The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alpha(l)-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IκB-alpha

Neuropharmacology

Volumn 38, Issue 9, 1999, Pages 1325-1333

  Fiebich, Bernd L ^a   Hofer, Thomas J ^a   Lieb, Klaus ^a   Huell, Michael ^a   Butcher, Russ D ^a   Schumann, Gunter ^a   Schulze Osthoff, Klaus ^b   Bauer, Joachim ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Alzheimer's disease; Astrocytes; Interleukin 1 ; Interleukin 6; Microglia; NSAIDs; Tepoxalin; Therapy

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; NONSTEROID ANTIINFLAMMATORY AGENT; TEPOXALIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; ASTROCYTOMA CELL; CONTROLLED STUDY; CYTOKINE RELEASE; ELECTROPHORESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; RAT; REPORTER GENE;

ALPHA 1-ANTICHYMOTRYPSIN; ALZHEIMER DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTROCYTES; CELL LINE; CELLS, CULTURED; DNA-BINDING PROTEINS; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-1; INTERLEUKIN-6; MICROGLIA; NF-KAPPA B; PYRAZOLES; RATS; RATS, WISTAR;

EID: 0032782290     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00055-6     Document Type: Article

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