Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins

Journal of Biological Chemistry

Volumn 273, Issue 28, 1998, Pages 17483-17490

  Huang, Yadong ^a   Liu, Xiao Qin ^a   Rail Jr , Stanley C ^a   Mahley, Robert W ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E2; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; DOSE RESPONSE; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERCHOLESTEROLEMIA; LIPOLYSIS; LIPOPROTEIN METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIMALS; APOLIPOPROTEIN E2; APOLIPOPROTEINS E; FEMALE; LIPOLYSIS; LIPOPROTEIN LIPASE; LIPOPROTEINS, LDL; MALE; MICE; MICE, TRANSGENIC; RECEPTORS, LDL; TRIGLYCERIDES;

ANIMALIA; MUS MUSCULUS;

EID: 0032504182     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.28.17483     Document Type: Article

References (50)

1. Mahley, R. W., and Rail, S. C., Jr. (1995) in The Metabolic and Molecular Bases of Inherited Disease (Scriver, C. R., Beaudet, A. L., Sly, W. S., and Valle, D., eds) 7th Ed., pp. 1953-1980, McGraw-Hill, New York
2. Utermann, G., Pruin, N., and Steinmetz, A. (1979) Clin. Genet. 15, 63-72
3. Utermann, G., Langenbeck, U., Beisiegel, U., and Weber, W. (1980) Am. J. Hum. Genet. 32, 339-347
4. Davignon, J., Gregg, R. E., and Sing, C. F. (1988) Arteriosclerosis 8, 1-21
5. Cumming, A. M., and Robertson, F. W. (1984) Clin. Genet. 25, 310-313
6. Kuusi, T., Nieminen, M. S., Ehnholm, C., Yki-Järvinen, H., Valle, M., Nikkilä, E. A., and Taskinen, M.-R. (1989) Arteriosclerosis 9, 237-241
7. Luc, G., Bard, J.-M., Arveiler, D., Evans, A., Cambou, J.-P., Bingham, A., Amouyel, P., Schaffer, P., Ruidavets, J.-B., Cambien, F., Fruchart, J.-C., and Ducimetiere, P. (1994) Arterioscler. Thromb. 14, 1412-1419
8. Stengård, J. H., Pekkanen, J., Ehnholm, C., Nissinen, A., and Sing, C. F. (1996) Hum. Genet. 97, 677-684
9. Eichner, J. E., Kuller, L. H., Orchard, T. J., Grandits, G. A., McCallum, L. M., Ferrell, R. E., and Neaton, J. D. (1993) Am. J. Cardiol. 71, 160-165
10. Mahley, R. W. (1988) Science 240, 622-630
11. Hixson, J. E., and the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group (1991) Arterioscler. Thromb. 11, 1237-1244
12. Huang, Y., Schwendner, S. W., Rall, S. C., Jr., Sanan, D. A., and Mahley, R. W. (1997) J. Biol. Chem. 272, 22685-22694
13. Woollett, L. A., Osono, Y., Herz, J., and Dietschy, J. M. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 12500-12504
14. Chait, A., Brunzell, J. D., Albers, J. J., and Hazzard, W. R. (1977) Lancet 1, 1176-1178
15. Chait, A., Hazzard, W. R., Albers, J. J., Kushwaha, R. P., and Brunzell, J. D. (1978) Metabolism 27, 1055-1066
16. Ehnholm, C., Mahley, R. W., Chappell, D. A., Weisgraber, K. H., Ludwig, E., and Witztum, J. L. (1984) Proc. Natl. Acad. Sci. U. S. A. 81, 5566-5570
17. Chung, B. H., and Segrest, J. P. (1983) J. Lipid Res. 24, 1148-1159
18. Huang, Y., Schwendner, S. W., Rall, S. C., Jr., and Mahley, R. W. (1996) J. Biol. Chem. 271, 29146-29151
19. Huang, Y., Rall, S. C., Jr., and Mahley, R. W. (1997) Arterioscler. Thromb. Vasc. Biol. 17, 2817-2824
20. Fazio, S., Yao, Z., McCarthy, B. J., and Rall, S. C., Jr. (1992) J. Biol. Chem. 267, 6941-6945
21. Fazio, S., Lee, Y.-L., Ji, Z.-S., and Rall, S. C., Jr. (1993) J. Clin. Invest. 92, 1497-1503
22. Horie, Y., Fazio, S., Westerlund, J. R., Weisgraber, K. H., and Rall, S. C., Jr. (1992) J. Biol. Chem. 267, 1962-1968
23. de Silva, H. V., Más-Oliva, J., Taylor, J. M., and Mahley, R. W. (1994) J. Lipid Res. 35, 1297-1310
24. Connelly, P. W., Maguire, G. F., Vezina, C., Hegele, R. A., and Kuksis, A. (1994) J. Biol. Chem. 269, 20554-20560
25. Iverius, P.-H., Lindahl, U., Egelrud, T., and Olivecrona, T. (1972) J. Biol. Chem. 247, 6610-6616
26. Pittman, R. C., Glass, C. K., Atkinson, D., and Small, D. M. (1987) J. Biol. Chem. 262, 2435-2442
27. Dong, L.-M., and Weisgraber, K. H. (1996) J. Biol. Chem. 271, 19053-19057
28. Spooner, P. J. R., Clark, S. B., Gantz, D. L., Hamilton, J. A., and Small, D. M. (1988) J. Biol. Chem. 263, 1444-1453
29. Bellosta, S., Nathan, B. P., Orth, M., Dong, L.-M., Mahley, R. W., and Pitas, R. E. (1995) J. Biol. Chem. 270, 27063-27071
30. Ishibashi, S., Brown, M. S., Goldstein, J. L., Gerard, R. D., Hammer, R. E., and Herz, J. (1993) J. Clin. Invest. 92, 883-893
31. Utermann, G., Kindermann, I., Kaffarnik, H., and Steinmetz, A. (1984) Hum. Genet. 65, 232-236
32. Dallongeville, J., Lussier-Cacan, S., and Davignon, J. (1992) J. Lipid Res. 33, 447-454
33. de Silva, H. V., Lauer, S. J., Wang, J., Simonet, W. S., Weisgraber, K. H., Mahley, R. W., and Taylor, J. M. (1994) J. Biol. Chem. 269, 2324-2335
34. Weisgraber, K. H., Mahley, R. W., Kowal, R. C., Herz, J., Goldstein, J. L., and Brown, M. S. (1990) J. Biol. Chem. 265, 22453-22459
35. Aalto-Setälä, K., Fisher, E. A., Chen, X., Chajek-Shaul, T., Hayek, T., Zechner, R., Walsh, A., Ramakrishnan, R., Ginsberg, H. N., and Breslow, J. L. (1992) J. Clin. Invest. 90, 1889-1900
36. Shachter, N. S., Hayek, T., Leff, T., Smith, J. D., Rosenberg, D. W., Walsh, A., Ramakrishnan, R., Goldberg, I. J., Ginsberg, H. N., and Breslow, J. L. (1994) J. Clin. Invest. 93, 1683-1690
37. Hospattankar, A. V., Fairwell, T., Ronan, R., and Brewer, H. B., Jr. (1984) J. Biol. Chem. 259, 318-322
38. Olivecrona, T., and Bengtsson-Olivecrona, G. (1990) Curr. Opin. Lipidol. 1, 222-230
39. Havel, R. J., Kotite, L., Vigne, J.-L., Kane, J. P., Tun, P., Phillips, N., and Chen, G. C. (1980) J. Clin. Invest. 66, 1351-1362
40. Eisenberg, S. (1984) J. Lipid Res. 25, 1017-1058
41. Brunzell, J. D. (1995) in The Metabolic and Molecular Bases of Inherited Disease (Scriver, C. R., Beaudet, A. L., Sly, W. S., and Valle, D., eds) 7th Ed., Vol. 2, pp. 1913-1932, McGraw-Hill, New York
42. Goldberg, I. J., Le, N.-A., Ginsberg, H. N., Krauss, R. M., and Lindgren, F. T. (1988) J. Clin. Invest. 81, 561-568
43. Patsch, J. R., Prasad, S., Gotto, A. M., Jr., and Patsch, W. (1987) J. Clin. Invest. 80, 341-347
44. Zhang, S. H., Reddick, R. L., Piedrahita, J. A., and Maeda, N. (1992) Science 258, 468-471
45. Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., and Breslow, J. L. (1992) Cell 71, 343-353
46. Gómez-Coronado, D., Sáez, G. T., Lasunción, M. A., and Herrera, E. (1993) Biochim. Biophys. Acta 1167, 70-78
47. Rensen, P. C. N., and van Berkel, T. J. C. (1996) J. Biol. Chem. 271, 14791-14799
48. Mahley, R. W. (1996) Isr. J Med. Sci. 32, 414-429
49. Ji, Z.-S., Fazio, S., and Mahley, R. W. (1994) J. Biol. Chem. 269, 13421-13428
50. Kowal, R. C., Herz, J., Weisgraber, K. H., Mahley, R. W., Brown, M. S., and Goldstein, J. L. (1990) J. Biol. Chem. 265, 10771-10779