Hyperinsulinemia and vascular dysfunction: The role of nuclear factor-κB, yet again

Circulation Research

Volumn 87, Issue 9, 2000, Pages 722-724

  Schmidt, Ann Marie ^a   Stern, David M ^a  

^a Columbia University ^*  (United States)

Author keywords

Insulin; Nuclear factor B; Oxidant stress; Rho GTPases

Indexed keywords

ADVANCED GLYCATION END PRODUCT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

GENE ACTIVATION; GENE TARGETING; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; REVIEW; VASCULAR DISEASE;

EID: 0034721766     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.9.722     Document Type: Review

References (27)

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2. Contribution of fasting hyperinsulinemia to prediction of atherosclerotic cardiovascular disease status in 293 hyperlipidemic patients
3. Insulin and risk of cardiovascular disease: A meta-analysis
4. Atherosclerosis seems not to be associated with hyperinsulinemia in patients with familial hypercholesterolemia
5. Hyperinsulinemia enhances transcriptional activity of nuclear factor-κB induced by angiotensin II, hyperglycemia, and advanced glycosylation end products in vascular smooth muscle cells
6. The NF-κB signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation
7. NF-κB as a frequent target for immunosuppressive and anti-inflammatory molecules
8. In vivo transfection of cis element 'decoy' against nuclear factor κB binding sites prevents myocardial infarction
9. NF-κB is activated and promotes cell death in focal cerebral ischemia
10. Activation of the receptor for advanced glycation end products triggers a MAP kinase pathway regulated by oxidant stress
11. Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-κB
12. Transcription factor NF-κB/Rel is activated in the atherosclerotic lesion
13. Advanced glycosylation in diabetes and aging
14. Enhanced cellular oxidant stress by the interaction of AGEs with their receptors/binding proteins
15. N-(carboxymethyl)lysine modifications of proteins are ligands for RAGE that activate cell signalling pathways and modulate gene expression
16. RAGE mediates a novel proinflammatory axis: A central cell surface receptor for S100/calgranulin polypeptides
17. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
18. Hyperglycemia-induced activation of nuclear transcription factor κB in vascular smooth muscle cells
19. Effects of insulin on famesyltransferase activity in 3T30L1 adipocytes
20. Insulin promotes phosphorylation and activation of geranylgeranyltransferase II: Studies with geranylgeranylation of Rab-3 and Rab-4
21. Multiple signalling pathways lead to the activation of nuclear factor κB by the Rho family of GTPases
22. The role and regulation of the jun proteins in response to phorbol ester and UV light
23. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
24. Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
25. Nuclear factor-κB regulates induction of apoptosis and inhibitor of apoptosis protein-1 expression in vascular smooth muscle cells
26. Activation of NF-κB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration
27. NF-κB: Ten years after