Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: A model of bisphosphonate-induced gastrointestinal toxicity

Bone

Volumn 29, Issue 4, 2001, Pages 336-343

  Suri, S ^a   Monkkonen J ^b   Taskinen, M ^b   Pesonen, J ^b   Blank, M A ^c   Phipps, R J ^c   Rogers, M J ^d  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Apoptosis; Bisphosphonate; Caco 2; Epithelium; Mevalonate; Prenylation

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CHOLESTEROL; CLODRONIC ACID; ETIDRONIC ACID; FARNESOL; GERANYLGERANIOL; MEVALONIC ACID; NITROGEN; OXIDIZED LOW DENSITY LIPOPROTEIN; PAMIDRONIC ACID; PROTEIN SUBUNIT; RAP PROTEIN; RISEDRONIC ACID; STEROL;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN CACO 2; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG INDUCED DISEASE; ESOPHAGUS ULCER; GASTROINTESTINAL TOXICITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE EPITHELIUM CELL; PRENYLATION; PROTEIN PROCESSING;

APOPTOSIS; CACO-2 CELLS; CELL DIVISION; CELL SURVIVAL; DIPHOSPHONATES; DITERPENES; EPITHELIAL CELLS; GASTROINTESTINAL DISEASES; HUMANS; IN SITU NICK-END LABELING; MEVALONIC ACID; NITROGEN COMPOUNDS; PROTEIN ISOPRENYLATION; RAP1 GTP-BINDING PROTEINS;

EID: 0034804940     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(01)00589-0     Document Type: Article

References (50)

1. Quercetin exerts a preferential cytotoxic effect on active dividing colon carcinoma HT29 and Caco-2 cells
2. Caco-2-monolayers in experimental and theoretical predictions of drug transport
3. Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: Biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs
4. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase
5. Nonclinical model for assessing gastric effects of bisphosphonates
6. Importance of the paracellular pathway for the transport of a new bisphosphonate using the human CACO-2 monolayers model
7. Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs
8. Protein geranylgeranylation is required for osteoclast formation, function, and survival: Inhibition by bisphosphonates and GGTI-298
9. Esophagitis associated with the use of alendronate
10. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates
11. Alendronate induces gastric injury and delays ulcer healing in rodents
12. Alendronate mechanism of action: Geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption and kinase activation in vitro
13. Pamidronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease
14. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice
15. Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5′-(β,γ-dichloromethylene) triphosphate, by mammalian cells in vitro
16. Induction of apoptosis in caco-2 cells by wheat gliadin peptides
17. Excess gastric ulcers are associated with alendronate therapy
18. Alendronate gastric ulcers
19. The effect of zoledronate and pamidronate on the intestinal permeability barrier in vitro and in vivo
20. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
21. Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo
22. Endoscopic comparison of esophageal and gastroduodenal effects of risedronate and alendronate in postmenopausal women
23. Effect of bisphosphonates on the surface hydrophobicity and phosphatidylcholine concentration of rodent gastric mucosa
24. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
25. Pamidronate: An unrecognized problem in gastrointestinal tolerability
26. Multiple ulcerative esophagitis caused by alendronate
27. Development of a minimum-calcium Caco-2 monolayer model: Calcium and magnesium ions retard the transport of pamidronate
28. Comparative study of potential for bisphosphonates to damage gastric mucosa of rats
29. An in vitro model for the analysis of intestinal brush border assembly. I. Ultrastructural analysis of cell contact-induced brush border assembly in Caco-2BBe cells
30. Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease
31. Apoptosis and gastrointestinal pharmacology
32. Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase
33. Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation
34. Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism
35. Cellular and molecular mechanisms of action of bisphosphonates
36. Bisphosphonates: From the laboratory to the clinic and back again
37. Cytotoxicity of absorption enhancers in Caco-2 cell monolayers
38. Apoptotic cell death in activated monocytes following incorporation of clodronate-liposomes
39. Protein-tyrosine phosphatase activity regulates osteoclast formation and function: Inhibition by alendronate
40. Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages
41. The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway
42. Bisphosphonates induce apoptosis in human myeloma cell lines: A novel anti-tumour activity
43. Cytotoxic effects of pamidronate on monolayers of human intestinal epithelial (Caco-2) cells and its epithelial transport
44. The effects of nitrogen-containing bisphosphonates on human epithelial (Caco-2) cells, an in vitro model for intestinal epithelium
45. The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates
46. Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates
47. Upper gastrointestinal adverse events and cyclical etidronate
48. N-bisphosphonates cause gastric epithelial injury independent of effects on the microcirculation
49. Cell death: The significance of apoptosis
50. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man