Pharmacogenomics and addiction to opiates

European Journal of Pharmacology

Volumn 410, Issue 2-3, 2000, Pages 269-279

  Lichtermann, Dirk ^a   Franke, Petra ^a   Maier, Wolfgang ^a   Rao, Marie Luise ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Addiction; Candidate gene; Genetic; Heroin; Opiate; Pharmacogenomics

Indexed keywords

DIAMORPHINE; OPIATE;

ARTICLE; DNA MICROARRAY; GENE EXPRESSION; GENE MAPPING; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; LIMBIC SYSTEM; NONHUMAN; OPIATE ADDICTION; PHARMACODYNAMICS; PHARMACOGENOMICS; PRIORITY JOURNAL; RISK FACTOR;

ANIMALS; HUMANS; OPIOID-RELATED DISORDERS; PHARMACOGENETICS;

EID: 0034723047     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00820-7     Document Type: Article

References (81)

1. Further evidence for a quantitative trait locus on murine chromosome 10 controlling morphine preference in inbred mice
2. Morphine self-administration in μ-opioid receptor-deficient mice
3. Chromosome mapping of gene loci affecting morphine and amphetamine responses in BXD recombinant inbred mice
4. Voluntary consumption of morphine in 15 inbred mouse strains
5. Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 strains
6. A study of oral morphine preference in inbred mouse strains
7. Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains
8. Common and specific factors in the familial transmission of substance dependence
9. Allelic association of human dopamine D2 receptor gene in alcoholism
10. Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction
11. Region-specific up-regulation of opioid receptor binding in enkephalin knockout mice
12. μ- and δ-opioid receptor gene expression after chronic treatment with opioid agonist
13. Chronic morphine and naltrexone fail to modify μ-opioid receptor mRNA levels in the rat brain
14. Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors
15. Cannabinoid receptor gene (CNR1): Association with i.v. drug use
16. Genetic animal models of alcohol and drug abuse
17. Identifying genes for alcohol and drug sensitivity: Recent progress and future directions
18. Dopamine receptors and dopamine transporter in brain function and addictive behaviors: Insights from targeted mouse mutants
19. Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence
20. Agonist selective μ-opioid receptor trafficking in rat central nervous system
21. Opiate drugs: 'Guilt by association'
22. Human δ-opioid receptor gene and susceptibility to heroin and alcohol dependence
23. DRD4 exon III VNTR polymorphism- susceptibility factor for heroin dependence? Results of a case-control and a family-based association approach
24. D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects
25. Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology
26. Molecular mechanisms of cognition: Genetics of mouse learning and memory as a route to human psychiatry
27. Genetic and environmental risk factors in the aetiology of illicit drug initiation and subsequent misuse in women
28. Hallucinogen, opiate, sedative and stimulant use and abuse in a population-based sample of female twins
29. Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins
30. Acute morphine dependence in mice selectively-bred for high and low analgesia
31. Opioids: First lessons from knockout mice
32. No heroin or morphine 6β-glucuronide analgesia in μ-opioid receptor knockout mice
33. Quantitative autoradiographic mapping of μ-, δ- and κ-opioid receptors in knockout mice lacking the μ-opioid receptor gene
34. Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects
35. No association between the serotonin transporter promoter region (5-HTTLPR) and the dopamine D3 receptor (BalI D3DR) polymorphisms and heroin addiction
36. Opiates, opioids and addiction
37. Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
38. Association analysis of the dopamine D4 gene exon III VNTR and heroin abuse in Chinese subjects
39. Allelic association analysis of dopamine D2, D3, 5-HT2A and GABAg2 receptors and the serotonin transporter genes with heroin abuse in chinese subjects
40. Support for allelic association of a polymorphic site in the promoter region of the serotonin transporter gene with risk for alcohol dependence
41. Genomics, gene expression and DNA arrays
42. Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB
43. Absence of opiate rewarding effects in mice lacking dopamine D2 receptors
44. Genetic variability in morphine sensitivity and tolerance between different strains of rats
45. Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB(1) receptor knockout mice
46. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioid-receptor gene
47. Association between a delta opioid receptor gene polymorphism and heroin dependence in man
48. The use of single-nucleotide polymorphism maps in pharmacogenomics
49. Relevance of deficient CYP2D6 in opiate dependence
50. Expression profiling and behavioral responses to drugs of abuse
51. Rewarding effects of opiates are absent in mice lacking the receptor for substance P
52. Molecular and cellular basis of addiction
53. Comparison of G-protein activation in the brain by μ-, δ-, and κ-opioid receptor agonists in μ-opioid receptor knockout mice
54. D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: Enhanced frequencies in psychostimulant-preferring polysubstance abusers
55. Genome-wide search for genes affecting the risk for alcohol dependence
56. The future of genetic studies of complex human diseases
57. Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor
58. Absence of opioid stress-induced analgesia in mice lacking β-endorphin by site-directed mutagenesis
59. The neurochemistry of morphine addiction in the neocortex
60. Disruption of the κ-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ-agonist U-50,488H and attenuates morphine withdrawal
61. 1 opioid receptors in κ-opioid receptor knockout mice
62. Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I B1 restriction fragment length polymorphism appears more frequently in polysubstance abusers
63. The dopamine hypothesis of reward: Past and current status
64. Increased rewarding properties of morphine in dopamine-transporter knockout mice
65. The TDT and other family-based tests for linkage disequilibrium and association
66. Evidence for an association between heroin dependence and a VNTR polymorphism at the serotonin transporter locus
67. 1 opioid receptor mechanism
68. Forward and reverse genetic approaches to behavior in the mouse
69. Genetic influences on DSM-III-R drug abuse and dependence: A study of 3,372 twin pairs
70. Genetic and environmental influences on transitions in drug use
71. Using twin data to define drug abuse phenotypes
72. Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence
73. Relevance of deficient CYP2D6 in opiate dependence
74. The μ opiate receptor as a candidate gene for pain: Polymorphisms, variations in expression, nociception, and opiate responses
75. Chronic opioid antagonist administration upregulates mu opioid receptor binding without altering mu opioid receptor mRNA levels
76. An association between a microsatellite polymorphism at the DRD5 gene and the liability to substance abuse: Pilot study
77. Acute intermittent morphine increases preprodynorphin and kappa opioid receptor mRNA levels in the rat brain
78. Cocaine and the serotonin saga
79. Getting the brain's attention
80. Steady-state methadone in rats does not change mRNA levels of corticotropin-releasing factor, its pituitary receptor or proopiomelanocortin
81. Retention of supraspinal delta-like analgesia and loss of morphine tolerance in δ opioid receptor knockout mice