Mechanisms of molecular recognition in the pikromycin polyketide synthase

Chemistry and Biology

Volumn 7, Issue 12, 2000, Pages 907-918

  Chen, Shuo ^a   Xue, Yongquan ^b   Sherman, David H ^b   Reynolds, Kevin A ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Molecular recognition; Pikromycin; Polyketide synthase; Streptomyces venezuelae

Indexed keywords

10 DEOXYMETHYNOLIDE; ACYL CARRIER PROTEIN; DIMERIZATION; ELONGATION FACTOR; HYBRID PROTEIN; LACTONE; METHYLMALONYL COENZYME A CARBOXYLTRANSFERASE; MOLECULAR RECOGNITION; MUTANT; PIKROMYCIN; POLYKETIDE SYNTHASE; PROTEIN DOMAIN; PROTEIN EXPRESSION; STREPTOMYCES VENEZUELAE; THIOL ESTER HYDROLASE;

ANTI-BACTERIAL AGENTS; DIMERIZATION; LACTONES; MACROLIDES; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECOMBINANT FUSION PROTEINS; STREPTOMYCES; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ILEX COOKII; STREPTOMYCES VENEZUELAE;

EID: 0034523044     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00039-9     Document Type: Article

References (25)

1. Manipulation of modular polyketide synthases
2. The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin
3. Modular organization of the genes required for complex polyketide biosynthesis
4. Harnessing the biosynthetic potential of modular polyketide synthases
5. Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthaseses
6. Multiple genetic modifications of the erythromycin potyketide synthase to produce a library of novel 'unnatural' natural products
7. Evidence for a double-helical structure for modular polyketide synthases
8. Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase
9. Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase
10. Biosynthesis of erythromcyin and rapamycin
11. A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezulae: Architecture of metabolic diversity
12. Alternative modular polyketide synthase expression controls macrolactone structure
13. Biosynthesis of desosamine: Construction of a new methymycin/neomethymycin analogue by deletion of a desosamine biosynthetic gene
14. Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase
15. Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of the enzymatic domains in the modular polyketide synthase
16. Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tu 1892.
17. Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives
18. Divergent structural motifs correlated with the substrate specificity of (methyl)malonyl-CoA: Acyl carrier protein transacylase domains in modular polyketide synthases
19. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units
20. Dissecting and exploiting intermodular communication in polyketide synthases
21. Engineered intermodular and intramodular polyketide synthase fusions
22. Ketolides-a novel form of macrolide: The way forward?
23. Transformation of Streptomyces erythraeus
24. Isolation and characterization of 10-deoxymethynolide produced by Streptomyces venezuelae
25. Isolation and structure of narbonolide, narbomycin aglycone, from Streptomyces venezuelae and its biological transformation into picomyccin via narbomycin