Estimation of deleterious-mutation parameters in natural populations

Genetics

Volumn 144, Issue 1, 1996, Pages 349-360

  Deng, Hong Wen ^a,b   Lynch, Michael ^a  

^a UNIVERSITY OF OREGON   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREEDING; COMPUTER SIMULATION; EVOLUTION; GENETIC VARIABILITY; MATHEMATICAL ANALYSIS; MUTATION; PHYLOGENY; POPULATION GENETICS; PRIORITY JOURNAL;

GENE DELETION; MATHEMATICAL COMPUTING; MODELS, GENETIC;

EID: 0029744512     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. BARTON, N. H. 1990 Pleiotropic models of quantitative variation. Genetics 124: 773-782.
2. BURGER, R., and J. HOFBAUER, 1994 Mutation load and quantitative genetic traits. J. Math. Biol. 32: 193-218.
3. CABALLERO, A., and P. D. KEIGHTLEY, 1994 A pleiotropic nonadditive model of variation in quantitative traits. Genetics 138: 883-900.
4. CHARLESWORTH, B., D. CHARLESWORTH and M. T. MORGAN, 1990 Genetic loads and estimates of mutation rates in highly inbred plant populations. Nature 347: 380-382.
5. CHARLESWORTH, D., M. T. MORGAN, and B. CHARLESWORTH, 1992 The effect of linkage and population size on inbreeding depres- sion due to mutational load. Genet. Res. 59: 49-61.
6. CHARLESWORTH, D., M. T. MORGAN, and B. CHARLESWORTH, 1993 Mutation accumulation in finite outbreeding and inbreeding populations. Genet. Res. 61: 39-56.
7. CHARLESWORTH, D., E. E. LYONS, and L. B. LITCHFIELD, 1994 Inbreeding depression in two highly inbreeding populations of Leavenworthia. Proc. Royal Soc. Lond. B. Biol. Sci. 258: 209-214.
8. COMSTOCK; R. E., and H. F. ROBINSON, 1948 The components of genetic variance in populations of biparental progenies and their use in estimating the average degree of dominance. Biometrics 4: 254-266.
9. CROW, J. F., and M. KIMURA, 1970 An Introduction to Population Genetics Theory. Harper and Row, New York.
10. CROW, J. F., and M. J. SIMMONS, 1983 The mutation load in Droiophila, pp. 1-35 in The Genetics and Biology of Drosophila, Vol. 3c, edited by M. ASHBURNER, H. L. CARSON, and J. N. THOMPSON, JR. Academic Press, New York.
11. GREGORY, W. C., 1965 Mutation frequency, magnitude of change and the probability of improvement in adaptation. Radiat. Bot. 5 (Suppl.): 429-441.
12. HALDANE, J. B. S., 1937 The effect of variation on fitness. Am. Nat. 71: 337-349.
13. HAYMAN, B. I., 1954 The theory and analysis of diallel crosses. Genetics 39: 789-809.
14. HOULE, D. 1989 Allozyme-associated heterosis in Drosophila melanogaster. Genetics 123: 789-801.
15. HOULE, D. 1994 Adaptive distance and the genetic basis of heterosis. Evolution 48: 1410-1417.
16. HOULE, D., D. K. HOFFMASTER, S. ASSIMACOPOULOS, and B. CHARLESWORTH, 1992 The genomic mutation rate for fitness in Drosophila. Nature 359: 58-60.
17. HOULE, D., B. MORIKAWA, and M. LYNCH, 1996 Comparing mutational variabilities. Genetics 143: 1467-1483.
18. JOHNSTON, M. O., and D.J. SCHOEN, 1995 Mutation rates and dominance levels of genes affecting total fitness in two angiosperm species. Science 267: 226-229.
19. KACSER, H., and J. A. BURNS, 1981 The molecular basis of dominance. Genetics 97: 639-666.
20. KEIGHTLEY, P. D., 1994 The distribution of mutation effects on viability in Drosophila melanogaster. Genetics 138: 1315-1322.
21. KIMURA, M., T. MARUYAMA, andj. F. CROW, 1963 The mutation load in small populations. Genetics 48: 1303-1312.
22. KONDRASHOV, A. S., 1988 Deleterious mutations and the evolution of sexual reproduction. Nature 334: 435-440.
23. KONDRASHOV, A. S., 1995 Contamination of the genome by very slightly deleterious mutations: why have we not died 100 times over? J. Theor. Biol. 175: 583-594.
24. LANDE, R., 1994 Risk of population extinction from new deleterious mutations. Evolution 48: 1460-1469.
25. LYNCH, M., 1985 Spontaneous mutations for life history characters in an obligate parthenogen. Evolution 39: 804-818.
26. LYNCH, M., 1994 Neutral models of phenotypic evolution, pp. 86-108 in Ecological Genetics, edited by L. REAL. Princeton University Press, Princeton, NJ.
27. LYNCH, M., and W. G. HILL, 1986 Phenotypic evolution by neutral mutation. Evolution 40: 915-935.
28. LYNCH, M., R. BÜRGER, D. BUTCHER, and W. GABRIEL, 1993 The mutational meltdown in asexual populations. J. Hered. 84: 339-344.
29. LYNCH, M., J. CONERY, and R. BÜRGER, 1995a Mutational meltdowns in sexual populations. Evolution 49: 1067-1080.
30. LYNCH, M., J. CONERY, and R. BÜRGER, 1995b Mutation accumulation and the extinction of small populations. Am. Nat. 146: 489-518.
31. MACKAY, T. F. C., R. F. LYMAN, and M. S. JACKSON, 1992 Effects of P element insertions on quantitative traits in Drosophila melanogaster. Genetics 130: 315-332.
32. MORTON, N. E., J. F. CROW, and H.J. MULLER, 1956 An estimate of the mutational damage in man from data on consanguineous marriages. Proc. Natl. Acad. Sci. USA 42: 855-863.
33. MUKAI, T., 1979 Polygenic mutations, pp. 177-196 in Quantitative Genetic Variation, edited by J. N. THOMPSON, JR., and J. M. THODAY. Academic Press, New York.
34. MUKAI, T., S. I. CHIGUSA, L. E. METTLER, and J. F. CROW, 1972 Mutation rate and dominance of genes affecting viability in Drosophila melanogaster. Genetics 72: 335-355.
35. PAMILO, P., M. NEI, and W.-H. LI, 1987 Accumulation of mutations in sexual and asexual populations. Genet. Res. 49: 135-146.