The virtuoso of versatility: POU proteins that flex to fit

Journal of Molecular Biology

Volumn 302, Issue 5, 2000, Pages 1023-1039

  Phillips, Kathryn ^a   Luisi, Ben ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

DNA protein interactions; Folding induced recognition; Oct 1; POU domain; Transcription regulation

Indexed keywords

DNA BINDING PROTEIN;

CRYSTAL STRUCTURE; HUMAN; HYPOPHYSIS; IMMUNOREGULATION; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NERVOUS SYSTEM DEVELOPMENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; REVIEW; TRANSCRIPTION REGULATION; VIRUS TRANSCRIPTION;

EUKARYOTA;

EID: 0034612994     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4107     Document Type: Review

References (111)

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12. Mechanisms for flexibility in DNA-sequence recognition and VP16-induced complex formation by the Oct-1 POU domain
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14. Structural flexibility in transcription complex formation revealed by protein-DNA photocrosslinking
15. The B-cell-specific Oct-2 protein contains POU box-type and homeo box-type domains
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25. The Oct-1 POU domain activates snRNA gene transcription by contacting a region the SNAP(c) largest subunit that bears sequence similarities to the Oct-1 co-activator OBF-1
26. POU domain factors of the Brn-3 class recognize functional DNA elements which are distinctive, symmetrical, and highly conserved in evolution
27. A B-cell co-activator of oxtamer-binding transcription factors
28. The B cell co-activator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation
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34. Histone H2B gene-transcription during Xenopus early development requires functional co-operation between proteins bound to the CCAAT and octamer motifs
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36. Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator
37. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype
38. The POU-specific domain of Pit-1 is essential for sequence-specific, high-affinity DNA-binding and DNA-dependent Pit-1-Pit-1 interactions
39. Structure of Pit-1 POU domain bound to DNA as a dimer: Unexpected arrangement and flexibility
40. Identification of redox/repair protein Ref-1 as a potent activator of p53
41. SP1 binds to promoter sequences and activates herpes-simplex virus immediate-early gene-transcription in vitro
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45. Crystal-structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules
46. B-cell co-activator OBF-1 exhibits unusual transcriptional properties and functions in a DNA-bound Oct-1-dependent fashion
47. The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides
48. Concerted activity of host cell factor subregions in promoting stable VP16 complex assembly and preventing interference by the acidic activation domain
49. Interaction of cell-type-specific nuclear proteins with immunoglobulin Vh promoter region sequences
50. Allosteric effects of DNA on transcriptional regulators
51. Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors
52. Dwarf locus mutants lacking 3 pituitary cell-types result from mutations in the POU-domain gene Pit-1
53. Crystal structure of the MATa1/MAT alpha 2 homeodomain heterodimer bound to DNA
54. Characterization of sequence-specific DNA binding by the transcription factor Oct-1
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58. The Oct-1 POU-specific domain can stimulate small nuclear RNA gene transcription by stabilizing the basal transcription complex SNAP(c)
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60. Secondary structure of the Oct-3 POU homeodomain as determined by H-1-15N NMR-spectroscopy
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62. Composite co-activator ARC mediates chromatin-directed transcriptional activation
63. Structural features of protein-nucleic acid recognition sites
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66. Secondary structure determination for the antennapedia homeodomain by nuclear magnetic-resonance and evidence for a helix-turn-helix motif
67. Structure of the 5' ends of immunoglobulin genes: A novel conserved sequence
68. Pit-1: Clinical aspects
69. Activation of octamer-containing promoters by either octamer-binding transcription factor-I (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of immunoglobulin promoters
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73. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
74. Highly co-operative homodimerization is a conserved property of neural POU proteins
75. Sequence-specific interactions between cellular DNA-binding proteins and the Adenovirus origin of DNA-replication
76. Comparative genomics of the eukaryotes
77. Transcription factors and the control of inner ear development
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79. Targeting TBP to a non-TATA box cis-regulatory element: A Tbp-containing complex activates transcription from snRNA promoters through the PSE
80. Co-activator OBF-1 makes selective contacts with both the POU-specific domain and the POU homeodomain and acts as a molecular clamp on DNA
81. Gene structure and characterization of the murine homologue of the B cell-specific transcriptional co-activator OBF-1
82. SMART: A web-based tool for the study of genetically mobile domains
83. Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA-binding activity
84. Cell fate specification and differentiation in the nervous system, of Caenorhabditis elegans
85. Class III POU genes of zebrafish are predominantly expressed in the central nervous system
86. Coupling of local folding to site-specific binding of proteins to DNA
87. A lymphoid-specific protein-binding to the octamer motif of immunoglobulin genes
88. OBF-1, a novel B-cell-specific co-activator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins
89. The Pou domain is a bipartite DNA-binding structure
90. The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain
91. Crystal structure of the yeast MAT alpha 2/MCM1/DNA ternary complex
92. Evidence of DNA-protein interactions that mediate hsv-1 immediate early gene activation by VP16
93. The POU-domain factor Brn-3.0 recognizes characteristic sites in the herpes simplex virus genome
94. TATA-binding protein-independent initiation: YY1, TFIIB, and RNA polymerase-II direct basal transcription on supercoiled template DNA
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96. Linker length and composition influence the flexibility of Oct-1 DNA binding
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98. The novel co-activator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP
99. Regulations of JC virus by the POU-domain transcription factor Tst-1: Implications for progressive multifocal leukoencephalopathy
100. The Vp16 accessory protein HCF is a family of polypeptides processed from a large precursor protein
101. The HCF repeat is an unusual proteolytic cleavage signal
102. The large subunit of basal transcription factor SNAP(C) is a Myb domain protein that interacts with Oct-1
103. Intrinsically unstructured proteins: Re-assessing the protein structure-function paradigm
104. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice
105. Expression of a large family of POU-domain regulatory genes in mammalian brain development
106. Targeted deletion of the mouse POU domain gene Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling
107. Signal-specific co-activator domain requirements for Pit-1 activation
108. Both Oct-1 and Oct-2a contain domains which can activate the ubiquitously expressed U2 snRNA genes
109. The POU domains of the Oct-1 and Oct-2 transcription factors mediate specific interaction with TBP