Cyclosporin a protects striatal neurons in vitro and in vivo from 3-nitropropionic acid toxicity

Journal of Comparative Neurology

Volumn 425, Issue 4, 2000, Pages 471-478

  Leventhal, Liza ^a   Sortwell, Caryl E ^a   Hanbury, Rose ^a   Collier, Timothy J ^a   Kordower, Jeffrey H ^a   Palfi, Stéphane ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

DARPP32; Huntington's disease; Rat; Stereology; Striatum

Indexed keywords

3 NITROPROPIONIC ACID; CYCLOSPORIN A; GLUTAMATE DECARBOXYLASE; PHOSPHOPROTEIN DARPP 32;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; FEMALE; HUNTINGTON CHOREA; MITOCHONDRION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; STEREOLOGY; STRIATE CORTEX;

ANIMALS; CELL DEATH; CELLS, CULTURED; CORPUS STRIATUM; CYCLOSPORINE; EMBRYO; MALE; NEURONS; NEUROPROTECTIVE AGENTS; NITRO COMPOUNDS; PROPIONIC ACIDS; RATS; RATS, INBRED F344; RATS, INBRED LEW;

EID: 0034597411     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-9861(20001002)425:4<471::AID-CNE1>3.0.CO;2-U     Document Type: Article

References (32)

1. Alternative excitotoxic hypotheses
2. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-Nitropropionic acid
3. Optimized survival of hippocampal neurons in B27-supplemented neurobasal, a new serum-free medium combination
4. Neurobasal medium/B27 supplement: A new serum-free medium combination for focus of neurons
5. Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates
6. Recruitment of mitochondrial cyclophilin to the mitochondrial inner-membrane under conditions of oxidative stress that enhance opening of a calcium-sensitive non-specific channel
7. Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria
8. Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death
9. Cyclosporine neurotoxicity: A review
10. Mitochondria and apoptosis
11. Mechanisms by which mitochondria transport calcium
12. Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-Nitropropionic acid
13. DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Purification and characterization of the phosphoprotein from bovine caudate nucleus
14. Protein A, avidin, and biotin in immunohistochemistry
15. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
16. Grafts of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice: Trophic and tropic effects in a rodent model of Huntington's Disease
17. The proto-oncogene Bcl-2 and its role in regulating apoptosis
18. Mitochondrial permeability transition is a central coordinating event of apoptosis
19. Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: Evidence of the mitochondrial permeability transition
20. An intrathecal bolus of cyclosporin A before injury preserves mitochondrial integrity and attenuates axonal disruption in traumatic brain injury
21. Major strain differences in response to chronic 3-Nitropriopionic acid in rats: Implications for neuroprotection studies
22. Increased proportion of acetylcholiineserase-rich zones and improved morphological integration in host striatum of fetal grafts derived from lateral but not medial ganglionic eminence
23. Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease
24. Mechanisms of cell death induced by the mitochondrial toxin 3-Nitropropionic acid: Acute excitotoxic necrosis and delayed apoptosis
25. Oxidative stress, mitochodrial permeability transition and activation of caspases in calium ionophore A23187-induced death of cultured striatal neurons
26. Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization
27. Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins
28. Cyclosporin A protects against ischemia-reperfusion injury in the brain
29. Co-grafted embyronic striatum increases the survival of grafted embyronic dopamine neurons
30. Standardized methods to bioassay neurotrophic factors for dopaminergic neurons
31. Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat