Dioxin-like and non-dioxin-like toxic effects of polychlorinated biphenyls (PCBs): Implications for risk assessment

Critical Reviews in Toxicology

Volumn 28, Issue 6, 1998, Pages 511-569

  Giesy, John P ^a   Kannan, Kurunthachalam ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Neurotoxicity; PCB congeners; Polychlorinated biphenyls; Risk assessment

Indexed keywords

DIOXIN; POLYCHLORINATED BIPHENYL;

ARTICLE; BIOACCUMULATION; BIOASSAY; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; FOWL; MINK; NEUROTOXICITY; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REPRODUCTION; RISK ASSESSMENT; TELEOST; TOXICOKINETICS;

ANIMALIA; ERAGROSTIS TEF; GALLIFORMES; MUSTELA VISON; TELEOSTEI;

EID: 0031797496     PISSN: 10408444     EISSN: None     Source Type: Journal    
DOI: 10.1080/10408449891344263     Document Type: Article

References (286)

1. Hutzinger, O., Safe, S., and Zitko, V., The Chemistry of PCBs. CRC Press, Boca Raton, FL, 1974, 269.
2. Safe, S. and Hutzinger, O., Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology. Environmental Toxin Series, Vol. I., Springer-Verlag, Berlin, 1987, 152.
3. de Voogt, P. and Brinkman, U. A. Th., Production, properties and usage of polychlorinated biphenyls. In: Halogenated Biphenyls and Related Products, 2nd ed., Kimbrough, R. D. and Jensen, A. A., Eds., Elsevier, Amsterdam, The Netherlands, 1989, pp. 3-45.
4. Mullin, M. D., Pochini, C. M., McCrindle, S., Romkes, M., Safe, S. H., and Safe, L. M., High-resolution PCB analysis: synthesis and Chromatographic properties of all 209 PCB congeners, Environ. Sci. Technol., 18, 468, 1984.
5. Bletchly, J. D., Polychlorinated biphenyls: production, current use and possible rate of future disposal in OECD member countries. In: Proceedings of PCB Seminar. Barros, M. C., Koemann, H., and Visser, R., Eds., Ministry of Housing, Physical Planning and Environment, The Netherlands, 1984, pp. 343-372.
6. Tanabe, S., PCB problems in the future: foresight from current knowledge, Environ. Pollut., 50, 5, 1988.
7. Ivanov, V. and Sandell, E., Characterization of polychlorinated biphenyl isomers in Sovol and Trichlorodiphenyl formulations by high resolution gas chromatography with electron capture detection and high-resolution gas chromatography-mass spectrometry techniques, Environ. Sci. Technol., 26, 2012, 1992.
8. Ballschmiter, K. and Zell, M., Analysis of polychlorinated biphenyls (PCB) by glass capillary gas chromatography, Fresenius Z. Anal. Chem., 302, 20, 1980.
9. Erickson, M. D., Analytical Chemistry of PCBs. Lewis Publishers, Boca Raton, Florida, 1997, 667.
10. Jensen, S., Report of a new chemical hazard, New Scientist, 32, 612, 1966.
11. Risebrough, R. W., Rieche, P., Peakall, D. B., Herman, S. G., and Kirven, M. N., Polychlorinated biphenyls in the global ecosystem, Nature, 220, 1098, 1968.
12. Atlas, E. and Giam, C. S., Global transport of organic pollutants: ambient concentrations in remote marine atmosphere, Science, 211, 163, 1981.
13. Tanabe, S., Hidaka, H., and Tatsukawa, R., PCBs and chlorinated hydrocarbon pesticides in Antarctic atmosphere and hydrosphere, Chemosphere, 12, 277, 1983.
14. Mackay, D., Shiu, W. Y., and Ma, K. C., Monoaromatic hydrocarbons, chlorobenzenes and PCBs. In Illustrated Handbook of Physicochemical Properties and Environmental Fate for Organic Chemicals, Vol. 1, Lewis Publishers, Chelsea, MI, 1992.
15. Loganathan, B. G. and Kannan, K., Global organochlorine contamination trends: an overview, Ambio, 23, 187, 1994.
16. Waid, J. S., PCBs and the Environment. Volumes I to III, CRC Press, Boca Raton, Florida, 1987.
17. Schulz, D. E., Petrick, G., and Duinker, J. C., Complete characterization of polychlorinated biphenyl congeners in commercial Aroclor and Clophen mixtures by multidimensional gas chromatography-electron capture detection, Environ. Sci. Technol., 23, 852, 1989.
18. McFarland, V. A. and Clarke, J. U., Environmental occurrence, abundance, and potential toxicity of polychlorinated biphenyl congeners: considerations for a congener-specific analysis, Environ. Health Perspect., 81, 225, 1989.
19. Kannan, K., Maruya, K., and Tanabe, S., Distribution and characterization of polychlorinated biphenyl congeners in soil and sediments from a Superfund site contaminated with Aroclor 1268, Environ. Sci. Technol., 31, 1483, 1997.
20. Kimbrough, R. D. and Jensen, A. A., Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, 2nd edition, Elsevier, Amsterdam, The Netherlands, 1989.
21. World Health Organization, Environmental Health Criteria 140. Polychlorinated Biphenyls and Terphenyls, 2nd edition, WHO, Geneva, 1993, 682.
22. Delzell, E., Doull, J., Giesy, J. P., Mackay, D., Munro, I., and Williams, G., Interpretive review of the potential adverse effects of chlorinated organic chemicals on human health and environment, Reg. Toxicol. Pharmacol., 20, 1, 1994.
23. Swain, W. R., Effects of organochlorine chemicals on the reproductive outcome of humans who consumed contaminated Great Lakes fish: an epidemiologic consideration, J. Toxicol. Environ. Health, 33, 587, 1991.
24. Ringer, R. K., Aulerich, R. J., and Bleavins, M. R., Biological effects of PCBs and PBBs on minks and ferrets - a review. In Halogenated Hydrocarbons: Health and Ecological Effects., Khan, M. A. Q., Ed., Pergamon Press, New York, 1991, pp. 329-343.
25. Safe, S. H., Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses and implications for risk assessment, Crit. Rev. Toxicol., 24, 87, 1994.
26. Swanson, G. M., Ratcliffe, H. E., and Fischer, L. J., Human exposure to polychlorinated biphenyls (PCBs): a critical assessment of the evidence for adverse health effects, Reg. Toxicol. Pharmacol., 21, 136, 1995.
27. Kimbrough, R. D., Polychlorinated biphenyls (PCBs) and human health: an update, Crit. Rev. Toxicol., 25, 133, 1995.
28. Strang, C., Levine, S. P., Orlan, B. P., Gouda, T. A., and Saner, W. A., High-resolution GC analysis of cytochrome P-448 inducing PCB congeners in hazardous waste, J. Chromatog., 314, 482, 1984.
29. Safe, S., Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): Biochemistry, toxicology and mechanism of action, Crit. Rev. Toxicol., 12, 319, 1984.
30. Seegal, R. F., Epidemiological and laboratory evidence of PCB-induced neurotoxicity, Crit. Rev. Toxicol., 26, 709, 1996.
31. U.S. Environmental Protection Agency, Interim Procedures for Estimating Risks Associated with Exposures to Mixtures of Chlorinated Dibenzo-p-dioxins and Dibenzofurans (CDDs and CDFs), an 1989 Update. EPA/ 625/3-89/016. Washington, D.C., 1989.
32. Barnes, D., Alford-Stevens, A., Birnbaum, L., Kutz, F. W., Wood, W., and Patton, D., Toxicity equivalency factors for PCBs? Qual. Assur: Good Practice, Regulations and Law, 1, 70, 1991.
33. Ahlborg, U. G., Nordic risk assessment of PCDDs and PCDFs, Chemosphere, 19, 603, 1989.
34. Kutz, F. W, Barnes, D. G., Bretthauer, E. W., Bottimore, D. P., and Greim, H., The international toxic equivalency factor (ITEF) method for estimating risks associated with exposures to complex mixtures of dioxins and realted compounds, Toxicol. Environ. Chem., 26, 99, 1990.
35. Poland, A. and Knutson, J. C., 2,3,7,8-tetrachloro dibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity, Ann. Rev. Pharmacol. Toxicol., 22, 517, 1982.
36. Smith, M. A., Reassessment of the carcinogenicity of polychlorinated biphenyls, J. Toxicol. Environ. Health, 50, 567, 1997.
37. Birnbaum, L. S. and De Vito, M. J., Use of toxic equivalency factors for risk assessment for dioxins and related compounds, Toxicology, 105, 391, 1995.
38. Tilson, H. A., Jacobson, J. L., and Rogan, W. J., Polychlorinated biphenyls and the developing nervous system: cross-species comparisons, Neurotoxicol. Teratol., 12, 239, 1990.
39. Evangelista de Duffard, A. M. and Duffard, R., Behavioral toxicology, risk assessment and chlorinated hydrocarbons, Environ. Health Perspect., 104, 353, 1996.
40. Barrett, J. C., Mechanisms for species differences in receptor-mediated carcinogenesis, Mutat. Res., 333, 189, 1995.
41. Silberhorn, E. M., Glauert, H. P., and Robertson, L. W., Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs, Crit. Rev. Toxicol., 20, 439, 1990.
42. U.S. Environmental Protection Agency, Use of Uncertainty Factors in Toxicity Extrapolations Involving Terrestrial Wildlife. Technical Basis. Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, 1996.
43. Eisler, R. and Belisle, A. A., Planar PCB Hazards to Fish, Wildlife and Invertebrates: A Synoptic Review. U.S. Fish and Wildlife Service Biological Report, 1994, 75 p.
44. Danse, I. R., Jaeger, R. J., Kava, R., Kroger, M., London, W. M., Lu, F. C., Maickel, R. P., McKetta, J. J., Newell, G. W., Shindell, S., Stare, F. J., and Whelan, E. M., Position paper of the American council on science and health: public health concerns about environmental polychlorinated biphenyls (PCBs), Ecotoxicol Environ. Saf., 38, 71, 1997.
45. Kannan, K., Tanabe, S., Giesy, J. P., and Tatsukawa, R., Organochlorine pesticides and polychlorinated biphenyls in foodstuffs from Asian and Oceanic countries, Rev. Environ. Contain. Toxicol., 152, 1, 1997.
46. Cordle, F., Locke, R., and Springer, J., Risk assessment in a federal regulatory agency: an assessment of risk associated with the human consumption of some species of fish contaminated with polychlorinated biphenyls (PCBs), Environ. Health Perspect., 45, 171, 1982.
47. Barren, M. G., Yurk, J. J., and Crothers, D. M., Assessment of potential cancer risk from consumption of PCBs bioaccumulated in fish and shellfish, Environ. Health Perspect., 102, 562, 1994.
48. Finley, B. L., Trowbridge, K. R., Burton, S., Proctor, D. M., Panko, J. M., and Paustenbach, D. J., Preliminary assessment of PCB risks to human and ecological health in the lower Passaic River, J. Toxicol. Environ. Health, 52, 95, 1997.
49. Solomon, K. R., Overview of recent developments in ecotoxicological risk assessment, Risk Analysis, 16, 627, 1996.
50. Giesy, J. P., Verbrugge, D. A., Othout, R. A., Bowerman, W. W., Mora. M, A., Jones, P. D., Newsted, J. L., Vandervoort, C., Heaton, S. N., Aulerich, R. J., Bursian, S. J., Ludwig, J. P., Dawson, G. A., Kubiak, T. J., Best, D. A., and Tillitt, D. E., Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. II. Implications for health of mink, Arch. Environ. Contam. Toxicol., 27, 213, 1994.
51. Bowerman, W. W., Giesy, J. P., Best, D. A., and Kramer, V. J., A review of factors affecting productivity of bald eagles in the Great Lakes region: Implications for recovery, Environ. Health Perspect., 103, 51, 1995.
52. Henry, K. S., Kannan, K., Nagy, B. W., Kevern, N. R., Zabik, M. J., and Giesy, J. P., Concentrations and hazard assessment of organochlorine contaminants and mercury in smallmouth bass from a remote lake in the Upper Peninsula of Michigan, Arch. Environ. Contam. Toxicol., 34, 81, 1998.
53. Yamashita, N., Tanabe, S., Ludwig, J. P., Kurita, H., Ludwig, M. E., and Tatsukawa, R., Embryonic abnormalities and organochlorine contamination in double-crested cormorants (Phalacrocorax auritus) and Caspian terns (Hydropogne caspia) from the upper Great Lakes in 1988, Environ. Pollut., 79, 163, 1993.
54. Kannan, K., Tanabe, S., Borrell, A., Aguilar, A., Focardi, S., and Tatsukawa, R., Isomer-specific analysis and toxic evaluation of polychlorinated biphenyls in striped dolphins affected by an epizootic in the western Mediterranean Sea, Arch. Environ. Contam. Toxicol., 25, 227, 1993.
55. Corsolini, S., Focardi, S., Kannan, K., Tanabe, S., Borrell, A., and Tatsukawa, R., Congener profile and toxicity assessment of polychlorinated biphenyls in dolphins, sharks and tuna collected from Italian coastal waters, Mar. Environ. Res., 40, 33, 1995.
56. Corsolini, S., Focardi, S., Kannan, K., Tanabe, S., and Tatsukawa, R., Isomer-specific analysis of polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TEQs) in red fox and human adipose tissue from central Italy, Arch. Environ. Contam. Toxicol., 29, 61, 1995.
57. Heath, R. G., Spann, J. W., Hill, E. F., and Kreitzer, J. F., Comparative dietary toxicities of pesticides to birds, Special Scientific Report - Wildlife, No. 152, U.S. Department of Interior, 1972.
58. Williams, L. L., Giesy, J. P., DeGalan, N., Verbrugge, D. A., Tillitt, D. E., Ankley, G. T., and Welch, R. L., Prediction of concentrations of 2,3,7,8-tetrachlorodibenzo-p-di-oxin equivalents from total concentrations of polychlorinated biphenyls in fish fillets, Environ. Sci. Technol., 26, 1151, 1992.
59. Jones, P. D., Giesy, J. P., Newsted, J. L., Verbrugge, D. A., Beaver, D. L., Ankley, G. T., Tillitt, D. E., Lodge, K. B., and Niemi, G. J., 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in tissues of birds at Green Bay, Wisconsin, USA, Arch. Environ. Contam. Toxicol., 24, 345, 1993.
60. Falandysz, J., Kannan, K., Tanabe, S., and Tatsukawa, R., Concentrations, clearance rates and toxic potential of non-ortho coplanar PCBs in cod liver oil from the southern Baltic Sea from 1971 to 1989, Mar. Pollut. Bull., 28, 259, 1994.
61. Falandysz, J., Kannan, K., Tanabe, S., and Tatsukawa, R., Concentrations and 2,3,7,8-tetrachlorodibenzo-p-dioxin toxic equivalents of non-ortho coplanar PCBs in adipose fat of Poles, Bull. Environ. Contam. Toxicol., 53, 267, 1994.
62. Giesy, J. P., Ludwig, J. P., and Tillitt, D. E., Dioxins, dibenzofurans, PCBs and colonial, fish-eating water birds. In: Dioxins and Health, Schecter, A., Ed., Plenum Press, New York, 1994, pp. 249-307.
63. Loganathan, B. G., Kannan, K., Watanabe, I., Kawano, M., Irvine, K., Kumar, S., and Sikka, H. C., Isomer-specific determination and toxic evaluation of polychlorinated biphenyls, polychlorinated/brominated dibenzo-p-dioxins, polybrominated biphenyl ethers, and extractable organic halogen in carp from the Buffalo River, New York, Environ. Sci. Technol., 29, 1832, 1995.
64. Coristine, S., Haffner, G. D., Ciborowski, J. J. H., Lazar, R., Nanni, M. E., and Metcalfe, C. D., Elimination rates of selected di-ortho, mono-ortho and non-ortho substituted polychlorinated biphenyls in rainbow trout (Oncorhynchus mykiss), Environ. Toxicol. Chem., 15, 1382, 1996.
65. Kannan, K., Imagawa, T., Blankenship, A., and Giesy, J. P., Isomer-specific analysis and toxic evaluation of polychlorinated naphthalenes in soil, sediment and biota collected near the site of a former chlor-alkali plant, Environ. Sci. Technol., 32, 2507, 1998.
66. Blankenship, A. L., Kannan, K., Villalobos, A., Falandysz, J., and Giesy, J. P., Dioxin-like potencies of polychlorinated naphthalene congeners. Environ. Toxicol. Chem. (submit-ted), 1999.
67. Kociba, R. J., Keyes, D. G., Beyer, J. E., Carreon, R. M., Wade, C. E., Dittenber, D. A., Kalnins, R. P., Frauson, L. E., Park, C. N., Barnard, S. D., Hummel, R. A., and Humiston, C. G., Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats, Toxicol. Appl. Pharmacol., 46, 279, 1978.
68. Schecter, A., Startin, J., Wright, C., Kelly, M., Påpke, O., Lis, A., Ball, M., and Olson, J. R., Congener-specific levels of dioxins and dibenzofurans in U.S. food and estimated daily dioxin toxic equivalent intake, Environ. Health Perspect., 102, 962, 1994.
69. De Vito, M. J., Birnbaum, L. S., Farland, W. H., and Gasiewicz, T. A., Comparisons of estimated body burdens of dioxinlike chemicals and TCDD body burdens in experimentally exposed animals, Environ. Health Perspect., 103, 820, 1995.
70. Lawrence, G. S. and Gobas, F. A. P. C., A pharmacokinetic analysis of interspecies extrapolation in dioxin risk assessment, Chemosphere, 35, 427, 1997.
71. Burreau, S., Axelman, J., Broman, D., and Jakobsson, E., Dietary uptake in pike (Esox lucius) of some polychlorinated biphenyls, polychlorinated naphthalenes and polybrominated diphenyl ethers administered in natural diet, Environ. Toxicol. Chem., 16, 2508, 1997.
72. Tanabe, S., Nakagawa, Y., and Tatsukawa, R., Absorption efficiency and biological halflife of individual chlorobiphenyls in rats treated with Kanechlor products, Agric. Biol. Chem., 45, 717, 1981.
73. Summer, C. L., Giesy, J. P., Bursian, S. J., Render, J. A., Kubiak, T. J., Jones, P. D., Verbrugge, D. A., and Aulerich, R. J., Effects induced by feeding organochlorine-contaminated carp from Saginaw Bay, Lake Huron, to laying white leghorn hens. I. Effects on health of adult hens, egg production and fertility, J. Toxicol. Environ. Health, 49, 389, 1996.
74. Summer, C. L., Giesy, J. P., Bursian, S. J., Render, J. A., Kubiak, T. J., Jones, P. D., Verbrugge, D. A., and Aulerich, R. J., Effects induced by feeding organochlorine-contaminated carp from Saginaw Bay, Lake Huron, to laying white leghorn hens. II. Embryotoxic and teratogenic effects, J. Toxicol. Environ. Health, 49, 409, 1996.
75. Heaton, S. N., Bursian, S. J., Giesy, J. P., Tillitt, D. E., Render, J. A., Jones, P. D., Verbrugge, D. A., Kubiak, T. J., and Aulerich, R. J., Dietary exposure of mink to carp from Saginaw Bay. 1. Effects on reproduction and survival, and the potential risks to wild mink populations, Arch. Environ. Contam. Toxicol., 28, 334, 1995.
76. Heaton, S. N., Bursian, S. J., Giesy, J. P., Tillitt, D. E., Render, J. A., Jones, P. D., Verbrugge, D. A., Kubiak, T. J., and Aulerich, R. J., Dietary exposure of mink to carp from Saginaw Bay, Michigan. 2. Hematology and liver pathology, Arch. Environ. Contam. ToxicoL, 29, 411, 1995.
77. Tillitt, D. E., Gale, R. W., Meadows, J. C., Zajicek, J. L., Peterman, P. H., Heaton, S. N., Jones, P. D., Bursian, S. J., Kubiak, T. J., Giesy, J. P., and Aulerich, R. J., Dietary exposure of mink to carp from Saginaw Bay. 3. Characterization of dietary exposure to planar halogenated hydrocarbons, dioxin equivalents, and biomagnification, Environ. Sci. Technol., 30, 283, 1996.
78. Schwartz, T. R., Stalling, D. L., and Rice, C. L., Are polychlorinated biphenyl residues adequately described by Aroclor mixture equivalents? Isomer-specific principal component analysis of such residues in fish and turtles, Environ. Sci. Technol, 21, 72, 1987.
79. Burkhard, L. P. and Weininger, D., Determination of polychlorinated biphenyls using multiple regression with outlier detection and elimination, Anal. Chem., 59, 1187, 1987.
80. Giesy, J. P., Jude, D. J., Tillitt, D. E., Gale, R. W., Meadows, J. C., Zajieck, J. L., Peterman, P. H., Verbrugge, D. A., Sanderson, J. T., Schwartz, T. R., and Tuchman, M. L., Polychlorinated dibenzo-p-dioxins, dibenzo-furans, biphenyls and 2,3,7,8-tetrachloro-dibenzo-p-dioxin equivalents in fishes from Saginaw Bay, Michigan, Environ. ToxicoL Chem., 16, 713, 1997.
81. McCarthy, L. S. and Mackay, D., Enhancing ecotoxicological modeling and assessment: Body residues and modes of toxic action, Environ. Sci. Technol., 27, 1719, 1993.
82. Leonards, P. E. G., de Vries, T. H., Minnaard, W., Stuijfzand, S., de Voogt, P., Cofino, W. P., van Straalen, N. M., and van Hattum, B., Assessment of experimental data on PCB-induced reproduction inhibition in mink, based on an isomer- and congenerspecific approach using 2,3,7,8-tetra-chlorodiben/.o-p-dioxjn loxic equivalency, Environ. Toxicol. Chem., 14, 639, 1995.
83. Powell, D. C., Aulerich, R. J., Meadows, J. C., Tillitt, D. E., Powell, J. F., Restum, J. C., Stromborg, K. L., Giesy, J. P., and Bursian, S. J., Effects of 3,3′,4,4′,5-pentachlorobiphneyl (PCB 126), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or an extract derived from field-collected cormorant eggs injected into double-crested cormorant (Phalacrocorax auritus) eggs, Environ. Toxicol. Chem., 16, 1450, 1997.
84. Bergman, Å., Norstrom, R. J., Haraguchi, K., Kuroki, H., and Béland, P., PCB and DDE methylsulfones in marine mammals from Canada and Sweden, Environ. Toxicol. Chem., 13, 121, 1994.
85. Norén, K., Lundén, C., Pettersson, E., and Bergman, Å., Methylsulfonyl metabolites of PCBs and DDE in human milk in Sweden, 1972-1992, Environ. Health Perspect., 104, 766, 1996.
86. Klasson-Wehler, E., Bergman, Å., Athanasiadou, M., Ludwig, J. P., Auman, H. J., Kannan, K., Van den Berg, M., Murk, A. J., Feyk, L. A., and Giesy, J. P., Hydroxylated and methylsulfonyl PCB metabolites in albatrosses from Midway Atoll, North Pacific Ocean, Environ. Toxicol. Chem., 17, 1620, 1998.
87. Brouwer, A., Morse, D. C., Lans, M. C., Schuur, G., Murk, A. J., Klasson-Wehler, E., Bergman, Å., and Visser, T. J., Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanism and possible consequences for animal and human health, J. Toxicol. Ind. Health, 1997.
88. Poland, A., Glover, E., and Kende, A. S., Stereospecific, high-affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol: evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase, J. Biol. Chem., 251, 4936, 1976.
89. Poland, A. and Glover, E., Chlorinated biphenyl induction of aryl hydrocarbon hydroxylase activity: a study of the structure-activity relationship, Mol. Pharmacol, 13, 924, 1977.
90. Poland, A., Greenlee, W. F., and Kende, A. S., Studies on the mechanism of action of chlorinated dibenzo-p-dioxins and related compounds, Ann. N.Y. Acad. Sci., 320, 214, 1979.
91. Safe, S. H., Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans, Ann. Rev. Pharmacol. Toxicol., 26, 371, 1986.
92. Whitlock, J. P., Jr., The regulation of gene expression by 2,3,7,8 tetrachlorodibenzo-p-dioxin, Pharmacol. Rev., 39, 147, 1987.
93. Goldstein, J. A. and Safe, S., Mechanism of action and structure-activity relationships for the chlorinated dibenzo-p-dioxins and related compounds. In: Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, 2nd ed., Kimbrough, R. D. and Jensen, A. A., Eds., Elsevier, Amsterdam, The Netherlands, 1989, pp. 239-293.
94. Safe, S., Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs), Crit. Rev. Toxicol., 21, 51, 1990.
95. U.S. Environmental Protection Agency, Interim Evaluation of Health Risks Associated with Emissions of Tetrachlorinated Dioxins from Municipal Waste Resource Recovery Facilities. U.S. Environmental Protection Agency, Office of the Administrator, Washington, D.C., 1981.
96. U.S. Environmental Protection Agency, PCB Disposal by Thermal Destruction. U.S. Environmental Protection Agency, National Technical Information Service, Springfield, VA, PB 82-241860, 1982.
97. Olie, K., Van den Berg, M., and Hutzinger, O., Formation rate of PCDD and PCDF from combustion process, Chemosphere, 12, 627, 1983.
98. Barnes, D. G., Toxic equivalents and EPA's risk assessment of 2,3,7,8-TCDD, Sci. Total Environ., 104, 73, 1991.
99. World Health Organization, Derivation of toxic equivalency factors (TEFs) for dioxin-like compounds in humans and wildlife, Organohalogen Compounds, 34, 237, 1997.
100. Safe, S., Robertson, L. W., Safe, L., Parkinson, A., Bandiera, S., Sawyer, T., and Campbell, M. A., Halogenated biphenyls: molecular toxicology, Can. J. Physiol. Pharmacol., 60, 1057, 1982.
101. Goldstein, J. A., Hickman, P., Bergman, H., McKinney, J. D., and Walker, M. P., Separation of pure polychlorinated biphenyl isomers into two types of inducers on the basis of induction of cytochrome P-450 or P-448, Chem. -Biol. Interactions, 17, 69, 1977.
102. Parkinson, A., Robertson, L., Safe, L., and Safe, S., Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: structure-activity rules, Chem. -Biol. Interactions, 30, 271, 1980.
103. Bandiera, S., Safe, S., and Okey, A. B., Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methyl-cholanthrene-, or mixed-type inducers to cytosolic Ah receptor, Chem. -Biol. Interactions, 39, 259, 1982.
104. Parkinson, A., Safe, S. H., Robertson, L. W., Thomas, P. E., Ryan, D. E., Reik, L. M., and Levin, W., Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated and polybrominated biphenyls: A study of structure-activity relationships, J. Biol. Chem., 258, 5967, 1983.
105. Yoshimura, H., Yoshihara, S., Koga, N., Nagata, K., Wada, I., Kuroki, J., and Hokama, Y., Inductive effect on hepatic enzymes and toxicity of congeners of PCBs and PCDFs, Environ. Health Perspect., 59, 113, 1985.
106. Leece, B., Denomme, M. A., Towner, R., Li, S. M. A., and Safe, S., Polychlorinated biphenyls: correlation between in vivo and in vitro quantitative structure-activity relationships (QSARs), J. Toxicol. Environ. Health, 16, 379, 1985.
107. Ahlborg, U. G., Becking, G. C., Birnbaum, L. S., Brouwer, A., Derks, H. J. G. M., Feeley, M., Golor, G., Hanberg, A., Larsen, J. C., Liem, A. K. D., Safe, S. H., Schlatter, C., Wrn, F., Younes, M., and Yrjänheikki, E., Toxic equivalency factors for dioxin-like PCBs, Chemosphere, 28, 1049, 1994.
108. Boseveld, A. T. C. and Van den Berg, M., Effects of polychlorinated biphenyls, dibenzo-p-dioxins and dibenzofurans on fish-eating birds, Environ. Rev., 2, 147, 1994.
109. Brunströööm, B., Engwall, M., Hjelm, K., Lindqvist, L., and Zebühr, Y., EROD induction in cultured chick embryo liver: a sensitive bioassay for dioxin-like environmental pollutants, Environ. Toxicol. Chem., 14, 837, 1995.
110. Newsted, J. L., Giesy, J. P., Ankley, G. T., Tillitt, D. E., Crawford, R. A., Gooch, J. W., Jones, P. D., and Denison, M. S., Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout, Environ. Toxicol. Chem., 14, 861, 1995.
111. Zabel, E. W., Cook, P. M., and Peterson, R. E., Toxic equivalency factors of polychlorinated dibenzo-p-dioxin, dibenzofuran and biphenyl congeners based on early life stage mortality in rainbow trout (Oncorhynchus mykiss), Aquat. Toxicol., 31, 315, 1995.
112. Kennedy, S. W., Lorenzen, A., Jones, S. P., Hahn, M. E., and Stegeman, J. J., Cytochrome P4501A induction in avian hepatocyte cultures: A promising approach for predicting the sensitivity of avian species to toxic effects of halogenated aromatic hydrocarbons, Toxicol. Appl. Pharmacol., 141, 214, 1996.
113. Kennedy, S. W., Lorenzen, A., and Norstrom, R. J., Chick embryo hepatocyte bioassay for measuring cytochrome P4501A-based 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalent concentrations in environmental samples, Environ. Sci. Technol., 30, 706, 1996.
114. 3H] 2,3,7,8-tetra-chlorodibenzo-p-dioxin binding to Ah receptor in a rainbow trout hepatoma cell line, Toxicol. Appl. Pharmacol., 106, 53, 1990.
115. 125I]iodo-7,8-dibromodibenzo-p-dioxin in cell culture, Toxicol. Lett., 58, 85, 1991.
116. Hahn, M. E., Poland, A., Glover, E., and Stegeman, J. J., The Ah receptor in marine animals: phylogenetic distribution and rela-tionship to P4501A inducibility, Mar. Environ. Res., 34, 87, 1992.
117. Janz, D. M. and Metcalfe, C. D., Relative induction of aryl hydrocarbon hydroxylase by 2,3,7,8-TCDD and two coplanar PCBs in rainbow trout (Oncorhynchus mykiss), Environ. Toxicol, Chem., 10, 917, 1991.
118. Williams, L. L. and Giesy, J. P., Relationship among concentrations of individual polychlorinated biphenyl (PCB) congeners, 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TCDD-EQ) and rearing mortality of chinook salmon (Oncorhynchus tshawytscha) eggs from Lake Michigan, J. Great Lakes Res., 18, 108, 1992.
119. Walker, M. K. and Peterson, R. E., Poten-cies of polychlorinated dibenzo-p-dioxin, dibenzofuran and biphenyl congeners, relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin for producing early life stage mortality in rainbow trout (Oncorhynchus mykiss), Aquat. Toxicol, 21, 219, 1991.
120. Zabel, E. W., Pollenz, R., and Peterson, R. E., Relative potencies of individual polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congener mixtures based on induction of cytochrome P4501A mRNA in a rainbow trout gonadal cell line (RTG-2), Environ. Toxicol. Chem., 15, 2310, 1996.
121. Harris, G. E., Metcalfe, T. L., Metcalfe, C. D., and Huestis, S. Y., Embryotoxicity of extracts from Lake Ontario rainbow trout (Oncorhynchus mykiss) to Japanese medaka (Oryzias latipes), Environ. Toxicol. Chem., 13, 1393, 1994.
122. Metcalfe, C. D. and Haffner, G. D., The ecotoxicology of coplanar polychlorinated biphenyls, Environ. Rev., 3, 171, 1995.
123. Hornung, M. W., Zabel, E. W., and Peterson, R. E., Toxic equivalency factors of polybrominated dibenzo-p-dioxin, dibenzofuran, biphenyl, and polyhalogenated diphenyl ether congeners based on rainbow trout early life stage mortality, Toxicol. Appl. Pharmacol., 140, 227, 1996.
124. Walker, M. K., Cook, P. M., Butterworth, B. C., Zabel, E. W., and Peterson, R. E., Potency of a complex mixture of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin in causing fish early life stage mortality, Fund. Appl. Toxicol., 30, 178, 1996.
125. U.S. Environmental Protection Agency, Interim Report on Data and Methods for As-sessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin Risks to Aquatic Life and Associated Wildlife, EPA/600/R-93/005, 1993.
126. Van der Weiden, M. E. J., van der Kolk, J., Bleumink, R., Seinen, W., and Van den Berg, M., Occurrence of P4501A1 induction and toxic effects after administration of a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rainbow trout (Oncorhynchus mykiss), Aquat. Toxicol., 24, 123, 1992.
127. Yao, C., Panigrahy, B., and Safe, S., Utilization of cultured chick embryo hepatocytes as in vitro bioassays for polychlorinated biphenyls (PCBs): quantitative-structure-induction relationships, Chemosphere, 21, 1007, 1990.
128. Boseveld, A. T. C., Van den Berg, M., and Theelen, R., Assessment of the EROD inducting potency of eleven 2,3,7,8-substituted PCDD/DFs and three coplanar PCBs in the chick embryo, Chemosphere, 25, 911, 1992.
129. Brunström, B., Toxicity of coplanar polychlorinated biphenyls to avian embryos, Chemosphere, 19, 765, 1989.
130. Brunström, B., Mono-ortho-chlorinated chlorobiphenyls: toxicity and induction of 7-ethoxyresorufin-O-deethylase-inducing potency of coplanar polychlorinated biphenyls (PCBs) in chick embryos, Arch. Toxicol., 64, 188, 1990.
131. Bosveld, A. T. C., Kennedy, S. W., Seinen, W., and Van den Berg, M., Ethoxyresorufin-0-deethylase (EROD) inducing potencies of planar chlorinated aromatic hydrocarbons in primary cultures of hepatocytes from different developmental stages of the chicken, Arch. Toxicol., 71, 746, 1997.
132. Lorenzen, A., Shutt, J. L., and Kennedy, S. W., Sensitivity of common tern (Sterna hirundo) embryo hepatocyte cultures to CYP1A induction and porphyrin accumulation by halogenated aromatic hydrocarbons and common tern egg extracts, A rch. Environ. Contam. Toxicol., 32, 126, 1997.
133. Sanderson, J. T., Kennedy, S. W., and Giesy, J. P., In vitro induction of ethoxyresorufin-0-deethylase and porphyrins by halogenated aromatic hydrocarbons in avian primary hepatocytes, Environ. Toxicol. Chem., 17, 2006, 1998.
134. Tanabe, S., Kannan, N., Wakimoto, T., Tatsukawa, R., Okamoto, T., and Masuda, Y., Isomer-specific determination and toxic evaluation of potentially hazardous coplanar PCBs, dibenzofurans and dioxins in the tissues of "Yusho" PCB poisoning victim and in the causal oil, Toxicol. Environ. Chem., 24, 215, 1989.
135. Tanabe, S., Kannan, N., Wakimoto, T., and Tatsukawa, R., Method for the determination of three toxic non-ortho chlorine substituted coplanar PCBs in environmental samples at parts-per-trillion levels, Intern. J. Environ. Anal. Chem., 29, 199, 1987.
136. Tanabe, S., Kannan, N., Subramanian, A., Watanabe, S., Ono, M., and Tatsukawa, R., Highly toxic coplanar PCBs: occurrence, source, persistency and toxic implications to wildlife and humans, Environ. Pollut., 47, 147, 1987.
137. Kannan, N., Tanabe, S., Ono, M., and Tatsukawa, R., Critical evaluation of polychlorinated biphenyl toxicity in terrestrial and marine mammals: increasing impact of nonortho and mono-ortho coplanar polychlorinated biphenyls from land to ocean, Arch. Environ. Contam. Toxicol., 18, 850, 1989.
138. Sawyer, T. W. and Safe, S., PCB isomers and congeners: induction of aryl hydrocarbon hydroxylase and ethoxyresorufin-O-deethylase enzyme activities in rat hepatoma cells, Toxicol. Lett., 13, 87, 1982.
139. Kubiak, T. J., Harris, H. J., Smith, L. M., Schwartz, T. R., Stalling, D. L., Trick, J. A., Sileo, L., Doherty, D. E., and Erdman, T. C., Microcontaminants and reproductive impairment of the Forster's tern on Green Bay, Lake Michigan (U.S.A.) 1983, Arch. Environ. Contam. Toxicol., 18, 706, 1989.
140. Tarhanen, J., Koistinen, J., Paasivirta, J., Vuorinen, P. J., Koivusaari, J., Nuuja, I., Kannan, N., and Tatsukawa, R., Toxic significance of planar aromatic compounds in Baltic ecosystem - new studies on extremely toxic coplanar PCBs, Chemosphere, 18, 1067, 1989.
141. Asplund, L., Grafström, A.-K., Haglund, P., Jansson, B., Järnberg, U., Mace, D., Strandell, M., and De Wit, C., Analysis of non-ortho polychlorinated biphenyls and polychlorinated naphthalenes in Swedish dioxin survey samples, Chemosphere, 20, 1481, 1990.
142. Dewailly, É., Weber, J.-P., Gingras, S., and Laliberté, C., Coplanar PCBs in human milk in the province of Quebec, Canada: are they more toxic than dioxin for breast fed-infants? Bull. Environ. Contam. Toxicol., 47, 491, 1991.
143. Davidson, R. D., Harrad, S. J., Allen, S., Stewart, A. S., and Jones, K. C., The relative contribution of individual polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) to toxic equivalent values derived for bulked human adipose tissue samples from Wales, United Kingdom, Arch. Environ. Contam. Toxicol., 24, 100, 1993.
144. Harris, H. J., Erdman, T. C., Ankley, G. T., and Lodge, K. B., Measures of reproductive success and polychlorinated biphenyl residues in eggs and chicks of Forster's terns on Green Bay, Lake Michigan, Wisconsin - 1988, Arch. Environ. Contam. Toxicol., 25, 304, 1993.
145. Tillitt, D. E., Giesy, J. P., and Ankley, G. T., Characterization of the H4IIE rat hepatoma cell bioassay as a tool for assessing toxic potency of planar halogenated hydrocarbons in environmental samples, Environ. Sci. Technol., 25, 87, 1991.
146. Tillitt, D. E., Ankley, G. T., Giesy, J. P., Ludwig, J. P., Kurita-Matsuba, H., Weseloh, D. V., Ross, P. S., Bishop, C. A., Sileo, L., Stromborg, K. L., Larson, J., and Kubiak, T. J., Polychlorinated biphenyl residues and egg mortality in double crested cormorants from the Great Lakes, Environ. Toxicol. Chem., 11, 1281, 1992.
147. Mac, M. J., Schwartz, T. R., Edsall, C. C., and Frank, A. M., Polychlorinated biphenyls in Great Lakes lake trout and their eggs: relation to
148. Sawyer, T. W. and Safe, S., In vitro AHH induction by polychlorinated biphenyl and dibenzofuran mixtures: additive effects, Chemosphere, 14, 79, 1985.
149. Pluess, N., Poiger, H., Hochbach, C., and Schlatter, C., Subchronic toxicity of some chlorinated dibenzofurans (PCDFs) and a mixture of PCDFs and chlorinated dibenzodioxins (PCDDs) in rats, Chemosphere, 17, 973, 1988.
150. Haake, J. M., Safe, S., Mayara, K., and Phillips, T. D., Aroclor 1254 as an antagonist of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin, Toxicol. Lett., 38, 299, 1987.
151. Biegel, L., Harris, M., Davis, D., Rosengren, R., Safe, S., and Safe, S., 2,2',4,4',5,5'-hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/ 6J mice, Toxicol. Appl. Pharmacol., 97, 561, 1989.
152. Birnbaum, L. S., Weber, H., Harris, M. W., Lamb, J. C., and McKinney, J. D., Toxic interaction of specific polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin: increased incidence of cleft palate in mice, Toxicol. Appl. Pharmacol., 77, 292, 1985.
153. Bannister, R. and Safe, S., Synergistic interactions of 2,3,7,8-TCDD and 2,2′,4,4′,5,5′-hexachlorobiphenyl in C57BL/6J and DBA/ 2J mice: role of the Ah receptor, Toxicology, 44, 159, 1987.
154. Pohjanvirta, R., Unkila, M., Lindén, J., Tuomisto, J. T., and Tuomisto, J., Toxic equivalency factors do not predict the acute toxicities of dioxins in rats, Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. Section, 293, 341, 1995.
155. Harper, N., Connor, K., Steinberg, M., and Safe, S., Immunosuppressive activity of polychlorinated biphenyl mixtures and congeners: nonadditive (antagonistic) interactions, Fundam. Appl. Toxicol., 27, 131, 1995.
156. Van Birgelen, A. P. J. M., Fase, K. M., van der Kolk, J., Poiger, H., Brouwer, A., Seinen, W., and Van den Berg, M., Synergistic effect of 2,2′,4,4′,5,5′-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic porphyrin levels in rat, Environ. Health Perspect., 104, 550, 1996.
157. Li, M.-H. and Hansen, L. G., Enzyme induction and acute endocrine effects in prepu-bertal female rats receiving environmental PCB/PCDF/PCDD mixtures, Environ. Health Perspect., 104, 712, 1996.
158. Li, M.-H. and Hansen, L.G., Considerations of enzyme and endocrine interactions in the risk assessment of PCBs. In: Reviews in Toxicology, Series D. In Vivo Toxicology and Risk Assessment, 1, 85, 1996.
159. Vamvakas, A., Keller, J., and Dufresne, M., In vitro induction of CYP1A1-associated activities in human and rodent cell lines by commercial and tissue-extracted halogenated aromatic hydrocarbons, Environ. Toxicol. Chem., 15, 814, 1996.
160. Sanderson, J. T., Aarts, J. M. M. J. G., Brouwer, A., Froese, K. L., Denison, M. S., and Giesy, J. P., Comparison of Ah receptor-mediated luciferase and ethoxyresorufin-O-deethylase induction in H4IIE cells: implications for their use as bioanalytical tools for the detection of polyhalogenated aromatic hydrocarbons, Toxicol. Appt. Pharmacol., 137, 316, 1996.
161. Ahlborg, U. G., Brouwer, A., Fingerhut, M. A., Jacobson, J. L., Jacobson, S. W., Kennedy, S. W., Kettrup, A. A. F., Koeman, J. H., Poiger, H., Rappe, C., Safe, S. H., Seegal, R. F., Tuomisto, J., and van den Berg, M., Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept, Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. Section, 228, 179, 1992.
162. Seed, J., Brown, R. P., Olin, S. S., and Foran, J. A., Chemical mixtures: Current risk assessment methodologies and future directions, Reg. Toxicol. Pharmacol., 22, 76, 1995.
163. Neubert, D., Golor, G., and Neubert, R., TCDD-toxicity equivalencies for PCDD/ PCDF congeners: prerequisites and limitations, Chemosphere, 25, 65, 1992.
164. Neumann, H.-G., Toxic equivalence factors, problems and limitations, Food Chem. Toxicol., 34, 1045, 1996.
165. Bowman, R. E., Heironimus, M. P., and Allen, J. R., Correlation of PCB body burden with behavioral toxicology in monkeys, Pharmacol. Biochem. Behav., 9, 49, 1978.
166. Bowman, R. E., Heironimus, M. P., and Barsotti, D. A., Locomotor hyperactivity in PCB-exposed rhesus monkeys, Neurotoxicology, 2, 251, 1981.
167. Schantz, S. L., Levin, E. D., and Bowman, R. E., Long-term neurobehavioral effects of perinatal polychlorinated biphenyl (PCB) exposure in monkeys, Environ. Toxicol. Chem., 10, 747, 1991.
168. Fingerman, S. W. and Russel, L. C., Effects of the polychlorinated biphenyl Aroclor 1242 on locomotor activity and on the neurotransmitters dopamine and norepinephrine in the brain of the Gulf killifish, Fundulus grandis. Bull. Environ. Contam. Toxicol., 25, 682, 1980.
169. Seegal, R. F., Bush, B., and Shain, W., Lightly chlorinated ortho-substituted PCB congener decrease dopamine in nonhuman primate brain and in tissue culture, Toxicol. Appl. Pharmacol., 106, 136, 1990.
170. Kodavanti, P. R. S. and Tilson, H. A., Structure-activity relationships of potentially neurotoxic PCB congeners in the rat, Neurotoxi-cology, 18, 425, 1997.
171. Ahlborg, U. G., Lipworth, L., Titus-Ernstoff, L., Hsieh, C-C., Hanberg, A., Baron, J., Trichopoulos, D., and Adami, H.-O., Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: An assessment of the biological and epidemiological evidence, Crit. Rev. Toxicol., 25, 463, 1995.
172. Brouwer, A., Role of biotransformation in PCB-induced alterations in vitamin A and thyroid hormone metabolism in laboratory and wildlife species. Biochem. Soc. Transac., 19, 731, 1991.
173. Van Birgelen, A. P. J. M., Smit, E. A., Kampen, I. M., Groeneveld, C. N., Fase, K. M., Van der Kolk, J., Poiger, H., Van den Berg, M., Koeman, J. H., and Brouwer, A., Subchronic effects of 2,3,7,8-TCDD or PCBs on thyroid hormone metabolism: use in risk assessment, Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. Section, 293, 77, 1995.
174. Kramer, V. J., Helferich, W. G., Bergman, Å., Klasson-Wehler, E., and Giesy, J. P., Hydroxylated polychlorinated biphenyl metabolites are anti-estrogenic in a stably transfected human breast adenocarcinoma (MCF7) cell line, Toxicol. Appl. Pharmacol., 144, 363, 1997.
175. Brouwer, A., Ahlborg, U. G., Van den Berg, M., Birnbaum, L., Boersma, E. R., Bosveld, B., Denison, M. S., Gray, L. E., Hagmar, L., Holene, E., Huisman, M., Jacobson, S. W., Jacobson, J. L., Koopman-Esseboom, C., Koppe, J. G., Kulig, B. M., Morse, D. C., Muckle, G., Peterson, R. E., Sauer, P. J. J., Seegal, R. F., Prooije, A. E. S.-V., Touwen, B. C. L., Weisglas-Kuperus, N., and Winneke, G., Functional aspects of developmental toxicity of polyhalogenated aromatic hydrocarbons in experimental animals and human infants, Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. Section, 293, 1, 1995.
176. Putzrath, R. M., Estimating relative potency for receptor-mediated toxicity: Reevaluating the toxicity equivalence factor (TEF) model, Reg. Toxicol. Pharmacol., 25, 68, 1997.
177. De Vito, M. J., Ma, X., Babish, J. G., Menache, M., and Birnbaum, L. S., Dose-response relationships in mice following subchronic exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin: CYP1A1, CYP1A2, estrogen receptor and protein tyrosine phosphorylation, Toxicol. Appl. Pharmacol., 124, 82, 1994.
178. Bradlaw, J. A. and Casterline, J. L., Jr., Induction of enzyme activity in cell culture: a rapid screen for detection of planar polychlorinated organic compounds, J. Assoc. Off. Anal. Chem., 62, 904, 1979.
179. Knutson, J. C. and Poland, A., Keratinization of mouse teratoma cell line XB produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin: an in vitro model of toxicity, Cell, 22, 27, 1980.
180. Bradfield, C. A. and Poland, A., A competitive binding assay for 2,3,7,8-tetrachloro-dibenzo-p-dioxin and related ligands for the Ah receptor, Mol. Pharmacol., 34, 682, 1988.
181. Kennedy, S. W., Lorenzen, A., James, C. A., and Collins, B. T., Ethoxyresorufin-O-deethylase (EROD) and porphyrin analysis in chicken embryo hepatocyte cultures with a fluorescence multiwell plate reader, Anal. Biochem.,211, 102, 1993.
182. El-Fouly, M. H., Ritcher, C., Giesy, J. P., and Denison, M. S., Production of a novel recombinant cell line for use as a bioassay system for detection of 2,3,7,8-tetrachloro-dibenzo-p-dioxin-like chemicals. Environ. Toxicol. Chem., 13, 1581, 1994.
183. Schneider, U. A., Brown, M. M., Logan, R. A., Millar, L. C., and Bunce, N. J., Screening assay for dioxin-like compounds based on competitive binding to the murine hepatic Ah receptor. I. Assay development, Environ. Sci. Technol., 29, 2595, 1995.
184. Garrison, P. M., Tullis, K., Aarts, J. M. M. J. G., Brouwer, A., Giesy, J. P., and Denison, M. S., Species-specific recom-binant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-di-oxin-like chemicals, Fund. Appl. Toxicol., 30, 194, 1996.
185. Ritcher, C. A., Tieber, V. L., Denison, M. L., and Giesy, J. P., An in vitro rainbow trout cell bioassay for aryl hydrocarbon receptormediated toxins, Environ. Toxicol. Chem., 16, 543, 1997.
186. Zacharewski, T., In vitro bioassays for assessing estrogenic substances, Environ. Sci. Technol., 31, 613, 1997.
187. Kannan, K., Villeneuve, D. L., Blankenship, A. L., and Giesy, J. P., Interaction of tributyltin with 3,3',4,4',5-penta-chloro-biphe-nyl induced ethoxyresorufin-O-deethylase (EROD) activity in rat hepatoma cells, J. Toxicol. Environ. Health, 55, 101, 1998.
188. Whitlock, J. P., Jr., Mechanistic aspects of dioxin action, Chem. Res. Toxicol., 6, 754, 1993.
189. Denison, M. S. and Yao, E. F., Characterization of the interaction of transformed rat hepatic Ah receptor with a dioxin responsive transcriptional enhancer, Arch. Biochem. Biophys., 284, 158, 1991.
190. Alam, J. and Cook, J. L., Reporter genes: application to the study of mammalian gene transcription, Anal. Biochem., 188,245,1990.
191. Chen, Y.-C. J. and Hsu, C.-C., Effects of prenatal exposure to PCBs on the neurological function of children: a neuropsychologi-cal and neurophysiological study, Dev. Med. Child Neurol., 36, 312, 1994.
192. Chen, Y.-C. J., Yu, M.-L. M., Rogan, W. J., Gladen, B. C., and Hsu, C.-C., A 6-year follow up of behavior and activity disorders in the Taiwan Yu-Cheng children, Am. J. Public Health, 84, 415, 1994.
193. Masuda, Y., Health status of Japanese and Taiwanese after exposure to contaminated rice oil, Environ. Health Perspect., 60, 321, 1985.
194. Yu, M.-L., Hsu, C.-C., Gladen, B. C., and Rogan, W. J., In utero PCB/PCDF exposure: relation to developmental delay to dysmor-phology and dose, Neurotoxicol. Terata., 13, 195, 1991.
195. Rogan, W. J. and Gladen, B. C., Neurotoxicology of PCBs and related compounds, Neurotoxicology, 13, 27, 1992.
196. Kuratsune, M., Yoshimura, T., Matsuzaka, J., and Yamaguchi, A., Epidemiologic study on Yusho: a poisoning caused by ingestion of rice oil contaminated with a commercial brand of polychlorinated biphenyls, Environ. Health Perspect., 1, 119, 1972.
197. Hsu, C.-C., Chen, T.-C., Soong, W. T., Tsung, C.-C., Sue, S.-J., and Liu, C-Y., six-year follow up study of intellectual and behavioral development of Yu-Cheng children: cross-sectional findings of the first field work, Clin. Psych., 2, 26, 1988.
198. Jacobson, J. L., Jacobson, S. W., and Humphrey, H. E. B., Effects of in utero exposure to PCBs and related compounds on growth and activity in children, Neurotoxicol. Teratol., 12, 319, 1990.
199. Seegal, R. F. and Schantz, S. L., Neurochemical and behavioral sequelae of exposure to dioxins and PCBs. In: Dioxins and Health, Schecter, A., Ed., Plenum Press, New York, 1994, pp. 409-447.
200. Huisman, M., Koopman-Esseboom, C., Fidler, V., Hadders-Algra, M., van der Paauw, C. G., Tuinstra, L. G., Weisglas-Kuperus, N., Sauer, P.J., Touwen, B. C., and Boersma, E. R., Perinatal exposure to polychlorinated biphenyls and dioxins and its effect on neonatal neurological development, Early Human Development, 41, 111, 1995.
201. Maier, W. E., Kodavanti, P. R. S., Harry, G. J., and Tilson, H. A., Sensitivity of adenosine triphosphatases in different brain regions to polychlorinated biphenyl congeners, J. Appl. Toxicol., 14, 225, 1994.
202. Chu, I., Villeneuve, D. C., Yagminas, A., Lecavalier, P., Hkansson, H., Ahlborg, U. G., Valli, V. E., Kennedy, S. W., Bergman, Å., Seegal, R. F., and Feeley, M., Toxicity of PCB 77 (3,3′,4,4′-tetrachlorobiphenyl) and PCB 118 (2,3′,4,4′,5-pentachlorobiphenyl) in the rat following subchronic dietary exposure, Fundam. Appl. Toxicol., 26, 282, 1995.
203. Chu, I., Villeneuve, D. C., Yagminas, A., Lecavalier, P., Poon, R., Feeley, M., Kennedy, S. W., Seegal, R. F., Hkansson, H., Ahlborg, U. G., Valli, V. E., and Bergman, Å., Toxicity of 2,2′,4,4′,5,5′-hexachlorobiphenyl in rats: effects following 90-day oral exposure, J. Appl. Toxicol., 16, 121, 1996.
204. Eriksson, P. and Fredriksson, A., Neonatal exposure to 2,2′,5,5′-tetrachlorobiphenyl causes increased susceptibility in the cholinergic transmitter system at adult age, Environ. Toxicol. Pharmacol., 1, 217, 1996.
205. Eriksson, P. and Fredriksson, A., Developmental neurotoxicity of four ortho-substituted polychlorinated biphenyls in the neonatal mouse, Environ. Toxicol. Pharmacol., 1, 155, 1996.
206. Chishti, M. A., Fisher, J. P., and Seegal, R. F., Aroclors 1254 and 1260 reduce dopamine concentrations in rat striatal slices, Neurotoxicology, 17, 653, 1996.
207. Morse, D. C., Seegal, R. F., Borsch, K. O., and Brouwer, A., Long-term alterations in regional brain serotonin metabolism following maternal polychlorinated biphenyl expo-sure in the rat, Neurotoxicology, 17, 631, 1996.
208. Morse, D. C., Klasson Wehler, E., Wesseling, W., Koeman, J. H., and Brouwer, A., Alterations in rat brain thyroid hormone status following pre- and post-natal exposure to polychlorinated biphenyls (Aroclor 1254), Toxicol. Appl. Pharmacol., 136, 269, 1996.
209. Gasiewicz, T. A., Dioxins and the Ah receptor: probes to uncover processes in neuroendocrine development, Neurotoxicology, 18, 393, 1997.
210. Wong, P. W., Joy, R. M., Albertson, T. E., Schantz, S. L., and Pessah, I. N., Orthosubstituted 2,2′,3,5′,6-pentachlorobiphenyl (PCB 95) alters rat hippocampal ryanodine receptors and neuroplasticity In vitro: evidence for altered hippocampal function, Neurotoxicology, 18, 443, 1997.
211. Jacobson, J. L. and Jacobson, S. W., Evidence for PCBs as neurodevelopmental toxicants in humans, Neurotoxicology, 18, 415, 1997.
212. Greene, L. A. and Rein, G., Release, storage and uptake of catecholamines by a clonal cell line of nerve growth factor (NGF) responsive pheochromocytoma cells, Brain Res., 129, 247, 1977.
213. Kittner, B., Brautigam, M., and Herken, H., PC 12 cells: a model system for studying drug effects on dopamine synthesis and release, Arch. Int. Pharamacodyn. The., 286, 181, 1987.
214. Seegal, R. F., Brosch, K. O., Bush, B., Ritz, M., and Shain, W., Effects of Aroclor 1254 on dopamine and norepinephrine concentrations in pheochromocytoma (PC-12) cells, Neurotoxicology, 10, 757, 1989.
215. Seegal, R. F., Bush, B., and Shain, W., Neurotoxicology of ortho-substituted polychlorinated biphenyls, Chemosphere, 23, 1941, 1991.
216. Shain, W., Bush, B., and Seegal, R., Neurotoxicity of polychlorinated biphenyls: struc-ture-activity relationship of individual conge-ners, Toxicol. Appl. Pharmacol., 111, 33, 1991.
217. 3H]phorbol ester binding in rat cerebellar granule cells by PCB mixtures and congeners: structure-activity relationships, Toxicol. Appl. Pharmacol., 130, 140, 1995.
218. Schantz, S. L., Moshtaghian, J., and Ness, D. K., Long-term perinatal exposure to PCB congeners and mixtures on locomotor activity of rats, Teratology, 45, 524, 1992.
219. Holene, E., Nafstad, I., Skaare, J. U., Bernhoft, A., Engen, P., and Sagvolden, T., Behavioral effects of pre- and postnatal exposure to individual polychlorinated biphenyl congeners in rat, Environ. Toxicol. Chem., 14, 967, 1995.
220. Seegal, R. F., Bush, B., and Brosch, K.O., Polychlorinated biphenyls induce regional changes in brain norepinephrine concentrations in adult rats, Neurotoxicology, 6, 13, 1985.
221. Seegal, R. F., Bush, B., and Brosch, K. O., Polychlorinated biphenyls produce regional alterations of dopamine metabolism in rat brain, Toxicol. Lett., 30, 197, 1986.
222. Seegal, R. F., Bush, B., and Brosch, K. O., Regional alterations in serotonin metabolism induced by oral exposure of rats to polychlorinated biphenyls, Neurotoxicology, 7, 155, 1986.
223. Seegal, R. F., Bush, B., and Brosch, K. O., Subchronic exposure of the rat to Aroclor 1254 selectively alters central dopaminergic function, Neurotoxicology, 12, 55, 1991.
224. Seegal, R. F., Bush, B., and Brosch, K. O., Comparison of effects of Aroclors 1016 and 1260 on non-human primate catecholamine function, Toxicology, 66, 145, 1991.
225. Seegal, R. F., Bush, B., and Brosch, K. O., Decreases in dopamine concentrations in adult, non-human primate brain persist following removal from polychlorinated biphenyls, Toxicology, 86, 71, 1994.
226. Kodavanti, P. R. S., Mundy, W. R., Tilson, H. A., and Harry, G. J., Effects of selected neuroactive chemicals on calcium transporting systems in rat cerebellum and on survival of cerebellar granule cells, Fundam. Appl. Toxicol., 21, 308, 1993.
227. Kodavanti, P. R. S., Shin, D., Tilson, H. A., and Harry, G. J., Comparative effects of two polychlorinated biphenyl congeners on calcium homeostasis in rat cerebellar granule cells, Toxicol. Appl. Pharmacol., 123, 97, 1993.
228. Kodavanti, P. R. S., Shafer, T. J., Ward, T. R., Mundy, W. R., Freudenrich, T., Harry, G. J., and Tilson, H. A., Differential effects of PCB cogeners on phosphoinositide hydrolysis and protein kinase C translocation in rat cerebellar granule cells, Brain Res., 662, 75, 1994.
229. 2+ sequestration in rat cerebellum by polychlorinated biphenyl mixtures and congeners: structure-activity relationships, Arch. Toxicol., 70, 150, 1996.
230. Corrigan, F. M., French, M., and Murray, L., Organochlorine compounds in human brain, Human Exp. Toxicol., 15, 262, 1996.
231. Chen, P. H. and Hsu, S.-T., PCB poisoning from toxic rice-bran oil in Taiwan. In: PCBs and the Environment, Vol. III, Waid, J. S. Ed., CRC Press, Boca Raton, Florida, 1986, pp. 27-38.
232. Jenssen, B. M., Skaare, J. U., Ekker, M., Vongraven, D., and Lorentsen, S.-H., Or-ganochlorine compounds in blubber, liver and brain in neonatal grey seal pups, Chemosphere, 32, 2115, 1996.
233. Tilbury, K. L., Stein, J. E., Meador, J. P., Krone, C. A., and Chan, S.-L., Chemical contaminants in harbor porpoise (Phocoena phocoena) from the North Atlantic coast: tissue concentrations and intra- and inter-organ distribution, Chemosphere, 34, 2159, 1997.
234. Georgakopoulou-Gregoriadou, E., Psyllidou-Giouranovits, R., Voutsinou-Taliadouri, F., and Catsiki, U. A., Organochlorine residues in marine mammals from the Greek waters, Fresenius Environ. Bull., 4, 375, 1995.
235. Tanabe, S., Watanabe, S., Kan, H., and Tatsukawa, R., Capacity and mode of PCB metabolism in small cetaceans, Mar. Mamm. Sci., 4, 103, 1988.
236. Walker, C. H., Persistent pollutants in fisheating birds -bioaccumulation, metabolism and effects, Aquat. Toxicol., 17, 293, 1990.
237. Kannan, K., Tanabe, S., Tatsukawa, R., and Sinha, R. K., Biodegradation capacity and residue pattern of organochlorines in Ganges river dolphins from India, Toxicol. Environ. Chem., 42, 249, 1994.
238. Boon, J. P., van der Meer, J., Allchin, C. R., Law, R. J., Klungsøyr, J., Leonards, P. E. G., Spliid, H., Storr-Hansen, E., Mckenzie, C., and Wells, D. E., Concentration-dependent changes of PCB patterns in fish-eating mammals: structure evidence for induction of cytochrome P450, Arch. Environ. Contam. Toxicol., 33, 298, 1997.
239. Leonards, P. E. G., Zierikzee, Y., Brinkman, U. A. Th., Cofino, W. P., van Straalen, N. M., and van Hattum, B., The selective dietary accumulation of planar polychlorinated biphenyls in the otter (Lutra lutra), Environ. Toxicol. Chem., 16, 1807, 1997.
240. Hertzler, D. R., Neurotoxic behavioral effects of Lake Ontario salmon diet in rats, Neurotoxicol. Teratol., 12, 139, 1990.
241. Daly, H. B., Laboratory rat experiments show consumption of Lake Ontario salmon causes behavioral changes: support for wildlife and human research results, J. Great Lakes Res., 19, 784, 1993.
242. Beattie, M. K., Gerstenberger, S., Hoffman, R., and Dellinger, J. A., Rodent neurotoxicity bioassays for screening contaminated Great Lakes fish, Environ. Toxicol. Chem., 15, 313, 1996.
243. Agarwal, A. K., Tilson, H. A., and Bondy, S. C., 3,3′,4,4′-tetrachlorobiphenyl given to mice prenatally produces long-term decreases in striatal dopamine and receptor binding sites in the caudate nucleus, Toxicol. Lett., 7, 417, 1981.
244. Chishti, M. A. and Seegal, R. F., Intrastriatal injection of PCBs decresases striatal dopamine concentrations in rats, Toxicologist, 12, 320, 1992.
245. Eriksson, P., Lundkvist, U., and Fredriksson, A., Neonatal exposure to 3,3′,4,4′-tetrachlorobiphenyl: changes in spontaneous behaviour and cholinergic muscarinic receptors in the adult mouse, Toxicology, 69, 27, 1991.
246. Eriksson, P. and Fredriksson, A., Neurotoxic effects in adult mice neonatally exposed to 3,3′,4,4′,5-pentachlorobiphenyl or 2,3,3′,4,4′-pentachlorobiphenyl. Changes in brain nicotinic receptors and behaviour, Environ. Toxicol. Pharmacol., 5, 17, 1998.
247. Angus, W. G. R. and Contreras, M. L., Effects of polychlorinated biphenyls on dopamine release from PC12 cells, Toxicol. Lett., 89, 191, 1996.
248. Gierthy, J. F. and Crane, D., Reverse inhibition of in vitro epithelial cell proliferation by 2,3,7,8-tetrachlorodibenzo-p-dioxin, Toxicol. Appl. Pharmacol., 74, 91, 1984.
249. Lloyd, T. and Weisz, J., Direct inhibition of tyrosine hydroxylase activity by catechol estrogens, J. Biol. Chem., 243, 4841, 1978.
250. Foreman, M. M. and Porter, J. C., Effects of catechol estrogens and catecholamines on hypothalamic and corpus striatal tyrosine hydroxylase activity, J. Neurochem., 34, 1175, 1980.
251. Henshel, D. S., Martin, J. W., Norstrom, R. J., Whitehead, P., Steeves, J. D., and Cheng, K. M., Morphometric abnormalities in brains of great blue heron hatchlings exposed in the wild to PCDDs, Environ. Health Perspect., 103,61, 1995.
252. Henshel, D. S., Martin, J. W., Norstrom, R. J., Elliott, J., Cheng, K. M., and DeWitt, J. C., Morphometric brain abnormalities in double-crested cormorant chicks exposed to polychlorinated dibenzo-p-dioxins, dibenzo-furans, and biphenyls, J. Great Lakes Res., 23, 11, 1997.
253. Aulerich, R. J., Bursian, S. J., Breslin, W. J., Oison, B. A., and Ringer, R. K., Toxicological manifestations of 2,4,5,2′,4′,5′-, 2,3,6,2′,3′,6′-, and 3,4,5,3′,4′,5′-hexachloro-biphenyls and Aroclor 1254 in mink, J. Toxicol. Environ. Health, 15, 63, 1985.
254. Suedel, B. C., Dillon, T. M., and Benson, W. H., Subchronic effects of five di-ortho PCB congeners on survival, growth and reproduction in the fathead minnow Pimephales promelas, Environ. Toxicol. Chem., 16, 1526, 1997.
255. Qi, M., Anderson, M., Meyer, S., and Carson, J., Contamination of PCB congeners in bear lake fish tissues, livers, and brains, Toxicol. Environ. Chem., 61, 147, 1997.
256. Willman, E. J., Manchester-Neesvig, J. B., and Armstrong, D. E., Influence of ortho-substitution on patterns of PCB accumulation in sediment, plankton and fish in a freshwater estuary, Environ. Sci. Technol., 31, 3712, 1997.
257. Kreitzer, J. F. and Heinz, G. H., The effect of sublethal dosages of five pesticides and a polychlorinated biphenyl on the avoidance response of Coturnix quail chicks, Environ. Pollut., 6, 21, 1974.
258. Aulerich, R. J. and Ringer, R. K., Current status of PCB toxicity to mink and effect on their reproduction, Arch. Environ. Contam. Toxicol., 6, 279, 1977.
259. Aulerich, R. J., Ringer, R. K., and Safronoff, J., Assessment of primary vs secondary toxicity of Aroclor 1254 to mink, Arch. Environ. Contam. Toxicol., 15, 393, 1986.
260. Aulerich, R. J., Bursian, S. J., Evans, M. G., Hochstein, J. R., Koudele, K. A., Olson, B. A., and Napolitano, A. C., Toxicity of 3,4,5,3′,4′,5′-hexachlorobiphenyl to mink, Arch. Environ. Contam. Toxicol., 16, 53, 1987.
261. Gillette, D. M., Corey, R. D., Helferich, W. G., McFarland, J. M., Lowenstine, L. J., Moody, D. E., Hammock, B. D., and Shull, L. R., Comparative toxicology of tetrachlorobiphenyls in mink and rats. I. Changes in hepatic enzyme activity and smooth endoplasmic reticulum volume, Fundam. Appl. Toxicol., 8, 5, 1987.
262. Aulerich, R. J., Bursian, S. J., and Napolitano, A. C., Biological effects of epidermal growth factor and 2,3,7,8-tetrachloro-dibenzo-p-dioxin on the developmental parameters of neonatal mink, Arch. Environ. Contam. Toxicol, 17, 27, 1988.
263. Hochstein, J. R., Aulerich, R. J., and Bursian, S. J., Acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin to mink, Arch. Environ. Contam. Toxicol., 17, 33, 1988.
264. Wren, C. D., Cause-effect linkages between chemicals and populations of mink (Mustela vison) and otter (Lutra canadensis) in the Great Lakes basin, J. Toxicol. Environ. Health, 33, 549, 1991.
265. Williams, L. L. and Giesy, J. P., Selective enrichment of coplanar polychlorinated biphenyls in Lake Michigan chinook salmon: a comparison of calculation methods. In: Toxicology-Environment, Food and Exposure Risk for Halogenated Hydrocarbons. Hutzinger, O. and Fiedler, H., Eds., ECO-INFORMA, Bayreuth, Germany, 1990, pp. 401-404.
266. Williams, L. L. and Giesy, J. P., Polychlorinated biphenyls and 2,3,7,8-tetrachloro-dibenzo-p-dioxin equivalents in eggs of red-breasted mergansers near Green Bay, Wisconsin, USA, in 1977-1978 and 1990, Arch. Environ. Contam. Toxicol, 29, 327, 1995.
267. Williams, L. L., Giesy, J. P., Verbrugge, D. A., Jurzysta, S., Larson, J., and Stromberg, K., Polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in eggs of double-crested cormorants from a colony near Green Bay, Wisconsin, USA, Arch. Environ. Contam. Toxicol., 29, 52, 1995.
268. Hornshaw, T. C., Aulerich, R. J., and Johnson, H. E., Feeding Great Lakes fish to mink: effects on mink and accumulation and elimination of PCBs by mink, J. Toxicol. Environ. Health, 11, 933, 1983.
269. Restum, J. C., Bursian, S. J., Giesy, J. P., Render, J. A., Helferich, W. G., Shipp, E. B., Verbrugge, D. A., and Aulerich, R. J., A multigenerational study of the effects of consumption of PCB-contaminated carp from Saginaw Bay, Lake Huron, on mink. I. Effects on mink reproduction, kit growth and survival and selected biological parameters, Arch. Environ. Contam. Toxicol., 54, 343, 1998.
270. Angus, W. G. R., The Effects of Polychlorinated Biphenyls on Dopaminergic PC 12 Cells. Ph.D. thesis, Michigan State University, East Lansing, MI, 1994.
271. Tilson, H. A., Davis, G. J., McLachlan, J. A., and Lucier, G. W., The effects of PCBs given prenatally on the neurobehavioral development of mice, Environ. Res., 18, 466, 1979.
272. Chu, I., Villeneuve, D. C., Yagminas, A., Lecavalier, P., Poon, R., Feeley, M., Kennedy, S. W., Seegal, R. F., Håkansson, H., Ahlborg, U. G., and Valli, V. E., Subchronic toxicity of 3,3′,4,4′5-penta-chlorobiphenyl in the rat: clinical, biochemi-cal and hematological, and histopathological changes, Fundam. Appl. Toxicol., 22, 457, 1994.
273. Lecavalier, P., Chu, I., Yagminas, A., Villeneuve, D. C., Håkansson, H., Ahlborg, U. G., Valu, V. E., Bergman, A., Seegal, R. F., and Kennedy, S. W., Subchronic toxicity of 2,2′,3,3′,4,4′-hexachlorobiphenyl in rats, J. Toxicol. Environ. Health, 51, 265, 1997.
274. Bernhoft, A., Nafstad, I., Engen, P., and Skaare, J. U., Effects of pre- and postnatal exposure to 3,3′,4,4′,5-pentachlorobiphenyl on physical development, neurobehavior and xenobiotic metabolizing enzymes in rat, Environ. Toxicol. Chem., 13, 1589, 1994.
275. Weinand-Hårer, A., Lilienthal, H., Bucholski, K-A., and Winneke, G., Behavioral effects of maternal exposure to an orthosubstituted or a coplanar PCB congener in rats, Environ. Toxicol. Pharmacol., 3, 97, 1997.
276. Pantaleoni, G., Fannini, D., Sponta, A. M., Palumbo, G., Giorgi, R., and Adams, P., Effects of maternal exposure to polychlorinated biphenyls (PCBs) on F1 generation behaviour in the rat, Fundam. Appl. Toxicol., 11,440, 1988.
277. Overmann, S. R., Kostas, J., Wilson, L. R., Shain, W., and Bush, B., Neurobehavioral and somatic effects of perinatal PCB exposure to rats, Environ. Res., 44, 56, 1987.
278. Lilienthal, H., Neuf, M., Munoz, C., and Winneke, G., Behavioral effects of pre- and postnatal exposure to a mixture of low chlo-rinated PCBs in rats, Fundam. Appl. Toxicol., 15, 457, 1990.
279. Bleavins, M. R., Aulerich, R. J., and Ringer, R. K., Polychlorinated biphenyls (Aroclors 1016 and 1242): effects on survival and reproduction in mink and ferrets, Arch. Environ. Contam. Toxicol., 9, 627, 1980.
280. Wren, C. D., Hunter, D. B., Leatherland, J. F., and Stokes, P. M., The effects of polychlorinated biphenyls and methyl mercury singly or in combination on mink. II. Reproduction and kit development, Arch. Environ. Contam. Toxicol., 16, 449, 1987.
281. de Voogt, P., Wells, D. E., Reutergrådh, L., and Brinkman, U. A. Th., Biological activity, determination and occurrence of planar, mono- and di-ortho PCBs, Intern. J. Environ. Anal. Chem., 40, 1, 1990.
282. Harris, M., Zacahrewski, T., and Safe, S., Comparative potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in male Wistar rats - Assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs), Fund. Appl. Toxicol., 20, 456, 1993.
283. Schantz, S. L., Developmental neurotoxicity of PCBs in humans: what do we know and where do we go from here?, Neurotoxicol. Teratol., 18, 217, 1996.
284. van den Berg, M., Birnbaum, L., Bosveld, B. T. C., Brunström, B., Cook, P., Feeley, M., Giesy, J. P., Hanberg, A., Hasegawa, R., Kennedy, S. W., Kubiak, T., Larsen, J. C., van Leeuwen, F. X., Liem, A. K. D., Noit, C., Peterson, R. E., Poellinger, L., Safe, S., Schrenk, D., Tililtt, D., Tysklind, M., Younes, M., Waern, F., and Zacharewski, T., Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife, Environ. Health Perspect. (in press).
285. Kihlström, J. E., Olsson, M., Jensen, S., Johansson, A., Ahlbom, J., and Bergman, A., Effects of PCB and different fractions of PCB on the reproduction of the mink (Mustela vison), Ambio, 21, 563, 1992.
286. Bäcklin, B.-M. and Bergman, Å., Morphological aspects on the reproductive organs in female mink (Mustela vison) exposed to polychlorinated biphenyls and fractions thereof, Ambio, 21, 596, 1992.