Reconstitution of an SOS response pathway: Derepression of transcription in response to DNA breaks

Cell

Volumn 95, Issue 7, 1998, Pages 975-979

  Anderson, Daniel G ^a   Kowalczykowski, Stephen C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; DNA DAMAGE; DNA REPLICATION; DNA STRAND BREAKAGE; DNA TRANSCRIPTION; ENZYME DEGRADATION; GENETIC ANALYSIS; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SOS CHROMOTEST; TRANSCRIPTION REGULATION;

ESCHERICHIA COLI;

EID: 0032428175     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81721-3     Document Type: Article

References (25)

1. Χ is a regulatory element that switches the polarity of DNA degradation by the RecBCD enzyme. Genes Dev. 11, 571-581.
2. Χ-regulated manner. Cell 90, 77-86.
3. Anderson, D.G., Churchill, J.J., and Kowalczykowski, S.C. (1997). Chi-activated RecBCD enzyme possesses 5′→3′ nucleolytic activity, but RecBC enzyme does not: evidence suggesting that the alteration induced by Chi is not simply ejection of the RecD subunit. Genes Cells 2, 117-128.
4. Blattner, F.R., Plunkett, G., 3rd, Bloch, C.A., Perna, N.T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J.D., Rode, C.K., Mayhew, G.F. et al. (1997). The complete genome sequence of Escherichia coli K-12. Science 277, 1453-1474.
5. Brent, R., and Ptashne, M. (1981). Mechanism of action of the lexA gene product. Proc. Natl. Acad. Sci. USA 78, 4204-4208.
6. Chaudhury, A.M., and Smith, G.R. (1985). Role of Escherichia coli RecBC enzyme in SOS induction. Mol. Gen. Genet. 201, 525-528.
7. Χ is a regulatory sequence that acts by attenuating the nuclease activity of the E. coli RecBCD enzyme. Cell 73, 87-96.
8. Eggleston, A.K., and West, S.C. (1997). Recombination initiation: easy as A, B, C, D... chi? Curr. Biol. 7, R745-R749.
9. Harmon, F.G., Rehrauer, W.M., and Kowalczykowski, S.C. (1996). Interaction of Escherichia coli RecA protein with LexA represser. II. Inhibition of DNA strand exchange by the uncleavable LexA S119A repressor argues that recombination and SOS induction are competitive processes. J. Biol. Chem. 271, 23874-23883.
10. Kowalczykowski, S.C., Clow, J.C., Somani, R., and Varghese, A. (1987). Effects of the Escherichia coli SSB protein on the binding of Escherichia coli RecA protein to single-stranded DNA: demonstration of competitive binding and the lack of a specific protein-protein interaction. J. Mol. Biol. 193, 81-95.
11. Kowalczykowski, S.C., Dixon, D.A., Eggleston, A.K., Lauder, S.D., and Rehrauer, W.M. (1994). Biochemistry of homologous recombination in Escherichia coli. Microbiol. Rev. 58, 401-465.
12. Kuzminov, A. (1995). Collapse and repair of replication forks in Escherichia coli. Mol. Microbiol. 16, 373-384.
13. Lee, S.E., Moore, J.K., Holmes, A., Umezu, K., Kolodner, R.D., and Haber, J.E. (1998). Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell 94, 399-409.
14. Little, J.W., Edmiston, S.H., Pacelli, L.Z., and Mount, D.W. (1980). Cleavage of the Escherichia coli lexA protein by the recA protease. Proc. Natl. Acad. Sci. USA 77, 3225-3229.
15. Little, J.W., Mount, D.W., and Yanisch-Perron, C.R. (1981). Purified lexA protein is a repressor of the recA and lexA genes. Proc. Natl. Acad. Sci. USA 78, 4199-4203.
16. Michel, B., Ehrlich, S.D., and Uzest, M. (1997). DNA double-strand breaks caused by replication arrest. EMBO J. 16, 430-438.
17. Myers, R.S., and Stahl, F.W. (1994). Chi and the RecBCD enzyme of Escherichia coli. Annu. Rev. Genet. 28, 49-70.
18. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual, Second Edition (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press).
19. Slilaty, S.N., and Little, J.W. (1987). Lysine-156 and serine-119 are required for LexA repressor cleavage: a possible mechanism. Proc. Natl. Acad. Sci. USA 84, 3987-3991.
20. Smith, G.R., Kunes, S.M., Schultz, D.W., Taylor, A., and Triman, K.L. (1981). Structure of Chi hotspots of generalized recombination. Cell 24, 429-436.
21. Taylor, A.F., and Smith, G.R. (1985). Substrate specificity of the DNA unwinding activity of the RecBC enzyme of Escherichia coli. J. Mol. Biol. 185, 431-443.
22. Tracy, R.B., Chedin, F., and Kowalczykowski, S.C. (1997). The recombination hot spot chi is embedded within islands of preferred DNA pairing sequences in the E. coli genome. Cell 90, 205-206.
23. Tracy, R.B., and Kowalczykowski, S.C. (1996). In vitro selection of preferred DNA pairing sequences by the Escherichia coli RecA protein. Genes Dev. 10, 1890-1903.
24. Walker, G.C. (1985). Inducible DNA repair systems. Annu. Rev. Biochem. 54, 425-457.
25. Weinert, T. (1998). DNA damage and checkpoint pathways: molecular anatomy and interactions with repair. Cell 94, 555-558.