The cytoplasmic carboxy-terminal amino acid determines the subcellular localization of proTGF-α and membrane type matrix metalloprotease (MT1-MMP)

Journal of Cell Science

Volumn 112, Issue 6, 1999, Pages 773-784

  Ureña, Jesús M ^a   Merlos Suárez, Anna ^a   Baselga, José ^a   Arribas, Joaquín ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

ER retention; MT1 MMP; Protein sorting; Protein trafficking; ProTGF

Indexed keywords

CYTOPLASM PROTEIN; MATRIX METALLOPROTEINASE; PROTEIN KINASE C; PROTEIN PRECURSOR; TRANSFORMING GROWTH FACTOR ALPHA; VALINE;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CELLULAR DISTRIBUTION; CYTOPLASM; ENDOPLASMIC RETICULUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CYTOPLASM; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; PROTEIN PRECURSORS; PROTEOGLYCANS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT PROTEINS; TRANSFECTION; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 0032921863     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Arribas, J., Coodly, L., Vollmer, P., Kishimoto, T. K., Rose-john, S. and Massagué, J. (1996). Diverse cell surface protein eclodomains are shed by a system sensitive to metalloprotease inhibitors. J. Biol. Chem. 271, 11376-11382.
2. Arribas, J. and Massagué, J. (1995). Transforming growth factor alpha and beta amyloid precursor protein share a secretory mechanism. J. Cell Biol. 128, 433-441.
3. Arribas, J., López-Casillas, F. and Massagué, J. (1997) Role of the juxtamembrane domains of the transforming growth factor-α precursor and the β-amyloid precursor protein in regulated ectodomain shedding. J. Biol. Chem. 272, 17160-17165.
4. Birkedal-Hansen, H. (1995). Proteolytic remodeling of extracellular matrix. Curr. Opin. Cell. Biol. 7, 728-735.
5. Bosenberg, M. W., Pandiella, A. and Massagué, J. (1992). The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGF-α into soluble growth factor. Cell 71, 1157-1165.
6. Brachmann, R., Lindquist, P. B., Nagashima, M., Kohr, W., Lipari, T., Napier, N. and Derynck, R. (1989). Transmembrane TGF-α precursors activate EGF/TGF-α receptors. Cell 56, 691-700.
7. Briley, G. P., Hissong, M. A., Chiu, M. L. and Lee, D. C. (1997). The carboxyl-terminal residues of proTGF-a are required for its efficient maturation and intracellular routing. Mol. Biol. Cell 8, 1619-1631.
8. Bringman, T. S., Lindquist, P. B. and Derynck, R. (1987). Different transforming growth factor-α species are derived from a glycosylated and palmitoylated transmembrane precursor. Cell 48, 429-440.
9. Dempsey, P. J. and Coffey, R. J. (1994). Basolateral targeting and efficient consumption of transforming growth factor-α when expressed in MadinDarby canine kidney cells. J. Biol. Chem. 269, 7131-7136.
10. Derynck, R., Roberts, A. B., Winkler, M. E., Chen, E. Y. and Goeddel, D. V. (1984). Human transforming growth factor-α: precursor structure and expression in E. coli. Cell 38, 287-297.
11. Hammond, C. and Helenius, A. (1995). Quality control in the secretory pathway. Curr. Opin. Cell Biol. 7, 523-529.
12. Heffernan, M. and Dennis, J. W. (1991). Polyoma and hamster papovavirus large T antigen-mediated replication of expression shuttle vectors in Chinese hamster ovary cells. Nucl. Acids Res. 19, 85-92.
13. Lee, D. C., Rose, T. M., Webb, N. R. and Todaro, G. J. (1985). Cloning and sequence analysis of a cDNA for rat transforming growth factor-α. Nature 313, 489-491.
14. Lopez-Casillas, F., Cheifetz, S., Doody, J., Andres, J. L., Lane, W. S. and Massague, J. (1991). Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system. Cell 67, 785-795.
15. Marks, M. S., Woodruff, L., Ohno, H. and Bonifacino, J. S. (1996). Protein targeting by tyrosine-and di-leucine-based signals: evidence for disticnt saturable components. J. Cell Biol. 135, 341-354.
16. Meloche, S., Pages, G. and Poyssegur, J. (1992). Functional expression and growth factor activation of an epitope-tagged p44 mitogen activated protein kinase, p44mapk. Mol. Cell. Biol. 3, 63-71.
17. Okada, A., Bellocq, J. P., Rouyer, N., Chenard, M. P., Rio, M. C., Chambon, P. and Basset, P. (1995). Membrane-type matrix melalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc. Nat. Acad. Sci. USA 92, 2730-2734.
18. Pandiella, A. and Massagué, J. (1991). Cleavage of the membrane precursor for transforming growth factor a is a regulated process. Proc. Nat. Acad. Sci. USA 88, 1726-1730.
19. Pei, D. and Weiss, S. J. (1995). Furin-dependent intracellular activation of the human stromelysin-3 zymogen. Nature 375, 244-247.
20. Puente, X. S., Pendas, A. M., Llano, E., Velasco, G. and Lopez-Otin, C. (1996). Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. Cancer Res. 56, 944-949.
21. Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E. and Seiki, M. (1994). A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 370, 61-64.
22. Sato, H., Kinoshita, T., Takino, T., Nakayama, K. and Seiki, M. (1996). Activation of a recombinant membrane type I-matrix metalloproteinase (MTI-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2. FEBS Lett. 393, 101-104.
23. Schafer, W., Stroh, A., Berghofer, S., Seiler, J., Vey, M., Kruse, M. L., Kern, H. F., Klenk, H. D. and Garte, W. (1995). Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin. EMBO J. 14, 2424-2435.
24. Scott, G. K., Robles, R., Park, J. W., Montgomery, P. A., Daniel, J., Holmes, W. E., Lee, J., Keller, G. A., Li, W. L., Fendly, B. M., Wood, W. I., Shephard, H. M. and Benz, C. C. (1993). A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cells. Mol. Cell Biol. 13, 2247-2257.
25. Shum, L., Reeves, S. A., Kuo, A. C., Fromer, E. S. and Derynck, R. (1994). Association of the transmembranes TGF-α precursor with a protein kinase complex. J. Cell Biol. 125, 903-916.
26. Takino, T., Sato, H., Shinagawa, A. and Seiki, M. (1995). Identificaction of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. J. Biol. Chem. 270, 23013-23020.
27. Teixidó, J., Gilmore, R., Lee, D. C. and Massagué, J. (1987). Integral membrane glycoprotein properties of the prohormone pro-transforming growth factor-α. Nature 326, 883-885.
28. Will, B. and Hinzmann, B. (1995). cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment. Eur. J. Biochem. 231, 602-608.
29. Wong, S. T., Winchell, L. F., McCune, B. K., Earp, H. S., Teixidó, J., Massagué, J., Herman, B. and Lee, D. C. (1989). The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction. Cell 56, 495-506.