Structure of the agonist-binding sites of the Torpedo nicotinic acetylcholine receptor: Affinity-labeling and mutational analyses identify γTyr-111/δArg-113 as antagonist affinity determinants

Biochemistry

Volumn 38, Issue 20, 1999, Pages 6689-6698

  Chiara, David C ^a   Xie, Yu ^a,b   Cohen, Jonathan B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ALPHA BUNGAROTOXIN; ARGININE; CONOTOXIN; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT; TUBOCURARINE CHLORIDE; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING KINETICS; BINDING SITE; CONTROLLED STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SECONDARY STRUCTURE; RECEPTOR AFFINITY; RECEPTOR BINDING; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURFACE CHARGE; TORPEDO CALIFORNICA; VOLTAGE CLAMP;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; BINDING SITES; CONOTOXINS; DNA MUTATIONAL ANALYSIS; ELECTROPHYSIOLOGY; MOLECULAR SEQUENCE DATA; MOLLUSK VENOMS; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; OOCYTES; PEPTIDES, CYCLIC; PHOTOAFFINITY LABELS; RECEPTORS, NICOTINIC; TORPEDO; TRITIUM; TUBOCURARINE; TYROSINE; XENOPUS;

EID: 0033580614     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9901735     Document Type: Article

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