The fitness effects of spontaneous mutations in Caenorhabditis elegans

Evolution

Volumn 54, Issue 4, 2000, Pages 1234-1246

  Vassilieva, Larissa L ^a,b   Hook, Aaron M ^a,b   Lynch, Michael ^a,b  

^a UNIVERSITY OF OREGON   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Caenorhabditis elegans; Deleterious mutation; Dominance; Fitness; Life history characters; Mutation load; Mutation rate; Quantitative traits

Indexed keywords

EVOLUTIONARY BIOLOGY; FITNESS; GENETICS; MUTATION;

CAENORHABDITIS ELEGANS; NEMATODA;

EID: 0033831346     PISSN: 00143820     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0014-3820.2000.tb00557.x     Document Type: Article

References (48)

1. The viability of near-normal irradiated chromosomes
2. The selection-mutation-drift theory of synonymous codon usage
3. Inferences on genome-wide deleterious mutation rates in inbred populations of Drosophila and mice
4. Mutation-selection balance and the evolutionary advantage of sex and recombination
5. The population genetics of Drosophila transposable elements
6. Inbreeding depression and its evolutionary consequences
7. The high spontaneous mutation rate: Is it a health risk?
8. The mutation load in Drosophila
9. High frequency of cryptic deleterious mutations in Caenorhabditis elegans
10. Inbreeding depression and inferred deleterious mutation parameters in Daphnia
11. Spontaneous mutational genotype-environment interaction for fitness-related traits in Drosophila melanogaster
12. The preservation of duplicate genes by complementary, degenerative mutations
13. New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster
14. The rate and effects distribution of viability mutation in Drosophila: Minimum distance estimation
15. The mutation rate and the distribution of mutational effects of viability and fitness in Drosophila melanogaster
16. Male phenotype and mating efficiency in Caenorhabditis elegans
17. Sexual dimorphism and sex determination
18. The distribution of mutation effects on viability in Drosophila melanogaster
19. Nature of deleterious mutation load in Drosophila
20. Inference of genome wide mutation rates and distributions of mutation effects for fitness traits: A simulation study
21. Genomic mutation rates for lifetime reproductive output and lifespan in Caenorhabditis elegans
22. EMS-induced polygenic mutation rates for nine quantitative characters in Drosophila melanogaster
23. Deleterious mutations and the evolution of sexual reproduction
24. Contamination of the genome by very slightly deleterious mutations: Why have we not died 100 times over?
25. Genotype-environment interactions and the estimation of the genomic mutation rate in Drosophila melanogaster
26. The evolution of self-fertilization and inbreeding depression in plants. I. Genetic models
27. Basic cultural methods
28. Spontaneous mutations for life-history characters in an obligate parthenogen
29. Design and analysis of experiments on random drift and inbreeding depression
30. Deleterious mutation accumulation in organelle genomes
31. Mutational meltdowns in sexual populations
32. Mutation, selection, and the maintenance of life-history variation in a natural population
33. Spontaneous deleterious mutation
34. Estimation of response to selection and utilization of control populations for additional information and accuracy
35. The genetic structure of a natural population of Drosophila melanogaster. I. Spontaneous mutation rate of polygenes controlling viability
36. The genetic structure of natural populations of Drosophila melanogaster. VII. Synergistic interaction of spontaneous mutant polygenes controlling viability
37. The genetic structure of natural populations of Drosophila melanogaster. III. Dominance effect of spontaneous mutant polygenes controlling viability in heterozygous genetic backgrounds
38. Mutation rate and dominance of genes affecting viability in Drosophila melanogaster
39. Our load of mutations
40. The genomic rate of transposable element movement in Drosophila melanogaster
41. Positive association between copia transposition rate and copy number in Drosophila melanogaster
42. Spontaneous and ethyl methane-sulfonate induced mutations controlling viability in Drosophila melanogaster. III. Heterozygous effect of polygenic mutations
43. The nearly neutral theory of molecular evolution
44. Degeneration of a nonrecombining chromosome
45. Deleterious mutation and extinction: Effects of variable mutational effects, synergistic epistasis, beneficial mutations, and degree of outcrossing
46. Rapid decline of fitness in panmictic populations of Drosophila melanogaster maintained under relaxed natural selection
47. The rate of spontaneous mutation for life-history traits in Caenorhabditis elegans