Site-specific incorporation of nucleoside analogs by HIV-1 reverse transcriptase and the template grip mutant P157S. Template interactions influence substrate recognition at the polymerase active site

Journal of Biological Chemistry

Volumn 275, Issue 1, 2000, Pages 359-366

  Klarmann, George J ^a   Smith, Robert A ^a   Schinazi, Raymond F ^b   North, Thomas W ^c   Preston, Bradley D ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EMTRICITABINE; LAMIVUDINE; NUCLEOSIDE ANALOG; RNA DIRECTED DNA POLYMERASE; ZIDOVUDINE;

AMINO ACID COMPOSITION; ANTIBIOTIC RESISTANCE; ARTICLE; DNA TEMPLATE; DRUG DNA BINDING; DRUG DNA INTERACTION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION;

CATALYTIC DOMAIN; CYTIDINE TRIPHOSPHATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; MUTATION; PROLINE; REVERSE TRANSCRIPTASE INHIBITORS; THIONUCLEOSIDES; THIOPHENES; THYMINE NUCLEOTIDES; TRANSCRIPTION, GENETIC; ZALCITABINE; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0034614504     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.1.359     Document Type: Article

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