POU domain factors of the Brn-3 class recognize functional DNA elements which are distinctive, symmetrical, and highly conserved in evolution

Molecular and Cellular Biology

Volumn 17, Issue 5, 1997, Pages 2391-2400

  Gruber, Craig A ^a   Rhee, Jerry M ^a   Gleiberman, Anatoli ^a   Turner, Eric E ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; OLIGONUCLEOTIDE; TRANSCRIPTION FACTOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CAENORHABDITIS ELEGANS; DNA SEQUENCE; EVOLUTION; GENE EXPRESSION; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; PRIORITY JOURNAL; PROTEIN DNA BINDING;

CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 0030973864     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.5.2391     Document Type: Article

References (28)

1. Assa-Munt, N., R. J. Mortishire-Smith, R. Aurora, W. Herr, and P. E. Wright. 1993. The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage λ repressor DNA-binding domain. Cell 73:193-205.
2. Aurora, R., and W. Herr. 1992. Segments of the POU domain influence one another's DNA-binding specificity. Mol. Cell. Biol. 12:455-467.
3. Ausubel, F. M., et al. (ed.). 1995. Current protocols in molecular biology. John Wiley and Sons, New York, N.Y.
4. Dekker, N., M. Cox, R. Boelens, C. P. Verrijzer, P. C. van der Vliet, and R. Kaptein. 1993. Solution structure of the POU-specific DNA-binding domain of Oct-1. Nature 362:852-855.
5. Erkman, L., R. J. McEvilly, L. Luo, A. K. Ryan, F. Hooshmand, S. M. O'Connell, E. M. Keithley, D. H. Rapaport, A. F. Ryan, and M. G. Rosenfeld. 1996. Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature 381:603-606.
6. Fedtsova, N., and E. E. Turner. 1995. Brn-3.0 Expression identifies early post-mitotic CNS neurons and sensory neural precursors. Mech. Dev. 53: 291-304.
7. Finney, M., G. Ruvkun, and H. R. Horvitz. 1988. The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors. Cell 55:757-769.
8. Fried, M. G., and D. M. Crothers. 1984. Kinetics and mechanism in the reaction of gene regulatory proteins with DNA. J. Mol. Biol. 172:263-282.
9. Gan, L., M. Xiang, L. Zhou, D. S. Wagner, W. H. Klein, and J. Nathans. 1996. POU-domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc. Natl. Acad. Sci. USA 93:3920-3925.
10. Gerrero, M. R., R. McEvilly, E. Turner, C. Lin, S. O'Connell, K. Jenne, M. V. Hobbs, and M. G. Rosenfeld. 1993. The mammalian POU protein, Brn-3, is linked to the pituitary, B cells and sensory neuronal development. Proc. Natl. Acad. Sci. USA 90:10841-10845.
11. He, X., M. N. Treacy, D. M. Simmons, H. A. Ingraham, L. W. Swanson, and M. G. Rosenfeld. 1989. Expression of a large family of POU-domain genes in mammalian brain development. Nature 340:35-42.
12. Herr, W., and M. A. Cleary. 1995. The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain. Genes Dev. 9:1679-1693.
13. Klemm, J. D., M. A. Rould, R. Aurora, W. Herr, and C. O. Pabo. 1994. Crystal structure of Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules. Cell 77:21-32.
14. Klemm, J. D., and C. O. Pabo. 1995. Oct-1 POU domain-DNA interactions: cooperative binding of isolated subdomains and effects of covalent linkage. Genes Dev. 10:27-36.
15. Li, P., X. He, M. R. Gerrero, M. Mok, A. Aggarwal, and M. G. Rosenfeld. 1993. Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU-domain factors. Genes Dev. 7:2483-2496.
16. McEvilly, R. J., L. Erkman, L. Luo, P. E. Sawchenko, A. F. Ryan, and M. G. Rosenfeld. 1996. Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons. Nature 384:574-577.
17. Morris, P. J., T. Theil, C. Ring, K. A. Lillycrop, T. Moroy, and D. S. Latchman. 1994. The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain. Mol. Cell. Biol. 14:6907-6914.
18. Poellinger, L., and R. G. Roeder. 1989. Octamer transcription factors 1 and 2 each bind to two different functional elements in the immunoglobin heavy-chain promoter. Mol. Cell. Biol. 9:747-756.
19. Treacy, M. N., X. He, and M. G. Rosenfeld. 1991. I-POU: a POU-domain protein that inhibits neuron specific gene activation. Nature 350:577-584.
20. Turner, E. E., K. Jenne, and M. G. Rosenfeld. 1994. Brn-3.2: a POU-domain transcription factor with distinctive CNS expression and regulation by retinoic acid. Neuron 12:205-218.
21. Turner, E. E., N. Fedtsova, and M. G. Rosenfeld. 1996. POU-domain factor expression in the trigeminal ganglion and implications for herpes virus regulation. NeuroReport 1: 2829-2832.
22. Turner, E. E. Conserved DNA recognition by alternatively spliced Drosophila POU factors. 1996. Proc. Natl. Acad. Sci. USA 93:15097-15101.
23. Verrijzer, C. P., M. J. Alkema, W. W. vanWeperen, H. C. VanLeeuwen, M.J. Strating, and P. C. van der Vliet. 1992. The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J. 11:4993-5003.
24. Way, J. C., L. Wang, J. Run, and A. Wang. 1991. The mec-3 gene contains cis-acting elements mediating positive and negative regulation in cells produced by asymmetric cell division in C. elegans. Genes Dev. 5:2199-2211.
25. Xiang, M., L. Zhou, Y.-W. Peng, R. Eddy, T. B. Shows, and J. Nathans. 1993. Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. Neuron 11:689-701.
26. Xiang, M., L. Zhou, J. P. Macke, T. Yoshioka, S. H. C. Hendry, R. L. Eddy, T. B. Shows, and J. Nathans. 1995. The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. J. Neurosci. 15:4762-4785.
27. Xiang, M., G. Lin, L. Zhou, W. H. Klein, and J. Nathans. 1996. Targeted deletion of the mouse POU-domain gene Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc. Natl. Acad. Sci. 93:11950-11955.
28. Xue, D., M. Finney, G. Ruvkun, and M. Chalfie. 1992. Regulation of the mec-3 gene by the C. elegans homeoproteins UNC-86 and MEC-3. EMBO J. 11:4969-4979.