IL-2 activation of NK cells: Involvement of MKK1/2/ERK but not p38 kinase pathway

Journal of Immunology

Volumn 164, Issue 12, 2000, Pages 6244-6251

  Yu, Tse Kuan ^a   Caudell, Eva G ^a   Smid, Christine ^a   Grimm, Elizabeth A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CD69 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE;

ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; NATURAL KILLER CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034660405     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.12.6244     Document Type: Article

References (40)

1. Su, B., and M. Karin. 1996. Mitogen-activated protein kinase cascade and regulation of gene expression. Curr. Opin. Immunol. 8:402.
2. Alberola-Ila, J., K. A. Hogquist, K. A. Swan, M. J. Bevan, and R. M. Perlmutter. 1996. Positive and negative selection invoke distinct signaling pathways. J. Exp. Med. 184:9.
3. Sharp, L. L., D. A. Schwarz, C. M. Bott, C. J. Marshall, and S. M. Hedrick. 1997. The influence of the MAPK pathway on T cell lineage commitment. Immunity 7:609.
4. Bommhardt, U., M. A. Basson, U. Krummrei, and R. Zamoyska. 1999. Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus. J. Immunol. 163:715.
5. Sugawara, T., T. Moriguchi, E. Nishida, and Y. Takahama. 1998. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes. Immunity 9:565.
6. Whitehurst, C. E., and T. D. Geppert. 1996. MEK1 and the extracellular signal-regulated kinases are required for the stimulation of 1L-2 gene transcription in T cells. J. Immunol. 156:1020.
7. Zhang, J., K. V. Salojin, J. X. Gao, M. J. Cameron, I. Bergerot, and T. L. Delovitch. 1999. p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells. J. Immunol 162:3819.
8. Trotta, R., P. Kanakaraj, and B. Perussia. 1996. FcγR-dependent mitogen-activated protein kinase activation in leukocytes: A common signal transduction event necessary for expression of TNF-α and early activation genes. J. Exp. Med. 184:1027.
9. Mainiero, F., A. Gismondi, A. Soriani, M. Cippitelli, G. Palmieri, J. Jacobelli, M. Piccoli, L. Frati, and A. Santoni. 1998. Integrin-mediated ras-extracellular regulated kinase (ERK) signaling regulates interferon gamma production in human natural killer cells. J. Exp. Med. 188:1267.
10. Karnitz, L. M., and R. T. Abraham. 1996. Interleukin-2 receptor signaling mechanisms. Adv. Immunol. 61:147.
11. Karnitz, L. M., L. A. Burns, S. L. Sutor, J. Blenis, and R. T. Abraham. 1995. Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway. Mol. Cell. Biol. 15:3049.
12. Perkins, G. R., J. Marvel, and M. K. Collins. 1993. Interleukin 2 activates extracellular signal-regulated protein kinase 2. J. Exp. Med. 178:1429.
13. Crawley, J. B., L. Rawlinson, F. V. Lali, T. H. Page, J. Saklatvala, and B. M. Foxwell. 1997. T cell proliferation in response to interleukins 2 and 7 requires p38 MAP kinase activation. J. Biol. Chem. 272:15023.
14. Fairhurst, R., M. Daeipour, M. Amaral, and A. Nel. 1993. Activation of mitogen-activated protein kinase/ERK-2 in phytohaemagglutinin blasts by recombinant interleukin-2: Contrasting features with CD3 activation. Immunology 79:112.
15. Gollob, J. A., C. P. Schnipper, E. A. Murphy, J. Ritz, and D. A. Frank. 1999. The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation. J. Immunol. 162:4472.
16. Biron, C. A. 1997. Activation and function of natural killer cell responses during viral infections. Curr. Opin. Immunol. 9:24.
17. Scharton-Kersten, T. M., and A. Sher. 1997. Role of natural killer cells in innate resistance to protozoan infections. Curr. Opin. Immunol. 9:44.
18. Unanue, E. R. Inter-relationship among macrophages, natural killer cells and neutrophils in early stages of Listeria resistance. Curr. Opin. Immunol. 9:35.
19. Whiteside, T. L., and R. B. Herberman. 1995. The role of natural killer cells in immune surveillance of cancer. Curr. Opin. Immunol. 7:704.
20. Lanier, L. L. 1995. The role of natural killer cells in transplantation. Curr. Opin. Immunol. 7:626.
21. Frederick, M., E. Grimm, E. Krohn, C. Smid, and T.-K. Yu. 1997. Cytokine-induced cytotoxic function expressed by lymphocytes of the innate immune system : distinguishing characteristics of NK and LAK based on functional and molecular markers. J. Interferon Cytokine Res. 17:435.
22. Trinchieri, G. 1995. Natural killer cells wear different hats: effector cells of innate resistance and regulatory cells of adaptive immunity and of hematopoiesis. Semin. Immunol. 7:83.
23. Alessi, D., A. Cuenda, P. Cohen, D. Dudley, and A. Saltiel. 1995. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:27489.
24. Frederick, M., T.-K. Yu, E. Krohn, D. Johnston, and E. Grimm. 1996. Protein tyrosine kinase inhibition blocks granule exocytosis and cytolytic function of lymphokine-activated killer cells. Immunopharmacology 35:83.
25. Hatakeyama, M., H. Mori, T. Doi, and T. Taniguchi. 1989. A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization. Cell 59:837.
26. DeSilva, D. R., E. A. Jones, M. F. Favata, B. D. Jaffee, R. L. Magolda, J. M. Trzaskos, and P. A. Scherle. 1998. Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy. J. Immunol. 160:4175.
27. Azzoni, L., P. Kanakaraj, O. Zatepina, and B. Perussia. 1996. IL-12-induced activation of NK and T cells occurs in the absence of immediate/early gene expression. J. Immunol. 157:3235.
28. Sweetser, M. T., T. Hoey, Y.-L. Sun, W. M. Weaver, G. A. Price, and C. B. Wilson. 1998. The role of nuclear factor of activated T cells and Ying-Yang 1 in activation-induced expression of the interferon-γ promoter in T cells. J. Biol. Chem. 273:34775.
29. Barbulescu, K., K.-H. Meyer zum Buschenfelde, and M. F. Neurath. 1997. Constitutive and inducible protein/DNA interactions of the interferon-γ promoter in in vivo CD45RA and CD45R0 T helper subsets. Eur. J. Immunol. 27:1098.
30. + T lymphocytes. J. Immunol. 160:3642.
31. Catellanos, M. C., C. Munoz, M. C. Montoya, E. Lara-Pezzi, M. Lopez-Cabrera, and M. O. de Landazuri. 1997. Expression of the leukocyte early activation antigen CD69 is regulated by the transcription factor AP-1. J. Immunol. 159:5463.
32. Serdobova, I., M. Pla, P. Reichenbach, P. Sperisen, J. Ghysdael, A. Wilson, J. Freeman, and M. Nabholz. 1997. EIf-1 contributes to the function of the complex Interleukin (IL)-2-responsive enhancer in the mouse IL-2 receptor α gene. J. Exp. Med. 185:1211.
33. Moretta, A., A. Poggi, D. Pende, G. Tripodi, A. Orengo, N. Pella, R. Augugliaro, C. Bottino, E. Ciccone, and L. Moretta. 1991. CD69-mediated pathway of lymphocyte activation: Anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic lymphocytes expressing T cell receptor a/β. J. Exp. Med. 174:1393.
34. Carbone, E., G. Ruggiero, G. Terrazzano, C. Palomba, C. Manzo, S. Fontana, H. Spits, K. Karre, and S. Zappacosta. 1997. A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction. J. Exp. Med. 185: 2053.
35. Vitale, M., C. Bottino, S. Sivori, L. Sanseverino, R. Castriconi, E. Marcenaro, R. Augugliaro, L. Moretta, and A. Moretta. 1998. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. J. Exp. Med. 187:2065.
36. Wei, S., A. M. Gamero, J. H. Liu, A. A. Daulton, N. I. Valkov, J. A. Trapani, A. C. Larner, M. J. Weber, and J. Y. Djeu. 1988. Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: Identification of perform and granzyme B mobilization by functional ERK2. J. Exp. Med. 187:1753.
37. Trotta, R., K. A. Puorro, M. Paroli, L. Azzoni, B. Abebe, L. C. Eisenlohr, and B. Perussia. 1998. Dependence of both spontaneous and antibody-dependent, granule exocytosis-mediated NK cell cytotoxicity on extracellular signal-regulated kinases. J. Immunol. 161:6648.
38. Spits, H., B. Blom, A. C. Jaleco, K. Weijer, M. C. Verschuren, J. J. van Dongen, M. H. Heemskerk, and P. C. Res. 1998. Early stages in the development of human T, natural killer and thymic dendritic cells. Immunol. Rev. 165:75.
39. Wang, K. S., J. Ritz, and D. A. Frank. 1999. IL-2 induces STAT4 activation in primary NK cells and NK cell lines, but not in T cells. J. Immunol. 162: 299.
40. Winston, L. A., and T. Hunter. 1995. JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone. J. Biol. Chem. 270:30837.