Impairment of T and B cell development by treatment with a type I interferon

Journal of Experimental Medicine

Volumn 187, Issue 1, 1998, Pages 79-87

  Lin, Qun ^a   Dong, Chen ^a,c   Cooper, Max D ^a,b,d  

^a University of Alabama at Birmingham   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ALPHA1 INTERFERON; ALPHA2 INTERFERON; BETA INTERFERON; CD19 ANTIGEN; INTERFERON; INTERLEUKIN 7; LEUKOSIALIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL GROWTH; CONTROLLED STUDY; FETUS LIVER; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOPOIESIS; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; ANIMALS, NEWBORN; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL DIVISION; HEMATOPOIESIS; INTERFERON-ALPHA; INTERLEUKIN-7; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; RECEPTORS, INTERFERON; T-LYMPHOCYTES;

EID: 0031962665     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.1.79     Document Type: Article

References (75)

1. Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature. 381:751-758.
2. Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature. 302:575-581.
3. Alt, F.W., E.M. Oltz, F. Young, J. Gorman, G. Taccioli, and J. Chen. 1992. VDJ recombination. Immunol. Today. 13:306-314.
4. Karasuyama, H., A. Rolink, and F. Melchers. 1996. Surrogate light chain in B cell development. Adv. Immunol. 63:1-41.
5. Lassoued, K., C.A. Nunez, L. Billips, H. Kubagawa, R.C. Monteiro, T.W. LeBlen, and M.D. Cooper. 1993. Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation. Cell. 73:73-86.
6. Karasuyama, H., A. Rolink, Y. Shinkai, F. Young, F.W. Alt, and F. Melchers. 1994. The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell. 77:133-143.
7. Cooper, M.D., D. Mulvaney, A. Coutinho, and P.-A. Cazenave. 1986. A novel cell surface molecule on early B-lineage cells. Nature. 321:616-618.
8. Osmond, D.G. 1986. Population dynamics of bone marrow B lymphocytes. Immunol. Rev. 93:103-124.
9. Hardy, R.R., C.E. Carmack, S.A. Shinton, J.D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213-1225.
10. Hardy, R.R., J.D. Kemp, and K. Hayakawa. 1989. Analysis of lymphoid population in scid mice; detection of a potential B lymphocyte progenitor population present at normal levels in scid mice by three color flow cytometry with B220 and S7. Curr. Top. Microbiol. Immunol. 152:19-25.
11. Li, Y.S., K. Hayakawa, and R.R. Hardy. 1993. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178:951-960.
12. von Boehmer, H. 1988. The developmental biology of T lymphocytes. Annu. Rev. Immunol. 6:309-326.
13. Jameson, S.C., K.A. Hogquist, and M.J. Bevan. 1995. Positive selection of thymocytes. Annu. Rev. Immunol. 13:93-126.
14. Kisielow, P., and H. von Boehmer. 1995. Development and selection of T cells: facts and puzzles. Adv. Immunol. 58:87-209.
15. - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 150:4244-4252.
16. Godfrey, D.I., and A. Zlotnik. 1993. Control points in early T-cell development. Immunol. Today. 14:547-553.
17. + stage are highly correlated in individual thymocytes. J. Exp. Med. 178:1867-1875.
18. Dudley, E.C., H.T. Petrie, L.M. Shah, M.J. Owen, and A.C. Hayday. 1994. T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice. Immunity. 1:83-93.
19. - thymocyte differentiation. J. Immunol. 152:4783-4792.
20. Namen, A.E., S. Lupton, K. Hjerrild, J. Wignall, D.Y. Mochizuki, A. Schmierer, B. Mosley, C.J. March, D. Urdal, S. Gillis, et al. 1988. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. 333:571-573.
21. Sudo, T., S. Nishikawa, N. Ohno, N. Akiyama, M. Tamakoshi, H. Yoshida, and S.-I. Nishikawa. 1993. Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. USA. 90:9125-9129.
22. Kincade, P.W. 1994. B lymphopoiesis: global factors, local control. Proc. Natl. Acad. Sci. USA. 91:2888-2889.
23. Melchers, F., D. Haasner, M. Streb, and A. Rolink. 1992. B-lymphocyte lineage-committed, IL-7 and stroma cell-reactive progenitors and precursors, and their differentiation to B cells. Adv. Exp. Med. Biol. 323:111-117.
24. Kunisada, T., M. Ogawa, S. Hayashi, T. Era, and S. Nishikawa. 1992. Interleukin-7 and B lymphopoiesis. Chem. Immunol. 51:205-235.
25. Namen, A.E., D.E. Williams, and K.G. Goodwin. 1990. Interleukin-7: a new hematopoietic growth factor. Prog. Clin. Biol. Res. 338:65-73.
26. Widmer, M.B., P.J. Morrissey, R.G. Goodwin, K.H. Grabstein, L.S. Park, J.D. Watson, P.W. Kincade, P.J. Conlon, and A.E. Namen. 1990. Lymphopoiesis and IL-7. Intl. J. Cell Cloning. 8 (Suppl. 1):168-172.
27. Wang, J., Q. Lin, H. Langston, and M.D. Cooper. 1995. Resident bone marrow macrophages produce type 1 interferons that can selectively inhibit interleukin-7-driven growth of B lineage cells. Immunity. 3:475-484.
28. - thymocytes. Immunology. 90:543-549.
29. De Maeyer, E., and J. De Maeyer-Guignard. 1988. Interferons and Other Regulatory Cytokines. John Wiley and Sons, Inc. New York. 448 pp.
30. Borden, E.C., T.F. Hogan, and J.G. Voelkel. 1982. Comparative antiproliferative activity in vitro of natural interferons alpha and beta for diploid and transformed human cells. Cancer Res. 42:4948-4953.
31. Broxmeyer, H.E., L. Lu, E. Platzer, C. Feit, L. Juliano, and B.Y. Rubin. 1983. Comparative analysis of the influences of human gamma, alpha and beta interferons on human multi-potential (CFU-GEMM), erythroid (BFU-E) and granulocyte-macrophage (CFU-GM) progenitor cells. J. Immunol. 131:1300-1305.
32. Clemens, M.J., and M.A. McNurlan. 1985. Regulation of cell proliferation and differentiation by interferons. Biochem. J. 226:345-360.
33. Moore, R.N., H.S. Larsen, D.W. Horohov, and B.T. Rouse. 1984. Endogenous regulation of macrophage proliferative expansion by colony-stimulating factor-induced interferon. Science. 223:178-181.
34. Resnitzky, D., A. Yarden, D. Zipori, and A. Kimchi. 1986. Autocrine beta-related interferon controls c-myc suppression and growth arrest during hematopoietic cell differentiation. Cell. 46:31-40.
35. Weber, H., D. Valenzuela, G. Lujber, M. Gubler, and C. Weissmann. 1987. Single amino acid changes that render human IFN-alpha 2 biologically active on mouse cells. EMBO (Eur. Mol. Biol. Organ.) J. 6:591-598.
36. Borzillo, G.V., K. Endo, and Y. Tsujimoto. 1992. Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture. Oncogene. 7:869-876.
37. Dumont, F.J., and L.Z. Coker. 1986. Interferon-alpha/beta enhances the expression of Ly-6 antigens on T cells in vivo and in vitro. Eur. J. Immunol. 16:735-740.
38. + cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. J. Exp. Med. 183:187-194.
39. Moore, T.A., and A. Zlotnik. 1995. T-cell lineage commitment and cytokine responses of thymic progenitors. Blood. 86:1850-1860.
40. Wu, L., C.L. Li, and K. Shortman. 1996. Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny. J. Exp. Med. 184: 903-911.
41. Ardavin, C., L. Wu, C.L. Li, and K. Shortman. 1993. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature. 362: 761-763.
42. -/- mice. J. Immunol. 157: 2366-2373.
43. Wang, J., H. Walker, Q. Lin, N. Jenkins, N.G. Copeland, T. Watanabe, P.D. Burrows, and M.D. Cooper. 1996. The mouse BP-1 gene: structure, chromosomal localization, and regulation of expression by type 1 interferons and interleukin-7. Genomics. 33:167-176.
44. Akashi, K., M. Kondo, U. von Freeden-Jeffry, R. Murray, and I.L. Weissman. 1997. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell. 89:1033-1041.
45. -/- mice. Cell. 89:1011-1019.
46. Grabstein, K.H., T.J. Waldschmidt, F.D. Finkelman, B.W. Hess, A.R. Alpert, N.E. Boiani, A.E. Namen, and P.J. Morrissey. 1993. Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. J. Exp. Med. 178:257-264.
47. Watson, J.D., P.J. Morrissey, A.E. Namen, P.J. Conlon, and M.B. Widmer. 1989. Effect of IL-7 on the growth of fetal thymocytes in culture. J. Immunol. 143:1215-1222.
48. -thymocytes. J. Immunol. 146:3068-3073.
49. +/- precursor cells and blocks the differentiation pathway of TCR-alpha beta cells in fetal thymus organ culture. J. Immunol. 150:2706-2716.
50. Candéias, S., K. Muegge, and S.K. Durum. 1997. IL-7 receptor and VDJ recombination: trophic versus mechanistic actions. Immunity. 6:501-508.
51. Bhatia, S.K., L.T. Tygrett, K.H. Grabstein, and T.J. Waldschmidt. 1995. The effect of in vivo IL-7 deprivation on T cell maturation. J. Exp. Med. 181:1399-1409.
52. von Freeden-Jeffry, U., P. Vieira, L.A. Lucian, T. McNeil, S.E. Burdach, and R. Murray. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181:1519-1526.
53. Peschon, J.J., P.J. Morrissey, K.H. Grabstein, F.J. Ramsdell, E. Maraskovsky, B.C. Gliniak, L.S. Park, S.F. Ziegler, D.E. Williams, C.B. Ware, J.D. Meyer, and B.L. Davison. 1994. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180:1955-1960.
54. Cao, X., E.W. Shores, J. Hu-Li, M.R. Anver, B.L. Kelsall, S.M. Russell, J. Drago, M. Noguchi, A. Grinberg, E.T. Bloom, et al. 1997. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain. Immunity. 2:223-238.
55. DiSanto, J.P., W. Muller, D. Guy-Grand, A. Fischer, and K. Rajewsky. 1995. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc. Natl. Acad. Sci. USA. 92:377-381.
56. Nosaka, T., J.M. van Deursen, R.A. Tripp, W.E. Thierfelder, B.A. Witthuhn, A.P. McMickle, P.C. Doherty, G.C. Grosveld, and J.N. Ihle. 1995. Defective lymphoid development in mice lacking Jak3. Science. 270:800-802.
57. Park, S.Y., K. Saijo, T. Takahashi, M. Osawa, H. Arase, N. Hirayama, K. Miyake, H. Nakauchi, T. Shirasawa, and T. Saito. 1995. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity. 3:771-782.
58. Thomis, D.C., C.B. Gurniak, E. Tivol, A.H. Sharpe, and L.J. Berg. 1995. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3 defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science. 270:794-797.
59. Witthuhn, B.A., O. Silvennoinen, O. Miura, K.S. Lai, C. Cwik, E.T. Liu, and J.N. Ihle. 1994. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature. 370:153-157.
60. Johnston, J.A., M. Kawamura, R.A. Kirken, Y.Q. Chen, T.B. Blake, K. Shibuya, J.R. Ortaldo, D.W. McVicar, and J.J. O'Shea. 1994. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature. 370:151-153.
61. Kondo, M., T. Takeshita, M. Higuchi, M. Nakamura, T. Sudo, S. Nishikawa, and K. Sugamura. 1994. Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. Science. 263:1453-1454.
62. Ihle, J.N. 1995. Cytokine receptor signalling. Nature. 377: 591-594.
63. Sharfe, N., H.K. Dadi, and C.M. Roifman. 1995. JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3′ kinase. Blood. 86:2077-2085.
64. Harada, H., T. Fujita, M. Miyamoto, Y. Kimura, M. Maruyama, A. Furia, T. Miyata, and T. Taniguchi. 1989. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell. 58:729-739.
65. Fujita, T., L.F. Reis, N. Watanabe, Y. Kimura, T. Taniguchi, and J. Vilcek. 1989. Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways. Proc. Natl. Acad. Sci. USA. 86:9936-9940.
66. Miyamoto, M., T. Fujita, Y. Kimura, M. Maruyama, H. Harada, Y. Sudo, T. Miyata, and T. Taniguchi. 1988. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell. 54:903-913.
67. Yamada, G., M. Ogawa, K. Akagi, H. Miyamoto, N. Nakano, S. Itoh, J.-I. Miyazaki, S.-I. Nishikawa, K.-I. Yamamura, and T. Taniguchi. 1991. Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice. Proc. Natl. Acad. Sci. USA. 88:532-536.
68. Diaz, M.O., S. Ziemin, M.M. Le Beau, P. Pitha, S.D. Smith, R.R. Chilcote, and J.D. Rowley. 1988. Homozygous deletion of the alpha-and beta 1-interferon genes in human leukemia and derived cell lines. Proc. Natl. Acad. Sci. USA. 85: 5259-5263.
69. Miyakoshi, J., K.D. Dobler, J. Allalunis-Turner, J.D.S. Mc-Kean. K. Petruk, P.B.R. Allen, K.N. Aronyk, B. Weir, D. Huyser-Wierenga, D. Fulton, et al. 1990. Absence of IFNA and IFNB genes from human malignant glioma cell lines and lack of correlation with cellular sensitivity to interferons. Cancer Res. 50:278-283.
70. Muller, U., U. Steinhoff, L.F. Reis, S. Hemmi, J. Pavlovic, R.M. Zinkernagel, and M. Aguet. 1994. Functional role of type I and type II interferons in antiviral defense. Science. 264: 1918-1921.
71. Grawunder, U., F. Melchers, and A. Rolink. 1993. Interferon-gamma arrests proliferation and causes apoptosis in stromal cell/interleukin-7-dependent normal murine pre-B cell lines and clones in vitro, but does not induce differentiation to surface immunoglobulin-positive B cells. Eur. J. Immunol. 23:544-551.
72. Hwang, S.Y., P.J. Hertzog, K.A. Holland, S.H. Sumarsono, M.J. Tymms, J.A. Hamilton, G. Whitty, I. Bertoncello, and I. Kola. 1995. A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses. Proc. Natl. Acad. Sci. USA. 92:11284-11288.
73. Lee, G., A.E. Namen, S. Gillis, L.R. Ellingsworth, and P.W. Kincade. 1989. Normal B cell precursors responsive to recombinant murine IL-7 and inhibition of IL-7 activity by transforming growth factor-beta. J. Immunol. 142:3875-3883.
74. Plum, J., M. De Smedt, G. Leclercq, and B. Vandekerckhove. 1995. Influence of TGF-beta on murine thymocyte development in fetal thymus organ culture. J. Immunol. 154: 5789-5798.
75. Binder, D., J. Fehr, H. Hengartner, and R.M. Zinkernagel. 1997. Virus-induced transient bone marrow aplasia: major role of interferon-α/β during acute infection with the non-cytopathic lymphocytic choriomeningitis virus. J. Exp. Med. 185:517-530.