Re-engineering of human urokinase provides a system for structure-based drug design at high resolution and reveals a novel structural subsite

Journal of Biological Chemistry

Volumn 275, Issue 10, 2000, Pages 7239-7248

  Nienaber, Vicki ^a   Wang, Jieyi ^a   Davidson, Don ^a   Henkin, Jack ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; GUANIDINE DERIVATIVE; PHENYL GROUP; PLASMINOGEN ACTIVATOR INHIBITOR; UROKINASE;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; METASTASIS; PRIORITY JOURNAL; TUMOR GROWTH;

AMILORIDE; BINDING SITES; CRYSTALLIZATION; DRUG DESIGN; GUANIDINES; HUMANS; MOLECULAR WEIGHT; PROTEIN ENGINEERING; URINARY PLASMINOGEN ACTIVATOR;

EID: 0034629461     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.10.7239     Document Type: Article

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