Na+/H+ exchanger: An emerging therapeutic target in cardiovascular disorders

Drugs of Today

Volumn 36, Issue 11, 2000, Pages 793-802

  Sharma, A ^a   Singh, M ^a  

^a PUNJABI UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

(3 METHYLSULFONYL 4 PIPERIDINOBENZOYL)GUANIDINE METHANESULFONATE; 5 (2,5 DICHLOROTHIENYL) 3 (2 DIMETHYLAMINOETHYLCARBAMOYL)BENZOYLGUANIDINE; [4 [4 (2 FUROYL) 1 PIPERAZINYL] 3 (METHYLSULFONYL)BENZOYL]GUANIDINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMILORIDE; AMILORIDE DERIVATIVE; CALCIUM ION; CALMODULIN; CARIPORIDE; CARRIER PROTEIN; CCAAT ENHANCER BINDING PROTEIN; CONNEXIN 43; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENIPORIDE; N AMIDINO 1,4 DIMETHYL 1H INDOLE 2 CARBOXAMIDE; PROTEIN INHIBITOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CORONARY ARTERY OBSTRUCTION; DRUG EFFICACY; HEART FAILURE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; NONHUMAN; PROTON SODIUM EXCHANGE; REPERFUSION INJURY; REVIEW;

EID: 0034534225     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2000.36.11.601533     Document Type: Review

References (83)

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3. + exchanger
4. + exchange: Structure, regulation and its role in heart disease
5. Structure-function studies and molecular regulation of the growth factor activatable sodium-hydrogen exchanger (NHE-1)
6. + exchanger isoforms (NHE-1,-2 and-3) are differentially responsive to second messenger agonists of the protein kinase A and C pathways
7. + exchanger isoform NHE1: Role of phosphorylation
8. Gαq and Gα13 regulate NHE-1 and intracellular calcium in epithelial cells
9. + exchange through distinct Cdc41-dependent and RhoA-dependent pathways
10. + exchanger through mitogen-activated protein kinase
11. + exchange in neonatal rat cardiac myocytes
12. + exchanger (NHE-1 isoform) in response to growth factors
13. + antiporter in salivary acinar cells
14. + exchanger isoform 1 (NHE-1) is a novel member of the calmodulin-binding proteins: Identification characterization of calmodulin-binding sites
15. + exchange in the sheep cardiac Purkinje fibre
16. + exchanger (NHE-1) gene
17. Regulation of the NHE-1 promoter in mammalian myocardium
18. + exchanger gene expression: Role of a novel poly(dA.dT) element in regulation of the NHE-1 promoter
19. Role of bicarbonate in pH recovery from intracellular acidosis in the guinea-pig ventricular myocyte
20. Influence of sodium-hydrogen exchange on intracellular pH, sodium and tension in sheep cardiac Purkinje fibres
21. + antiport
22. The sodium/hydrogen exchange system in cardiac cell: Its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH
23. 87Rb NMR spectroscopic study
24. + exchanger
25. 2+ exchange
26. 2+ exchanger increases susceptibility to ischemia/reperfusion injury in male, but not female, transgenic mice
27. The pH paradox in ischemia reperfusion injury to cardiac myocytes
28. + exchange inhibitors in cardiac ischemia
29. Influence of perfusate pH on the postischemic recovery of cardiac contractile function: Involvement of sodium-hydrogen exchange
30. Effect of amiloride and selected analogues on postischemic recovery of cardiac contractile function
31. + exchange inhibitor methylisobutyl amiloride against post-ischemic contractile dysfunction in rat and guinea-pig hearts
32. Inhibition of sodium-hydrogen exchange reduces infarct size in the isolated rat heart: A protective additive to ischemic preconditioning
33. + exchange
34. + exchange inhibitor and its effects in cardiac ischemia
35. 2+ overload in isolated perfused rabbit heart
36. + exchange inhibition in ischemic, reperfused porcine heart
37. Effects and interaction of cariporide and preconditioning on cardiac arrhythmias and infarction in rat in vivo
38. Dose-dependent reduction of myocardial infarct mass in rabbits by the NHE-1 inhibitor cariporide (HOE 642)
39. + exchange inhibitor. Hoe 642: Difference from preconditioning in the role of protein kinase C
40. + exchange inhibition with cariporide limits functional impairment caused by repetitive ischemia
41. + exchange inhibitor suppresses the reperfusion-induced lethal arrhythmias and "overshoot" phenomenon of creatine phosphate in situ rat heart
42. + exchange inhibitor, on ventricular arrhythmias in animal hearts
43. + exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs
44. + exchange (NHE-1) inhibitor, EMD 85131, limits infarct size in dogs when administered prior to or after coronary artery occlusion
45. +-exchange inhibitor, FR183998, shows cardioprotective effects in rats with cardiac ischemia and reperfusion
46. 2+ overload
47. + exchange inhibitors reverse lactate induced depression in postischemic ventricular recovery
48. Hydrogen peroxide induced impairment of post-ischemic ventricular function is prevented by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide)
49. + exchange inhibition protects against mechanical, ultrastructural and biochemical impairment induced by low concentrations of lysophosphatidylcholine in isolated rat hearts
50. Orally administered NHE-1 inhibitor cariporide reduces acute response to coronary occlusion and reperfusion
51. Preconditioning rabbit cardiomyocytes: Role of pH, vacuolar proton ATPase, and apoptosis
52. + exchanger attenuates neutrophil-mediated reperfusion injury
53. A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide)
54. GUARD During Ischemia Against Necrosis (GUARDIAN) trial in acute coronary syndromes
55. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
56. Ischemic preconditioning preserves creatine phosphate and intracellular pH
57. + exchange inhibitor, on cardioprotective effect of ischemic and angiotensin preconditioning
58. + exchanger activity does not contribute to protection by ischemic preconditioning in isolated rat heart
59. Role of angiotensin in cardioprotective effect of ischemic preconditioning
60. Possible mechanism of cardioprotective effect of angiotensin preconditioning in isolated rat heart
61. Hypertensive sodium-proton exchanger phenotype persists in immortalized lymphoblasts from essential hypertensive patients: A cell culture model for human hypertension
62. + exchange in pulmonary artery smooth muscle from spontaneously hypertensive and Wistar-Kyoto rats
63. + exchanger expression in vascular smooth muscle of spontaneously hypertensive and Wistar-Kyoto rats
64. Sodium-hydrogen antiporter protein in normotensive Wistar-Kyoto rats and spontaneously hypertensive rats
65. + exchange in vascular smooth muscle cells from WKY and SHR: Effects of phorbol ester
66. + exchanger isoform-1
67. + antiporter phenotype, abundance, and phosphorylation of immortalized lymphoblasts from humans with hypertension
68. + exchanger isoform of renal brush border
69. + exchanger isoforms 1 and 3 in kidney proximal tubules of hypertensive rats
70. + exchanger overactivity in essential hypertension
71. Correlations between cardiac protein synthesis rates, intracellular pH and the concentrations of creatine metabolites
72. + exchange in norephinephrine-induced protein synthesis in neonatal cultured cardiomyocytes
73. Role of ion channels and exchanger in mechanical stretch induced cardiomyocyte hypertrophy
74. Stretch-induced alkalinization of feline papillary muscle: An autocrine-paracrine system
75. + exchange blocker amiloride on left ventricular remodelling after anterior myocardial infarction in rats
76. + exchange inhibition attenuates hypertrophy and heart failure in one-week postinfarcted rat myocardium
77. + exchange blocker, in a murine model of dilated myopathy
78. + exchange inhibitor cariporide in infarct-induced heart failure
79. + exchange is impaired in cardiac hypertrophy
80. i, and contraction in rabbit ventricular myocytes from infarcted hearts
81. + exchange
82. + exchange inhibitors decrease neointimal formation after rat carotid injury: Effect on smooth muscle cell migration proliferation