N-bisphosphonates cause gastric epithelial injury independent of effect on the microcirculation

Alimentary Pharmacology and Therapeutics

Volumn 13, Issue 12, 1999, Pages 1675-1682

  Wallace, J L ^a   Dicay, M ^a   McKnight, W ^a   Bastaki, S ^a   Blank, M A ^b  

^a UNIVERSITY OF CALGARY   (Canada)

^b PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; NITRIC OXIDE DONOR; PAMIDRONIC ACID; PROSTAGLANDIN E2;

ANIMAL TISSUE; ARTICLE; MALE; MICROCIRCULATION; NONHUMAN; POTENTIAL DIFFERENCE; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; RAT; STOMACH EPITHELIUM; STOMACH INJURY;

ADMINISTRATION, TOPICAL; ALENDRONATE; ANIMALS; DINOPROSTONE; DIPHOSPHONATES; DRUG INTERACTIONS; EPITHELIUM; MALE; MICROCIRCULATION; NEUTROPHIL INFILTRATION; NITRIC OXIDE; NITRIC OXIDE DONORS; RATS; RATS, WISTAR; STOMACH; TIME FACTORS;

EID: 0033458764     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1999.00658.x     Document Type: Article

References (30)

1. Jeal W, Barradell LB, McTavish D. Alendronate. A review of its pharmacological properties and therapeutic efficacy in postmenopausal osteoporosis. Drugs 1997; 53: 415-34.
2. Black DM, Cummings SR, Karpe DB, et al. Randomized trial of the effect of alendronate on risk of fracture in women with existing vertebral fractures. Lancet 1996; 348: 1535-41.
3. Coleman RK, Houston S, Purohit OP, Rubens RD, Kandra A, Ford J. A randomized phase II study of oral pamidronate for the treatment of bone metastases from breast cancer. Eur J Cancer 1998; 34: 820-4.
4. De Groen PC, Lubbe DF, Hirsch LJ, et al. Esophagitis associated with the use of alendronate. N Eng J Med 1996: 335: 1016-21.
5. Maconi G, Porro GB. Multiple ulcerative esophagitis caused by alendronate. Am J Gastroenterol 1995; 90: 1889-90.
6. Adami S, Mian M, Gatti P, et al. Effects of alendronate in the treatment of Paget's disease of bone. Bone 1994; 15; 415-7.
7. Lufkin EG, Argueta R, Whitaker MD, et al. An unrecognized problem in gastrointestinal tolerability. Osteoporos Int 1994; 4: 320-2.
8. Graham DY, Malaty HM, Goodgame R. Primary aminobisphosphonates: a new class of gastrotoxic drugs-comparison of alendronate and aspirin. Am J Gastroenterol 1997; 92: 1322-5.
9. Graham DY, Malaty HM. Alendronate gastric ulcers. Aliment Pharmacol Ther 1999; 13: 515-9.
10. Blank MA, Ems BL, Gibson GW, et al. Nonclinical model for assessing gastric effects of bisphophonates. Dig Dis Sci 1997; 42: 281-8.
11. Elliott SN, McKnight W, Davies NM, MacNaughton WK, Wallace JL. Alendronate induces gastric injury and delays ulcer healing in rodents. Life Sci 1998; 62: 77-91.
12. Geddes AD, D'Souza SM, Ebetino FH, et al. Structure-activity relationships and therapeutic implications. In: Heersche JNM, Kanis JA, eds. Bone and Mineral Research, Vol 8. Amsterdam: Elsevier Science, 1994: 265-306.
13. Terano A, Mach T, Stachura J, Tarnawski A, Ivey KJ. Effect of 16, 16 dimethyl prostaglandin E2 on aspirin induced damage to rat gastric epithelial cells in tissue culture. Gut 1984; 25: 19-25.
14. Morris GP, Wallace JL. The roles of ethanol and of acid in the production of gastric mucosal erosions in rats. Virchows Arch B 1981; 38: 23-38.
15. Pihan G, Majzoubi D, Haudenschild C, Trier JS, Szabo S. Early microcirculatory stasis in acute gastric mucosal injury in the rat and prevention by 16, 16-dimethyl prostaglandin E2 or sodium thiosulfate. Gastroenterology 1986; 91: 1415-26.
16. Wallace JL, Keenan CM, Granger DN. Gastric ulceration induced by non-steroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol 1990; 259: G462-7.
17. MacNaughton WK, Cirino G, Wallace JL. Endothelium-derived relaxing factor (nitric oxide) has protective action in the stomach. Life Sci 1989; 45: 1869-76.
18. Wallace JL, Morris GP, Krausse EJ, Greaves SE. Reduction of ethanol-induced gastric mucosal damage by cytoprotective agents: a correlated morphological and physiological study. Can J Physiol Pharmacol 1982; 60: 1686-99.
19. McGreevy JM. Gastric surface cell function: potential difference and mucosal barrier. Am J Physiol 1984; 247: 79-87.
20. Wallace JL, Whittle BJR. Role of mucus in the repair of gastric epithelial damage in the rat. Inhibition of epithelial recovery by mucolytic agents. Gastroenterology 1996; 91: 603-11.
21. Ferraz JGP, McKnight W, Sharkey KA, Wallace JL. Impaired vasodilatory responses in the gastric microcirculation of anesthetized rats with secondary biliary cirrhosis. Gastroenterology 1995: 108: 1183-91.
22. Ferraz JGP, Sharkey KA, Reuter BK, et al. Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: Role in resistance to damage. Gastroenterology 1997; 113: 195-204.
23. Wallace JL, McKnight W, Wilson TL, Del Soldato P, Cirino G. Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: role of neutrophils. Am J Physiol 1997; 273: G1246-51.
24. Kvietys PR, Twohig B, Danzell J, Specian RD. Ethanol-induced injury to the rat gastric mucosa. Role of neutrophils and xanthine oxidase-derived radicals. Gastroenterology 1990; 98: 909-20.
25. Asako H, Kubes P, Wallace JL, Wolf RE, Granger DN. Modulation of leukocyte adhesion in rat mesenteric venules by aspirin and salicylate. Gastroenterology 1992; 103: 146-52.
26. Robert A, Nezamis JE, Lancaster C, Davis JP, Field SO, Hanchar AJ. Mild irritants prevent gastric necrosis through 'adaptive cytoprotection' mediated by prostaglandins. Am J Physiol 1983; 245: G113-21.
27. Gretzer B, Ehrlich K, Maricic N, Lambrecht N, Respondek M, Peskar B. Selective cyclo-oxygenase-2 inhibitors and their influence on the protective effect of a mild irritant in the rat stomach. Br J Pharmacol 1998; 123: 927-35.
28. Castell DO. 'Pill esophagitis'-the case of alendronate. New Engl J Med 1996; 335: 1058-9.
29. Lichtenberger LM, Romero JJ, Blank MA. Effect of bisphosphonates (BPs) on the surface hydrophobicity and phosphatidylcholine (PC) concentration of the gastric mucosa. Gastroenterology 1999; 116: A237 (Abstract).
30. Lichtenberger LM. The hydrophobic barrier properties of gastrointestinal mucus. Annu Rev Physiol 1995; 57: 565-83.