Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene [1]

Journal of Medicinal Chemistry

Volumn 41, Issue 16, 1998, Pages 2928-2931

  Rosati, R L ^a   Jardine, P D S ^a   Cameron, K O ^a   Thompson, D D ^a   Hua Zhu Ke, ^a   Toler, S M ^a   Brown, T A ^a   Pan, L C ^a   Ebbinghaus, C F ^a   Reinhold, A R ^a   Elliott, N C ^a   Newhouse, B N ^a   Tjoa, C M ^a   Sweetnam, P M ^a   Cole, M J ^a   Arriola, M W ^a   Gauthier, J W ^a   Crawford, D T ^a   Nickerson, D F ^a   Pirie, C M ^a   Qi, H ^a   Simmons, H A ^a   Tkalcevic, G T ^a   more..

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; CHOLESTEROL; DIARYLTETRAHYDRONAPHTHALENE DERIVATIVE; ESTRADIOL; ESTROGEN DERIVATIVE; ESTROGEN RECEPTOR; ETHINYLESTRADIOL; LASOFOXIFENE; NAFOXIDINE; NAPHTHALENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; BONE ATROPHY; BONE DENSITY; BONE MINERAL; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HYPERTROPHY; LETTER; MONKEY; NONHUMAN; ORAL DRUG ADMINISTRATION; OSTEOPOROSIS; OVARIECTOMY; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTILIPEMIC AGENTS; BIOLOGICAL AVAILABILITY; BONE DENSITY; BREAST NEOPLASMS; CELL DIVISION; CHOLESTEROL; ESTROGEN ANTAGONISTS; ETHINYL ESTRADIOL; FEMALE; HUMANS; NEOPLASMS, HORMONE-DEPENDENT; ORGAN SIZE; OVARIECTOMY; PYRROLIDINES; RATS; RECEPTORS, ESTROGEN; TETRAHYDRONAPHTHALENES; TUMOR CELLS, CULTURED; UTERUS;

EID: 0032581614     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980048b     Document Type: Letter

References (28)