mak J, Horuk R, Schall T. 1993. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell 72:415-425.
46. Oberlin E, Amara A, Bachelerie F, Bessia C, Virelizier JL, Arenzana-Seisdedos F, Schwartz O, Heard JM, Clark-Lewis I, Legler D, Loetscher M, Baggiolini M, Moser B. 1996. The CXC chemokine SDF-1 is the ligand for LESTR/ fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382:833-835.
47. Oppenheim JJ, Zachariae CO, Mukaida N, Matsushima K. 1991. Properties of the novel proinflammatory supergene "intercrine" cytokine family. Annu Rev Immunol 9:617-648.
48. Power CA, Meyer A, Nemeth K, Bacon KB, Hoogewerf AJ, Proudfoot AEI, Wells TNC. 1995. Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. J Biol Chem 270:19495-19500.
49. Rajarathnam K, Sykes BD, Kay CM, Dewald B, Geiser T, Baggiolini M, Clark-Lewis I. 1994. Neutrophil activation by monomeric interleukin-8. Science 264:90-92.
50. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular cloning: A laboratory manual, 2nd ed. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
51. Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M. 1996. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 35:3362-3367.
52. Scraufstatter IU, Ma M, Oades ZG, Barritt DS, Cochrane CG. 1995. The role of Tyr13 and Lys15 of interleukin-8 in the high affinity interaction with the interleukin-8 receptor type A. J Biol Chem 270:10428-10431.
53. Standiford TJ, Stricter RM, Lukacs NW, Kunkel SL. 1995. Neutralization of IL-10 increases lethality in endotoxemia: Cooperative effects of MIP-2 and TNF. J Immunol 155:2222-2229.
54. St. Charles R, Walz DA, Edwards BFP. 1989. The three-dimensional structure of bovine platelet factor 4 at 3.0 Å resolution. J Biol Chem 264:2092-2099.
55. Villanueva GB, Allen N, Walz D. 1988. Circular dichroism of platelet factor 4. Arch Biochem Biophys 261:170-174.
56. Walz A, Dewald B, von Tscharner V, Baggiolini M. 1989. Effects of the neutrophil-activating peptide NAP-2, platelet basic protein, connective tissue-activating peptide III and platelet factor 4 on human neutrophils. J Exp Med 170:1745-1750.
57. White CE, Kempi NM, Komives EA. 1994. Expression of highly disulfide-bonded proteins in Pichia pastoris. Structure 21:1003-1005.
58. Wolpe S, Sherry B, Juers D, Davatelis G, Yurt R, Cerami A. 1989. Identification and characterization of macrophage inflammatory protein 2. Proc Natl Acad Sci USA 86:612-616.