Differential expression of a novel C-terminally truncated splice form of SMAD5 in hematopoietic stem cells and leukemia

Blood

Volumn 95, Issue 12, 2000, Pages 3945-3950

  Jiang, Yunfang ^a   Liang, Hong ^a   Guo, Wei ^a   Kottickal, Lazar V ^a   Nagarajan, Lalitha ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ACUTE GRANULOCYTIC LEUKEMIA; AMINO ACID SEQUENCE; ARTICLE; CELL GROWTH; CHROMOSOME 5; CHROMOSOME LOSS; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMOGENESIS; MYELODYSPLASIA; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0034660656     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.12.3945.012k42_3945_3950     Document Type: Article

References (34)

1. Eaves CJ, Cashman JD, Kay RJ, et al. Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures: II. analysis of positive and negative regulators produced by stromal cells within the adherent layer. Blood. 1991;78:110.
2. Wrana JL, Attisano L, Wieser R, Ventura F, Massague J. Mechanism of activation of the TGF-beta receptor. Nature. 1994;370:341.
3. Heldin CH, Miyazono K, Dijke PT. TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature. 1997;390:465.
4. Kretzschmar M, Massague J. SMADs: mediators and regulators of TGF-beta signaling. Curr Opin Genet Dev. 1998;8:103.
5. Massague J. TGF-beta signal transduction. Annu Rev Biochem. 1998;67:753.
6. Hata A, Lo RS, Wotton D, Lagna G, Massague J. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature. 1997;388:82.
7. Shi Y, Wang JL, Jayaraman L, Yang H, Massague J, Pavletich NP, Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell. 1998;94:585.
8. Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science. 1996;271:350.
9. Eppert K, Scherer SW, Ozcelik H, et al. MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell. 1996;86:543.
10. Hejlik DP, Kottickal LV, Liang H, et al. Localization of SMAD5 and its evaluation as a candidate myeloid tumor suppressor. Cancer Res. 1997;57: 3779.
11. Zavadil J, Brezinova J, Svoboda P, et al. Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60. Leukemia. 1997;11:1187-1192.
12. Riggins GJ, Kinzler KW, Vogelstein B, Thiagalingam S. Frequency of Smad gene mutations in human cancers. Cancer Res. 1997;57:2578.
13. Gamma A, Hagiwara K, Vincent F, et al. hSmad5 gene, a human hSmad family member: its full length cDNA, genomic structure, promoter region and mutation analysis in human tumors. Oncogene. 1998;16:951.
14. Suzuki A, Chang C, Yingling JM, Wang XF, Hemmati-Brivanlou A. Smad5 induces ventral fates in Xenopus embryo. Dev Biol. 1997;184:402.
15. Chang H, Huylebroeck D, Verschueren K, Guo Q, Matzuk MM, Zwijsen A. Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development. 1999;126: 1631.
16. Yang X, Castilla LH, Xu X, et al. Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development. 1999;126:1571.
17. Bhatia M, Bonnet D, Wu D, et al. Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells. J Exp Med. 1999;189:1139.
18. Krystal G, Lam V, Dragowska W, et al. J Exp Med. 1994;180:851.
19. Garbe A, Spyridonidis A, Mobest D, Schmoor C, Mertelsmann R, Henschler R. Transforming growth factor-beta 1 delays formation of granulocyte-macrophage colony-forming cells, but spares more primitive progenitors during ex vivo expansion of CD34+ haemopoietic progenitor cells. Br J Haematol. 1997;99:951.
20. Drexler HG, Meyer C, Zaborski M, Uphoff C, Quentmeir H. Growth-inhibitory effects of transforming growth factor-beta 1 on myeloid leukemia cell lines. Leuk Res. 1998;22:927.
21. Whitehead Institute genome database. Available at: http://www.genome.wi.mit.edu. Accessed.
22. National Library of Medicine. Expressed Sequence Tagged Sequences (EST) database (dbEST) (IMAGE consortium clones). Available at: http://www.genome.wustl.edu. Accessed.
23. C elegans genome database at Washington University, St Louis, MO. Available at: http://www. genome.wustl.edu. Accessed.
24. Lo RS, Chen YG, Shi Y, Pavletich NP, Massague J. The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors. EMBOJ. 1998;16:996.
25. Imamura T, Takase M, Nishihara A, Oeda E, Hanai J, Kawabata M, Miyazono K. Smad6 inhibits signalling by the TGF-beta superfamily. Nature. 1997;389:622.
26. Hata A, Lagna G, Massague J, Hemmati-Brivanlou A. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 1998;12:186.
27. Hayashi H, Abdollah S, Qiu Y, et al. The MAD-related protein Smad7 associates with the TGF-beta receptor and functions as an antagonist of TGFbeta signaling. Cell. 1997;89:1165.
28. Kim, J, Johnson K, Chen HJ, Carroll S, Laughon A. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature. 1997;388:304.
29. Nishimura R, Kato Y, Chen D, Harris SE, Mundy GR, Yoneda T. Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J Biol Chem. 1998; 273:1872.
30. Yamamoto N, Akiyama S. Katagiri T, Namiki M, Kurokawa T, Suda T. Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts. Biochem Biophys Res Commun. 1997;238:574.
31. Tamaki K, Souchelnytskyi S, Itoh S, et al. Intracellular signaling of osteogenic protein-1 through Smad5 activation. J Cell Physiol. 1998;177:355.
32. Bruno E, Horrigan SK, Van Den Berg D, et al. The Smad5 gene is involved in the intracellular signaling pathways that mediate the inhibitory effects of transforming growth factor-beta on human hematopoiesis. Blood. 1998;91:1917.
33. Zhu Y, Richardson JA, Parada LF, Graff JM. Smad3 mutant mice develop metastatic colorectal cancer. Cell. 1998;94:703.
34. Zavadil J, Svoboda P, Liang H, Kottickal LV, Nagarajan L. An antisense transcript to SMAD5 expressed in fetal and tumor tissues. Biochem Biophys Ras Commun. 1999;255:668.