Down-regulation of p27Kip1 expression is required for development and function of T cells

Journal of Immunology

Volumn 166, Issue 1, 2001, Pages 304-312

  Tsukiyama, T ^a   Ishida, N ^a   Shirane, M ^a   Minamishima, Y A ^a   Hatakeyama, S ^a   Kitagawa, M ^a   Nakayama, K ^a   Nakayama, K I ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; PROTEIN P27; CDKN1B PROTEIN, MOUSE; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MICROTUBULE ASSOCIATED PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINEAGE; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GERMINAL CENTER; IMMUNOGLOBULIN PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE; THYMOCYTE; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL DIVISION; CROSS BREEDING; DBA MOUSE; DRUG ANTAGONISM; FEMALE; GENETICS; IMMUNOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; LYMPH NODE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; METABOLISM; MOUSE MUTANT; PATHOLOGY; SPLEEN; THYMUS;

ANIMALS; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; CROSSES, GENETIC; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; DOWN-REGULATION; FEMALE; LYMPH NODES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOPENIA; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, INBRED ICR; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND; TUMOR SUPPRESSOR PROTEINS;

EID: 0034746820     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.1.304     Document Type: Article

References (46)

1. Cancer cell cycles
2. Cyclins and cancer. II. Cyclin D and CDK inhibitors come of age
3. 1 phase progression: Cycling on cue
4. The retinoblastoma protein and cell cycle control
5. Retinoblastoma protein recruits histone deacetylase to repress transcription
6. 1 cyclin-dependent kinases
7. 1-phase progression
8. Cip/Kip cyclin-dependent kinase inhibitors: Brakes of the cell cycle engine during development
9. 1 cyclin-Cdk protein kinase activity, is related to p21
10. Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
11. Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
12. Kip1 for restriction point control of the fibroblast cell cycle
13. o state) in fibroblasts
14. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
15. Kip1 accumulation during the cell cycle
16. Kip1
17. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
18. Skp2 complex through phosphorylated Thr187 in p27
19. Kip1, polyploidy and centrosome overduplication
20. Kip1 by two mechanisms, ubiquitin-mediated degradation and proteolytic processing
21. Kip1 is instigated by Jab1
22. Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes
23. Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
24. Productive T-cell receptor β-chain gene rearrangement: Coincident regulation of cell cycle and clonality during development in vivo
25. Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
26. Kip1-deficient mice
27. Kip1
28. Disruption of thymocyte development and lympomagenesis induced by SV40 T-antigen
29. Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase
30. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
31. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2
32. In vivo function of an interleukin 2 receptor β chain (IL-2Rβ)/IL-4Rα cytokine receptor chimera potentiates allergic airway disease
33. -/- mice in the absence of TCR β chain expression
34. - thymocyte differentiation
35. RAG-1-deficient mice have no mature B and T lymphocytes
36. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
37. lck
38. Early αβ T cell development in the thymus of normal and genetically altered mice
39. 1 checkpoint control
40. KIP2 indicates a role in Beckwith-Wiedemann syndrome
41. Kip2 results in increased apoptosis and delayed differentiation during mouse development
42. Kip2, exhibit skeletal abnormalities and growth retardation
43. Role of different T cell receptors in the development of pre-T cells
44. Cell-fate decisions in early T cell development: Regulation by cytokine receptors and the pre-TCR
45. +) thymocytes in normal and genetically modified mice
46. 0 T cells