Effects of prenatal testosterone on sexual behavior, reproductive morphology and lh secretion in the female rat

Developmental Neuroscience

Volumn 19, Issue 5, 1997, Pages 430-437

  Rhees, Reuben W ^a   Kirk, Blair A ^a   Sephton, Sandra ^a   Lephart, Edwin D ^a  

^a BRIGHAM YOUNG UNIVERSITY   (United States)

Author keywords

Development; Feminine behavior; LH secretion; Prenatal period; Rat brain; Sexual differentiation; Testosterone

Indexed keywords

LUTEINIZING HORMONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN FUNCTION; CLITORIS; CONTROLLED STUDY; FEMALE; FEMALE GENITAL SYSTEM; LOCOMOTION; LORDOSIS; LUTEINIZING HORMONE RELEASE; NEWBORN; NONHUMAN; PERINATAL PERIOD; POSTNATAL DEVELOPMENT; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; SEX DIFFERENTIATION; SEXUAL BEHAVIOR; VIRILIZATION;

EID: 0030873734     PISSN: 03785866     EISSN: 14219859     Source Type: Journal    
DOI: 10.1159/000111240     Document Type: Article

References (40)

1. Bloch GJ, Mills R (1995) Prepubertal testosterone treatment of nconatally gonadectomizcd male rats: Defeminization or masculinization of behavioral and endocrine function in adulthood Neurosci Biobchav Rev 19:187-200.
2. Bloch GJ, Mills R. Gale S (1995) Prepubertal testosterone treatment of female rats: Defemint-zation of behavioral and endocrine function ir. Adulthood. Neurosci Biobchav Rev 19:177-186.
3. Caligaris L, Astrada J J, Taleisnik S (1971) Biphasic effect of progesterone on the release of gonadotropin in the rat. Endocrinology 89:331-337.
4. Davis EC. Shrync JE. Gorski RA (1995) A revised critical period for the sexual differentiation of the sexually dimorphic nucleus of the preoptic area in the rat. Neurocndocrinology 62:579-585.
5. Diaz DR. Fleming DE, Rhees RW (1995) The hormone-sensitive early postnatal periods for sexual differentiation of feminine behavior and luteinizing hormone secretion in male and female rats. Dev Brain Res 86:227-232.
6. Fleming DE, Kinghom EW, Rhees RW, Andcrsor, RH. Smythe E (1992) Biological predictors of masculine sexual behavior in prcnatally stressed and nonstressed rats. Bull Psychon Soc 30:513-514.
7. Gcrall AA. Ward IL (1966) Effects of prenatal exogenous androgen on the sexual behavior of the female albino rat. J Comp Physiol Psychol 62: 370-375.
8. Gorski RA (1971) Gonadal hormones and the perinatal development of neuroendocrine function; in Martin L, Ganong WF (eds): Frontiers in Neurocndocrinology, New York, Oxford Univ Press, pp 237-290.
9. Gorski RA (1985) Sexual differentiation of the brain: Possible mechanisms and implications. Can J Physiol Pharmacol 63:577-594.
10. Gorski RA (1988a) Hormone-induced sex differences in hypothalamic structure. Bull TMIN 16 (suppl 3):67-90.
11. Gorski RA (1988b) Sexual dimorphisms of the brain. J Anim Sci 61:38-61.
12. Harris GW, Lcvine S (1965) Sexual differentiation of the brain and its experimental control. J Physiol 181:379-400.
13. Huffman L, Hendricks SE (1981) Prenatally injected testosterone propionate and sexual behavior of female rats. Physiol Bchav 26:773-778.
14. Hocpfner BA. Ward IL (1988) Prenatal and neonatal androgen exposure interact to affect differentiation in female rats. Bchav Neurosci 102: 61-65.
15. Jones KJ. Pfaff DW, McEwen BS (1985) Early estrogen-induced nuclear changes in rat hypothalamic ventromedial neurons: An ultrastruc-tural and morphometric analysis. J Comp Neurol 239:255-266.
16. Kirschncr MA, Bardin CW (1972) Androgen production and metabolism in normal and virilized women. Metabolism 21:667-668.
17. Lcphart ED (1993) Review-Brain 5a-reductasc: Cellular, enzymatic, and molecular perspective and implications for biological function. Molec Cell Neurosci 4:473-484.
18. Lcphart ED (1996a) A review of brain aromatasc cytochrome P450. Brain Res Rev 22:1-26.
19. Lcphart ED (1996b) Dimorphic expression of cal-bindin-Disk in the medial basal hypothalamus from perinatal male and female rats. Dev Brain Res 96:281-284.
20. SK is regulated by adrenal steroids in hypothalamic tissue during prenatal development. Dev Brain Res, in press.
21. Mattson MP (1988) Components of neurite outgrowth that determine neural cytoarchitecture: Influence of calcium and the growth substrates. J Neurosci Res 20:331-345.
22. Mattson MP (1992) Calcium as sculptor and destroyer of neural circuitry. Exp Gerontol 27: 29-49.
23. McEwen BS, Licberburg I, Chaptal C, Krcy LC (1977) Aromatization: Important for sexual differentiation of the neonatal rat brain. Horm Behav 9:249-263.
24. Migeon C (1972) Adrenal androgens in man. Am J Med 53:606-626.
25. Morrell DW, Pfaff DW (1978) A neuroendocrine approach to brain function: Localization of sex steroid concentrating cells in vertebrate brains. AmZool 18:447-460.
26. Nadler RD (1969) Differentiation of the capacity for male sexual behavior in the rat. Horm Behav 1:530-563.
27. Pfaff DW (1980) Steroid sex hormone binding by cells in the vertebrate brain; in Pfaff DW (ed): Estrogens and Brain Function. New York, Springer, pp 77-105.
28. Pfaff DW (1983) Impact of estrogens on hypothalamic nerve cells: Ultrastructural, chemical, and electrical effects. Recent Prog Horm Res 39:127-179.
29. Popolow HP, Ward IL (1978) Effects of perinatal androstenedionc on sexual differentiation in female rats. J Comp Physiol Psychol 92:13-21.
30. Quadagno DM, Shrync JE, Anderson C, Gorski RA (1972) Influence of gonadal hormones on social, sexual, emergency, and open field behavior in the rat. Anim Behav 20:732-740.
31. Rhees RW, Shrync JE, Gorski RA (1990a) Onset of the hormone-sensitive perinatal period for sexual differentiation of the sexually dimorphic nucleus of the preoptic area in female rats. J Neurobiol 21:781-786.
32. Rhees RW, Shrync JE, Gorski RA (1990b) Termination of the hormone sensitive period for differentiation of the sexually dimorphic nucleus of the preoptic area in male and female rats. Develop Brain Res 52:17-23.
33. Rubin BS, Barfield RJ (1980) Priming of cstrous responsiveness by implants of 17p-cstradiol in the ventromedial hypothalamus nucleus of female rats. Endocrinology 106:504-509.
34. Swanson HE, VanDer Werfften Bosch JJ (1965) The 'carly-androgen’ syndrome: Differences in response to pre-natal and post-natal administration of various doses of testosterone propionate in female and male rats. Acta Endocrinol 47:37-50.
35. Vrccburg JTM, Woutcrsen PJA. Ooms MP. Vander Werfften Bosch JJ (1981) Androgens in the fetal guinea-pig after maternal infusion of radioactive testosterone. J Endocrinol 88:9-16.
36. Ward IL (1969) Differentiation effect of pre- and postnatal androgen on the sexual behavior of intact and sprayed female rats. Horm Behav 1: 25-36.
37. Ward IL, Rcnz FJ (1972) Consequences of perinatal hormone manipulation on the adult sexual behavior of female rats. J Comp Physiol Psychol 78:349-355.
38. Wcisz J, Ward IL (1980) Plasma testosterone and progesterone tilers of pregnant rats, their male and female fetuses and neonatal offspring. Endocrinology 106:306-316.
39. Whalen RE, Edwards Da (1967) Hormonal determinants of the development of masculine and feminine behavior in male and female rats. Anat Rcc 157:173-180.
40. Yanasc M, Gorski RA (1976) Sites of estrogen and progestcronee facilitation of lordosis behavior in the sprayed rat. Biol Rcprod 15:536-543.