Maturation of vulnerability to excitotoxicity: Intracellular mechanisms in cultured postnatal hippocampal neurons

Developmental Brain Research

Volumn 124, Issue 1-2, 2000, Pages 101-116

  Marks, Jeremy D ^a   Bindokas, Vytautas P ^a   Zhang, Xiao Min ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Calcium; Electrophysiology; Hypoxia; Im munohistochemistry; Morphology; N methyl D aspartate; Necrosis; Oxygen; Postnatal

Indexed keywords

CALCIUM ION; N METHYL DEXTRO ASPARTIC ACID;

AGE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BRAIN MATURATION; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL MEMBRANE STEADY POTENTIAL; CELL STRUCTURE; CONTROLLED STUDY; HIPPOCAMPUS; MITOCHONDRIAL MEMBRANE; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL MARKERS; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; DRUG RESISTANCE; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; HOMEOSTASIS; INTRACELLULAR MEMBRANES; MEMBRANE POTENTIALS; MITOCHONDRIA; N-METHYLASPARTATE; NEURONS; NEUROTOXINS; OSMOLAR CONCENTRATION; OXYGEN; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0034736080     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(00)00096-1     Document Type: Article

References (73)

1. Developmental regulation of the recovery process following glutamate-induced calcium rise in rodent primary neuronal cultures
2. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
3. Stable maintenance of glutamate receptors and other synaptic components in long-term hippocampal slices
4. Changes in calcium uptake rate by rat cardiac mitochondria during postnatal development
5. Development of glutamate binding sites and their regulation by calcium in rat hippocampus
6. Survival and growth of hippocampal neurons in defined medium at low density: Advantages of a sandwich culture technique or low oxygen
7. Development of kainic acid and N-methyl-D-aspartic acid toxicity in organotypic hippocampal cultures
8. Mechanisms of neuronal damage in brain hypoxia/ischemia: Focus on the role of mitochondrial calcium accumulation
9. 2+ homeostasis
10. Glutamate receptor phenotypes in the auditory brainstem and mid-brain of the developing rat
11. Oxidative stress, mitochondrial function, and acute glutamate excitotoxicity in cultured cerebellar granule cells
12. 2+](i) increases and NMDA receptor mRNA levels
13. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death
14. The mitochondrial permeability transition pore and its role in cell death
15. Developmental plasticity of NR1 and NR2B subunit expression in the supraoptic nucleus of the rat hypothalamus
16. Developmental expression of parvalbumin mRNA in the cerebral cortex and hippocampus of the rat
17. NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex
18. Developmentally regulated gene expression of all eight metabotropic glutamate receptors in hypothalamic suprachiasmatic and arcuate nuclei - A PCR analysis
19. N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture
20. 2-Mercaptoethanol is a survival factor for olfactory, cortical and hippocampal neurons in short-term dissociated cell culture
21. 2+ indicators with greatly improved fluorescence properties
22. 2+ concentration increases in cultured rat forebrain neurons
23. Trifluoperazine and dibucaine-induced inhibition of glutamate-induced mitochondrial depolarization in rat cultured forebrain neurones
24. Ionized intracellular calcium concentration predicts excitotoxic neuronal death: Observations with low-affinity fluorescent calcium indicators
25. Neuronal free calcium measurement using BTC/AM, a low affinity calcium indicator
26. 2+-dependent collapse of mitochondrial membrane potential and ultrastructural alterations of mitochondria
27. Effects of 2-mercaptoethanol on survival and differentiation of fetal mouse brain neurons cultured in vitro
28. The postnatal development of AMPA receptor subunits in the basal ganglia of the rat
29. Developmental expression, subcellular localization, and tyrosine phosphorylation of NR2A and NR2B in the rat brain
30. N-methyl-D-aspartate excitotoxicity: Relationships among plasma membrane potential, Na(+)/Ca(2+) exchange, mitochondrial Ca(2+) overload, and cytoplasmic concentrations of Ca(2+), H(+), and K(+)
31. Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis
32. Use of ranks in one-criterion variance analysis
33. Age-dependent effects of glutamate toxicity in the hippocampus
34. Potentiometric membrane dyes
35. Development of a culture system for pure rat neurons: Advantages of a sandwich technique
36. Vulnerability of CA1 neurons to glutamate is developmentally regulated
37. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis
38. Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist
39. Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system
40. 2+ homeostasis
41. Functional change of NMDA receptors related to enhancement of susceptibility to neurotoxicity in the developing pontine nucleus
42. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
43. The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro
44. Dissociation of postnatal hippocampal neurons for short term culture
45. Mitochondria and neuronal glutamate excitotoxicity
46. Mitochondria and neuronal survival
47. Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: Evidence of the mitochondrial permeability transition
48. Neurochemical mechanisms in brain injury and treatment: A review
49. Is high extracellular glutamate the key to excitotoxicity in traumatic brain injury?
50. Visualization of NMDA receptor-induced mitochondrial calcium accumulation in striatal neurons
51. N-methyl-D-aspartate receptor proteins NR2A and NR2B are differentially distributed in the developing rat central nervous system as revealed by subunit-specific antibodies
52. Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons
53. Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum
54. Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity
55. Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives
56. A method for judging all contrasts in the analysis of variance
57. Mitochondrial dysfunction is a primary event in glutamate neurotoxicity
58. Glutamate-induced neuron death requires mitochondrial calcium uptake
59. High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations
60. Effect of glutamate receptor ligands on mitochondrial membrane potential in rat dissociated cerebellar cells
61. Transient increased density of NMDA binding sites in the developing rat hippocampus
62. Cytosolic calcium concentrations and cell death in vitro
63. Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
64. Developmental aspects of NMDA receptor function
65. Metabotropic glutamate receptor mGluR5 subcellular distribution and developmental expression in hypothalamus
66. Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones
67. 2+ in cerebral cortex neurons is transient in immature cells but permanent in mature cells
68. New concepts for drug therapy after stroke. Can we enhance recovery?
69. NMDA receptor heterogeneity during postnatal development of the rat brain: Differential expression of the NR2A, NR2B, and NR2C subunit proteins
70. Modulation of calcium efflux from cultured rat dorsal root ganglion neurons
71. Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure
72. Kainate resistant neurons in peripheral ganglia of the rat