Selective and controlled hydrolysis of chloropeptin I. HIV-1 integrase activity of fragments

Tetrahedron Letters

Volumn 39, Issue 48, 1998, Pages 8769-8770

  Singh, Sheo B ^a   Jayasuriya, Hiranthi ^a   Hazuda, Daria L ^b   Felock, Peter ^b   Homnick, Carl F ^b   Sardana, Mohinder ^b   Patane, Michael A ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; CHLOROPEPTIN I; COMPLESTATIN; GLYCOPROTEIN GP 120; HYDROCHLORIC ACID; INTEGRASE; INTEGRASE INHIBITOR; THIOGLYCOLIC ACID; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG PURIFICATION; DRUG SOLUBILITY; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYDROLYSIS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0032569855     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01993-5     Document Type: Article

References (12)

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8. 4. For isolation, structure and details of HIV-1 integrase activity see Jayasuriya, H. J. et al manuscript in preparation.
9. 3CN in another 20 min +0.1% TFA, 1mL/min, retention times (in min), 2 (37.04), 3 (38.04, 38.55), 4 (31.58, 32.83), 5 (27.78), and 6 (21.57).
10. 6. Similar observations have been reported (a) Kock, M.; Kessler, H.; Seebach, D.; Thaler, A. J. Am. Chem. Soc. 1992, 114, 2676.
11. (b) Boger, D. L.; Patane, M. A.; Zhou, J. J. Amer. Chem. Soc. 1995, 117, 7357.
12. 7. Hazuda, D. J.; Hastings, J. C.; Wolfe, A. L.; Emini, E. A. Nucleic Acids Res. 1994, 22, 1121.