Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription

Molecular and Cellular Biology

Volumn 16, Issue 10, 1996, Pages 5708-5716

  Gugneja, Sajiv ^a   Virbasius, Ching Man A ^a,b   Scarpulla, Richard C ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; GENE EXPRESSION REGULATION; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; REGULATORY MECHANISM; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION;

EUKARYOTA;

EID: 0029791552     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.10.5708     Document Type: Article

References (38)

1. Andrews, N. C., and D. V. Faller. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:2499.
2. Attardi, G., and G. Schatz. 1988. Biogenesis of mitochondria. Annu. Rev. Cell Biol. 4:289-333.
3. Boulikas, T. 1993. Nuclear localization signals (NLS). Crit. Rev. Eukaryotic Gene Expr. 3:193-227.
4. Braidotti, G., I. A. Borthwick, and B. K. May. 1993. Identification of regulatory sequences in the gene for 5-aminolevulinate synthase from rat. J. Biol. Chem. 268:1109-1117.
5. Calzone, F. J., C. Hoog, D. B. Teplow, A. E. Cutting, R. W. Zeller, R. J. Britten, and E. H. Davidson. 1991. Gene regulatory factors of the sea urchin embryo. I. Purification by affinity chromatography and cloning of P3A2, a novel DNA binding protein. Development 112:335-350.
6. Chau, C. A., M. J. Evans, and R. C. Scarpulla. 1992. Nuclear respiratory factor 1 activation sites in genes encoding the gamma-subunit of ATP synthase, eukaryotic initiation factor 2α, and tyrosine aminotransferase. Specific interaction of purified NRF-1 with multiple target genes. J. Biol. Chem. 267:6999-7006.
7. Clayton, D. A. 1991. Replication and transcription of vertebrate mitochondrial DNA. Annu. Rev. Cell Biol. 7:453-478.
8. Courey, A. J., D. A. Holtzman, S. P. Jackson, and R. Tjian. 1989. Synergistic activation by the glutamire-rich domains of human transcription factor Sp1. Cell 59:827-836.
9. Courey, A. J., and R. Tjian. 1988. Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell 55:887-898.
10. Cress, W. D., and S. J. Triezenberg. 1991. Critical structural elements of the VP16 transcriptional activation domain. Science 251:87-90.
11. De la Brousse, F. C., E. H. Birkenmeier, D. S. King, L. B. Rowe, and S. L. McKnight. 1994. Molecular and genetic characterization of GABPβ. Genes Dev. 8:1853-1865.
12. Desimone, S. M., and K. While. 1993. The Drosophita erect wing gene, which is important for both neuronal and muscle development, encodes a protein which is similar to the sea urchin P3A2 DNA binding protein. Mol. Cell. Biol. 13:3641-3949.
13. Evans, M. J., and R. C. Scarpulla. 1990. NRF-1: a trans-activator of nuclear-encoded respiratory genes in animal cells. Genes Dev. 4:1023-1034.
14. II110 component of the Drosophila TFHD complex and mediates transcriptional activation. Proc. Natl. Acad. Sci. USA 91:192-196.
15. Gomez-Cuadrado, A., M. Martin, M. Noël, and A. Ruiz-Carrillo. 1995. Initiation binding repressor, a factor that binds to the transcription initiation site of the histone h5 gene, is a glycosylated member of a family of cell growth regulators. Mol. Cell. Biol. 15:6670-6685. (Erratum, 16:735, 1996.)
16. Gopalakrishnan, L., and R. C. Scarpulla. 1995. Structure, expression, and chromosomal assignment of the human gene encoding nuclear respiratory factor 1. J. Biol. Chem. 270:18019-18025.
17. Gossen, M., and H. Bujard. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89:5547-5551.
18. Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467.
19. Gugneja, S., J. V. Virbasius, and R. C. Scarpulla. 1995. Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. Mol. Cell. Biol. 15:102-111.
20. Hoog, C., F. J. Calzone, A. E. Culling, R. J. Britten, and E. H. Davidson. 1991. Gene regulatory factors of the sea urchin embryo. II. Two dissimilar proteins. P3A1 and P3A2, bind to the same target sites that are required for early territorial gene expression. Development 112:351-354.
21. Hopp, T. P., and K. R. Woods. 1981. Prediction of protein antigenic determinants from amino acid sequences. Proc. Natl. Acad. Sci. USA 78:3824-3828.
22. Kadonaga, J. T., A. J. Courey, J. Ladika, and R. Tjian. 1988. Distinct regions of Sp1 modulate DNA binding and transcriptional activation. Science 242: 1566-1570.
23. Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488-492.
24. LaMarco, K., C. C. Thompson, B. P. Byers, E. M. Walton, and S. L. McKnight. 1991. identification of Ets- and notch-related subunits in GA binding protein. Science 253:789-792.
25. Lillie, J. W., and M. R. Green. 1989. Transcription activation by the adenovirus E1a protein. Nature (London) 338:39-44.
26. MacGregor, G. R., A. E. Mogg, J. F. Burke, and C. T. Caskey. 1987. Histochemical staining of clonal mammalian cell lines expressing E. coli beta-galactosidase indicates heterogeneous expression of the bacterial gene. Somat. Cell Mol. Genet. 13:253-265.
27. Nagley, P. 1991. Coordination of gene expression in the formation of mammalian mitochondria. Trends Genet. 7:1-4.
28. Regier, J. L., F. Shen, and S. J. Triezenberg. 1993. Pattern of aromatic and hydrophobic amino acids critical for one of two subdomains of the VP16 transcriptional activator. Proc. Natl. Acad. Sci. USA 90:883-887.
29. Rosenthal, N. 1987. Identification of regulatory elements of cloned genes with functional assays. Methods Enzymol. 152:704-720.
30. Sadowski, I., and M. Ptashne. 1989. A vector for expressing GAL4(1-147) fusions in mammalian cells. Nucleic Acids Res. 17:7539.
31. Scarpulla, R. C. 1996. Nuclear respiratory factors and the pathways of nuclear-mitochondrial interaction. Trends Cardiovasc. Med. 6:39-45.
32. Seelan, R. S., L. Gopalakrishnan, R. C. Scarpulla, and L. I. Grossman. 1996. Cytochrome c oxidase subunit VIIa liver isoform: characterization and identification of promoter elements in the bovine gene. J. Biol. Chem. 271:2112-2120.
33. Shadel, G. S., and D. A. Clayton. 1993. Mitochondrial transcription initiation. Variation and conservation. J. Biol. Chem. 268:16083-16086.
34. Thompson, C. C., T. A. Brown, and S. L. McKnight. 1991. Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complex. Science 253:762-768.
35. Virbasius, C. A., J. V. Virbasius, and R. C. Scarpulla. 1993. NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators. Genes Dev. 7:2431-2445.
36. Virbasius, J. V., and R. C. Scarpulla. 1991. Transcriptional activation through ETS domain binding sites in the cytochrome c oxidase subunit IV gene. Mol. Cell. Biol. 11:5631-5638.
37. Virbasius, J. V., and R. C. Scarpulla. 1994. Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Proc. Natl. Acad. Sci. USA 91:1309-1313.
38. Virbasius, J. V., C. A. Virbasius, and R. C. Scarpulla. 1993. Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters. Genes Dev. 7:380-392.