메뉴 건너뛰기




Volumn 80, Issue 2, 1998, Pages 203-229

Mechanisms of neuronal damage in brain hypoxia/ischemia: Focus on the role of mitochondrial calcium accumulation

Author keywords

Apoptosis; Calcium; Ischemia; Mitochondria; Mitochondrial permeability transition; Neuron

Indexed keywords

CALCIUM; EXCITOTOXIN; GLUTAMATE RECEPTOR; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 0031770414     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(98)00029-1     Document Type: Review
Times cited : (114)

References (280)
  • 1
    • 0030957787 scopus 로고    scopus 로고
    • Mechanisms and effects of intracellular calcium buffering on neuronal survival in organotypic hippocampal cultures exposed to anoxia/aglycemia or to excitotoxins
    • Abdel-Hamid, K. M. and Tymianski, M. (1997) Mechanisms and effects of intracellular calcium buffering on neuronal survival in organotypic hippocampal cultures exposed to anoxia/aglycemia or to excitotoxins. J. Neurosci. 17: 3538-3553.
    • (1997) J. Neurosci. , vol.17 , pp. 3538-3553
    • Abdel-Hamid, K.M.1    Tymianski, M.2
  • 2
    • 0019859824 scopus 로고
    • Intrasynaptosomal compartmentation of calcium during depolarisation-induced calcium uptake across the plasma membrane
    • Åkerman, K. E. O. and Nicholls, D. G. (1981) Intrasynaptosomal compartmentation of calcium during depolarisation-induced calcium uptake across the plasma membrane. Biochim. Biophys. Acta 645: 41-48.
    • (1981) Biochim. Biophys. Acta , vol.645 , pp. 41-48
    • Åkerman, K.E.O.1    Nicholls, D.G.2
  • 3
    • 0010297325 scopus 로고
    • Physiological and bioenergetic aspects of mitochondrial calcium transport
    • Âkerman, K. E. O. and Nicholls, D. G. (1983) Physiological and bioenergetic aspects of mitochondrial calcium transport. Rev. Physiol. Biochem. Pharmacol. 95: 149-201.
    • (1983) Rev. Physiol. Biochem. Pharmacol. , vol.95 , pp. 149-201
    • Âkerman, K.E.O.1    Nicholls, D.G.2
  • 4
    • 0027058138 scopus 로고
    • Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate
    • Allbritton, N. L., Meyer, T. and Stryer, L. (1992) Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate. Science 258: 1812-1815.
    • (1992) Science , vol.258 , pp. 1812-1815
    • Allbritton, N.L.1    Meyer, T.2    Stryer, L.3
  • 6
    • 0026052493 scopus 로고
    • Changes in extracellular amino acids and spontaneous neuronal activity during ischemia and extended reflow in the CA1 of the rat hippocampus
    • Andiné, P., Orwar, O., Jacobsen, I., Sandberg, M. and Hagberg, H. (1991) Changes in extracellular amino acids and spontaneous neuronal activity during ischemia and extended reflow in the CA1 of the rat hippocampus. J. Neurochem. 57: 222-229.
    • (1991) J. Neurochem. , vol.57 , pp. 222-229
    • Andiné, P.1    Orwar, O.2    Jacobsen, I.3    Sandberg, M.4    Hagberg, H.5
  • 7
    • 0026650875 scopus 로고
    • 5-(N-ethyl-N-isopropyl)amiloride and mild acidosis protect cultured cerebellar granule cells against glutamate-induced delayed neuronal death
    • Andreeva, N., Khodorov, B., Stelmashook, E., Sokolova, S., Cragoe, E., Jr. and Victorov, I. (1992) 5-(N-ethyl-N-isopropyl)amiloride and mild acidosis protect cultured cerebellar granule cells against glutamate-induced delayed neuronal death. Neuroscience 49: 175-181.
    • (1992) Neuroscience , vol.49 , pp. 175-181
    • Andreeva, N.1    Khodorov, B.2    Stelmashook, E.3    Sokolova, S.4    Cragoe E., Jr.5    Victorov, I.6
  • 8
    • 0028793257 scopus 로고
    • Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
    • Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A. and Nicotera, P. (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15: 961-973.
    • (1995) Neuron , vol.15 , pp. 961-973
    • Ankarcrona, M.1    Dypbukt, J.M.2    Bonfoco, E.3    Zhivotovsky, B.4    Orrenius, S.5    Lipton, S.A.6    Nicotera, P.7
  • 9
    • 0030574021 scopus 로고    scopus 로고
    • Calcineurin and mitochondrial function in glutamate-induced neuronal cell death
    • Ankarcrona, M., Dypbukt, J. M., Orrenius, S. and Nicotera, P. (1996) Calcineurin and mitochondrial function in glutamate-induced neuronal cell death. FEBS Lett. 394: 321-324.
    • (1996) FEBS Lett. , vol.394 , pp. 321-324
    • Ankarcrona, M.1    Dypbukt, J.M.2    Orrenius, S.3    Nicotera, P.4
  • 10
    • 0000186480 scopus 로고
    • The NMDA receptor, its channel, and its modulation by glycine
    • Collingridge, G. L. and Watkins, J. C. (eds.) Oxford University Press, New York
    • Ascher, P. and Johnson, J. W. (1994) The NMDA receptor, its channel, and its modulation by glycine. In: The NMDA Receptor, 2nd edn., pp. 177-205, Collingridge, G. L. and Watkins, J. C. (eds.) Oxford University Press, New York.
    • (1994) The NMDA Receptor, 2nd Edn. , pp. 177-205
    • Ascher, P.1    Johnson, J.W.2
  • 11
    • 0023265493 scopus 로고
    • Electrophysiological studies of NMDA receptors
    • Ascher, P. and Nowak, L. (1987) Electrophysiological studies of NMDA receptors. Trends Neurosci. 10: 284-288.
    • (1987) Trends Neurosci. , vol.10 , pp. 284-288
    • Ascher, P.1    Nowak, L.2
  • 12
    • 0029834431 scopus 로고    scopus 로고
    • Rapid uncoupling of oxidative phosphorylation accompanies glutamate toxicity in rat cerebellar granule cells
    • Atlante, A., Gagliardi, S., Minervini, G. M., Marra, E., Passarella, S. and Calissano, P. (1996) Rapid uncoupling of oxidative phosphorylation accompanies glutamate toxicity in rat cerebellar granule cells. Neurochemistry 7: 2519-2523.
    • (1996) Neurochemistry , vol.7 , pp. 2519-2523
    • Atlante, A.1    Gagliardi, S.2    Minervini, G.M.3    Marra, E.4    Passarella, S.5    Calissano, P.6
  • 13
    • 0027376769 scopus 로고
    • Nonvesicular release of neurotransmitter
    • Attwell, D., Barbour, B. and Szatkowski, M. (1993) Nonvesicular release of neurotransmitter. Neuron 11: 401-407.
    • (1993) Neuron , vol.11 , pp. 401-407
    • Attwell, D.1    Barbour, B.2    Szatkowski, M.3
  • 15
    • 0026615855 scopus 로고
    • 2+ efflux mechanisms following depolarization evoked calcium transients in cultured rat sensory neurons
    • 2+ efflux mechanisms following depolarization evoked calcium transients in cultured rat sensory neurons. J. Physiol. 455: 567-583.
    • (1992) J. Physiol. , vol.455 , pp. 567-583
    • Benham, C.D.1    Evans, M.L.2    McBain, C.J.3
  • 16
    • 0021707433 scopus 로고
    • Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
    • Benveniste, H., Drejer, J., Schousboe, A. and Diemer, N. H. (1984) Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43: 1369-1374.
    • (1984) J. Neurochem. , vol.43 , pp. 1369-1374
    • Benveniste, H.1    Drejer, J.2    Schousboe, A.3    Diemer, N.H.4
  • 17
    • 0028053663 scopus 로고
    • Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane
    • Bernardi, P., Broekemeier, K. M. and Pfeiffer, D. R. (1994) Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane. J. Bioenerg. Biomembr. 26: 509-518.
    • (1994) J. Bioenerg. Biomembr. , vol.26 , pp. 509-518
    • Bernardi, P.1    Broekemeier, K.M.2    Pfeiffer, D.R.3
  • 18
    • 0027397544 scopus 로고
    • Inositol trisphosphate and calcium signalling
    • Berridge, M. J. (1993) Inositol trisphosphate and calcium signalling. Nature 361: 315-325.
    • (1993) Nature , vol.361 , pp. 315-325
    • Berridge, M.J.1
  • 19
    • 0030932943 scopus 로고    scopus 로고
    • Elementary and global aspects of calcium signalling
    • Berridge, M. J. (1997) Elementary and global aspects of calcium signalling. J. Physiol. 499: 291-306.
    • (1997) J. Physiol. , vol.499 , pp. 291-306
    • Berridge, M.J.1
  • 20
    • 0029240274 scopus 로고
    • AMPA and kainate receptors
    • Bettler, B. and Mulle, C. (1995) AMPA and kainate receptors. Neuropharmacology 34: 123-139.
    • (1995) Neuropharmacology , vol.34 , pp. 123-139
    • Bettler, B.1    Mulle, C.2
  • 21
    • 0028838282 scopus 로고
    • Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons
    • Bindokas, V. P. and Miller, R. C. (1995) Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons. J. Neurosci. 15: 6999-7011.
    • (1995) J. Neurosci. , vol.15 , pp. 6999-7011
    • Bindokas, V.P.1    Miller, R.C.2
  • 22
    • 0030008052 scopus 로고    scopus 로고
    • Superoxide production in rat hippocampal neurons: Selective imaging with hydroethidine
    • Bindokas, V. P., Jordán, J., Lee, C. C. and Miller, R. C. (1996) Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J. Neurosci. 15: 1324-1336.
    • (1996) J. Neurosci. , vol.15 , pp. 1324-1336
    • Bindokas, V.P.1    Jordán, J.2    Lee, C.C.3    Miller, R.C.4
  • 23
    • 0023679101 scopus 로고
    • Calcium transport and buffering in neurons
    • Blaustein, M. P. (1988) Calcium transport and buffering in neurons. Trends Neurosci. 11: 438-443.
    • (1988) Trends Neurosci. , vol.11 , pp. 438-443
    • Blaustein, M.P.1
  • 24
    • 0023856682 scopus 로고
    • The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils
    • Boast, C. A., Gearhardt, S. C., Pastor, E., Lehmann, J. and Etienne, P. E. (1988) The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils. Brain Res. 442B: 345-348.
    • (1988) Brain Res. , vol.442 B , pp. 345-348
    • Boast, C.A.1    Gearhardt, S.C.2    Pastor, E.3    Lehmann, J.4    Etienne, P.E.5
  • 25
    • 0029848750 scopus 로고    scopus 로고
    • Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation
    • Bonfoco, E., Leist, M., Zhivotovsky, B., Orrenius, S., Lipton, S. A. and Nicotera, P. (1996) Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation. J. Neurochem. 67: 2484-2493.
    • (1996) J. Neurochem. , vol.67 , pp. 2484-2493
    • Bonfoco, E.1    Leist, M.2    Zhivotovsky, B.3    Orrenius, S.4    Lipton, S.A.5    Nicotera, P.6
  • 26
    • 0026463206 scopus 로고
    • The glial cell glutamate uptake carrier countertransports pH-changing anions
    • Bouvier, M., Szatkowski, M., Amato, A. and Attwell, D. (1992) The glial cell glutamate uptake carrier countertransports pH-changing anions. Nature 360: 471-474.
    • (1992) Nature , vol.360 , pp. 471-474
    • Bouvier, M.1    Szatkowski, M.2    Amato, A.3    Attwell, D.4
  • 29
    • 0016593950 scopus 로고
    • 2+ uptake supported by hydrolysis of endogenous ATP in rat liver mitochondria
    • 2+ uptake supported by hydrolysis of endogenous ATP in rat liver mitochondria. J. Biol. Chem. 250: 7958-7960.
    • (1975) J. Biol. Chem. , vol.250 , pp. 7958-7960
    • Brand, M.D.1    Lehninger, A.L.2
  • 30
    • 0017102320 scopus 로고
    • Re-evaluation of the H+/site ratio of the mitochondrial electron transport with oxygen pulse technique
    • Brand, M. D., Reynafarje, B. and Lehninger, A. L. (1976) Re-evaluation of the H+/site ratio of the mitochondrial electron transport with oxygen pulse technique. J. Biol. Chem. 251: 5670-5679.
    • (1976) J. Biol. Chem. , vol.251 , pp. 5670-5679
    • Brand, M.D.1    Reynafarje, B.2    Lehninger, A.L.3
  • 31
    • 0027074622 scopus 로고
    • Calcium directly permeates kainate/alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in cultured cerebellar purkinje neurons
    • Brorson, J. R., Bleakman, D., Chard, P. S. and Miller, R. J. (1992) Calcium directly permeates kainate/alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in cultured cerebellar purkinje neurons. Mol. Pharmacol. 41: 603-608.
    • (1992) Mol. Pharmacol. , vol.41 , pp. 603-608
    • Brorson, J.R.1    Bleakman, D.2    Chard, P.S.3    Miller, R.J.4
  • 32
    • 0028178139 scopus 로고
    • 2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar purkinje cells
    • 2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar purkinje cells. J. Neurosci. 14: 187-197.
    • (1994) J. Neurosci. , vol.14 , pp. 187-197
    • Brorson, J.R.1    Manzolillo, P.A.2    Miller, R.J.3
  • 33
    • 0029131714 scopus 로고
    • Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells
    • Bruno, V., Copani, A., Knopfel, T., Khun, R., Casabona, G., Dell'Albani, P., Condorelli, D. F. and Nicoletti, F. (1995) Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells. Neuropharmacology 34: 1089-1098.
    • (1995) Neuropharmacology , vol.34 , pp. 1089-1098
    • Bruno, V.1    Copani, A.2    Knopfel, T.3    Khun, R.4    Casabona, G.5    Dell'Albani, P.6    Condorelli, D.F.7    Nicoletti, F.8
  • 35
    • 0030071252 scopus 로고    scopus 로고
    • A reevaluation of the role of mitochondria in neuronal calcium homeostasis
    • Budd, S. L. and Nicholls, D. G. (1996a) A reevaluation of the role of mitochondria in neuronal calcium homeostasis. J. Neurochem. 66: 403-411.
    • (1996) J. Neurochem. , vol.66 , pp. 403-411
    • Budd, S.L.1    Nicholls, D.G.2
  • 36
    • 0029827804 scopus 로고    scopus 로고
    • Mitochondria, calcium and acute glutamate excitotoxicity in cultured cerebellar granule cells
    • Budd, S. L. and Nicholls, D. G. (1996b) Mitochondria, calcium and acute glutamate excitotoxicity in cultured cerebellar granule cells. J. Neurochem. 67: 2282-2291.
    • (1996) J. Neurochem. , vol.67 , pp. 2282-2291
    • Budd, S.L.1    Nicholls, D.G.2
  • 37
    • 0026727807 scopus 로고
    • Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor
    • Burnashev, N., Schoepfer, R., Monyer, H., Ruppersberg, J. P., Günther, W., Seeburg, P. H. and Sakmann, B. (1992) Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor. Science 257: 1415-1419.
    • (1992) Science , vol.257 , pp. 1415-1419
    • Burnashev, N.1    Schoepfer, R.2    Monyer, H.3    Ruppersberg, J.P.4    Günther, W.5    Seeburg, P.H.6    Sakmann, B.7
  • 38
    • 0026761765 scopus 로고
    • Pathological phosphorylation causes neuronal death: Effect of okadaic acid in primary culture of cerebellar granule cells
    • Candeo, P., Favaron, M., Lengyel, I., Manev, R. M., Rimland, J. M. and Manev, H. (1992) Pathological phosphorylation causes neuronal death: effect of okadaic acid in primary culture of cerebellar granule cells. J. Neurochem. 59: 1558-1561.
    • (1992) J. Neurochem. , vol.59 , pp. 1558-1561
    • Candeo, P.1    Favaron, M.2    Lengyel, I.3    Manev, R.M.4    Rimland, J.M.5    Manev, H.6
  • 39
    • 0023069451 scopus 로고
    • Intracellular calcium homeostasis
    • Carafoli, E. (1987) Intracellular calcium homeostasis. Ann. Rev. Biochem. 56: 395-433.
    • (1987) Ann. Rev. Biochem. , vol.56 , pp. 395-433
    • Carafoli, E.1
  • 41
    • 0029944880 scopus 로고    scopus 로고
    • Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis
    • Castedo, M., Hirsch, T., Susin, S. A., Zamzami, N., Marchetti, P., Macho, A. and Kroemer, G. (1996) Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis. J. Immunol. 157: 512-521.
    • (1996) J. Immunol. , vol.157 , pp. 512-521
    • Castedo, M.1    Hirsch, T.2    Susin, S.A.3    Zamzami, N.4    Marchetti, P.5    Macho, A.6    Kroemer, G.7
  • 44
    • 0031034997 scopus 로고    scopus 로고
    • Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death
    • Chinnaiyan, A. M., O'Rourke, K., Lane, B. R. and Dixit, V. M. (1997) Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science 275: 1122-1126.
    • (1997) Science , vol.275 , pp. 1122-1126
    • Chinnaiyan, A.M.1    O'Rourke, K.2    Lane, B.R.3    Dixit, V.M.4
  • 45
    • 0025438029 scopus 로고
    • Methods for antagonizing glutamate neurotoxicity
    • Choi, D. W. (1990) Methods for antagonizing glutamate neurotoxicity. Cerebrovasc. Brain Metab. Rev. 2: 105-147.
    • (1990) Cerebrovasc. Brain Metab. Rev. , vol.2 , pp. 105-147
    • Choi, D.W.1
  • 46
    • 0027116042 scopus 로고
    • Bench to bedside: The glutamate connection
    • Choi, D. W. (1992) Bench to bedside: the glutamate connection. Science 258: 241-243.
    • (1992) Science , vol.258 , pp. 241-243
    • Choi, D.W.1
  • 47
    • 0025265926 scopus 로고
    • The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death
    • Choi, D. W. and Rothman, S. M. (1990) The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu. Rev. Neurosci. 13: 171-182.
    • (1990) Annu. Rev. Neurosci. , vol.13 , pp. 171-182
    • Choi, D.W.1    Rothman, S.M.2
  • 48
    • 0023870521 scopus 로고
    • Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists
    • Choi, D. W., Koh, J. Y. and Peters, S. (1988) Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J. Neurosci. 8: 185-196.
    • (1988) J. Neurosci. , vol.8 , pp. 185-196
    • Choi, D.W.1    Koh, J.Y.2    Peters, S.3
  • 51
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • Conn, P. J. and Pin, J.-P. (1997) Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37: 205-237.
    • (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.-P.2
  • 52
    • 0025580921 scopus 로고
    • The interactions between plasma membrane depolarisation and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells
    • Courtney, M. J., Lambert, J. J. and Nicholls, D. G. (1990) The interactions between plasma membrane depolarisation and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells. J. Neurosci. 10: 3873-3879.
    • (1990) J. Neurosci. , vol.10 , pp. 3873-3879
    • Courtney, M.J.1    Lambert, J.J.2    Nicholls, D.G.3
  • 53
    • 0026664921 scopus 로고
    • Ionic basis of membrane potential changes induced by anoxia in rat dorsal vagal motoneurons
    • Cowan, A. I. and Martin, R. L. (1992) Ionic basis of membrane potential changes induced by anoxia in rat dorsal vagal motoneurons. J. Physiol. 455: 89-109.
    • (1992) J. Physiol. , vol.455 , pp. 89-109
    • Cowan, A.I.1    Martin, R.L.2
  • 54
    • 0017132461 scopus 로고
    • The sodium-induced efflux of calcium from heart mitochondria
    • Crompton, M., Capano, M. and Carafoli, E. (1976) The sodium-induced efflux of calcium from heart mitochondria. Eur. J. Biochem. 69: 453-462.
    • (1976) Eur. J. Biochem. , vol.69 , pp. 453-462
    • Crompton, M.1    Capano, M.2    Carafoli, E.3
  • 55
    • 0018792008 scopus 로고
    • The resolution of calcium fluxes in heart and liver mitochondria using the lanthanide series
    • Crompton, M., Heid, I., Baschera, C. and Carafoli, E. (1979) The resolution of calcium fluxes in heart and liver mitochondria using the lanthanide series. FEBS Lett. 104: 352-354.
    • (1979) FEBS Lett. , vol.104 , pp. 352-354
    • Crompton, M.1    Heid, I.2    Baschera, C.3    Carafoli, E.4
  • 56
    • 0031036086 scopus 로고    scopus 로고
    • Parallel antioxidant and antiexcitotoxic therapy improves outcome after incomplete global ischemia in dogs
    • Davis, S., Helfaer, M. A., Traystman, R. J. and Hurn, P. D. (1997) Parallel antioxidant and antiexcitotoxic therapy improves outcome after incomplete global ischemia in dogs. Stroke 28: 198-204.
    • (1997) Stroke , vol.28 , pp. 198-204
    • Davis, S.1    Helfaer, M.A.2    Traystman, R.J.3    Hurn, P.D.4
  • 57
    • 0027453536 scopus 로고
    • Immunosuppressant FK-506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity
    • Dawson, T. M., Steiner, J. P., Dawson, V. L., Dinerman, J. L., Uhl, G. R. and Snyder, S. H. (1993) Immunosuppressant FK-506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc. Natl. Acad. Sci. USA 90: 9808-9812.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9808-9812
    • Dawson, T.M.1    Steiner, J.P.2    Dawson, V.L.3    Dinerman, J.L.4    Uhl, G.R.5    Snyder, S.H.6
  • 59
    • 0027215170 scopus 로고
    • Glutamate-induced neuronal death is not a programmed cell death in cerebellar culture
    • Dessi, F., Charriaut-Marlangue, C., Khrestchatisky, M. and Ben-Ari, Y. (1993) Glutamate-induced neuronal death is not a programmed cell death in cerebellar culture. J. Neurochem. 60: 1953-1955.
    • (1993) J. Neurochem. , vol.60 , pp. 1953-1955
    • Dessi, F.1    Charriaut-Marlangue, C.2    Khrestchatisky, M.3    Ben-Ari, Y.4
  • 60
    • 0028338767 scopus 로고
    • Glutamate-induced neuronal death in cerebellar culture is mediated by two distinct components: A sodium-chloride component and a calcium component
    • Dessi, F., Charriaut-Marlangue, C. and Ben-Ari, Y. (1994) Glutamate-induced neuronal death in cerebellar culture is mediated by two distinct components: a sodium-chloride component and a calcium component. Brain Res. 650: 49-55.
    • (1994) Brain Res. , vol.650 , pp. 49-55
    • Dessi, F.1    Charriaut-Marlangue, C.2    Ben-Ari, Y.3
  • 61
    • 0028882282 scopus 로고
    • Ruthenium red protects against glutamate-induced neuronal death in cerebellar culture
    • Dessi, F., Charriaut-Marlangue, C. and Ben-Ari, Y. (1995) Ruthenium red protects against glutamate-induced neuronal death in cerebellar culture. Neurosci. Lett. 201: 53-56.
    • (1995) Neurosci. Lett. , vol.201 , pp. 53-56
    • Dessi, F.1    Charriaut-Marlangue, C.2    Ben-Ari, Y.3
  • 62
    • 0021829328 scopus 로고
    • Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro
    • Drejer, J., Benveniste, H., Diemer, N. H. and Schousboe, A. (1985) Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro. J. Neurochem. 45: 145-151.
    • (1985) J. Neurochem. , vol.45 , pp. 145-151
    • Drejer, J.1    Benveniste, H.2    Diemer, N.H.3    Schousboe, A.4
  • 63
    • 0027474291 scopus 로고
    • Intracellular calcium levels during the period of delayed excitotoxicity
    • Dubinsky, J. M. (1993) Intracellular calcium levels during the period of delayed excitotoxicity. J. Neurosci. 13: 623-631.
    • (1993) J. Neurosci. , vol.13 , pp. 623-631
    • Dubinsky, J.M.1
  • 64
    • 0029126134 scopus 로고
    • On the probalistic nature of excitotoxic neuronal death in hippocampal neurons
    • Dubinsky, J. M., Kristal, B. S. and Elizondo-Fournier, M. (1995) On the probalistic nature of excitotoxic neuronal death in hippocampal neurons. Neuropharmacology 34: 701-711.
    • (1995) Neuropharmacology , vol.34 , pp. 701-711
    • Dubinsky, J.M.1    Kristal, B.S.2    Elizondo-Fournier, M.3
  • 65
    • 0026555280 scopus 로고
    • 2+ dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons
    • 2+ dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons. Biochem. J. 283: 41-50.
    • (1992) Biochem. J. , vol.283 , pp. 41-50
    • Duchen, M.R.1
  • 66
    • 0025345054 scopus 로고
    • Effects of metabolic blockade on the regulation of intracellular calcium on dissociated mouse sensory neurones
    • Duchen, M. R., Valdeolmillos, M., O'Neill, S. C. and Eisner, D. A. (1990) Effects of metabolic blockade on the regulation of intracellular calcium on dissociated mouse sensory neurones. J. Physiol. 424: 411-426.
    • (1990) J. Physiol. , vol.424 , pp. 411-426
    • Duchen, M.R.1    Valdeolmillos, M.2    O'Neill, S.C.3    Eisner, D.A.4
  • 67
    • 0027381281 scopus 로고
    • On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury
    • Duchen, M. R., McGuiness, O., Brown, L. A. and Crompton, M. (1993) On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury. Cardiovas. Res. 27: 1790-1794.
    • (1993) Cardiovas. Res. , vol.27 , pp. 1790-1794
    • Duchen, M.R.1    McGuiness, O.2    Brown, L.A.3    Crompton, M.4
  • 68
    • 0030045253 scopus 로고    scopus 로고
    • An early loss in membrane protein kinase C activity precedes the excitatory amino acid-induced death of primary cortical neurons
    • Durkin, J. P., Buchan, A., Blosser, J., Chakravarthy, B., Mealing, G., Morley, P. and Song, D. (1996) An early loss in membrane protein kinase C activity precedes the excitatory amino acid-induced death of primary cortical neurons. J. Neurochem. 66: 951-962.
    • (1996) J. Neurochem. , vol.66 , pp. 951-962
    • Durkin, J.P.1    Buchan, A.2    Blosser, J.3    Chakravarthy, B.4    Mealing, G.5    Morley, P.6    Song, D.7
  • 69
    • 0025765017 scopus 로고
    • Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA
    • Egebjerg, J., Bettler, B., Hermans-Borgmeyer, I. and Heinemann, S. (1991) Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA. Nature 351: 745-748.
    • (1991) Nature , vol.351 , pp. 745-748
    • Egebjerg, J.1    Bettler, B.2    Hermans-Borgmeyer, I.3    Heinemann, S.4
  • 70
    • 0028097733 scopus 로고
    • The quantity of calcium that appears to induce neuronal death
    • Eimerl, S. and Schramm, M. (1994) The quantity of calcium that appears to induce neuronal death. J. Neurochem. 62: 1223-1226.
    • (1994) J. Neurochem. , vol.62 , pp. 1223-1226
    • Eimerl, S.1    Schramm, M.2
  • 71
    • 0029115560 scopus 로고
    • 2+ after toxic NMDA receptor activity
    • 2+ after toxic NMDA receptor activity. J. Neurochem. 65: 739-743.
    • (1995) J. Neurochem. , vol.65 , pp. 739-743
    • Eimerl, S.1    Schramm, M.2
  • 72
    • 0028217760 scopus 로고
    • Ions and energy in mammalian brain
    • Erecinska, M. and Silver, I. A. (1994) Ions and energy in mammalian brain. Prog. Neurobiol. 43: 37-71.
    • (1994) Prog. Neurobiol. , vol.43 , pp. 37-71
    • Erecinska, M.1    Silver, I.A.2
  • 73
    • 0023180475 scopus 로고
    • A comparison of excitatory amino acid antagonists acting at primary afferent C fibres and motoneurons of the isolated spinal cord of the rat
    • Evans, R. H., Evans, S. J., Pook, P. C. and Sunter, D. C. (1987) A comparison of excitatory amino acid antagonists acting at primary afferent C fibres and motoneurons of the isolated spinal cord of the rat. Br. J. Pharmacol. 91: 531-537.
    • (1987) Br. J. Pharmacol. , vol.91 , pp. 531-537
    • Evans, R.H.1    Evans, S.J.2    Pook, P.C.3    Sunter, D.C.4
  • 74
    • 0025217415 scopus 로고
    • Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death
    • Favaron, M., Manev, H., Siman, R., Bertolino, M., Szekely, A. M., DeErausquin, G., Guidotti, A. and Costa, E. (1990) Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death. Proc. Natl. Acad. Sci. USA 87: 1983-1987.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 1983-1987
    • Favaron, M.1    Manev, H.2    Siman, R.3    Bertolino, M.4    Szekely, A.M.5    DeErausquin, G.6    Guidotti, A.7    Costa, E.8
  • 75
    • 0031067357 scopus 로고    scopus 로고
    • TPA for acute ischemic stroke
    • Fischer, J. (1997) TPA for acute ischemic stroke. South Dakota J. Med. 50: 69-70.
    • (1997) South Dakota J. Med. , vol.50 , pp. 69-70
    • Fischer, J.1
  • 78
    • 0027535084 scopus 로고
    • Excitatory amino acid-mediated cytotoxicity and calcium homeostasis in cultured neurons
    • Frandsen, A. and Schousboe, A. (1993) Excitatory amino acid-mediated cytotoxicity and calcium homeostasis in cultured neurons. J. Neurochem. 60: 1202-1211.
    • (1993) J. Neurochem. , vol.60 , pp. 1202-1211
    • Frandsen, A.1    Schousboe, A.2
  • 79
    • 0023162216 scopus 로고
    • Effects of hypoxia on rat hippocampal neurones in vitro
    • Fujiwara, N., Higashi, H., Shimoji, K. and Yoshimura, M. (1987) Effects of hypoxia on rat hippocampal neurones in vitro. J. Physiol. 384: 131-151.
    • (1987) J. Physiol. , vol.384 , pp. 131-151
    • Fujiwara, N.1    Higashi, H.2    Shimoji, K.3    Yoshimura, M.4
  • 80
    • 0028984353 scopus 로고
    • i and protects hippocampal neurons against excitotoxicity
    • i and protects hippocampal neurons against excitotoxicity. Brain Res. 689: 141-146.
    • (1995) Brain Res. , vol.689 , pp. 141-146
    • Furukawa, K.1    Mattson, M.P.2
  • 81
    • 0019853077 scopus 로고
    • Calcium transport mechanisms in membrane vesicles from guinea pig brain synaptosomes
    • Gill, D. L., Grollman, E. F. and Kohn, L. D. (1981) Calcium transport mechanisms in membrane vesicles from guinea pig brain synaptosomes. J. Biol. Chem. 256: 184-192.
    • (1981) J. Biol. Chem. , vol.256 , pp. 184-192
    • Gill, D.L.1    Grollman, E.F.2    Kohn, L.D.3
  • 82
    • 0023680850 scopus 로고
    • Intra-ischemic extracellular release of dopamine and glutamate is associated with striatal vulnerability to ischemia
    • Globus, M. Y., Busto, R., Dietrich, W. D., Martinez, E., Valdes, I. and Ginsberg, M. D. (1988) Intra-ischemic extracellular release of dopamine and glutamate is associated with striatal vulnerability to ischemia. Neurosci. Lett. 91: 36-40.
    • (1988) Neurosci. Lett. , vol.91 , pp. 36-40
    • Globus, M.Y.1    Busto, R.2    Dietrich, W.D.3    Martinez, E.4    Valdes, I.5    Ginsberg, M.D.6
  • 83
    • 0027443172 scopus 로고
    • Cyclosporin A protects mitochondria in an in vitro model of hypoxia/reperfusion injury
    • Gogvadze, V. and Richter, C. (1993) Cyclosporin A protects mitochondria in an in vitro model of hypoxia/reperfusion injury. FEBS Lett. 333: 334-338.
    • (1993) FEBS Lett. , vol.333 , pp. 334-338
    • Gogvadze, V.1    Richter, C.2
  • 84
    • 0027328680 scopus 로고
    • Combined oxygen and glucose deprivation in cortical cell culture: Calcium-dependent and calcium-independent mechanisms of neuronal injury
    • Goldberg, M. P. and Choi, D. W. (1993) Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury. J. Neurosci. 13, 3510-3524.
    • (1993) J. Neurosci. , vol.13 , pp. 3510-3524
    • Goldberg, M.P.1    Choi, D.W.2
  • 85
    • 0031034563 scopus 로고    scopus 로고
    • Controlling cell death
    • Goldstein, P. (1997) Controlling cell death. Science 275: 1081-1082.
    • (1997) Science , vol.275 , pp. 1081-1082
    • Goldstein, P.1
  • 86
    • 0025141246 scopus 로고
    • Changes in extracellular amino acid neurotransmitters produced by focal cerebral ischemia
    • Graham, S. H., Shiraishi, K., Panter, S. S., Simon, R. P. and Faden, A. I. (1990) Changes in extracellular amino acid neurotransmitters produced by focal cerebral ischemia. Neurosci. Lett. 110: 124-130.
    • (1990) Neurosci. Lett. , vol.110 , pp. 124-130
    • Graham, S.H.1    Shiraishi, K.2    Panter, S.S.3    Simon, R.P.4    Faden, A.I.5
  • 87
    • 0027198567 scopus 로고
    • Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum
    • Greene, J. G., Porter, R. H. P., Eller, R. V. and Greenamyre, J. T. (1993) Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum. J. Neurochem. 61: 1151-1154.
    • (1993) J. Neurochem. , vol.61 , pp. 1151-1154
    • Greene, J.G.1    Porter, R.H.P.2    Eller, R.V.3    Greenamyre, J.T.4
  • 88
    • 0026132165 scopus 로고
    • Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin
    • Griffiths, E. J. and Halestrap, A. P. (1991) Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin. Biochem. J. 274: 611-614.
    • (1991) Biochem. J. , vol.274 , pp. 611-614
    • Griffiths, E.J.1    Halestrap, A.P.2
  • 89
    • 0021895138 scopus 로고
    • A new generation of Ca indicators with greatly improved fluorescence properties
    • Grynkiewicz, G., Poenie, M. and Tsien, R. Y. (1985) A new generation of Ca indicators with greatly improved fluorescence properties. J. Biol. Chem. 260: 3440-3450.
    • (1985) J. Biol. Chem. , vol.260 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 90
    • 0028856368 scopus 로고
    • NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: Implications for cell death
    • Gunasekar, P. G., Kanthasamay, A. G., Borowitz, J. L. and Isom, G. E. (1995) NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: implications for cell death. J. Neurochem. 65: 2016-2021.
    • (1995) J. Neurochem. , vol.65 , pp. 2016-2021
    • Gunasekar, P.G.1    Kanthasamay, A.G.2    Borowitz, J.L.3    Isom, G.E.4
  • 91
    • 0027945340 scopus 로고
    • Transport of calcium by mitochondria
    • Gunter, K. K. and Gunter, T. E. (1994) Transport of calcium by mitochondria. J. Bioenerg. Biomemb. 26: 471-485.
    • (1994) J. Bioenerg. Biomemb. , vol.26 , pp. 471-485
    • Gunter, K.K.1    Gunter, T.E.2
  • 92
    • 0025292743 scopus 로고
    • Mechanisms by which mitochondria transport calcium
    • Gunter, T. E. and Pfeiffer, D. R. (1990) Mechanisms by which mitochondria transport calcium. Am. J. Physiol. 258: C755-C786.
    • (1990) Am. J. Physiol. , vol.258
    • Gunter, T.E.1    Pfeiffer, D.R.2
  • 94
    • 0025193488 scopus 로고
    • 2+-induced large amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase
    • 2+-induced large amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase. Biochem. J. 268: 153-160.
    • (1990) Biochem. J. , vol.268 , pp. 153-160
    • Halestrap, A.P.1    Davidson, A.M.2
  • 95
    • 0031013623 scopus 로고    scopus 로고
    • Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase
    • Halestrap, A. P., Woodfield, K.-Y. and Connern, C. P. (1997) Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. J. Biol. Chem. 272: 3346-3354.
    • (1997) J. Biol. Chem. , vol.272 , pp. 3346-3354
    • Halestrap, A.P.1    Woodfield, K.-Y.2    Connern, C.P.3
  • 96
    • 0021981842 scopus 로고
    • Effect of anoxia on ion distribution in the brain
    • Hansen, A. J. (1985) Effect of anoxia on ion distribution in the brain. Physiol. Rev. 65: 101-148.
    • (1985) Physiol. Rev. , vol.65 , pp. 101-148
    • Hansen, A.J.1
  • 98
    • 0021893597 scopus 로고
    • 2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes
    • 2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes. Biochem. J. 227: 129-136.
    • (1985) Biochem. J. , vol.227 , pp. 129-136
    • Hansford, R.G.1    Castro, F.2
  • 99
    • 0028987863 scopus 로고
    • An evaluation of the role of calcium in cell injury
    • Harman, A. W. and Maxwell, M. J. (1995) An evaluation of the role of calcium in cell injury. Annu. Rev. Pharmacol. Toxicol. 35: 129-144.
    • (1995) Annu. Rev. Pharmacol. Toxicol. , vol.35 , pp. 129-144
    • Harman, A.W.1    Maxwell, M.J.2
  • 104
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenbery, D., Nuñez, G., Milliman, C., Schreiber, R. D. and Korsmeyer, S. J. (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348: 334-336.
    • (1990) Nature , vol.348 , pp. 334-336
    • Hockenbery, D.1    Nuñez, G.2    Milliman, C.3    Schreiber, R.D.4    Korsmeyer, S.J.5
  • 106
    • 0025923461 scopus 로고
    • 2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition
    • 2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition. Science 252: 851-853.
    • (1991) Science , vol.252 , pp. 851-853
    • Hollmann, M.1    Hartley, M.2    Heinemann, S.3
  • 108
    • 0017089948 scopus 로고
    • Relationship between configuration, function, and permeability in calcium-treated mitochondria
    • Hunter, D. R., Haworth, R. A. and Southard, J. H. (1976) Relationship between configuration, function, and permeability in calcium-treated mitochondria. J. Biol. Chem. 251: 5069-5077.
    • (1976) J. Biol. Chem. , vol.251 , pp. 5069-5077
    • Hunter, D.R.1    Haworth, R.A.2    Southard, J.H.3
  • 110
    • 0025360229 scopus 로고
    • Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones
    • Iino, M., Ozawa, S. and Tsuzuki, K. (1990) Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones. J. Physiol. 424: 151-165.
    • (1990) J. Physiol. , vol.424 , pp. 151-165
    • Iino, M.1    Ozawa, S.2    Tsuzuki, K.3
  • 114
    • 0026550108 scopus 로고
    • + homeostasis during anoxia in rat hypoglossal neurons: Intracellular and extracellular in vitro studies
    • + homeostasis during anoxia in rat hypoglossal neurons: intracellular and extracellular in vitro studies. J. Physiol. 448: 697-708.
    • (1992) J. Physiol. , vol.448 , pp. 697-708
    • Jiang, C.1    Agulian, S.2    Haddad, G.G.3
  • 115
    • 0026521374 scopus 로고
    • + channels during anoxia: Major differences between rat (newborn and adult) and turtle neurons
    • + channels during anoxia: major differences between rat (newborn and adult) and turtle neurons. J. Physiol. 448: 599-612.
    • (1992) J. Physiol. , vol.448 , pp. 599-612
    • Jiang, C.1    Xia, Y.2    Haddad, G.G.3
  • 116
    • 0025731595 scopus 로고
    • Degradation of microtubule-associated protein 2 and brain spectrin by calpain: A comparative study
    • Johnson, G. V. W., Litersky, J. M. and Jope, R. S. (1991) Degradation of microtubule-associated protein 2 and brain spectrin by calpain: a comparative study. J. Neurochem. 56: 1630-1638.
    • (1991) J. Neurochem. , vol.56 , pp. 1630-1638
    • Johnson, G.V.W.1    Litersky, J.M.2    Jope, R.S.3
  • 117
    • 0023091647 scopus 로고
    • Glycine potentiates the NMDA response in cultured mouebrain neurons
    • Johnson, J. W. and Ascher, P. (1987) Glycine potentiates the NMDA response in cultured mouebrain neurons. Nature 325: 529-531.
    • (1987) Nature , vol.325 , pp. 529-531
    • Johnson, J.W.1    Ascher, P.2
  • 118
    • 0028179583 scopus 로고
    • 2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression
    • 2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression. Neuron 12: 1281-1289.
    • (1994) Neuron , vol.12 , pp. 1281-1289
    • Jonas, P.1    Racca, C.2    Sakmann, B.3    Seeburg, P.H.4    Monyer, H.5
  • 119
    • 0026653449 scopus 로고
    • Cell swelling, bleb formation, and death are dependent on ATP depletion and independent of calcium during chemical hypoxia in a glial cell line (ROC-1)
    • Jurkowitz-Alexander, M. S., Altschuld, R. A., Hohl, C. M., Johnson, J. D., McDonald, J. S., Simmons, T. D. and Horrocks, L. A. (1992) Cell swelling, bleb formation, and death are dependent on ATP depletion and independent of calcium during chemical hypoxia in a glial cell line (ROC-1). J. Neurochem. 59: 344-352.
    • (1992) J. Neurochem. , vol.59 , pp. 344-352
    • Jurkowitz-Alexander, M.S.1    Altschuld, R.A.2    Hohl, C.M.3    Johnson, J.D.4    McDonald, J.S.5    Simmons, T.D.6    Horrocks, L.A.7
  • 120
    • 0027179773 scopus 로고
    • Neuroprotective effects of glutamate antagonists and extracellular acidity
    • Kaku, D. A., Giffard, R. G. and Choi, D. W. (1993) Neuroprotective effects of glutamate antagonists and extracellular acidity. Science 260: 1516-1518.
    • (1993) Science , vol.260 , pp. 1516-1518
    • Kaku, D.A.1    Giffard, R.G.2    Choi, D.W.3
  • 122
    • 0023823059 scopus 로고
    • 2+ concentration in isolated nerve terminals following metabolic inhibition: Possible relevance to hypoglycaemia and anoxia
    • 2+ concentration in isolated nerve terminals following metabolic inhibition: possible relevance to hypoglycaemia and anoxia. Neuroscience 27: 175-182.
    • (1988) Neuroscience , vol.27 , pp. 175-182
    • Kauppinen, R.A.1    McMahon, H.T.2    Nicholls, D.G.3
  • 123
    • 0024435285 scopus 로고
    • Regulation of neuronal function by calcium
    • Kennedy, M. B. (1989) Regulation of neuronal function by calcium. Trends Neurosci. 12: 417-420.
    • (1989) Trends Neurosci. , vol.12 , pp. 417-420
    • Kennedy, M.B.1
  • 125
    • 0028842324 scopus 로고
    • Glutamate-induced destabilization of intracellular calcium concentration homeostasis in cultured cerebellar granule cells: Role of mitochondria in calcium buffering
    • Kiedrowski, L. and Costa, E. (1995) Glutamate-induced destabilization of intracellular calcium concentration homeostasis in cultured cerebellar granule cells: role of mitochondria in calcium buffering. Mol. Pharmacol. 47: 140-147.
    • (1995) Mol. Pharmacol. , vol.47 , pp. 140-147
    • Kiedrowski, L.1    Costa, E.2
  • 126
    • 0028256101 scopus 로고
    • Glutamate impairs neuronal calcium extrusion whilst reducing sodium gradient
    • Kiedrowski, L., Booker, G., Costa, E. and Wroblewski, J. T. (1994a) Glutamate impairs neuronal calcium extrusion whilst reducing sodium gradient. Neuron 12: 295-300.
    • (1994) Neuron , vol.12 , pp. 295-300
    • Kiedrowski, L.1    Booker, G.2    Costa, E.3    Wroblewski, J.T.4
  • 127
    • 0028340999 scopus 로고
    • Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate
    • Kiedrowski, L., Wroblewski, J. T. and Costa, E. (1994b) Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate. Mol. Pharmacol. 45: 1050-1054.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 1050-1054
    • Kiedrowski, L.1    Wroblewski, J.T.2    Costa, E.3
  • 128
    • 0020051129 scopus 로고
    • Delayed neuronal death in the gerbil hippocampus following ischemia
    • Kirino, T. (1982) Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239: 57-69.
    • (1982) Brain Res. , vol.239 , pp. 57-69
    • Kirino, T.1
  • 129
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • Kluck, R. M., Bossy-Wetzel, E., Green, D. R. and Newmeyer, D. D. (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275: 1132-1136.
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 130
    • 0025831357 scopus 로고
    • Selective blockade of non-NMDA receptors does not block rapidly triggered glutamate-induced neuronal death
    • Koh, J.-Y. and Choi, D. W. (1991) Selective blockade of non-NMDA receptors does not block rapidly triggered glutamate-induced neuronal death. Brain Res. 548: 318-321.
    • (1991) Brain Res. , vol.548 , pp. 318-321
    • Koh, J.-Y.1    Choi, D.W.2
  • 131
    • 0026062919 scopus 로고
    • A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture
    • Koh, J. Y., Palmer, E., Lin, A. and Cotman, C. W. (1991) A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture. Brain Res. 561: 338-343.
    • (1991) Brain Res. , vol.561 , pp. 338-343
    • Koh, J.Y.1    Palmer, E.2    Lin, A.3    Cotman, C.W.4
  • 132
    • 0027339892 scopus 로고
    • 2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: Diversity by RNA editing
    • 2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing. Neuron 10: 491-500.
    • (1993) Neuron , vol.10 , pp. 491-500
    • Köhler, M.1    Burnashev, N.2    Sakman, B.3    Seeburg, P.H.4
  • 134
    • 0022344168 scopus 로고
    • Hydrogen ion buffering during complete brain ischemia
    • Kraig, R. P., Pulsinelli, W. A. and Plum, F. (1985) Hydrogen ion buffering during complete brain ischemia. Brain Res. 342: 281-290.
    • (1985) Brain Res. , vol.342 , pp. 281-290
    • Kraig, R.P.1    Pulsinelli, W.A.2    Plum, F.3
  • 135
    • 0030567766 scopus 로고    scopus 로고
    • Calcium-related damage in ischemia
    • Kristián, T. and Siesjö, B. K. (1996) Calcium-related damage in ischemia. Life Sci. 59: 357-367.
    • (1996) Life Sci. , vol.59 , pp. 357-367
    • Kristián, T.1    Siesjö, B.K.2
  • 136
    • 0028846079 scopus 로고
    • Role of multiple cellular proteases in the execution of programmed cell death
    • Kumar, S. and Harvey, N. L. (1995) Role of multiple cellular proteases in the execution of programmed cell death. FEBS Lett. 375: 169-173.
    • (1995) FEBS Lett. , vol.375 , pp. 169-173
    • Kumar, S.1    Harvey, N.L.2
  • 137
    • 17544372082 scopus 로고    scopus 로고
    • A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells
    • Lawrie, A. M., Rizzuto, R., Pozzan, T. and Simpson, A. W. M. (1996) A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells. J. Biol. Chem. 271: 10753-10759.
    • (1996) J. Biol. Chem. , vol.271 , pp. 10753-10759
    • Lawrie, A.M.1    Rizzuto, R.2    Pozzan, T.3    Simpson, A.W.M.4
  • 138
    • 0025674468 scopus 로고
    • N-methyl-D-aspartate-sensitive glutamate receptors induced calcium-mediated arachidonic acid release in primary cultures of cerebellar granule cells
    • Lazarewicz, J. W., Wroblewski, J. T. and Costa, E. (1990) N-methyl-D-aspartate-sensitive glutamate receptors induced calcium-mediated arachidonic acid release in primary cultures of cerebellar granule cells. J. Neurochem. 55: 1875-1881.
    • (1990) J. Neurochem. , vol.55 , pp. 1875-1881
    • Lazarewicz, J.W.1    Wroblewski, J.T.2    Costa, E.3
  • 139
    • 0014125634 scopus 로고
    • Energy coupling in electron transport
    • Lehninger, A. L. (1967) Energy coupling in electron transport. Fed. Proc. 26: 1333-1334.
    • (1967) Fed. Proc. , vol.26 , pp. 1333-1334
    • Lehninger, A.L.1
  • 141
    • 0020004311 scopus 로고
    • Reduced ATP concentration as a basis for synaptic transmission failure during hypoxia in the in vitro guinea-pig hippocampus
    • Lipton, P. and Whittingham, T. S. (1982) Reduced ATP concentration as a basis for synaptic transmission failure during hypoxia in the in vitro guinea-pig hippocampus. J. Physiol. 325: 51-65.
    • (1982) J. Physiol. , vol.325 , pp. 51-65
    • Lipton, P.1    Whittingham, T.S.2
  • 142
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophillin-cyclosporin A and FKBP-FK506 complexes
    • Liu, J., Farmer, J. D., Jr., Lane, W. S., Friedman, J., Weissman, I. and Schreiber, S. L. (1991) Calcineurin is a common target of cyclophillin-cyclosporin A and FKBP-FK506 complexes. Cell 66: 807-815.
    • (1991) Cell , vol.66 , pp. 807-815
    • Liu, J.1    Farmer J.D., Jr.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 143
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • Liu, X., Kim, C. N., Yang, J., Jemmerson, R. and Wang, X. (1996) Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86: 147-157.
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 146
    • 84948011844 scopus 로고
    • The toxic effect of sodium L-glutamate on the inner layers of the retina
    • Lucas, D. R. and Newhouse, J. P. (1957) The toxic effect of sodium L-glutamate on the inner layers of the retina. Arch. Ophthalmol. 58: 193-201.
    • (1957) Arch. Ophthalmol. , vol.58 , pp. 193-201
    • Lucas, D.R.1    Newhouse, J.P.2
  • 147
    • 0024357646 scopus 로고
    • Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: Pharmacological characterization
    • Lysko, P. G., Cox, J. A., Vigano, M. A. and Henneberry, R. C. (1989) Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: pharmacological characterization. Brain Res. 499: 258-266.
    • (1989) Brain Res. , vol.499 , pp. 258-266
    • Lysko, P.G.1    Cox, J.A.2    Vigano, M.A.3    Henneberry, R.C.4
  • 148
    • 0022479032 scopus 로고
    • NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurons
    • MacDermott, A. B., Mayer, M. L., Westbrook, G. L., Smith, S. J. and Barker, J. L. (1986) NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurons. Nature 321: 519-522.
    • (1986) Nature , vol.321 , pp. 519-522
    • MacDermott, A.B.1    Mayer, M.L.2    Westbrook, G.L.3    Smith, S.J.4    Barker, J.L.5
  • 149
    • 0029895779 scopus 로고    scopus 로고
    • A prototypic intracellular calcium antagonist, TMB-8, protects cultured cerebellar granule cells against the delayed, calcium-dependent component of glutamate neurotoxicity
    • Malcolm, C. S., Ritchie, L., Grieve, A. and Griffiths, R. (1996) A prototypic intracellular calcium antagonist, TMB-8, protects cultured cerebellar granule cells against the delayed, calcium-dependent component of glutamate neurotoxicity. J. Neurochem. 66: 2350-2360.
    • (1996) J. Neurochem. , vol.66 , pp. 2350-2360
    • Malcolm, C.S.1    Ritchie, L.2    Grieve, A.3    Griffiths, R.4
  • 151
    • 0027240533 scopus 로고
    • Macrolide antibiotics protect neurons in culture against the N-methyl-D-aspartate (NMDA) receptor-mediated toxicity of glutamate
    • Manev, H., Favaron, M., Candeo, P., Fadda, E., Lipartiti, M. and Milani, D. (1993) Macrolide antibiotics protect neurons in culture against the N-methyl-D-aspartate (NMDA) receptor-mediated toxicity of glutamate. Brain Res. 624: 331-335.
    • (1993) Brain Res. , vol.624 , pp. 331-335
    • Manev, H.1    Favaron, M.2    Candeo, P.3    Fadda, E.4    Lipartiti, M.5    Milani, D.6
  • 155
    • 0028335125 scopus 로고
    • The early events of oxygen and glucose deprivation: Setting the scene for neuronal death?
    • Martin, R. L., Lloyd, H. G. E. and Cowan, A. I. (1994) The early events of oxygen and glucose deprivation: setting the scene for neuronal death? Trends Neurosci. 17: 251-257.
    • (1994) Trends Neurosci. , vol.17 , pp. 251-257
    • Martin, R.L.1    Lloyd, H.G.E.2    Cowan, A.I.3
  • 156
    • 0027056182 scopus 로고
    • Regulation of cytosolic free calcium concentration by intrasynaptic mitochondria
    • Martínez-Serrano, A. and Satrústegui, J. (1992) Regulation of cytosolic free calcium concentration by intrasynaptic mitochondria. Mol. Biol. Cell 3: 235-248.
    • (1992) Mol. Biol. Cell , vol.3 , pp. 235-248
    • Martínez-Serrano, A.1    Satrústegui, J.2
  • 157
    • 0026093312 scopus 로고
    • Sequence and expression of a metabotropic glutamate receptor
    • Masu, M., Tanabe, Y., Tsuchida, K., Shigemoto, R. and Nakanishi, S. (1991) Sequence and expression of a metabotropic glutamate receptor. Nature 349: 760-765.
    • (1991) Nature , vol.349 , pp. 760-765
    • Masu, M.1    Tanabe, Y.2    Tsuchida, K.3    Shigemoto, R.4    Nakanishi, S.5
  • 158
    • 0029150526 scopus 로고
    • 2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons
    • 2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons. J. Neurochem. 65: 1740-1751.
    • (1995) J. Neurochem. , vol.65 , pp. 1740-1751
    • Mattson, M.P.1    Lovell, M.A.2    Furukawa, K.3    Markesbery, W.R.4
  • 159
    • 0023492484 scopus 로고
    • Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in cultured mouse central neurons
    • Mayer, M. L. and Westbrook, G. L. (1987) Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in cultured mouse central neurons. J. Physiol. 394: 501-527.
    • (1987) J. Physiol. , vol.394 , pp. 501-527
    • Mayer, M.L.1    Westbrook, G.L.2
  • 160
    • 0023433171 scopus 로고
    • Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III
    • Mayer, M. L., MacDermott, A. B., Westbrook, G. L., Smith, S. J. and Barker, J. L. (1987) Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III. J. Neurosci. 7: 3230-3244.
    • (1987) J. Neurosci. , vol.7 , pp. 3230-3244
    • Mayer, M.L.1    MacDermott, A.B.2    Westbrook, G.L.3    Smith, S.J.4    Barker, J.L.5
  • 161
    • 0024834330 scopus 로고
    • Influence of calcium ions on mammalian intramitochondrial dehydrogenases
    • McCormack, J. G. and Denton, R. M. (1989) Influence of calcium ions on mammalian intramitochondrial dehydrogenases. Methods Enzymol. 174: 95-118.
    • (1989) Methods Enzymol. , vol.174 , pp. 95-118
    • McCormack, J.G.1    Denton, R.M.2
  • 162
    • 0026591024 scopus 로고
    • Isolation of the mitochondrial benzodiazepine receptor: Association with the voltage-dependent anion channel and the adenine nucleotide carrier
    • McEnery, M. W., Snowman, A. M., Trifiletti, R. R. and Snyder, S. H. (1992) Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc. Natl. Acad. Sci. USA 89: 3170-3174.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 3170-3174
    • McEnery, M.W.1    Snowman, A.M.2    Trifiletti, R.R.3    Snyder, S.H.4
  • 163
    • 0023772674 scopus 로고
    • The intracellular distribution of calcium
    • Meldolesi, J., Volpe, P. and Pozzan, T. (1988) The intracellular distribution of calcium. Trends Neurosci. 11: 449-452.
    • (1988) Trends Neurosci. , vol.11 , pp. 449-452
    • Meldolesi, J.1    Volpe, P.2    Pozzan, T.3
  • 164
    • 0025063609 scopus 로고
    • Excitatory amino acid neurotoxicity and neurodegenerative disease
    • Meldrum, B. and Garthwaite, J. (1990) Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci. 11: 379-387.
    • (1990) Trends Pharmacol. Sci. , vol.11 , pp. 379-387
    • Meldrum, B.1    Garthwaite, J.2
  • 165
    • 0025166328 scopus 로고
    • Glutamate neurotoxicity in vitro: Agonist pharmacology and intracellular calcium concentrations
    • Michaels, R. L. and Rothman, S. M. (1990) Glutamate neurotoxicity in vitro: agonist pharmacology and intracellular calcium concentrations. J. Neurosci. 10: 283-292.
    • (1990) J. Neurosci. , vol.10 , pp. 283-292
    • Michaels, R.L.1    Rothman, S.M.2
  • 167
    • 0029150482 scopus 로고
    • Regulation of calcium homeostasis in neurons: The role of calcium-binding proteins
    • Miller, R. J. (1995) Regulation of calcium homeostasis in neurons: the role of calcium-binding proteins. Biochem. Soc. Trans. 23: 629-632.
    • (1995) Biochem. Soc. Trans. , vol.23 , pp. 629-632
    • Miller, R.J.1
  • 170
    • 0002699079 scopus 로고
    • Anatomical, pharmacological, and molecular diversity of native NMDA receptor subtypes
    • Collingridge, G. L. and Watkins, J. C. (eds.) Oxford University Press, New York
    • Monaghan, D. T. and Buller, A. L. (1994) Anatomical, pharmacological, and molecular diversity of native NMDA receptor subtypes. In: The NMDA Receptor, 2nd edn., pp. 158-176, Collingridge, G. L. and Watkins, J. C. (eds.) Oxford University Press, New York.
    • (1994) The NMDA Receptor, 2nd Edn. , pp. 158-176
    • Monaghan, D.T.1    Buller, A.L.2
  • 172
    • 0028343648 scopus 로고
    • Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
    • Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B. and Seeberg, P. H. (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12: 529-540.
    • (1994) Neuron , vol.12 , pp. 529-540
    • Monyer, H.1    Burnashev, N.2    Laurie, D.J.3    Sakmann, B.4    Seeberg, P.H.5
  • 173
    • 0028810883 scopus 로고
    • Structure and function of the NMDA receptor channel
    • Mori, H. and Mishina, M. (1995) Structure and function of the NMDA receptor channel. Neuropharmacology 34: 1219-1237.
    • (1995) Neuropharmacology , vol.34 , pp. 1219-1237
    • Mori, H.1    Mishina, M.2
  • 175
    • 0001395584 scopus 로고
    • The role of NMDA receptors in learning and memory
    • Collingridge, G. L. and Watkins, J. C. (eds.) Oxford University Press, New York
    • Morris, R. G. M. and Davis, M. (1994) The role of NMDA receptors in learning and memory. In: The NMDA Receptor, 2nd edn., pp. 340-375, Collingridge, G. L. and Watkins, J. C. (eds.) Oxford University Press, New York.
    • (1994) The NMDA Receptor, 2nd Edn. , pp. 340-375
    • Morris, R.G.M.1    Davis, M.2
  • 177
    • 0028067770 scopus 로고
    • Rapid desensitization determines the pharmacology of glutamate neurotoxicity
    • Moudy, A. M., Yamada, K. A. and Rothman, S. M. (1994) Rapid desensitization determines the pharmacology of glutamate neurotoxicity. Neuropharmacology 33: 953-962.
    • (1994) Neuropharmacology , vol.33 , pp. 953-962
    • Moudy, A.M.1    Yamada, K.A.2    Rothman, S.M.3
  • 178
    • 0027336413 scopus 로고
    • 2+ influx in the pathogenesis of delayed neuronal death after brief forebrain ischemia in gerbils
    • 2+ influx in the pathogenesis of delayed neuronal death after brief forebrain ischemia in gerbils. Brain Res. 613: 181-192.
    • (1993) Brain Res. , vol.613 , pp. 181-192
    • Nakamura, K.1    Hatakeyama, T.2    Furuta, S.3    Sakaki, S.4
  • 179
    • 0026779363 scopus 로고
    • Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors
    • Nakanishi, N., Axel, R. and Shneider, N. A. (1992) Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors. Proc. Natl. Acad. Sci. USA 89: 8552-8556.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8552-8556
    • Nakanishi, N.1    Axel, R.2    Shneider, N.A.3
  • 180
    • 0028019746 scopus 로고
    • Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria
    • Newmeyer, D. D., Farschon, D. M. and Reed, J. C. (1994) Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria. Cell 79: 353-364.
    • (1994) Cell , vol.79 , pp. 353-364
    • Newmeyer, D.D.1    Farschon, D.M.2    Reed, J.C.3
  • 181
    • 0018269944 scopus 로고
    • The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria
    • Nicholls, D. G. (1978a) The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria. Biochem. J. 176: 463-474.
    • (1978) Biochem. J. , vol.176 , pp. 463-474
    • Nicholls, D.G.1
  • 182
    • 0017904468 scopus 로고
    • Calcium transport and proton electrochemical potential gradient in mitochondria from guinea-pig cerebral cortex and rat heart
    • Nicholls, D. G. (1978b) Calcium transport and proton electrochemical potential gradient in mitochondria from guinea-pig cerebral cortex and rat heart. Biochem. J. 170: 511-522.
    • (1978) Biochem. J. , vol.170 , pp. 511-522
    • Nicholls, D.G.1
  • 183
    • 0022333161 scopus 로고
    • A role for the mitochondrion in the protection of cells against calcium overload?
    • Kogure, K., Hossman, K. A., Siesjö, B. K. and Welsh, F. A. (eds.) Elsevier, Amsterdam
    • Nicholls, D. G. (1985) A role for the mitochondrion in the protection of cells against calcium overload? In: Molecular Mechanisms of Ischemic Brain Damage, pp. 97-106, Kogure, K., Hossman, K. A., Siesjö, B. K. and Welsh, F. A. (eds.) Elsevier, Amsterdam.
    • (1985) Molecular Mechanisms of Ischemic Brain Damage , pp. 97-106
    • Nicholls, D.G.1
  • 185
    • 0025052336 scopus 로고
    • The release and uptake of excitatory amino acids
    • Nicholls, D. G. and Attwell, D. (1990) The release and uptake of excitatory amino acids. Trends Pharmacol. Sci. 11: 462-468.
    • (1990) Trends Pharmacol. Sci. , vol.11 , pp. 462-468
    • Nicholls, D.G.1    Attwell, D.2
  • 187
    • 0345173346 scopus 로고
    • Mitochondrial regulation of external free calcium concentrations
    • Klingenberg, M., Palmieri, F. and Quagliariello, E. (eds.) Elsevier, Amsterdam
    • Nicholls, D. G. and Scott, I. D. (1979) Mitochondrial regulation of external free calcium concentrations. In: Function and Molecular Aspects of Biomembrane Transport, pp. 179-182, Klingenberg, M., Palmieri, F. and Quagliariello, E. (eds.) Elsevier, Amsterdam.
    • (1979) Function and Molecular Aspects of Biomembrane Transport , pp. 179-182
    • Nicholls, D.G.1    Scott, I.D.2
  • 188
    • 0019324973 scopus 로고
    • The regulation of brain mitochondrial calcium-ion transport: The role of ATP in the discrimination between kinetic and membrane-potential-dependent calcium-ion efflux mechanisms
    • Nicholls, D. G. and Scott, I. D. (1980) The regulation of brain mitochondrial calcium-ion transport: The role of ATP in the discrimination between kinetic and membrane-potential-dependent calcium-ion efflux mechanisms. Biochem. J. 186: 833-839.
    • (1980) Biochem. J. , vol.186 , pp. 833-839
    • Nicholls, D.G.1    Scott, I.D.2
  • 189
    • 0030029427 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors: A new target for therapy of neurodegenerative disorders?
    • Nicoletti, F., Bruno, V., Copani, A., Casabona, G. and Knopfel, T. (1996) Metabotropic glutamate receptors: A new target for therapy of neurodegenerative disorders? Trends Neurosci. 19: 267-271.
    • (1996) Trends Neurosci. , vol.19 , pp. 267-271
    • Nicoletti, F.1    Bruno, V.2    Copani, A.3    Casabona, G.4    Knopfel, T.5
  • 190
    • 0030051609 scopus 로고    scopus 로고
    • Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, a cyclosporin A-sensitive channel
    • Nicolli, A., Basso, E., Petronilli, V., Wenger, R. M. and Bernardi, P. (1996) Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, a cyclosporin A-sensitive channel. J. Biol. Chem. 271: 2185-2192.
    • (1996) J. Biol. Chem. , vol.271 , pp. 2185-2192
    • Nicolli, A.1    Basso, E.2    Petronilli, V.3    Wenger, R.M.4    Bernardi, P.5
  • 191
    • 0030298459 scopus 로고    scopus 로고
    • Cyclosporin a delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: Evidence of the mitochondrial permeability transition
    • Nieminen, A.-L., Petrie, T. G., Lemasters, J. J. and Selman, W. R. (1996) Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: evidence of the mitochondrial permeability transition. Neuroscience 75: 993-997.
    • (1996) Neuroscience , vol.75 , pp. 993-997
    • Nieminen, A.-L.1    Petrie, T.G.2    Lemasters, J.J.3    Selman, W.R.4
  • 192
    • 0028924890 scopus 로고
    • Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis
    • Nitatori, T., Sato, N., Waguri, S., Karasawa, Y., Araki, H., Shibanai, K., Kominami, E. and Uchiyama, Y. (1995) Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J. Neurosci. 15: 1001-1011.
    • (1995) J. Neurosci. , vol.15 , pp. 1001-1011
    • Nitatori, T.1    Sato, N.2    Waguri, S.3    Karasawa, Y.4    Araki, H.5    Shibanai, K.6    Kominami, E.7    Uchiyama, Y.8
  • 193
    • 0023895734 scopus 로고
    • Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced
    • Novelli, A., Reilly, J. A., Lysko, P. G. and Henneberry, R. C. (1988) Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res. 451: 205-212.
    • (1988) Brain Res. , vol.451 , pp. 205-212
    • Novelli, A.1    Reilly, J.A.2    Lysko, P.G.3    Henneberry, R.C.4
  • 194
    • 0026742968 scopus 로고
    • The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A
    • Novgorodov, S. A., Gudz, T. I., Milgrom, Y. M. and Brierley, G. P. (1992) The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A. J. Biol. Chem. 267: 16274-16282.
    • (1992) J. Biol. Chem. , vol.267 , pp. 16274-16282
    • Novgorodov, S.A.1    Gudz, T.I.2    Milgrom, Y.M.3    Brierley, G.P.4
  • 195
    • 0027255699 scopus 로고
    • Extracellular neuroactive amino acids in the rat striatum during ischaemia: Comparison between penumbral conditions and ischaemia with sustained anoxic depolarisation
    • Obrenovitch, T. P., Urenjak, J., Richards, D. A., Ueda, Y., Curzon, G. and Symon, L. (1993) Extracellular neuroactive amino acids in the rat striatum during ischaemia: comparison between penumbral conditions and ischaemia with sustained anoxic depolarisation. J. Neurochem. 61: 178-186.
    • (1993) J. Neurochem. , vol.61 , pp. 178-186
    • Obrenovitch, T.P.1    Urenjak, J.2    Richards, D.A.3    Ueda, Y.4    Curzon, G.5    Symon, L.6
  • 196
    • 0014668762 scopus 로고
    • Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate
    • Olney, J. W. (1969) Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 164: 719-721.
    • (1969) Science , vol.164 , pp. 719-721
    • Olney, J.W.1
  • 198
    • 0029982148 scopus 로고    scopus 로고
    • The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition
    • Pastorino, J. G., Simbula, G., Yamamoto, K., Glascott, P. A., Jr., Rothman, R. J. and Farber, J. L. (1996) The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition. J. Biol. Chem. 271: 29792-29798.
    • (1996) J. Biol. Chem. , vol.271 , pp. 29792-29798
    • Pastorino, J.G.1    Simbula, G.2    Yamamoto, K.3    Glascott P.A., Jr.4    Rothman, R.J.5    Farber, J.L.6
  • 200
    • 0027508994 scopus 로고
    • Modulation of the mitochondrial cyclosporin-A-sensitive permeability transition pore
    • Petronilli, V., Cola, C. and Bernardi, P. (1993a) Modulation of the mitochondrial cyclosporin-A-sensitive permeability transition pore. J. Biol. Chem. 268: 1011-1016.
    • (1993) J. Biol. Chem. , vol.268 , pp. 1011-1016
    • Petronilli, V.1    Cola, C.2    Bernardi, P.3
  • 201
    • 0027433653 scopus 로고
    • Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria
    • Petronilli, V., Cola, C., Massari, S., Colonna, R. and Bernardi, P. (1993b) Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria. J. Biol. Chem. 268: 21939-21945.
    • (1993) J. Biol. Chem. , vol.268 , pp. 21939-21945
    • Petronilli, V.1    Cola, C.2    Massari, S.3    Colonna, R.4    Bernardi, P.5
  • 202
    • 0028239794 scopus 로고
    • The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols
    • Petronilli, V., Costantini, P., Scorrano, P., Colonna, R., Passamonti, S. and Bernardi, P. (1994) The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. J. Biol. Chem. 269: 16638-16642.
    • (1994) J. Biol. Chem. , vol.269 , pp. 16638-16642
    • Petronilli, V.1    Costantini, P.2    Scorrano, P.3    Colonna, R.4    Passamonti, S.5    Bernardi, P.6
  • 203
    • 0025187798 scopus 로고
    • Structural and functional aspects of calcium homeostasis in eukaryotic cells
    • Pietrobon, D., Di Virgilio, F. and Pozzan, T. (1990) Structural and functional aspects of calcium homeostasis in eukaryotic cells. Eur. J. Biochem. 193: 599-622.
    • (1990) Eur. J. Biochem. , vol.193 , pp. 599-622
    • Pietrobon, D.1    Di Virgilio, F.2    Pozzan, T.3
  • 204
    • 0028912822 scopus 로고
    • The metabotropic glutamate receptors: Structure and functions
    • Pin, J.-P. and Duvoisin, R. (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34: 1-26.
    • (1995) Neuropharmacology , vol.34 , pp. 1-26
    • Pin, J.-P.1    Duvoisin, R.2
  • 205
    • 0027216836 scopus 로고
    • Attenuation of excitatory amino acid toxicity by metabotropic glutamate receptor agonists and aniracetam in primary cultures of cerebellar granule cells
    • Pizzi, M., Fallacara, C., Arrighi, V., Memo, M. and Spano, P. (1993) Attenuation of excitatory amino acid toxicity by metabotropic glutamate receptor agonists and aniracetam in primary cultures of cerebellar granule cells. J. Neurochem. 61: 683-689.
    • (1993) J. Neurochem. , vol.61 , pp. 683-689
    • Pizzi, M.1    Fallacara, C.2    Arrighi, V.3    Memo, M.4    Spano, P.5
  • 207
    • 0028283948 scopus 로고
    • Molecular and cellular physiology of intracellular calcium stores
    • Pozzan, T., Rizzuto, R., Volpe, P. and Meldolesi, J. (1994) Molecular and cellular physiology of intracellular calcium stores. Physiol. Rev. 74: 595-636.
    • (1994) Physiol. Rev. , vol.74 , pp. 595-636
    • Pozzan, T.1    Rizzuto, R.2    Volpe, P.3    Meldolesi, J.4
  • 208
    • 0028331717 scopus 로고
    • Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary culture
    • Prézeau, L., Carrette, J., Helpap, B., Curry, K., Pin, J. P. and Bockaert, J. (1993) Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary culture. Mol. Pharmacol. 45: 570-577.
    • (1993) Mol. Pharmacol. , vol.45 , pp. 570-577
    • Prézeau, L.1    Carrette, J.2    Helpap, B.3    Curry, K.4    Pin, J.P.5    Bockaert, J.6
  • 210
    • 0020584247 scopus 로고
    • Increased damage after stroke in patients with hyperglycemia with or without established diabetes mellitus
    • Pulsinelli, W. A., Levy, D. E., Sigsbee, B., Scherer, P. and Plum, F. (1983) Increased damage after stroke in patients with hyperglycemia with or without established diabetes mellitus. Am. J. Med. 74: 540-545.
    • (1983) Am. J. Med. , vol.74 , pp. 540-545
    • Pulsinelli, W.A.1    Levy, D.E.2    Sigsbee, B.3    Scherer, P.4    Plum, F.5
  • 212
    • 0027364206 scopus 로고
    • 2+ concentrations associated with glutamate excitotoxicity in cultured rat brain neurons
    • 2+ concentrations associated with glutamate excitotoxicity in cultured rat brain neurons. Neurosci. Lett. 162: 149-152.
    • (1993) Neurosci. Lett. , vol.162 , pp. 149-152
    • Rajdev, S.1    Reynolds, I.J.2
  • 213
    • 0026608995 scopus 로고
    • Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons
    • Randall, R. D. and Thayer, S. A. (1992) Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons. J. Neurosci. 12: 1882-1895.
    • (1992) J. Neurosci. , vol.12 , pp. 1882-1895
    • Randall, R.D.1    Thayer, S.A.2
  • 214
    • 0016246085 scopus 로고
    • The inhibition of mitochondrial calcium transport by lanthanides and ruthenium red
    • Reed, K. C. and Bygrave, F. L. (1974) The inhibition of mitochondrial calcium transport by lanthanides and ruthenium red. Biochem. J. 140: 143-155.
    • (1974) Biochem. J. , vol.140 , pp. 143-155
    • Reed, K.C.1    Bygrave, F.L.2
  • 216
    • 0030005401 scopus 로고    scopus 로고
    • Function of metabotropic glutamate receptors in learning and memory
    • Riedel, G. (1996) Function of metabotropic glutamate receptors in learning and memory. Trends Neurosci. 19: 219-224.
    • (1996) Trends Neurosci. , vol.19 , pp. 219-224
    • Riedel, G.1
  • 218
    • 0024471696 scopus 로고
    • +-isocitrate dehydrogenase and the 2-oxoglutarate complex
    • +-isocitrate dehydrogenase and the 2-oxoglutarate complex. Biochem. J. 263: 453-462.
    • (1989) Biochem. J. , vol.263 , pp. 453-462
    • Rutter, G.A.1    Denton, R.M.2
  • 220
    • 0027450488 scopus 로고
    • Neurotoxicity of HIV coat protein gp120, NMDa receptors, and protein kinase C: A study with rat cerebellar granule cell cultures
    • Savio, T. and Levi, G. (1993) Neurotoxicity of HIV coat protein gp120, NMDA receptors, and protein kinase C: a study with rat cerebellar granule cell cultures. J. Neurosci. Res. 34: 265-272.
    • (1993) J. Neurosci. Res. , vol.34 , pp. 265-272
    • Savio, T.1    Levi, G.2
  • 222
    • 0029810095 scopus 로고    scopus 로고
    • Mitochondrial dysfunction is a primary event in glutamate neurotoxicity
    • Schinder, A. F., Olson, E. C., Spitzer, N. C. and Montal, M. (1996) Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J. Neurosci. 16: 6125-6133.
    • (1996) J. Neurosci. , vol.16 , pp. 6125-6133
    • Schinder, A.F.1    Olson, E.C.2    Spitzer, N.C.3    Montal, M.4
  • 223
    • 0027371048 scopus 로고
    • Glutamate- and AMPA-mediated calcium influx through glutamate receptor channels in medial septal neurons
    • Schneggenburger, R., Tempia, F. and Konnerth, A. (1993) Glutamate- and AMPA-mediated calcium influx through glutamate receptor channels in medial septal neurons. Neuropharmacology 32: 1221-1228.
    • (1993) Neuropharmacology , vol.32 , pp. 1221-1228
    • Schneggenburger, R.1    Tempia, F.2    Konnerth, A.3
  • 224
    • 0028243862 scopus 로고
    • Novel functions for subtypes of metabotropic glutamate receptors
    • Schoepp, D. D. (1994) Novel functions for subtypes of metabotropic glutamate receptors. Neurochem. Int. 24: 439-449.
    • (1994) Neurochem. Int. , vol.24 , pp. 439-449
    • Schoepp, D.D.1
  • 225
    • 0027395275 scopus 로고
    • Metabotropic glutamate receptors in brain function and pathology
    • Schoepp, D. D. and Conn, P. J. (1993) Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol. Sci. 14: 13-20.
    • (1993) Trends Pharmacol. Sci. , vol.14 , pp. 13-20
    • Schoepp, D.D.1    Conn, P.J.2
  • 226
    • 0019398842 scopus 로고
    • Role of astroglial cells in glutamate homeostasis
    • Schousboe, A. and Hertz, L. (1981) Role of astroglial cells in glutamate homeostasis. Adv. Biochem. Psychopharmacol. 27: 103-113.
    • (1981) Adv. Biochem. Psychopharmacol. , vol.27 , pp. 103-113
    • Schousboe, A.1    Hertz, L.2
  • 227
    • 0025139268 scopus 로고
    • Serum and depolarising agents cause acute neurotoxicity in cultured cerebellar granule cells: The role of the glutamate receptor responsive to N-methyl-D-aspartate
    • Schramm, M., Eimerl, S. and Costa, E. (1990) Serum and depolarising agents cause acute neurotoxicity in cultured cerebellar granule cells: the role of the glutamate receptor responsive to N-methyl-D-aspartate. Proc. Natl. Acad. Sci. USA 87: 1193-1197.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 1193-1197
    • Schramm, M.1    Eimerl, S.2    Costa, E.3
  • 229
    • 0030995428 scopus 로고    scopus 로고
    • On the voltage dependence of the mitochondrial permeability transition pore
    • Scorrano, L., Petronilli, V. and Bernardi, P. (1997) On the voltage dependence of the mitochondrial permeability transition pore. J. Biol. Chem. 272: 12295-12299.
    • (1997) J. Biol. Chem. , vol.272 , pp. 12295-12299
    • Scorrano, L.1    Petronilli, V.2    Bernardi, P.3
  • 230
    • 0027234701 scopus 로고
    • The molecular biology of mammalian glutamate receptor channels
    • Seeburg, P. H. (1993) The molecular biology of mammalian glutamate receptor channels. Trends Neurosci. 16: 359-365.
    • (1993) Trends Neurosci. , vol.16 , pp. 359-365
    • Seeburg, P.H.1
  • 231
    • 0010673819 scopus 로고
    • Molecular biology of NMDA receptors
    • Ch. 5, Collingridge, G. L. and Watkins, J. C. (eds.) Oxford University Press, New York
    • Seeburg, P. H., Monyer, H., Sprengel, R. and Burnashev, N. (1994) Molecular biology of NMDA receptors. In: The NMDA Receptor, 2nd edn., Ch. 5, pp. 147-157, Collingridge, G. L. and Watkins, J. C. (eds.) Oxford University Press, New York.
    • (1994) The NMDA Receptor, 2nd Edn. , pp. 147-157
    • Seeburg, P.H.1    Monyer, H.2    Sprengel, R.3    Burnashev, N.4
  • 232
    • 0027937489 scopus 로고
    • Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia
    • Sharkey, J. and Butcher, S. P. (1994) Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. Nature 371: 336-339.
    • (1994) Nature , vol.371 , pp. 336-339
    • Sharkey, J.1    Butcher, S.P.2
  • 233
    • 0031017696 scopus 로고    scopus 로고
    • Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease
    • Sheehan, J. P., Swerdlow, R. H., Parker, W. D., Miller, S. W., Davis, R. E. and Tuttle, J. B. (1997) Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease. J. Neurochem. 68: 1221-1233.
    • (1997) J. Neurochem. , vol.68 , pp. 1221-1233
    • Sheehan, J.P.1    Swerdlow, R.H.2    Parker, W.D.3    Miller, S.W.4    Davis, R.E.5    Tuttle, J.B.6
  • 236
    • 0021743001 scopus 로고
    • Blockade of N-methyl-D-aspartate receptors may protect against ischemic brain damage in the brain
    • Simon, R. P., Swan, J. H., Griffiths, T. and Meldrum, B. S. (1984) Blockade of N-methyl-D-aspartate receptors may protect against ischemic brain damage in the brain. Science 226: 850-852.
    • (1984) Science , vol.226 , pp. 850-852
    • Simon, R.P.1    Swan, J.H.2    Griffiths, T.3    Meldrum, B.S.4
  • 238
    • 0029765443 scopus 로고    scopus 로고
    • Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants
    • Skulachev, V. P. (1996) Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants. Q. Rev. Biophys. 29: 169-202.
    • (1996) Q. Rev. Biophys. , vol.29 , pp. 169-202
    • Skulachev, V.P.1
  • 239
    • 0028324377 scopus 로고
    • Protein kinase C activation attenuates N-methyl-D-aspartate-induced increases in intracellular calcium in cerebellar granule cells
    • Snell, L. D., Iorio, K. R., Tabakoff, B. and Hoffman, P. L. (1994) Protein kinase C activation attenuates N-methyl-D-aspartate-induced increases in intracellular calcium in cerebellar granule cells. J. Neurochem. 62: 1783-1789.
    • (1994) J. Neurochem. , vol.62 , pp. 1783-1789
    • Snell, L.D.1    Iorio, K.R.2    Tabakoff, B.3    Hoffman, P.L.4
  • 241
    • 0025995296 scopus 로고
    • RNA editing in the brain controls a determinant of ion flow in glutamate-gated channels
    • Sommer, B., Köhler, M., Sprengel, R. and Seeburg, P. H. (1991) RNA editing in the brain controls a determinant of ion flow in glutamate-gated channels. Cell 67: 11-19.
    • (1991) Cell , vol.67 , pp. 11-19
    • Sommer, B.1    Köhler, M.2    Sprengel, R.3    Seeburg, P.H.4
  • 242
    • 0029737355 scopus 로고    scopus 로고
    • + channels, glutamate release, and NMDA receptors mediates delayed neurodegeneration through nitric oxide formation
    • + channels, glutamate release, and NMDA receptors mediates delayed neurodegeneration through nitric oxide formation. J. Neurosci. 16: 5004-5013.
    • (1996) J. Neurosci. , vol.16 , pp. 5004-5013
    • Strijbos, P.J.L.M.1    Leach, M.J.2    Garthwaite, J.3
  • 245
    • 0025251185 scopus 로고
    • Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake
    • Szatkowski, M., Barbour, B. and Attwell, D. (1990) Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature 348: 443-446.
    • (1990) Nature , vol.348 , pp. 443-446
    • Szatkowski, M.1    Barbour, B.2    Attwell, D.3
  • 246
    • 0024959451 scopus 로고
    • Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein
    • Takahashi, N., Hayano, T. and Suzuki, M. (1989) Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein. Nature 337: 473-475.
    • (1989) Nature , vol.337 , pp. 473-475
    • Takahashi, N.1    Hayano, T.2    Suzuki, M.3
  • 247
    • 0030888097 scopus 로고    scopus 로고
    • Susceptibility of cerebellar granule neurons derived from Bcl-2-deficient and transgenic mice to cell death
    • Tanabe, H., Eguchi, Y., Kamada, S., Martinou, J.-C. and Tsujimoto, Y. (1997) Susceptibility of cerebellar granule neurons derived from Bcl-2-deficient and transgenic mice to cell death. Eur. J. Neurosci. 9: 848-856.
    • (1997) Eur. J. Neurosci. , vol.9 , pp. 848-856
    • Tanabe, H.1    Eguchi, Y.2    Kamada, S.3    Martinou, J.-C.4    Tsujimoto, Y.5
  • 248
    • 0027410488 scopus 로고
    • Signal transduction, pharmacological properties, and expression patterns of two metabotropic glutamate receptors, mGluR3 and mGluR4
    • Tanabe, Y., Nomura, A., Masu, M., Shigemoto, R., Mizuno, N. and Nakanishi, S. (1993) Signal transduction, pharmacological properties, and expression patterns of two metabotropic glutamate receptors, mGluR3 and mGluR4. J. Neurosci. 13: 1372-1378.
    • (1993) J. Neurosci. , vol.13 , pp. 1372-1378
    • Tanabe, Y.1    Nomura, A.2    Masu, M.3    Shigemoto, R.4    Mizuno, N.5    Nakanishi, S.6
  • 249
    • 0025142479 scopus 로고
    • Modulation of the N-methyl-D-aspartate channel by extracellular H+
    • Tang, C.-M., Dichter, M. and Morad, M. (1990) Modulation of the N-methyl-D-aspartate channel by extracellular H+. Proc. Natl. Acad. Sci. USA 87: 6445-6449.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6445-6449
    • Tang, C.-M.1    Dichter, M.2    Morad, M.3
  • 250
    • 0027256475 scopus 로고
    • Regulation of the intracellular free calcium concentration in acutely dissociated neurones from rat nucleus basalis
    • Tatsumi, H. and Katayama, Y. (1993) Regulation of the intracellular free calcium concentration in acutely dissociated neurones from rat nucleus basalis. J. Physiol. 464: 165-181.
    • (1993) J. Physiol. , vol.464 , pp. 165-181
    • Tatsumi, H.1    Katayama, Y.2
  • 251
    • 0025331705 scopus 로고
    • Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro
    • Thayer, S. A. and Miller, R. J. (1990) Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro. J. Physiol. 425: 85-115.
    • (1990) J. Physiol. , vol.425 , pp. 85-115
    • Thayer, S.A.1    Miller, R.J.2
  • 252
    • 0027324191 scopus 로고
    • Evolving concepts about the role of acidosis in ischemic neuropathology
    • Tombaugh, G. C. and Sapolsky, R. M. (1993) Evolving concepts about the role of acidosis in ischemic neuropathology. J. Neurochem. 61: 793-803.
    • (1993) J. Neurochem. , vol.61 , pp. 793-803
    • Tombaugh, G.C.1    Sapolsky, R.M.2
  • 253
    • 0025350861 scopus 로고
    • Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons
    • Traynelis, S. F. and Cull-Candy, S. G. (1990) Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons. Nature 345: 347-350.
    • (1990) Nature , vol.345 , pp. 347-350
    • Traynelis, S.F.1    Cull-Candy, S.G.2
  • 254
    • 0027497936 scopus 로고
    • Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
    • Tymianski, M., Charlton, M. P., Carlen, P. L. and Tator, C. H. (1993a) Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. J. Neurosci. 13: 2085-2104.
    • (1993) J. Neurosci. , vol.13 , pp. 2085-2104
    • Tymianski, M.1    Charlton, M.P.2    Carlen, P.L.3    Tator, C.H.4
  • 258
    • 0027982155 scopus 로고
    • Extracellular glutamate during focal cerebral ischemia in rats: Time course and calcium dependency
    • Wahl, F., Obrenovitch, T. P., Hardy, A. M., Plotkine, M., Boulu, R. and Symon, L. (1994) Extracellular glutamate during focal cerebral ischemia in rats: time course and calcium dependency. J. Neurochem. 63: 1003-1011.
    • (1994) J. Neurochem. , vol.63 , pp. 1003-1011
    • Wahl, F.1    Obrenovitch, T.P.2    Hardy, A.M.3    Plotkine, M.4    Boulu, R.5    Symon, L.6
  • 260
    • 0025191432 scopus 로고
    • Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists
    • Watkins, J. C., Krogsgaard-Larsen, P. and Honoré, T. (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. Trends Pharmacol. Sci. 11: 25-33.
    • (1990) Trends Pharmacol. Sci. , vol.11 , pp. 25-33
    • Watkins, J.C.1    Krogsgaard-Larsen, P.2    Honoré, T.3
  • 261
    • 0028137844 scopus 로고
    • Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies
    • Wenthold, R. J., Trumpy, V. A., Zhu, W. S. and Pertralia, R. S. (1994) Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies. J. Biol. Chem. 269: 1332-1339.
    • (1994) J. Biol. Chem. , vol.269 , pp. 1332-1339
    • Wenthold, R.J.1    Trumpy, V.A.2    Zhu, W.S.3    Pertralia, R.S.4
  • 262
    • 0025810536 scopus 로고
    • Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells
    • Werner, P., Voigt, M., Keinän, K., Wisden, W. and Seeburg, P. H. (1991) Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells. Nature 351: 742-744.
    • (1991) Nature , vol.351 , pp. 742-744
    • Werner, P.1    Voigt, M.2    Keinän, K.3    Wisden, W.4    Seeburg, P.H.5
  • 263
    • 0028137817 scopus 로고
    • Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons
    • Werth, J. L. and Thayer, S. A. (1994) Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons. J. Neurosci. 14: 348-356.
    • (1994) J. Neurosci. , vol.14 , pp. 348-356
    • Werth, J.L.1    Thayer, S.A.2
  • 264
    • 0028985491 scopus 로고
    • 2+ exchange buffer glutamate-induced calcium loads in cultured cortical neurons
    • 2+ exchange buffer glutamate-induced calcium loads in cultured cortical neurons. J. Neurosci. 15: 1318-1328.
    • (1995) J. Neurosci. , vol.15 , pp. 1318-1328
    • White, R.J.1    Reynolds, I.J.2
  • 265
    • 0029788243 scopus 로고    scopus 로고
    • Mitochondrial depolarisation in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure
    • White, R. J. and Reynolds, I. J. (1996) Mitochondrial depolarisation in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure. J. Neurosci. 16: 5688-5697.
    • (1996) J. Neurosci. , vol.16 , pp. 5688-5697
    • White, R.J.1    Reynolds, I.J.2
  • 266
    • 0031016799 scopus 로고    scopus 로고
    • 2+ following intense glutamate stimulation of cultured rat forebrain neurons
    • 2+ following intense glutamate stimulation of cultured rat forebrain neurons. J. Physiol. 498: 31-47.
    • (1997) J. Physiol. , vol.498 , pp. 31-47
    • White, R.J.1    Reynolds, I.J.2
  • 267
    • 0030959560 scopus 로고    scopus 로고
    • Activation and desensitization of hippocampal kainate receptors
    • Wilding, T. J. and Huettner, J. E. (1997) Activation and desensitization of hippocampal kainate receptors. J. Neurosci. 17: 2713-2721.
    • (1997) J. Neurosci. , vol.17 , pp. 2713-2721
    • Wilding, T.J.1    Huettner, J.E.2
  • 268
    • 0021132331 scopus 로고
    • Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria
    • Wingrove, D. E., Amatruda, J. M. and Gunter, T. E. (1984) Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria. J. Biol. Chem. 259: 9390-9394.
    • (1984) J. Biol. Chem. , vol.259 , pp. 9390-9394
    • Wingrove, D.E.1    Amatruda, J.M.2    Gunter, T.E.3
  • 269
    • 0031020227 scopus 로고    scopus 로고
    • Interaction and regulation of subcellular localization of CED-4 by CED-9
    • Wu, D., Wallen, H. D. and Nunez, G. (1997) Interaction and regulation of subcellular localization of CED-4 by CED-9. Science 275: 1126-1129.
    • (1997) Science , vol.275 , pp. 1126-1129
    • Wu, D.1    Wallen, H.D.2    Nunez, G.3
  • 271
    • 0030058865 scopus 로고    scopus 로고
    • In vivo evidence of hydroxyl radical formation induced by elevation of extracellular glutamate after cerebral ischemia in the cortex of anesthetized rats
    • Yang, C.-S., Lin, N.-N., Tsai, P.-J., Liu, L. and Kuo, J.-S. (1996) In vivo evidence of hydroxyl radical formation induced by elevation of extracellular glutamate after cerebral ischemia in the cortex of anesthetized rats. Free Radic. Biol. Med. 20: 245-250.
    • (1996) Free Radic. Biol. Med. , vol.20 , pp. 245-250
    • Yang, C.-S.1    Lin, N.-N.2    Tsai, P.-J.3    Liu, L.4    Kuo, J.-S.5
  • 273
    • 0030898061 scopus 로고    scopus 로고
    • Membrane-delimited modulation of NMDA currents by metabotropic glutamate receptor subtypes 1/5 in cultured mouse cortical neurons
    • Yu, P. S., Sensi, S. L., Canzoniero, L. M. T., Buisson, A. and Choi, D. W. (1997) Membrane-delimited modulation of NMDA currents by metabotropic glutamate receptor subtypes 1/5 in cultured mouse cortical neurons. J. Physiol. 499: 721-732.
    • (1997) J. Physiol. , vol.499 , pp. 721-732
    • Yu, P.S.1    Sensi, S.L.2    Canzoniero, L.M.T.3    Buisson, A.4    Choi, D.W.5
  • 274
  • 275
    • 0028903933 scopus 로고
    • Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
    • Zamzami, N., Marchetti, P., Castedo, M., Vayssière, J.-L., Petit, P. X. and Kroemer, G. (1995b) Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med. 181: 1661-1672.
    • (1995) J. Exp. Med. , vol.181 , pp. 1661-1672
    • Zamzami, N.1    Marchetti, P.2    Castedo, M.3    Vayssière, J.-L.4    Petit, P.X.5    Kroemer, G.6
  • 277
    • 0020410450 scopus 로고
    • The role of phosphate in the regulation of the independent calcium-efflux pathway of liver mitochondria
    • Zoccorato, F. and Nicholls, D. G. (1982) The role of phosphate in the regulation of the independent calcium-efflux pathway of liver mitochondria. Eur. J. Biochem. 127: 333-338.
    • (1982) Eur. J. Biochem. , vol.127 , pp. 333-338
    • Zoccorato, F.1    Nicholls, D.G.2
  • 278
    • 0028091583 scopus 로고
    • Electrophysiology of the inner mitochondrial membrane
    • Zoratti, M. and Szabó, I. (1994) Electrophysiology of the inner mitochondrial membrane. J. Bioenerg. Biomembr. 26: 543-553.
    • (1994) J. Bioenerg. Biomembr. , vol.26 , pp. 543-553
    • Zoratti, M.1    Szabó, I.2
  • 279
    • 0029116916 scopus 로고
    • The mitochondrial permeability transition
    • Zoratti, M. and Szabó, I. (1995) The mitochondrial permeability transition. Biochim. Biophys. Acta 1241: 139-176.
    • (1995) Biochim. Biophys. Acta , vol.1241 , pp. 139-176
    • Zoratti, M.1    Szabó, I.2
  • 280
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome-c-dependent activation of caspase-3
    • Zou, H., Henzel, W. J., Liu, X., Lutschg, A. and Wang, X. (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome-c-dependent activation of caspase-3. Cell 90: 405-413.
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.