-
1
-
-
0022340594
-
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
-
Hsiang, Y. H., Hertzberg, R., Hecht, S., and Liu, L. F. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem., 260: 14873-14878, 1985.
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 14873-14878
-
-
Hsiang, Y.H.1
Hertzberg, R.2
Hecht, S.3
Liu, L.F.4
-
2
-
-
0029960812
-
Eukaryotic DNA topoisomerase I: Genome gatekeeper and its intruders, camptothecins
-
Pommier, Y. Eukaryotic DNA topoisomerase I: genome gatekeeper and its intruders, camptothecins. Semin. Oncol., 23: 3-10, 1996.
-
(1996)
Semin. Oncol.
, vol.23
, pp. 3-10
-
-
Pommier, Y.1
-
3
-
-
0029060959
-
Eukaryotic DNA topoisomerases I
-
Gupta, M., Fujimori, A., and Pommier, Y. Eukaryotic DNA topoisomerases I. Biochim. Biophys. Acta., 1262: 1-14, 1995.
-
(1995)
Biochim. Biophys. Acta.
, vol.1262
, pp. 1-14
-
-
Gupta, M.1
Fujimori, A.2
Pommier, Y.3
-
4
-
-
0021192054
-
Intercalate antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II
-
Tewey, K. M., Chen, G. L., Nelson, E. M., and Liu, L. F. Intercalate antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J. Biol. Chem., 259 9182-9187, 1984.
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 9182-9187
-
-
Tewey, K.M.1
Chen, G.L.2
Nelson, E.M.3
Liu, L.F.4
-
5
-
-
0021749639
-
Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II
-
Chen, G. L., Yang, L., Rowe, T. C., Halligan, B. D., Tewey, K. M., and Liu, L. F. Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J. Biol. Chem., 259: 13560-13566, 1984.
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 13560-13566
-
-
Chen, G.L.1
Yang, L.2
Rowe, T.C.3
Halligan, B.D.4
Tewey, K.M.5
Liu, L.F.6
-
6
-
-
0022356520
-
Effects of DNA intercalating agents on topoisomerase II induced DNA strand cleavage in isolated mammalian cell nuclei
-
Pommier, Y., Schwartz, R. E., Zwelling, L. A., and Kohn, K. W. Effects of DNA intercalating agents on topoisomerase II induced DNA strand cleavage in isolated mammalian cell nuclei. Biochemistry, 24: 6406-6410, 1985.
-
(1985)
Biochemistry
, vol.24
, pp. 6406-6410
-
-
Pommier, Y.1
Schwartz, R.E.2
Zwelling, L.A.3
Kohn, K.W.4
-
7
-
-
0029144134
-
Topoisomerase poisons: Harnessing the dark side of enzyme mechanism
-
Froelich-Ammon, S. J., and Osheroff, N. Topoisomerase poisons: harnessing the dark side of enzyme mechanism. J. Biol. Chem., 270: 21429-21432, 1995.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 21429-21432
-
-
Froelich-Ammon, S.J.1
Osheroff, N.2
-
8
-
-
0027484629
-
Dual topoisomerase I and II inhibition by intoplicine (RP-60475), a new antitumor agent in early clinical trials
-
Poddevin, B., Riou, J. F., Lavelle, F., and Pommier, Y. Dual topoisomerase I and II inhibition by intoplicine (RP-60475), a new antitumor agent in early clinical trials. Mol. Pharmacol., 44: 767-774, 1993.
-
(1993)
Mol. Pharmacol.
, vol.44
, pp. 767-774
-
-
Poddevin, B.1
Riou, J.F.2
Lavelle, F.3
Pommier, Y.4
-
9
-
-
0027137938
-
Intoplicine (RP 60475), and its derivatives, a new class of antitumor agents inhibiting both topoisomerase I and II activities
-
Riou, J. F., Fosse, P., Nguyen, C. H., Larsen, A. K., Bissery, M. C., Grondard, L., Saucier, J. M., Bisagni, E., and Lavelle, F. Intoplicine (RP 60475), and its derivatives, a new class of antitumor agents inhibiting both topoisomerase I and II activities. Cancer Res., 53: 5987-5993, 1993.
-
(1993)
Cancer Res.
, vol.53
, pp. 5987-5993
-
-
Riou, J.F.1
Fosse, P.2
Nguyen, C.H.3
Larsen, A.K.4
Bissery, M.C.5
Grondard, L.6
Saucier, J.M.7
Bisagni, E.8
Lavelle, F.9
-
10
-
-
0027988123
-
Saintopin, a dual inhibitor of DNA topoisomerases I and II, as a probe for drug-enzyme interactions
-
Leteurtre, F., Fujimori, A., Tanizawa, A., Chhabra, A., Mazumder, A., Kohlhagen, G., Nakano, H., and Pommier, Y. Saintopin, a dual inhibitor of DNA topoisomerases I and II, as a probe for drug-enzyme interactions. J. Biol. Chem., 269: 28702-28707, 1994.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 28702-28707
-
-
Leteurtre, F.1
Fujimori, A.2
Tanizawa, A.3
Chhabra, A.4
Mazumder, A.5
Kohlhagen, G.6
Nakano, H.7
Pommier, Y.8
-
11
-
-
0025165637
-
Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces
-
Tokyo
-
Yamashita, Y., Saitoh, Y., Ando, K., Takahashi, K., Ohno, H., and Nakano, H. Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces (Letter). J. Antibiot. (Tokyo), 43: 1344-1346, 1990.
-
(1990)
J. Antibiot.
, vol.43
, pp. 1344-1346
-
-
Yamashita, Y.1
Saitoh, Y.2
Ando, K.3
Takahashi, K.4
Ohno, H.5
Nakano, H.6
-
12
-
-
0028357995
-
Phase I trial of low-dose continuous topotecan infusion in patients with cancer: An active and well-tolerated regimen
-
Hochster, H., Liebes, L., Speyer, J., Sorich, J., Taubes, B., Oratz, R., Wernz, J., Chachoua, A., Raphael, B., Vinci, R. Z., and Blum, R. H. Phase I trial of low-dose continuous topotecan infusion in patients with cancer: an active and well-tolerated regimen. J. Clin. Oncol., 12: 553-559, 1994.
-
(1994)
J. Clin. Oncol.
, vol.12
, pp. 553-559
-
-
Hochster, H.1
Liebes, L.2
Speyer, J.3
Sorich, J.4
Taubes, B.5
Oratz, R.6
Wernz, J.7
Chachoua, A.8
Raphael, B.9
Vinci, R.Z.10
Blum, R.H.11
-
13
-
-
0028147296
-
Phase II study of topotecan in metastatic non-small-cell lung cancer
-
Lynch, T. J., Jr., Kalish, L., Strauss, G., Elias, A., Skarin, A., Shulman, L. N., and Posner, M. Phase II study of topotecan in metastatic non-small-cell lung cancer. J. Clin. Oncol., 12: 347-352, 1994.
-
(1994)
J. Clin. Oncol.
, vol.12
, pp. 347-352
-
-
Lynch Jr., T.J.1
Kalish, L.2
Strauss, G.3
Elias, A.4
Skarin, A.5
Shulman, L.N.6
Posner, M.7
-
14
-
-
0028142714
-
Camptothecin analogues: Studies from the Johns Hopkins Oncology Center
-
Slichenmyer, W. J., Rowinsky, E. K., Grochow, L. B., Kaufmann, S. H., and Donehower, R. C. Camptothecin analogues: studies from the Johns Hopkins Oncology Center. Cancer Chemother. Pharmacol., 34 (Suppl.): S53-S57, 1994.
-
(1994)
Cancer Chemother. Pharmacol.
, vol.34
, Issue.SUPPL.
-
-
Slichenmyer, W.J.1
Rowinsky, E.K.2
Grochow, L.B.3
Kaufmann, S.H.4
Donehower, R.C.5
-
15
-
-
0029870413
-
CPT-11: An original spectrum of clinical activity
-
Rothenberg, M. L. CPT-11: an original spectrum of clinical activity. Semin. Oncol., 23: 21-26, 1996.
-
(1996)
Semin. Oncol.
, vol.23
, pp. 21-26
-
-
Rothenberg, M.L.1
-
16
-
-
0024316466
-
DNA topoisomerase poisons as antitumor drugs
-
Liu, L. F. DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem., 58: 351-375, 1989.
-
(1989)
Annu. Rev. Biochem.
, vol.58
, pp. 351-375
-
-
Liu, L.F.1
-
17
-
-
0025303197
-
Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II
-
Wassermann, K., Markovits, J., Jaxel, C., Capranico, G., Kohn, K. W., and Pommier, Y. Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II. Mol. Pharmacol., 38: 38-45, 1990.
-
(1990)
Mol. Pharmacol.
, vol.38
, pp. 38-45
-
-
Wassermann, K.1
Markovits, J.2
Jaxel, C.3
Capranico, G.4
Kohn, K.W.5
Pommier, Y.6
-
18
-
-
0026333913
-
Effects of quinolone derivatives on eukaryotic topoisomerase II: A novel mechanism for enhancement of enzyme-mediated DNA cleavage
-
Robinson, M. J., Martin, B. A., Gootz, T. D., McGuirk, P. R., Moynihan, M., Sutcliffe, J. A., and Osheroff, N. Effects of quinolone derivatives on eukaryotic topoisomerase II: a novel mechanism for enhancement of enzyme-mediated DNA cleavage. J. Biol. Chem., 266: 14585-14592, 1991.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 14585-14592
-
-
Robinson, M.J.1
Martin, B.A.2
Gootz, T.D.3
McGuirk, P.R.4
Moynihan, M.5
Sutcliffe, J.A.6
Osheroff, N.7
-
19
-
-
0025046910
-
Structure-activity relations, cytotoxicity and topoisomerase II dependent cleavage induced by pendulum ring analogues of etoposide
-
Sinha, B. K., Politi, P. M., Eliot, H. M., Kerrigan, D., and Pommier, Y. Structure-activity relations, cytotoxicity and topoisomerase II dependent cleavage induced by pendulum ring analogues of etoposide. Eur. J. Cancer. 26: 590-593, 1990.
-
(1990)
Eur. J. Cancer.
, vol.26
, pp. 590-593
-
-
Sinha, B.K.1
Politi, P.M.2
Eliot, H.M.3
Kerrigan, D.4
Pommier, Y.5
-
20
-
-
0026794617
-
Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II
-
Nitiss, J. L., Liu, Y. X., Harbury, P., Jannatipour, M., Wasserman, R., and Wang, J. C. Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II. Cancer Res., 52: 4467-4472, 1992.
-
(1992)
Cancer Res.
, vol.52
, pp. 4467-4472
-
-
Nitiss, J.L.1
Liu, Y.X.2
Harbury, P.3
Jannatipour, M.4
Wasserman, R.5
Wang, J.C.6
-
21
-
-
0027402476
-
A temperature sensitive topoisomerase II allele confers temperature dependent drug resistance on amsacrine and etoposide: A genetic system for determining the targets of topoisomerase II inhibitors
-
Nitiss, J. L., Liu, Y. X., and Hsiung, Y. A temperature sensitive topoisomerase II allele confers temperature dependent drug resistance on amsacrine and etoposide: a genetic system for determining the targets of topoisomerase II inhibitors. Cancer Res., 53: 89-93, 1993.
-
(1993)
Cancer Res.
, vol.53
, pp. 89-93
-
-
Nitiss, J.L.1
Liu, Y.X.2
Hsiung, Y.3
-
22
-
-
1842325286
-
Topoisomerase poisons in cell killing and drug resistance
-
Liu, L. F. Topoisomerase poisons in cell killing and drug resistance. Pezcoller Found. Symp., 1: 251-269, 1990.
-
(1990)
Pezcoller Found. Symp.
, vol.1
, pp. 251-269
-
-
Liu, L.F.1
-
23
-
-
0028070579
-
Using yeast to study resistance to topoisomerase II-targeting drugs
-
Nitiss, J. L. Using yeast to study resistance to topoisomerase II-targeting drugs. Cancer Chemother. Pharmacol., 34 (Suppl.): S6-S13, 1994.
-
(1994)
Cancer Chemother. Pharmacol.
, vol.34
, Issue.SUPPL.
-
-
Nitiss, J.L.1
-
24
-
-
0030014783
-
DNA topoisomerases
-
Wang, J. C. DNA topoisomerases. Ann. Rev. Biochem., 65: 635-692, 1996.
-
(1996)
Ann. Rev. Biochem.
, vol.65
, pp. 635-692
-
-
Wang, J.C.1
-
25
-
-
0027193302
-
Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzyme
-
Corbett, A. H., Hong, D., and Osheroff, N. Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzyme. J. Biol. Chem., 268: 14394-14398, 1993.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 14394-14398
-
-
Corbett, A.H.1
Hong, D.2
Osheroff, N.3
-
26
-
-
1842319108
-
Energy coupling in DNA gyrase and the mechanism of action of novobiocin
-
Sugino, A., Higgins, N. P., Brown, P. O., Peebles, C. L., and Cozzarelli, N. R. Energy coupling in DNA gyrase and the mechanism of action of novobiocin. Proc. Natl. Acad. Sci. USA, 75: 4838-4842, 1978.
-
(1978)
Proc. Natl. Acad. Sci. USA
, vol.75
, pp. 4838-4842
-
-
Sugino, A.1
Higgins, N.P.2
Brown, P.O.3
Peebles, C.L.4
Cozzarelli, N.R.5
-
27
-
-
0030007125
-
Mapping of DNA topoisomerase II poisons (etoposide, clerocidin) and catalytic inhibitors (aclarubicin, ICRF-187) to four distinct steps in the topoisomerase II catalytic cycle
-
Sehested, M., and Jensen, P. B. Mapping of DNA topoisomerase II poisons (etoposide, clerocidin) and catalytic inhibitors (aclarubicin, ICRF-187) to four distinct steps in the topoisomerase II catalytic cycle. Biochem. Pharmacol., 51: 879-886, 1996.
-
(1996)
Biochem. Pharmacol.
, vol.51
, pp. 879-886
-
-
Sehested, M.1
Jensen, P.B.2
-
28
-
-
0026425654
-
Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: Mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors
-
Ishida, R., Miki, T., Narita, T., Yui, R., Sato, M., Utsumi, K. R., Tanabe, K., and Andoh, T. Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors. Cancer Res., 51: 4909-4916, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 4909-4916
-
-
Ishida, R.1
Miki, T.2
Narita, T.3
Yui, R.4
Sato, M.5
Utsumi, K.R.6
Tanabe, K.7
Andoh, T.8
-
29
-
-
0028345406
-
Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp
-
Roca, J., Ishida, R., Berger, J. M., Andoh, T., and Wang, J. C. Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp. Proc. Natl. Acad. Sci. USA, 91: 1781-1785, 1994.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 1781-1785
-
-
Roca, J.1
Ishida, R.2
Berger, J.M.3
Andoh, T.4
Wang, J.C.5
-
30
-
-
0028030324
-
Novel actions of inhibitors of DNA topoisomerase II in drug-resistant tumor cells
-
Beck, W. T., Kim, R., and Chen, M. Novel actions of inhibitors of DNA topoisomerase II in drug-resistant tumor cells. Cancer Chemother. Pharmacol., 34 (Suppl.): S14-S18, 1994.
-
(1994)
Cancer Chemother. Pharmacol.
, vol.34
, Issue.SUPPL.
-
-
Beck, W.T.1
Kim, R.2
Chen, M.3
-
31
-
-
0024329909
-
In vitro and intracellular inhibition of topoisomerase D by the antitumor agent merbarone
-
Drake, F. H., Hofmann, G. A., Mong, S. M., Bartus, J. O., Hertzberg, R. P., Johnson, R. K., Mattern, M. R., and Mirabelli, C. K. In vitro and intracellular inhibition of topoisomerase D by the antitumor agent merbarone. Cancer Res., 49: 2578-2583, 1989.
-
(1989)
Cancer Res.
, vol.49
, pp. 2578-2583
-
-
Drake, F.H.1
Hofmann, G.A.2
Mong, S.M.3
Bartus, J.O.4
Hertzberg, R.P.5
Johnson, R.K.6
Mattern, M.R.7
Mirabelli, C.K.8
-
32
-
-
0025298540
-
Antagonistic effect of aclarubicin on the cytotoxicity of etoposide and 4′-(9-acridinylamino)methanesulfon-m-anisidide in human small cell lung cancer cell lines and on topoisomerase II-mediated DNA cleavage
-
Jensen, P. B., Sørensen, B. S., Demant, E. J., Sehested, M., Jensen, P. S., Vindeløv, L., and Hansen, H. H. Antagonistic effect of aclarubicin on the cytotoxicity of etoposide and 4′-(9-acridinylamino)methanesulfon-m-anisidide in human small cell lung cancer cell lines and on topoisomerase II-mediated DNA cleavage. Cancer Res., 50: 3311-3316, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 3311-3316
-
-
Jensen, P.B.1
Sørensen, B.S.2
Demant, E.J.3
Sehested, M.4
Jensen, P.S.5
Vindeløv, L.6
Hansen, H.H.7
-
33
-
-
0025988304
-
Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: Relationship to DNA integrity and topoisomerase II
-
Jensen, P. B., Jensen, P. S., Demant, E. J., Friche, E., Sørensen, B. S., Sehested, M., Wassermann, K., Vindeløv, L., Westergaard, O., and Hansen, H. H. Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II. Cancer Res., 51: 5093-5099, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 5093-5099
-
-
Jensen, P.B.1
Jensen, P.S.2
Demant, E.J.3
Friche, E.4
Sørensen, B.S.5
Sehested, M.6
Wassermann, K.7
Vindeløv, L.8
Westergaard, O.9
Hansen, H.H.10
-
34
-
-
0028697603
-
Roles of DNA topoisomerases in chromosomal replication and segregation
-
Nitiss, J. L. Roles of DNA topoisomerases in chromosomal replication and segregation. Adv. Pharmacol., 29: 103-134, 1994.
-
(1994)
Adv. Pharmacol.
, vol.29
, pp. 103-134
-
-
Nitiss, J.L.1
-
35
-
-
0028619817
-
Postincubation with aclarubicin reverses topoisomerase II mediated DNA cleavage, strand breaks, and cytotoxicity induced by VP-16
-
Petersen, L. N., Jensen, P. B., Sørensen, B. S., Engelholm, S. A., and Spang-Thomsen, M. Postincubation with aclarubicin reverses topoisomerase II mediated DNA cleavage, strand breaks, and cytotoxicity induced by VP-16. Invest. New Drugs, 12: 289-297, 1994.
-
(1994)
Invest. New Drugs
, vol.12
, pp. 289-297
-
-
Petersen, L.N.1
Jensen, P.B.2
Sørensen, B.S.3
Engelholm, S.A.4
Spang-Thomsen, M.5
-
36
-
-
0001855848
-
Yeast as a genetic system in the dissection of the mechanism of cell killing by topoisomerase-targeting anti-cancer drugs
-
M. Potmesil and K. Kohn (eds.), London: Oxford University Press
-
Nitiss, J. L., and Wang, J. C. Yeast as a genetic system in the dissection of the mechanism of cell killing by topoisomerase-targeting anti-cancer drugs. In: M. Potmesil and K. Kohn (eds.), DNA Topoisomerases and Cancer, pp. 77-91. London: Oxford University Press, 1991.
-
(1991)
DNA Topoisomerases and Cancer
, pp. 77-91
-
-
Nitiss, J.L.1
Wang, J.C.2
-
37
-
-
0027163315
-
The top2-5 mutant of yeast topoisomerase II encodes an enzyme resistant to etoposide and amsacrine
-
Jannatipour, M., Liu, Y. X., and Nitiss, J. L. The top2-5 mutant of yeast topoisomerase II encodes an enzyme resistant to etoposide and amsacrine. J. Biol. Chem., 268: 18586-18592, 1993.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 18586-18592
-
-
Jannatipour, M.1
Liu, Y.X.2
Nitiss, J.L.3
-
38
-
-
15844415445
-
Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I
-
Rossi, F., Labourier, E., Forne, T., Divita, G., Derancourt, J., Riou, J. F., Antoine, E., Cathaia, G., Brunel, C., and Tazi, J. Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I. Nature (Lond.), 381: 80-82, 1996.
-
(1996)
Nature (Lond.)
, vol.381
, pp. 80-82
-
-
Rossi, F.1
Labourier, E.2
Forne, T.3
Divita, G.4
Derancourt, J.5
Riou, J.F.6
Antoine, E.7
Cathaia, G.8
Brunel, C.9
Tazi, J.10
-
39
-
-
0029133721
-
DNA recombinase activity of eukaryotic DNA topoisomerase I: Effects of camptothecin and other inhibitors
-
Pommier, Y., Jenkins, J., Kohlhagen, G., and Leteurtre, F. DNA recombinase activity of eukaryotic DNA topoisomerase I: effects of camptothecin and other inhibitors. Mutat. Res., 337: 135-145 1995.
-
(1995)
Mutat. Res.
, vol.337
, pp. 135-145
-
-
Pommier, Y.1
Jenkins, J.2
Kohlhagen, G.3
Leteurtre, F.4
-
40
-
-
0028485758
-
Overexpression of human DNA topoisomerase I in insect cells using a baculovirus vector
-
Zhelkovsky, A. M., and Moore, C. L. Overexpression of human DNA topoisomerase I in insect cells using a baculovirus vector. Protein Expr. Purif., 5: 364-370, 1994.
-
(1994)
Protein Expr. Purif.
, vol.5
, pp. 364-370
-
-
Zhelkovsky, A.M.1
Moore, C.L.2
-
41
-
-
0029046736
-
DNA topoisomerase II is the molecular target of bisdioxopiperazine derivatives ICRF-159 and ICRF-193 in Saccharomyces cerevisiae
-
Ishida, R., Hamatake, M., Wasserman, R. A., Nitiss, J. L., Wang, J. C., and Andoh, T. DNA topoisomerase II is the molecular target of bisdioxopiperazine derivatives ICRF-159 and ICRF-193 in Saccharomyces cerevisiae. Cancer Res., 55: 2299-2303, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 2299-2303
-
-
Ishida, R.1
Hamatake, M.2
Wasserman, R.A.3
Nitiss, J.L.4
Wang, J.C.5
Andoh, T.6
-
42
-
-
0028677818
-
Yeast as a genetic model system for studying topoisomerase inhibitors
-
Nitiss, J. L. Yeast as a genetic model system for studying topoisomerase inhibitors. Adv. Pharmacol., 29B: 201-226, 1994.
-
(1994)
Adv. Pharmacol.
, vol.29 B
, pp. 201-226
-
-
Nitiss, J.L.1
-
43
-
-
0024266139
-
New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites
-
Gietz, R. D., and Sugino, A. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene, 74: 527-534, 1988.
-
(1988)
Gene
, vol.74
, pp. 527-534
-
-
Gietz, R.D.1
Sugino, A.2
-
44
-
-
0022369729
-
A high affinity topoisomerase I binding sequence is clustered at DNase I hypersensitive sites in Tetrahymena R-chromatin
-
Bonven, B. J., Gocke, E., and Westergaard, O. A high affinity topoisomerase I binding sequence is clustered at DNase I hypersensitive sites in Tetrahymena R-chromatin. Cell, 41: 541-551, 1985.
-
(1985)
Cell
, vol.41
, pp. 541-551
-
-
Bonven, B.J.1
Gocke, E.2
Westergaard, O.3
-
45
-
-
0006832263
-
Sequence specificity of DNA topoisomerase I in the presence and absence of camptothecin
-
Thomsen, B., Mollerup, S., Bonven, B. J., Frank, R., Blocker, H., Nielsen, O. F., and Westergaard, O. Sequence specificity of DNA topoisomerase I in the presence and absence of camptothecin. EMBO J., 6: 1817-1823, 1987.
-
(1987)
EMBO J.
, vol.6
, pp. 1817-1823
-
-
Thomsen, B.1
Mollerup, S.2
Bonven, B.J.3
Frank, R.4
Blocker, H.5
Nielsen, O.F.6
Westergaard, O.7
-
46
-
-
0029081258
-
Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites
-
Pommier, Y., Kohlhagen, G., Kohn, K. W., Leteurtre, F., Wani, M. C., and Wall, M. E. Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites. Proc. Natl. Acad. Sci. USA, 92: 8861-5, 1995.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 8861-8865
-
-
Pommier, Y.1
Kohlhagen, G.2
Kohn, K.W.3
Leteurtre, F.4
Wani, M.C.5
Wall, M.E.6
-
47
-
-
0000536643
-
DNA topoisomerase-targeting antitumor drugs can be studied in yeast
-
Nitiss, J., and Wang, J. C. DNA topoisomerase-targeting antitumor drugs can be studied in yeast. Proc. Natl. Acad. Sci. USA, 85: 7501-7505, 1988.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 7501-7505
-
-
Nitiss, J.1
Wang, J.C.2
-
48
-
-
0024229066
-
Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin
-
Eng, W. K., Faucette, L., Johnson, R. K., and Sternglanz, R. Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin. Mol. Pharmacol., 34: 755-760, 1988.
-
(1988)
Mol. Pharmacol.
, vol.34
, pp. 755-760
-
-
Eng, W.K.1
Faucette, L.2
Johnson, R.K.3
Sternglanz, R.4
-
49
-
-
0023971164
-
Stabilization of type I topoisomerase-DNA covalent complexes by actinomycin D
-
Trask, D. K., and Muller, M. T. Stabilization of type I topoisomerase-DNA covalent complexes by actinomycin D. Proc. Natl. Acad. Sci. USA, 85; 1417-1421, 1988.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 1417-1421
-
-
Trask, D.K.1
Muller, M.T.2
-
50
-
-
0028223750
-
Antagonistic effect of aclarubicin on camptothecin induced cytotoxicity: Role of topoisomerase I
-
Sorensen, B. S., Jensen, P. B., Sehested, M., Jensen, P. S., Kjeldsen, E., Nielsen, O. F., and Alsner, J. Antagonistic effect of aclarubicin on camptothecin induced cytotoxicity: role of topoisomerase I. Biochem. Pharmacol., 47: 2105-2110, 1994.
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 2105-2110
-
-
Sorensen, B.S.1
Jensen, P.B.2
Sehested, M.3
Jensen, P.S.4
Kjeldsen, E.5
Nielsen, O.F.6
Alsner, J.7
-
51
-
-
0030010789
-
Enzymatic and chemical footprinting of anthracycline antitumor antibiotics and related saccharide side chains
-
Shelton, C. J., Harding, M. M., and Prakash, A. S. Enzymatic and chemical footprinting of anthracycline antitumor antibiotics and related saccharide side chains. Biochemistry, 35: 7974-7982, 1996.
-
(1996)
Biochemistry
, vol.35
, pp. 7974-7982
-
-
Shelton, C.J.1
Harding, M.M.2
Prakash, A.S.3
-
52
-
-
0028206164
-
Structure by NMR of antitumor drugs aclacinomycin A and B complexed to d(CGTACG)
-
Yang, D., and Wang, A. H. Structure by NMR of antitumor drugs aclacinomycin A and B complexed to d(CGTACG). Biochemistry, 33: 6595-6604, 1994.
-
(1994)
Biochemistry
, vol.33
, pp. 6595-6604
-
-
Yang, D.1
Wang, A.H.2
-
53
-
-
0029099079
-
Crystal structures of four morpholino-doxorubicin anticancer drugs complexed with d(CGTACG) and d(CGATCG): Implications in drug-DNA crosslink
-
Gao, Y. G., and Wang, A. H. Crystal structures of four morpholino-doxorubicin anticancer drugs complexed with d(CGTACG) and d(CGATCG): implications in drug-DNA crosslink. J. Biomol. Struct. Dyn., 13: 103-117, 1995.
-
(1995)
J. Biomol. Struct. Dyn.
, vol.13
, pp. 103-117
-
-
Gao, Y.G.1
Wang, A.H.2
-
54
-
-
0027202339
-
DNA minor groove-binding ligands: A different class of mammalian DNA topoisomerase I inhibitors
-
Chen, A. Y., Yu, C., Gatto, B., and Liu, L. F. DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors. Proc. Natl. Acad. Sci. USA, 90: 8131-8135, 1993.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 8131-8135
-
-
Chen, A.Y.1
Yu, C.2
Gatto, B.3
Liu, L.F.4
-
55
-
-
0028099895
-
Schedule-dependent cytotoxicity of topotecan alone and in combination chemotherapy regimens
-
Cheng, M. F., Chatterjee, S., and Berger, N. A. Schedule-dependent cytotoxicity of topotecan alone and in combination chemotherapy regimens. Oncol. Res., 6: 269-279, 1994.
-
(1994)
Oncol. Res.
, vol.6
, pp. 269-279
-
-
Cheng, M.F.1
Chatterjee, S.2
Berger, N.A.3
-
56
-
-
0029116438
-
Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors
-
Houghton, P. J., Cheshire, P. J., Hallman, J. D., Lutz, L., Friedman, H. S., Danks, M. K., Houghton, J. A., and Hallman, J. D. Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. Cancer Chemother. Pharmacol., 36: 393-403, 1995.
-
(1995)
Cancer Chemother. Pharmacol.
, vol.36
, pp. 393-403
-
-
Houghton, P.J.1
Cheshire, P.J.2
Hallman, J.D.3
Lutz, L.4
Friedman, H.S.5
Danks, M.K.6
Houghton, J.A.7
Hallman, J.D.8
-
57
-
-
0029847080
-
Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA
-
Nitiss, J. L., and Wang, J. C. Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA. Mol. Pharmacol., 50; 1095-1102, 1996.
-
(1996)
Mol. Pharmacol.
, vol.50
, pp. 1095-1102
-
-
Nitiss, J.L.1
Wang, J.C.2
-
58
-
-
0024420685
-
Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
-
Hsiang, Y. H., Lihou, M. G., and Liu, L. F. Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res., 49: 5077-5082, 1989.
-
(1989)
Cancer Res.
, vol.49
, pp. 5077-5082
-
-
Hsiang, Y.H.1
Lihou, M.G.2
Liu, L.F.3
-
59
-
-
0025133118
-
Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons
-
D'Arpa, P., Beardmore, C., and Liu, L. F. Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res., 50: 6919-6924, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 6919-6924
-
-
D'Arpa, P.1
Beardmore, C.2
Liu, L.F.3
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