Brain-to-blood efflux transport of estrone-3-sulfate at the blood-brain barrier in rats

Life Sciences

Volumn 67, Issue 22, 2000, Pages 2699-2711

  Hosoya, Ken Ichi ^a,b   Asaba, Hiroshi ^a   Terasaki, Tetsuya ^a,b  

^a TOHOKU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Blood brain barrier; Efflux transport; Estrone 3 sulfate; Organic anion transporting polypeptide

Indexed keywords

ANION; BILE ACID; BROMSULFOPHTHALEIN; CHOLIC ACID; ESTROGEN; ESTRONE; ESTRONE SULFATE; PRASTERONE SULFATE; PROBENECID; TAUROCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MICHAELIS CONSTANT; NONHUMAN; RAT;

ANIMALIA;

EID: 0034692869     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(00)00861-4     Document Type: Article

References (40)

1. Sex differences in the development of estrogen receptors in the rat brain
2. Sexual differentiation of estrogen receptor concentrations in the rat brain: Effects of neonatal testosterone exposure
3. Studies on neurosteroids IX, Characterization of estrogens in rat brains using gas chromatography-tandem mass spectrometry
4. Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain
5. Steroid sulfotransferases and steroid sulfate sulfatases: Characteristics and biological roles
6. Purification and immunochemical characterization of a male-specific rat liver oestrogen sulphotransferase
7. Senile dementia-Alzheimer's type and estrogen
8. Enhanced hepatic extraction of estrogens used for replacement therapy
9. The blood-brain barrier, a dynamic regulatory interface
10. Stereospecificity of triiodothyronine transport into brain, liver, and salivary gland: Role of carrier- and plasma protein-mediated transport
11. Unidirectional specific and modulated brain to blood transport of corticotropin-releasing hormone
12. Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
13. P-glyco-protein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells
14. Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier
15. Selective brain to blood efflux transport of para-aminohippuric acid across the blood-brain barrier: In vivo evidence using the brain efflux index method
16. In vivo evidence for carrier-mediated efflux transport of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system
17. Blood-brain barrier produces significant efflux of L-aspartic acid, but not D-aspartic acid: In vivo evidence using the Brain Efflux Index method
18. Estrone sulphate in rat brain: Uptake from blood and metabolism in vivo
19. The measurement of estrone sulfate in plasma
20. A pharmacokinetic analysis program (MULTI) for microcomputer
21. Carrir-mediated transport of enkephalins and N-Tyr-MIF-1 across blood-brain barrier
22. Modulation of the carrier-mediated transport of the Tyr-MIF-1 across the blood-brain barrier by essential amino acids
23. Quantitative brain microdialysis study on the mechanism of quinolones distribution in the central nervous system
24. Estrone sulfatase activity in rat brain and pituitary: Effects of gonadectomy and the estrous cycle
25. Uptake of estrone sulfate by isolated rat liver cells
26. Uptake of sulfate conjugates by isolated rat hepatocytes
27. +-independent organic anion transporter
28. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
29. Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver
30. Estradiol 17β-D-glucuronide is a high-affinity substrate for oatp organic anion transporter
31. Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver
32. The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABA(A) receptor
33. Polyspecific substrate uptake by the hepatic organic anion transporter Oatpin stably transfected CHO cells
34. Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2)
35. Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain
36. Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line
37. Probenecid-induced accumulation of 5-hydroxyindoleacetic acid and homovanillic acid in rat brain
38. Hepatic uptake of p-nitrophenyl sulfate by transporter that acetaminophen sulfate shares for uptake: Sulfate moiety as a vector for metabolite transport
39. Intrathecal chemotherapy: Brain tissue profiles after ventriculocisternal perfusion
40. Drug 'diffusion' within the brain