Selective estrogen receptor modulators and coronary heart disease

Trends in Cardiovascular Medicine

Volumn 11, Issue 5, 2001, Pages 196-202

  Bian, Zhao ^a   Nilsson, Stefan ^a   Gustafsson, Jan Åke ^a,b  

^a Karo Bio   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1,2 DIPHENYL 1 BUTENYL)CINNAMIC ACID; 4 [4 METHYL 2 [4 [2 (1 PIPERIDINYL)ETHOXY]PHENYL] 7 PIVALOYLOXY 2H 1 BENZOPYRAN 3 YLPHENYL] PIVALATE; ACOLBIFENE; ANTIESTROGEN; ANTIOXIDANT; CENTCHROMAN; DAIDZEIN; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; GENISTEIN; GW 7604; ISOFLAVONE DERIVATIVE; LASOFOXIFENE; NNC 45 0781; NNC 450781; NNC 46 0020; NNC 460020; OSPEMIFENE; PHYTOESTROGEN; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; UNCLASSIFIED DRUG;

BONE DENSITY; BREAST CARCINOMA; CANCER INCIDENCE; CARDIOVASCULAR RISK; CLINICAL TRIAL; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENDOMETRIUM TUMOR; HEART PROTECTION; HORMONAL THERAPY; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; META ANALYSIS; NONHUMAN; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; REVIEW; THROMBOEMBOLISM; TREATMENT OUTCOME; VEIN THROMBOSIS;

ANIMALS; CORONARY DISEASE; ESTROGENS; FEMALE; HUMANS; MALE; MOLECULAR STRUCTURE; POSTMENOPAUSE; PREMENOPAUSE; SELECTIVE ESTROGEN RECEPTOR MODULATORS;

EID: 0034773822     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(01)00102-5     Document Type: Review

References (75)

1. Effects of hormone replacement therapy on lipid peroxides and oxidation system in postmenopausal women
2. Meta-analysis of the effects of soy protein intake on serum lipids
3. Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I
4. Hypertension in women
5. Differential response of estrogen receptor α and estrogen receptor β to partial estrogen agonists/antagonists
6. Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain
7. Raloxifene inhibits aortic accumulation of cholesterol in ovariectomized, cholesterol-fed rabbits
8. Selective estrogen receptor modulators: An alternative to hormone replacement therapy
9. 17 Beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization
10. Coactivation and corepression in transcriptional regulation by steroid/nuclear hormone receptors
11. Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen
12. Identification of a splice variant of the rat estrogen receptor beta gene
13. Lack of effect of raloxifene on coronary artery atherosclerosis of postmenopausal monkeys
14. Estrogen hits the surface
15. Coronary heart disease risk factors in women
16. Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse
17. Both raloxifene and estrogen reduce major cardiovascular risk factors in healthy postmenopausal women: A 2-year, placebo-controlled study
18. Oestrogen receptors: An overview
19. Raloxifene acutely relaxes rabbit coronary arteries in vitro by an estrogen receptor-dependent and nitric oxide-dependent mechanism
20. Estradiol inhibition of arterial neointimal hyperplasia after balloon injury
21. Preventive cardiology
22. Coactivator peptides have a differential stabilizing effect on the binding of estrogens and antiestrogens with the estrogen receptor
23. Cardiac myocytes and fibroblasts contain functional estrogen receptors
24. Expression of oestrogen receptor alpha and beta in rat heart: Role of local oestrogen synthesis
25. The role of nitric oxide in coronary vascular effects of estrogen in postmenopausal women
26. Therapeutic potential of selective estrogen receptor modulators
27. Hormone replacement therapy with estradiol and risk of venous thromboembolism: A population-based case-control study
28. Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques
29. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women
30. Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice
31. Activation of transcription by estrogen receptor alpha and beta is cell type- and promoter-dependent
32. Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice
33. Human vascular smooth muscle cells contain functional estrogen receptor
34. A review of the clinical effects of phytoestrogens
35. Hormone replacement therapy
36. Estradiol accelerates functional endothelial recovery after arterial injury
37. Cloning of a novel receptor expressed in rat prostate and ovary
38. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
39. EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium
40. Increased expression of estrogen receptor-beta mRNA in male blood vessels after vascular injury
41. Upregulation of estrogen receptor-alpha expression in rabbit cardiac allograft
42. Estrogen receptor-alpha mRNA variants in murine and human tissues
43. Basic guide to the mechanisms of antiestrogen action
44. Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors alpha and beta
45. The protective effects of estrogen on the cardiovascular system
46. Estrogen receptor subtype-selective ligands: Asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11,12-tetrahydrochrysenes
47. Double-blind randomized placebo-controlled study of transdermal estrogen replacement therapy on hypertensive postmenopausal women
48. An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens
49. Protective effect of 17 beta-estradiol against the cytotoxicity of minimally oxidized LDL to cultured bovine aortic endothelial cells
50. Estrogen improves acetylcholine-induced but not metabolic vasodilation in biological males
51. Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha
52. Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells
53. Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and reproductive tissues in intact and ovariectomized rats
54. Conjugated estrogens acutely abolish abnormal cold-induced coronary vasoconstriction in male cardiac allografts
55. Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene
56. Estrogen and cardiovascular function after menopause
57. Hormone replacement therapy and cardiovascular disease
58. Body iron stores and the risk of coronary heart disease
59. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
60. Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study
61. Premature coronary artery disease associated with a disruptive mutation in the estrogen receptor gene in a man
62. Clinical review 110: Cardiovascular actions of estrogens in men
63. Estrogen inhibits the response-to-injury in a mouse carotid artery model
64. Hormone replacement therapy in postmenopausal women with essential hypertension increases circulating plasma levels of bradykinin
65. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta
66. Hormone replacement therapy reduces mean 24-hour blood pressure and its variability in postmenopausal women with treated hypertension
67. EM-800, a novel antiestrogen, acts as a pure antagonist of the transcriptional functions of estrogen receptors α and β
68. Molecular mechanisms of action of steroid/thyroid receptor superfamily members
69. Ambulatory-not office - Blood pressures decline during hormone replacement therapy in healthy postmenopausal women
70. Mortality and morbidity in transsexual subjects treated with cross-sex hormones
71. 17Beta-estradiol acts separately on the LDL particle and artery wall to reduce LDL accumulation
72. Induction of calcium-dependent nitric oxide synthases by sex hormones
73. Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism
74. Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone