Genomic structure of TBX2 indicates conservation with distantly related T-box genes

Mammalian Genome

Volumn 9, Issue 1, 1998, Pages 70-73

  Campbell, Christine E ^a   Casey, Graham ^a   Goodrich, Kristine ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEVELOPMENTAL GENETICS; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN GENOME; TATA BOX;

ANIMALS; BASE SEQUENCE; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; FEMALE; HUMANS; MALE; PEDIGREE; T-BOX DOMAIN PROTEINS;

CAENORHABDITIS ELEGANS;

EID: 0031896484     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003359900682     Document Type: Article

References (29)

1. Agulnik SI, Bollag RJ, Silver LM (1995) Conservation of the T-box gene family from Mus musculus to Caenorhabditis elegans. Genomics 25, 214-219
2. Agulnik SI, Garvey N, Hancock S, Ruvinsky I, Chapman DL, Agulnik I, Bollag R, Papaioannou V, Silver LM (1996) Evolution of mouse T-box genes by tandem duplication and cluster dispersion. Genetics 144, 249-254
3. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215, 403-410
4. Bamshad M, Lin RC, Law DJ, Watkins WS, Krakowiak PA, Moore ME, Franceschini P, Lala R, Holmes LoB, Gebuhr TC, Bruneau BG, Schinzel A, Seidman JG, Seidman CE, Jorde LB (1997) Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nature Genet 16, 311-315
5. Basson CT, Bachinsky DR, Lin RC, Levi T, Elkins JA, Soults J, Grayzel D, Kroumpouzou E, Traill TA, Leblanc-Straceski J, Renault B, Kucherlapati R, Seidman JG, Seidman CE (1997) Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome. Nature Genet 15, 30-35
6. Bollag RJ, Siegried Z, Cebra-Thomas JA, Garvey N, Davison EM, Silver LM (1994) An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus. Nature Genet 7, 383-389
7. Brook WJ, Cohen SM (1996) Antagonistic interactions between wingless and decapentaplegic responsible for dorsal-ventral pattern in the Drosophila leg. Science 273, 1373-1377
8. Bulfone A, Smiga S, Shimamura K, Peterson A, Puelles L, Rubenstein J (1995) T-brain-1: a homolog of brachyury whose expression defines molecularly distinct domains within the cerebral cortex. Neuron 15, 63-78
9. Campbell C, Goodrich K, Casey G, Beatty B (1995) Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene. Genomics 28, 255-260
10. Chapman DL, Agulnik I, Hancock S, Silver LM, Papaioannou VE (1996a) Tbx6, a mouse T-box gene implicated in paraxial mesoderm formation at gastrulation. Dev Biol 180, 534-542
11. Chapman DL, Garvey N, Hancock S, Alexiou M, Agulnik SI, Gibson-Brown JJ, Cebra-Thomas J, Bollag RJ, Silver LM, Papaioannou VE (1996b) Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development. Dev Dyn 206, 379-390
12. Edwards YH, Putt W, Lekoape KM, Stott D, Fox M, Hopkinson DA, Swoden J (1996) The human homolog T of the mouse T (brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27. Genome Res 6, 226-233
13. Gilbert W, Glynias M (1993) On the ancient nature of introns. Gene 135, 137-144
14. Herrmann BG, Labeit S, Poustka A, King TR, Lehrach H (1990) Cloning of the T gene required in mesoderm formation in the mouse. Nature 343, 617-622
15. Kispert A, Herrmann BG (1993) The brachyury gene encodes a novel DNA binding protein. EMBO J 12, 3211-3220
16. Kispert A, Herrmann BG, Leptin M, Reuter R (1994) Homologs of the mouse brachyury gene are involved in the specification of posterior terminal structures in Drosophila, Tribolium, and Locusta. Genes Dev 8, 2137-2150
17. Kwiatowski J, Krawczyk M, Kornacki M, Bailey K, Ayala FJ (1995) Evidence against the exon theory of genes derived from thee triosephosphate isomerase gene. Proc Natl Acad Sci USA 92, 8503-8506
18. Law DJ, Gebuhr T, Garvey N, Agulnik SI, Silver LM (1995) Identification, characterization and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family. Mamm Genome 6, 793-797
19. Li QY, Newbury-Ecob RA, Terrett JA, Wilson DL, Curtis ARJ, Yi CH, Gebur T, Bullen PJ, Robson SC, Strachan T, Bonnet D, Lyonnet S, Young ID, Raeburn JA, Buckler AJ, Law DJ, Brook JD (1997) Holt-Oram syndrome is caused by mutations in TBX5, a member of the brachyury (T) gene family. Nature Genet 15, 21-29
20. Long M, de Souza SJ, Gilbert W (1995a) Evolution of the intron-exon structure of eukaryotic genes. Curr Opin Genet Dev 5, 774-778
21. Long M, Rosenberg C, Gilbert W (1995b) Intron phase correlations and the evolution of the intron/exon structure of genes. Proc Natl Acad Sci USA 72, 2495-2499
22. Lustig KD, Kroll KL, Sun EE, Kirschner MW (1996) Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation. Development 122, 4001-4012
23. Mattick JS (1994) Introns: evolution and function. Current Opinion in Genetics and Development 4, 823-831
24. Pflugfelder GO, Roth H, Poeck B (1992a) A homology domain shared between Drosophila optomotor-blind and mouse brachyury is involved in DNA binding. Biochem Biophys Res Commun 186, 918-925
25. Pflugfelder GO, Roth H, Poeck B, Kerscher S, Schwarz H, Jonschker B, Heisenberg M (1992b) The lethal(l)optomotor-blind gene of Drosophila melanogaster is a major organizer of optic lobe development: isolation and characterization of the gene. Proc Natl Acad Sci USA 89, 1199-1203
26. Poeck B, Balles J, Pflugfelder GO (1993) Transcript identification in the optomotor-blind locus of Drosophila melanogaster by intragenic recombination mapping and PCR-aided sequence analysis of lethal point mutations. Mol Gen Genet 238, 325-332
27. Ryan K, Garrett N, Mitchell A, Gurdon JB (1996) Eomesodermin, a Key Early Gene in Xenopus Mesoderm Differentiation. Cell 87, 989-1000
28. Stennard F, Carnac G, Gurdon JB (1996) The Xenopus T-box gene, Antipodean, encodes a vegetally localised matermal mRNA and can trigger mesoderm formation. Development 122, 4179-4188
29. Zhang J, King ML (1996) Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning. Development 122, 4119-4129