Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator: Implications for the design of low molecular weight substrates and inhibitors

Journal of Biological Chemistry

Volumn 272, Issue 35, 1997, Pages 21713-21719

  Renatus, Martin ^a   Bode, Wolfram ^a   Huber, Robert ^a   Stürzebecher, Jörg ^b   Prasa, Dagmar ^b   Fischer, Stephan ^c   Kohnert, Ulrich ^c   Stubbs, Milton T ^a,d  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; NITROANILIDE; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG;

ARTICLE; ELECTRICITY; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOLECULAR WEIGHT; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ARGININE; BINDING SITES; CATALYSIS; ENZYME INHIBITORS; HUMANS; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; PEPTIDE MAPPING; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0030875839     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.35.21713     Document Type: Article

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