Mapping the agonist binding site of the nicotinic acetylcholine receptor. Orientation requirements for activation by covalent agonist

Journal of Biological Chemistry

Volumn 275, Issue 17, 2000, Pages 12651-12660

  Sullivan, Deirdre A ^a   Cohen, Jonathan B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; QUATERNARY AMMONIUM DERIVATIVE; REAGENT; THIOCHOLINE; THIOL DERIVATIVE; THIOMESYLIC ACID METHYL ESTER; TRIMETHYLAMMONIUM SALT DERIVATIVE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG BINDING SITE; DRUG RECEPTOR BINDING; NONHUMAN; OOCYTE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TORPEDO; XENOPUS LAEVIS;

ACETYLCHOLINE; AFFINITY LABELS; ALKYLATION; ANIMALS; BINDING SITES; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYL METHANESULFONATE; INDICATORS AND REAGENTS; KINETICS; MESYLATES; MODELS, CHEMICAL; MUTAGENESIS; NICOTINIC AGONISTS; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, QUATERNARY; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, NICOTINIC; TIME FACTORS; TRANSCRIPTION, GENETIC; XENOPUS;

ANIMALIA; XENOPUS LAEVIS;

EID: 0034724709     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.17.12651     Document Type: Article

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