Membrane-type-2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases

European Journal of Biochemistry

Volumn 244, Issue 2, 1997, Pages 653-657

  Butler, Georgina S ^a   Will, Horst ^b   Atkinson, Susan J ^a   Murphy, Gillian ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b InViTek GmbH   (Germany)

Author keywords

Activation; Metalloproteinase; Progelatinase A; Tissue inhibitor of metalloproteinase

Indexed keywords

ENZYME PRECURSOR; GELATINASE A; TISSUE INHIBITOR OF METALLOPROTEINASE;

ARTICLE; ENZYME ACTIVATION; HUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PROCESSING;

EID: 0031039965     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.t01-1-00653.x     Document Type: Article

References (23)

1. Overall, C. M. & Sodek, J. (1990) Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases, J. Biol. Chem. 265, 21141-21151.
2. Ward, R. V., Slocombe, P. M., Atkinson, S. J., Docherty, A. J. P., Reynolds, J. J. & Murphy, G. (1991) Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes, Biochim. Biophys. Acta 1079, 242-246.
3. Strongin, A. Y., Marmer, B. L., Grant, G. A. & Goldberg, G. I. (1993) Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2, J. Biol. Chem. 268, 14033-14039.
4. Brown, P. D., Kleiner, D. E., Unsworth, E. J. & Stetler-Stevenson, W. G. (1993) Cellular activation of the 72 kDa type IV procollagenase/TIMP-2 complex, Kidney Int. 43, 163-170.
5. Murphy, G., Willenbrock, F., Ward, R. V., Cockett, M. I., Eaton, D. & Docherty, A. J. P. (1992) The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases, Biochem. J. 283, 637-641.
6. Ward, R. V., Atkinson, S. J., Reynolds, J. J. & Murphy, G. (1994) Cell surface-mediated activation of progelatinase A: demonstration of the involvement of the C-terminal domain of progelatinase A in cell surface binding and activation of progelatinase A by primary fibroblasts, Biochem. J. 304, 263-269.
7. Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E. & Seiki, M. (1994) A matrix metalloproteinase expressed on the surface of invasive tumour cells, Nature 370, 61-65.
8. Atkinson, S. J., Crabbe, T., Cowell, S., Ward, R. V., Butler, M. J., Sato, H., Seiki, M., Reynolds, J. J. & Murphy, G. (1995) Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membranes, J. Biol. Chem. 270, 30479-30485.
9. Will, H. & Hinzmann, B. (1995) cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment, Eur. J. Biochem. 231, 602-608.
10. Takino, T., Sato, H., Shinagawa, A. & Seiki, M. (1995) Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library - MT-MMPs form a unique membrane-type subclass in the MMP family, J. Biol. Chem. 270, 23013-23020.
11. Puente, X. S., Pendás, A. M., Llano, E., Velasco, G. & López-Otín, C. (1996) Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma, Cancer Res. 56, 944-949.
12. Crabbe, T., Zucker, S., Cockett, M. I., Willenbrock, F., Tickle, S., O'Connell, J. P., Scothern, J. M., Murphy, G. & Docherty, A. J. P. (1994) Mutation of the active site glutamic acid of human gelatinase A: effects on latency, catalysis, and the binding of tissue inhibitor of metalloproteinases-1, Biochemistry 33, 6684-6690.
13. Murphy, G., Houbrechts, A., Cockett, M. I., Williamson, R. A., O'Shea, M. & Docherty, A. J. P. (1991) The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity, Biochemistry 30, 8097-8102.
14. Willenbrock, F., Crabbe, T., Slocombe, P. M., Sutton, C. W., Docherty, A. J. P., Cockett, M. I., O'Shea, M., Brocklehurst, K., Phillips, I. R. & Murphy, G. (1993) The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A, Biochemistry 32, 4330-4337.
15. Apte, S. S., Olsen, B. R. & Murphy, G. (1995) The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family, J. Biol. Chem. 270, 14313-14318.
16. Will, H., Atkinson, S. J., Butler, G. S., Smith, B. & Murphy, G. (1996) The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation - Regulation by TIMP-2 and TIMP-3, J. Biol. Chem. 271, 17119-17123.
17. Murphy, G. & Willenbrock, F. (1995) Tissue inhibitors of matrix metalloendopeptidases, Methods Enzymol. 248, 496-510.
18. Moore, W. M., Spilburg, C. A., Hirsch, S. K., Evans, C. L., Wester, W. N. & Martin, R. A. (1986) Purification of human collagenases with a hydroxamic acid affinity column, Biochemistry 25, 5189-5195.
19. Pei, D. Q. & Weiss, S. J. (1996) Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity, J. Biol. Chem. 271, 9135-9140.
20. Lohi, J., Lehti, K., Westermarck, J., Kähäri, V. M. & Keski-Oja, J. (1996) Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate, Eur. J. Biochem. 239, 239-247.
21. Strongin, A. Y., Collier, I., Bannikov, G., Marmer, B. L., Grant, G. A. & Goldberg, G. I. (1995) Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease, J. Biol. Chem. 270, 5331-5338.
22. Imai, K., Ohuchi, E., Aoki, T., Nomura, H., Fujii, Y., Sato, H., Seiki, M. & Okada, Y. (1996) Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2, Cancer Res. 56, 2707-2710.
23. Turck, J., Pollock, A. S., Lee, L. L., Marti, H-P. & Lovett, D. H. (1996) Matrix metalloproteinase 2 (gelatinase A) regulates glomerular mesangial cell proliferation and differentiation, J. Biol. Chem. 271, 15074-15083.