Hepatic uptake of p-nitrophenyl sulfate by transporter that acetaminophen sulfate shares for uptake: Sulfate moiety as a vector for metabolite transport

Research Communications in Molecular Pathology and Pharmacology

Volumn 97, Issue 2, 1997, Pages 131-138

  Sakuma Sawada, N ^a   Iida, S ^a   Mizuma, T ^a   Hayashi, M ^a,b   Awazu, S ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NITROPHENOL; PARACETAMOL SULFATE;

ANIMAL CELL; ARTICLE; DRUG CLEARANCE; DRUG TRANSPORT; DRUG UPTAKE; LIVER METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANALYSIS OF VARIANCE; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; LIVER; MALE; NITROBENZENES; PROBENECID; RATS; RATS, WISTAR; SULFATES; SULFOBROMOPHTHALEIN;

EID: 0030961049     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Baur, H., Kasperek, S. and Pfaff, E. (1975).: Criteria of viability of isolated liver cells. Hoppe-Seyler's Z. Physiol. Chem. 356: 827-838.
2. Blom, A., Keulemans, K. and Meijer, D. K. F. (1981).: Transport of dibromosulfophthalein by isolated rat hepatocytes. Biochem. Pharmacol. 30: 1809-1816.
3. Burkhardt, G. H. and Wood, H. (1929).: Nitroarylsulfuric acids and their reduction products. J. Chem. Soc. 1929: 141-152.
4. Gigon, P. L. and Guarino, A. M. (1970).: Uptake of probenecid by rat liver slices. Biochem. Pharmacol. 19: 2653-2662.
5. Hassen, A. M., Lam, D., Chiba, M., Tan, E., Geng, W. and Pang, K. S. (1996).: Uptake of sulfate conjugates by isolated rat hepatocytes. Drug Metab. Dispos. 24: 792-798 (and 925).
6. Iida, S., Mizuma, T., Sakuma, N., Hayashi, M. and Awazu, S. (1989).: Transport of acetaminophen conjugates in isolated rat hepatocytes. Drug Metab. Dispos. 17: 341-344.
7. Meijer D. K., Keulemans, K. and Mulder, G. J. (1981).: Isolated perfused rat liver technique. Methods in Enzymol. 77: 81-94.
8. Miyauchi, S., Sugiyama, Y., Iga, T. and Hanano, M. (1988).: Membrane-limited hepatic transport of the conjugate metabolites of 4-methylumbelliferone in rats. J. Pharm. Sci. 77: 688-692.
9. Mizuma, T., Machida, M., Hayashi, M. and Awazu, S. (1982).: Correlation of drug conjugate metabolism rates between in vivo and in vitro: glucuronidation and sulfation of p-nitrophenol as a model compounds in rat. J. Pharmacobio-Dyn. 5: 811-817.
10. Mizuma, T., Nagamine, Y. and Awazu, S. (1994).: Intestinal absorption of acetaminophen glycosides by glucose transporter (in Japanese). Xenobio. Metabol. Dispos. 9 (Supplement): s308 (1994).
11. Mizuma, T., Ohta, K. and Awazu, S. (1994).: The β-anomeric and glucose preferences of glucose transport carrier for intestinal active absorption of monosaccharide conjugates. Biochim. Biophys. Acta 1200: 117-122.
12. Mizuma, T., Ohta, K., Hayashi, M. and Awazu, S. (1992).: Intestinal active absorption of sugar-conjugate compounds by glucose transport system: implication of improvement of poorly absorbable drugs. Biochem. Pharmacol. 43: 2037-2039.
13. Mizuma, T., Ohta, K., Hayashi, M. and Awazu, S. (1993).: Comparative study of active absorption by the intestine and disposition of anomers of sugar-conjugate compounds. Biochem. Pharmacol. 45: 1520-1523.
14. Ratna, S., Chiba, M., Bandopadhay, L. and Pang, K. S. (1993).: Futile cycling between 4-methylumbelliferone and its conjugates in perfused rat liver. Hepatology 17: 836-853.
15. Sakuma-Sawada, N., Iida, S., Mizuma, T., Hayashi, M. and Awazu, S. (1997).: Inhibition of the Hepatic Uptake of Paracetamol Sulphate by Anionic Compounds. J. Pharm. Pharmacol. 49: 743-746.
16. Schwarz, L. R., Burr, R., Schwenk, M., Pfaff, E. and Greim, H. (1975).: Uptake of taurocholic acid into isolated rat liver cells. Eur. J. Biochem. 55: 617-623.
17. Schwenk, M., Burr, R., Schwarz, L. and Pfaff, E. (1976).: Uptake of Bromosulfophthalein by isolated liver cells. Eur. J. Biochem. 64: 189-197.
18. Sundheimer, D. W. and Brendel, K. (1983).: Metabolism of harmol and transport of harmol conjugates in isolated rat hepatocytes. Drug Metab. Dispos. 11: 433-439.