Antiarrhythmic effects of HOE642, a novel Na+-H+ exchange inhibitor, on ventricular arrhythmias in animal hearts

European Journal of Pharmacology

Volumn 317, Issue 2-3, 1996, Pages 309-316

  Xue, Yi Xue ^a   Aye, Nu Nu ^a   Hashimoto, Keitaro ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Arrhythmia ischemia; Arrhythmia reperfusion; Digitalis arrhythmia; HOE642; Na+ Ca2+ exchange; Na+ H+ exchange

Indexed keywords

ANTIARRHYTHMIC AGENT; CARIPORIDE; OUABAIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DOG; DRUG EFFECT; FEMALE; HEART HEMODYNAMICS; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; REPERFUSION INJURY; SODIUM CALCIUM EXCHANGE;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CARDIOTONIC AGENTS; CORONARY VESSELS; DIGITALIS GLYCOSIDES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUANIDINES; INJECTIONS, INTRAVENOUS; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-HYDROGEN ANTIPORTER; SULFONES; VENTRICULAR FIBRILLATION;

EID: 0030593923     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00755-8     Document Type: Article

References (42)

1. + exchange in myocardium: effects of hypoxia and acidification on Na and Ca, Am. J. Physiol. 259, C940.
2. Awaji, T., Z.J. Wu and K. Hashimoto, 1995, Acute antiarrhythmic effects of intravenously administered amiodarone on canine ventricular arrhythmia, J. Cardiovasc. Pharmacol. 26, 869.
3. Benndorf, K., M. Friedrich and H. Hirche, 1991, Reoxygenation-induced arrhythmogenic transient inward current in isolated cells of the guinea-pig heart, Pflüg. Arch. Eur. J. Physiol. 418, 248.
4. Corbalan, R., R.L. Verrier and B. Lown, 1976, Differing mechanisms for ventricular vulnerability during coronary artery occlusion and release, Am. Heart J. 92, 223.
5. Couper, G.S., J. Weiss, B. Hiltbrand and K.I. Shine, 1984, Extracellular pH and tension during ischemia in the isolated rabbit ventricle, Am. J. Physiol. 247, H916.
6. Duff, H.J., 1995, Clinical and in vivo antiarrhythmic potential of sodium-hydrogen exchange inhibitors, Cardiovasc. Res. 29, 189.
7. Duff, H.J., W.M. Lester and M. Rahmberg, 1988, Amiloride: antiarrhythmic and electrophysiologic activity in the dog, Circulation 78, 1469.
8. Duff, H.J., L.B. Mitchell, K.M. Kavanagh, D.E. Manyari, A.M. Gillis and D.G. Wyse, 1989, Amiloride: antiarrhythmic and electrophysiologic actions in patients with inducible sustainted ventricular tachycardia, Circulation 79, 1257.
9. Echt, D.S., R.P. Liebson, B. Mitchell, R.W. Peters, D. Obias-Manno, A.H. Barker, D. Arensberg, A. Baker, L. Friedman, L. Greene, M.L. Huther, D.W. Richardson and the CAST Investigators, 1991, Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The cardiac arrhythmias suppression trial, New Engl. J. Med. 324, 781.
10. Eisner, D.A., W.J. Lederer and R.D. Vaughan-Jones, 1984, The quantitative relationship between twitch tension and intracellular sodium activity in sheep cardiac Purkinje fibres, J. Physiol. 355, 251.
11. Ferrier, G.R., M.P. Moffat and A. Lukas, 1985, Possible mechanism of ventricular arrhythmia elicited by ischemia followed by reperfusion: studies on isolated canine ventricular tissues, Circ. Res. 56, 184.
12. + concentration. A molecular basis for the antagonistic effect of ouabain and amiloride on the heart, J. Biol. Chem. 259, 8880.
13. Greeff, K. and E. Kohler, 1975, Animal experiments on the effect of triamterene and amiloride in heart and circulation and the toxicity of digoxin, Arzneim.-Forsch. 25, 1766.
14. Hashimoto, K., 1992, Arrhythmias associated with myocardial ischemia and their modulation by antiarrhythmic drugs, Circ. Cont. 13, 127.
15. Hashimoto, K., M. Ishii, S. Komori and H. Mitsuhashi, 1985, Canine digitalis arrhythmia as a model for detecting Na-channel blocking antiarrhythmic drugs: a comparative study using other canine arrhythmia models and the new antiarrhythmic drugs, propafenone, tocainide and SUN 1165, Heart Vessels 1, 29.
16. Hashimoto K., A. Haruno, A. Hirasawa, T. Awaji and Y. Uemura, 1991a, Effects of a new class III antiarrhythmic drug (E-4031) on canine ventricular arrhythmia models, Asia Pacific J. Pharmacol. 6, 127.
17. Hashimoto, K., A. Sugiyama, A. Haruno, T. Matsuzaki, A. Hirasawa, 1991b, Effects of a new antiarrhythmic drug TYB-3823 on canine ventricular arrhythmia models, J. Cardiovasc. Pharmacol. 17, 336.
18. Hashimoto, K., A. Haruno, A. Hirasawa, T. Awaji, Y.X. Xue and Z.J. Wu, 1995, Effects of the class III antiarrhythmic drugs MS-551 and d-sotalol on canine coronary ligation-reperfusion ventricular arrhythmias, Jpn. J. Pharmacol. 68, 1.
19. Hashimoto, K., Y.X. Xue, J.G. Chen, K. Eto, C. Ni, A. Hirasawa, T. Awaji and A. Haruno, 1996, Effects of class III antiarrhythmic drug on ventricular arrhythmias in dogs, Exp. Clin. Cardiol. (in press).
20. Holland, O.B., L. Kuhnert, J. Pollard, M. Padia, R.J. Anderson and G. Blomqvist, 1988, Ventricular ectopic activity with diuretic therapy, Am. J. Hypertens. 1, 380.
21. Jounella, A. and K. Pyorala, 1975, Effect of amiloride on digitalis-induced electrocardiographic changes, Ann. Clin. Res. 7, 66.
22. + exchange, Am. J. Physiol. 255, H608.
23. Karmazyn, M., J.E. Watson and M.P. Moffat, 1990, Mechanisms for cardiac depression induced by phorbol myristate acetate in working rat hearts, Br. J. Pharmacol. 100, 826.
24. Kass, R.S., W.J. Lederer, R.W. Tsien and R. Weingart, 1978, Role of calcium ion in transient inward current and aftercontractions induced by strophanthidin in cardiac Purkinje fibres, J. Physiol. (London) 281, 187.
25. Komori. S., T. Sawanobori, K. Tamura, K.A. Kane and J.R. Parratt, 1994, Effects of NS-2, a new class I antiarrhythmic agent and AFD-19, its active metabolite on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats: comparison with disopyramide and mexiletine, Jpn. J. Pharmacol. 65, 193.
26. Lazdunski, M., C. Frelin and P. Vigne, 1985, The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH, J. Mol. Cell. Cardiol. 17, 1029.
27. Lee, C.O., P. Abete, M. Pecker, J.K. Sonn and M. Vassalle, 1985, Strophanthidin inotropy: role of intracellular sodium ion activity and sodium-calcium exchange, J. Mol. Cell. Cardiol. 17, 1043.
28. Meng, H. and G.N. Pierce, 1990, Protective effects of 5-(N,N-dimethyl) amiloride on ischemia-reperfusion injury in heart, Am. J. Physiol. 27, H1615.
29. Meng, H. and G.N. Pierce, 1991, Involvement of sodium in the protective effects of 5-(N,N-dimethyl) amiloride (DMA) on ischemia-reperfusion injury in isolated rat ventricular wall, J. Pharmacol. Exp. Ther. 256, 1094.
30. Moffat, M.P., 1989, Protective effects of amiloride on the response of canine Purkinje fibers to ischemia and reperfusion, J. Mol. Cell. Cardiol. 21 (Suppl. 2), S143 (Abstract).
31. Murphy, J.G., T.W. Smith and J.D. Marsh, 1988, Mechanisms of reoxygenation-induced calcium overload in cultured chick embryo heart cells, Am. J. Physiol. 254, H1133.
32. Myers, M.G., 1990, Diuretic therapy and ventricular arrhythmias in persons 65 years of age and older, Am. J. Cardiol. 65, 599.
33. Opie, L.H., 1989, Reperfusion injury and its pharmacologic modification, Circulation 80, 1049.
34. + exchange, Am. J. Physiol. 265, H2017.
35. Poole-Wilson, P.A., 1978, Measurement of myocardial intracellular pH in pathological states, J. Mol. Cell. Cardiol. 10, 511.
36. Scholz, W., U. Albus, L. Counillon, H. Gogelein, H.J. Lang, W. Line, A. Weichert and B.A. Scholkens, 1995, Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischemia and reperfusion, Cardiovasc. Res. 29, 260.
37. + exchange activity in purified canine cardiac sarcolemmal vesicles, J. Biol. Chem. 260, 4869.
38. Tosaki, A., M. Koltai and P. Braquet, 1989, Effects of low extracellular sodium concentration on reperfusion induced arrhythmias: changes in the myocardial sodium, potassium and calcium contents in isolated guinea pig hearts, Cardiovasc. Res. 22, 993.
39. Waldorff, S., P.B. Hansen, H. Kjaergard, J. Buch, H. Egeblad and E. Steiness, 1981, Amiloride-induced change in digoxin dynamics and kinetics. Abolition of digoxin-induced inotropism with amiloride, Clin. Pharmacol. Ther. 30, 172.
40. Walker, M.J., M.J. Curtis, D.J. Hearse, R.W. Campbell, M.J. Janse, D.M. Yellon, S.M. Cobbe, S.J. Coker, J.B. Harness, D.W. Harron, A.J. Higgins, D.G. Julian, M.J. Lab, A.S. Manning, B.J. Northover, J.R. Parratt, R.A. Riemersam, E. Riva, D.C. Russell, D.J. Sheridan, E. Winslow and B. Woodward, 1988, The Lambeth Conventions: guidelines for the study of arrhythmias in ischemia, infarction and reperfusion, Cardiovasc. Res. 22, 447.
41. Wu, Z.J., T. Awaji, A. Hirasawa, S. Motomura and K. Hashimoto, 1993, Effects of a new class I antiarrhythmic drug bidisomide on canine ventricular arrhythmia models, Mol. Cell. Biochem. 119, 159.
42. Xue, Y.X., K. Eto, Y. Akie and K. Hashimoto, 1996, Antiarrhythmic and proarrhythmic effects of sematilide in canine ventricular arrhythmia models, Jpn. J. Pharmacol. 70, 129.