Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase

Tetrahedron Letters

Volumn 39, Issue 16, 1998, Pages 2243-2246

  Singh, Sheo B ^a   Zink, Deborah L ^a   Goetz, Michael A ^a   Dombrowski, Anne W ^a   Polishook, Jon D ^a   Hazuda, Daria J ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; ANTIVIRUS AGENT; EQUISETIN; INTEGRASE; PHOMASETIN; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; DRUG CONFORMATION; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; VIRUS DNA CELL DNA INTERACTION; VIRUS INHIBITION;

EID: 0032537149     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00269-X     Document Type: Article

References (15)

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12. 3CN at -10 °C): only important signals shown, 3.62 (1H, t, J = 2.5 Hz, H-5′), 3.81 (1H, brdd, J = 2.5, 12 Hz, H-6′), 3.86 (1H, dd, J = 2.5, 12 Hz, H-6′).
13. 9. Koenig, T.; Kapus, A.; Sarkadi, B. J. Bioenerg. Biomembr. 1993, 25, 537.
14. 3CN at -10 °C): only important signals shown, 3.61 (1H, brt, J = 2.5 Hz, H-5′), 3.84 (1H, brdd, J = 2.5, 12 Hz, H-6′), 3.87 (1H, dd, J = 2.5, 12 Hz, H-6′).
15. max): 0 (330), +12.5 (291), +4.0 (250), +6 (235).