Damage inducible mutagenesis: Recent insights into the activities of the Umu family of mutagenesis proteins

Cancer Surveys

Volumn 28, Issue , 1996, Pages 117-140

  Woodgate, Roger ^a   Levine, Arthur S ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CHAPERONIN; DNA DIRECTED DNA POLYMERASE GAMMA; MUTAGENIC AGENT; RECA PROTEIN;

DNA DAMAGE; DNA REPAIR; DNA SYNTHESIS; GENETIC STABILITY; HUMAN; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; BASE SEQUENCE; DNA DAMAGE; DNA POLYMERASE III; DNA REPAIR; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; REC A RECOMBINASES; SOS RESPONSE (GENETICS);

EID: 0030469755     PISSN: 02612429     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (98)

1. Bagg A, Kenyon CJ and Walker GC (1981) Inducibility of a gene product required for UV and chemical mutagenesis in Escherichia coli. Proceedings of the National Academy of Sciences of the USA 78 5749-5753
2. Bailone A, Sommer S, Knezevic J and Devoret R (1991a) Substitution of UmuD' for UmuD does not affect SOS mutagenesis. Biochimie 73 471-478
3. Bailone A, Sommer S, Knezevic J, Dutreix M and Devoret R (1991b) A RecA protein mutant deficient in its interaction with the UmuDC complex. Biochimie 73 479-484
4. Barak Y, Cohen-Fix O and Livneh Z (1995) Deamination of cytosine-containing pyrimidine photodimers in UV-irradiated DNA: significance for UV light mutagenesis. Journal of Biological Chemistry 270 24174-24179
5. Bates H, Randall SK, Rayssiguier C, Bridges BA, Goodman MF and Radman M (1989) Spontaneous and UV-induced mutations in Escherichia coli K-12 strains with altered or absent DNA polymerase I. Journal of Bacteriology 171 2480-2484
6. Battista JR, Ohta T, Nohmi T, Sun W and Walker GC (1990) Dominant negative umuD mutations decreasing RecA-mediated cleavage suggest roles for intact UmuD in modulation of SOS mutagenesis. Proceedings of the National Academy of Sciences of the USA 87 7190-7194
7. Bezzubova O, Shinohara A, Mueller RG, Ogawa H and Buerstedde J-M (1993) A chicken RAD51 homologue is expressed at high levels in lymphoid and reproductive organs. Nucleic Acids Research 21 1577-1580
8. Bonner CA, Stukenberg PT, Rajagopalan M et al (1992) Processive DNA synthesis by DNA polymerase II mediated by DNA polymerase III accessory proteins. Journal of Biological Chemistry 267 11431-11438
9. Bridges BA (1988) Mutagenic DNA repair in Escherichia coli. XVI, Mutagenesis by ultraviolet light plus delayed photoreversal in recA strains. Mutation Research 198 343-350
10. Bridges BA and Bates H (1990) Mutagenic DNA repair in Escherichia coli. XVIII, Involvement of DNA polymerase III α-subunit (DnaE protein) in mutagenesis after exposure to UV light. Mutagenesis 5 35-38
11. Bridges BA and Woodgate R (1984) Mutagenic repair in Escherichia coli. X, The umuC gene product may be required for replication past pyrimidine dimers but not for the coding error in UV mutagenesis. Molecular and General Genetics 196 364-366
12. Bridges BA and Woodgate R (1985a) The two-step model of bacterial UV mutagenesis. Mutation Research 150 133-139
13. Bridges BA and Woodgate R (1985b) Mutagenic repair in Escherichia coli: products of the recA gene and of the umuD and umuC genes act at different steps in UV-induced mutagenesis. Proceedings of the National Academy of Sciences of the USA 82 4193-4197
14. Bridges BA, Mottershead RP and Sedgwick SG (1976) Mutagenic repair in Escherichia coli, III. Requirement for a function of DNA polymerase III in ultraviolet light mutagenesis . Molecular and General Genetics 144 53-58
15. Brotcome-Lannoye A and Maenhaut-Michel G (1986) Role of RecA protein in untargeted UV mutagenesis of bacteriophage λ: evidence for the requirement for the dinB gene. Proceedings of the National Academy of Sciences of the USA 83 3904-3908
16. Bruck I, Woodgate R, McEntee K and Goodman MF (1996) Purification of a soluble UmuD'C complex from Escherichia coli: cooperative binding of UmuD′C to single-stranded DNA. Journal of Biological Chemistry 271 10767-10774
17. Burckhardt SE, Woodgate R, Scheuermann RH and Echols H (1988) UmuD mutagenesis protein of Escherichia coli: overproduction, purification and cleavage by RecA. Proceedings of the National Academy of Sciences of the USA 85 1811-1815
18. Donnelly CE and Walker GC (1989) groE mutants of Escherichia coli are defective in umuDC-dependent UV mutagenesis. Journal of Bacteriology 171 6117-6125
19. Donnelly CE and Walker GC (1992) Coexpression of UmuD' with UmuC suppresses the UV mutagenesis deficiency of groE mutants. Journal of Bacteriology 174 3133-3139
20. +-dependent UV mutagenesis. Mutation Research 309 225-233
21. Doyle N and Strike P (1995) The spectra of base substitutions induced by the impCAB, mucAB and umuDC error-prone DNA repair operons differ following exposure to methyl methansulfonate. Molecular and General Genetics 247 735-741
22. Dutreix M, Moreau PL, Bailone A et al (1989) New recA mutations that dissociate the various RecA protein activities in Escherichia coli provide evidence for an additional role for RecA protein in UV mutagenesis. Journal of Bacteriology 171 2415-2423
23. Dutreix M, Burnett B, Bailone A, Radding CM and Devoret R (1992) A partially deficient mutant, recA1730, that fails to form normal nucleoprotein filaments. Molecular and General Genetics 232 489-497
24. Elledge SJ and Walker GC (1983) Proteins required for ultraviolet light and chemical mutagenesis. Identification of the products of the umuC locus of Escherichia coli. Journal of Molecular Biology 164 175-192
25. Ennis DG, Peterson KR and Mount DW (1988) Increased expression of the Escherichia coli umuDC operon restores SOS mutagenesis in lexA41 cells. Molecular and General Genetics 213 541-544
26. Ennis DG, Levine AS, Koch WH and Woodgate R (1995) Analysis of recA mutants with altered SOS functions. Mutation Research 336 39-48
27. Foster PL and Sullivan AD (1988) Interactions between epsilon, the proofreading subunit of DNA polymerase III and proteins involved in the SOS response of Escherichia coli. Molecular and General Genetics 214 467-473
28. Frank EG, Hauser J, Levine AS and Woodgate R (1993) Targeting of the UmuD, UmuD′ and MucA′ mutagenesis proteins to DNA by RecA protein. Proceedings of the National Academy of Sciences of the USA 90 8169-8173
29. Frank EG, Gonzalez M, Ennis DG, Levine AS and Woodgate R (1996a) Factors affecting the in vivo stability of the Umu mutagenesis proteins. Journal of Bacteriology 178 3550-3556
30. Frank EG, Ennis DG, Gonzalez M, Levine AS and Woodgate R (1996b) Regulation of SOS mutagenesis by proteolysis. Proceedings of the National Academy of Sciences of the USA 93 10291-10296
31. Friedberg EC, Walker GC and Siede W (1995) DNA Repair and Mutagenesis, American Society of Microbiology, Washington, DC
32. - proteins in the autodigestion and RecA-mediated cleavage reactions. Journal of Molecular Biology 192 39-47
33. Gimble FS and Sauer RT (1989) λ repressor mutants that are better substrates for RecA-mediated cleavage. Journal of Molecular Biology 206 29-39
34. Hagensee ME, Timme T, Bryan SK and Moses RE (1987) DNA polymerase III of Escherichia coli is required for UV and ethyl methanesulfonate mutagenesis. Proceedings of the National Academy of Sciences of the USA 84 4195-4199
35. Hauser J, Levine AS, Ennis DG, Chumakov KM and Woodgate R (1992) The enhanced mutagenic potential of the MucAB proteins correlates with the highly efficient processing of the MucA protein. Journal of Bacteriology 174 6844-6851
36. Janel-Bintz R, Maenhaut-Michel G and Fuchs RPP (1994) MucAB but not UmuDC proteins enhance - 2 frameshift mutagenesis induced by N-2-acetylaminofluorene at alternating GC sequences. Molecular and General Genetics 245 279-285
37. Jonczyk P, Fijalkowska I and Ciesla Z (1988) Overproduction of the E subunit of DNA polymerase HI counteracts the SOS mutagenic response of Escherichia coli. Proceedings of the National Academy of Sciences of the USA 85 9124-9127
38. Kanabus M, Nowicka A, Sledziewska-Gojska E, Jonczyk P and Ciesla Z (1995) The antimutagenic effect of a truncated ε subunit of DNA polymerase HI in Escherichia coli cells irradiated with UV light. Molecular and General Genetics 247 216-221
39. Kato T and Shinoura Y (1977) Isolation and characterization of mutants of Escherichia coli deficient in induction of mutations by ultraviolet light. Molecular and General Genetics 156 121-131
40. Kitagawa Y, Akaboshi E, Shinagawa H, Horii T, Ogawa H and Kato T (1985) Structural analysis of the umu operon required for inducible mutagenesis in Escherichia coli. Proceedings of the National Academy of Sciences of the USA 82 4336-4340
41. Koch WH, Cebula TA, Foster PL and Eisenstadt E (1992a) UV mutagenesis in Salmonella typhimurium is umuDC dependent despite the presence of samAB. Journal of Bacteriology 174 2809-2815
42. Koch WH, Ennis DG, Levine AS and Woodgate R (1992b) Escherichia coli umuDC mutants: DNA sequence alterations and UmuD cleavage. Molecular and General Genetics 233 443-448
43. Koch WH, Kopsidas G, Meffle B, Levine AS and Woodgate R (1996) Analysis of chimeric UmuC proteins: identification of regions in Salmonella typhimurium UmuC important for mutagenic activity. Molecular and General Genetics 251 121-129
44. Koffel-Schwartz N, Coin F, Veaute X and Fuchs RPP (1996) Cellular strategies for accommodating replication-hindering adducts in DNA: control by the SOS response in Escherichia coli. Proceedings of the National Academy of Sciences of the USA 93 7805-7810
45. Kow YW, Faundez G, Hays S, Bonner CA, Goodman MF and Wallace SS (1993) Absence of a role for DNA polymerase II in SOS-induced translesion bypass of φX174. Journal of Bacteriology 175 561-564
46. Kulaeva OI, Wootton JC, Levine AS and Woodgate R (1995) Characterization of the umu- complementing operon from R391. Journal of Bacteriology 177 2737-2743
47. Kulaeva OI, Koonin EV, McDonald JP et al Identification of a DinB/UmuC homolog in the archeon Sulfolobus solfataricus. Mutation Research (in press)
48. Larimer FW, Perry JR and Hardigree AA (1989) The REV1 gene of Saccharomyces cerevisiae: isolation, sequence and functional analysis. Journal of Bacteriology 171 230-237
49. Lawrence CW, Borden A and Woodgate R (1996) Analysis of the mutagenic properties of the UmuDC, MucAB and RumAB proteins, using a site specific abasic lesion. Molecular and General Genetics 251 493-498
50. Lee M, Ohta T and Walker GC (1994) A monocysteine approach for probing the structure and interactions of the UmuD protein. Journal of Bacteriology 176 4825-4837
51. Lewis LK, Harlow GR, Gregg-Jolly LA and Mount DW (1994) Identification of high affinity binding sites for LexA which define new DNA damage-inducible genes in Escherichia coli. Journal of Molecular Biology 241 507-523
52. Livneh Z, Cohen-Fix O, Skaliter R and Elizur T (1993) Replication of damaged DNA and the molecular mechanism of ultraviolet light mutagenesis. Critical Reviews in Biochemistry and Molecular Biology 28 465-513
53. Lu C, Scheuermann RH and Echols H (1986) Capacity of RecA protein to bind preferentially to UV lesions and inhibit the editing subunit of DNA polymerase III: a possible mechanism for SOS-induced targeted mutagenesis. Proceedings of the National Academy of Sciences of the USA 83 619-623
54. Maeshima K, Morimatsu K, Shinohara A and Horii T (1995) RAD51 homologues in Xenopus laevis: two distinct genes are highly expressed in ovary and testis. Gene 160 195-200
55. Marsh L and Walker GC (1985) Cold sensitivity induced by overproduction of umuDC in Escherichia coli. Journal of Bacteriology 162 155-161
56. Murli S and Walker GC (1993) SOS mutagenesis. Current Opinion in Genetics and Development 3 719-725
57. Nohmi T, Battista JR, Dodson LA and Walker GC (1988) RecA-mediated cleavage activates UmuD for mutagenesis: mechanistic relationship between transcriptional derepression and posttranslational activation. Proceedings of the National Academy of Sciences of the USA 85 1816-1820
58. Nohmi T, Hakura A, Nakai Y, Watanabe M, Murayama SY and Sofuni T (1991) Salmonella typhimurium has two homologous but different umuDC operons: cloning of a new umuDC-like operon (samAB) present in a 60-megadalton cryptic plasmid of S. typhimurium. Journal of Bacteriology 173 1051-1063
59. Nohmi T, Yamada M, Watanabe M, Murayama SY and Sofuni T (1992) Roles of Salmonella typhimurium umuDC and samAB in UV mutagenesis and UV sensitivity. Journal of Bacteriology 174 6948-6955
60. Nowicka A, Kanabus M, Sledziewska-Gójska E and Ciesla Z (1994) Different UmuC requirements for generation of different kinds of UV-induced mutations in Escherichia coli. Molecular and General Genetics 243 584-592
61. Ogawa T, Shinohara A, Nabetani A. et al (1993) RecA-like recombination proteins in eukaryotes: functions and structures of RAD51 genes. Cold Spring Harbor Symposia on Quantitative Biology 58 567-576
62. Ohmori H, Hatada E, Qiao Y, Tsuji M and Fukuda R (1995) dinP, a new gene in Escherichia coli, whose product shows similarities to UmuC and its homologues. Mutation Research 347 1-7
63. Palejwala VA, Wang GE, Murphy HS and Humayun MZ (1995) Functional recA, lexA, umuD, umuC, polA and polB genes are not required for the Escherichia coli UVM response. Journal of Bacteriology 177 6041-6048
64. Peat TS (1996) Structure of the Escherichia coli SOS response protein UmuD′, PhD thesis, Columbia University, New York
65. Peat TS, Frank EG, McDonald JP, Levine AS, Woodgate R and Hendrickson WA (1996a) Structure of the UmuD′ protein and its regulation in response to DNA damage. Nature 380 727-730
66. Peat TS, Frank EG, Woodgate R and Hendrickson WA (1996b) Production and crystallization of a selenomethionyl variant of UmuD′, an Escherichia coli SOS response protein. Proteins: Structure, Function and Genetics 25 506-509
67. Perry KL, Elledge SJ, Mitchell B, Marsh L and Walker GC (1985) umuDC and mucAB operons whose products are required for UV light and chemical-induced mutagenesis: UmuD, MucA and LexA products share homology. Proceedings of the National Academy of Sciences of the USA 82 4331-4335
68. Petit MA, Bedale W, Osipiuk J et al (1994) Sequential folding of UmuC by the Hsp70 and Hsp60 chaperone complexes of Escherichia coli. Journal of Biological Chemistry 269 23824-23849
69. Rajagopalan M, Lu C, Woodgate R, O'Donnell M, Goodman MF and Echols H (1992) Activity of the purified mutagenesis proteins UmuC, UmuD′ and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III. Proceedings of the National Academy of Sciences of the USA 89 10777-10781
70. Schaaper RM (1993) Base selection, proofreading and mismatch repair during DNA replication in Escherichia coli. Journal of Biological Chemistry 268 23762-23765
71. Sedgwick SG, Ho C and Woodgate R (1991a) Mutagenic DNA repair in enterobacteria. Journal of Bacteriology 173 5604-5611
72. Sedgwick SG, Lodwick DL, Doyle N, Crowne HM and Strike P (1991b) Functional complementation between chromosomal and plasmid mutagenic DNA repair genes. Molecular and General Genetics 229 428-436
73. Shinagawa H, Iwasaki H, Kato T and Nakata A (1988) RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis. Proceedings of the National Academy of Sciences of the USA 85 1806-1810
74. Shinohara A, Ogawa H, Matsuda Y, Ushio N, Ikeo K and Ogawa T (1993) Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA. Nature Genetics 4 239-243
75. Skaliter R, Paz-Elizur T and Livneh Z (1996) A smaller form of the sliding clamp subunit of DNA polymerase III is induced by UV irradiation in Escherichia coli. Journal of Biological Chemistry 271 2478-2481
76. Sommer S, Bailone A and Devoret R (1993a) The appearance of the UmuD′C protein complex in Escherichia coli switches repair from homologous recombination to SOS mutagenesis. Molecular Microbiology 10 963-971
77. Sommer S, Knezevic J, Bailone A and Devoret R (1993b) Induction of only one SOS operon, umuDC, is required for SOS mutagenesis in Escherichia coli. Molecular and General Genetics 239 137-144
78. Steinborn G (1978) Uvm mutants of Escherichia coli K12 deficient in UV mutagenesis. I. Isolation of uvm mutants and their phenotypical characterization in DNA repair and mutagenesis. Molecular and General Genetics 165 87-93
79. Strike P and Lodwick D (1987) Plasmid genes affecting DNA repair and mutation. Journal of Cell Science 6 (Supplement) 303-321
80. Sweasy JB, Witkin EM, Sinha N and Roegner-Maniscalco V (1990) RecA protein of Escherichia coli has a third essential role in SOS mutator activity. Journal of Bacteriology 172 3030-3036
81. Szekeres ES, Woodgate R and Lawrence CW (1996) Substitution of mucAB or rumAB for umuDC alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesis. Journal of Bacteriology 178 2559-2563
82. Tadmor Y, Ascarelli-Goell R, Skaliter R and Livneh Z (1992) Overproduction of the β subunit of DNA polymerase III holoenzyme reduces UV mutagenesis in Escherichia coli. Journal of Bacteriology 174 2517-2524
83. Tessman I and Kennedy MA (1991) The two-step model of UV mutagenesis reassessed: deamination of cytosine in cyclobutane dimers as the likely source of the mutations associated with photoreactivation. Molecular and General Genetics 227 144-148
84. Tessman I and Kennedy MA (1994) DNA polymerase II of Escherichia coli in the bypass of abasic sites in vivo. Genetics 136 439-448
85. Tosu M and Tanooka H (1990) Transformation of mouse BALB 3T3 cells by enterobacterial plasmid misrepair gene mucAB. Molecular and Cellular Biology 10 5359-5364
86. + plasmids in eleven DNA repair-deficient E. coli strains. Mutation Research 112 261-273
87. Walker GC (1995) SOS-regulated proteins in translesion DNA synthesis and mutagenesis. Trends in Biochemical Science 20 416-420
88. Watanabe M, Nohmi T and Ohta T (1994a) Effects of the umuDC, mucAB and samAB operons on the mutational specificity of chemical mutagenesis in Escherichia coli. I, Frameshift mutagenesis. Mutation Research 314 27-37
89. Watanabe M, Nohmi T and Ohta T (1994b) Effects of the umuDC, mucAB and samAB operons on the mutational specificity of chemical mutagenesis in Escherichia coli. II, Base substitution mutagenesis. Mutation Research 314 39-49
90. Wilson R, Ainscough R anderson K et al (1994) 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature 368 32-38
91. Woodgate R (1992) Construction of a umuDC operon substitution mutation in Escherichia coli. Mutation Research 281 221-225
92. Woodgate R and Ennis DG (1991) Levels of chromosomally encoded Umu proteins and requirements for in in vivo UmuD cleavage. Molecular and General Genetics 229 10-16
93. Woodgate R and Sedgwick SG (1992) Mutagenesis induced by bacterial UmuDC proteins and their plasmid homologues. Molecular Microbiology 6 2213-2218
94. Woodgate R, Singh M, Kulaeva OI, Frank EG, Levine AS and Koch WH (1994) Isolation and characterization of novel plasmid-encoded umuC mutants. Journal of Bacteriology 176 5011-5021
95. Woodgate R, Bridges BA, Herrera G and Blanco M (1987) Mutagenic repair in Escherichia coli. XIII, Proofreading exonuclease of DNA polymerase III holoenzyme is not operational during UV mutagenesis. Mutation Research 183 31-37
96. Woodgate R, Rajagopalan M, Lu C and Echols H (1989) UmuC mutagenesis protein of Escherichia coli: purification and interaction with UmuD and UmuD′. Proceedings of the National Academy of Sciences of the USA 86 7301-7305
97. Woodgate R, Levine AS, Koch WH, Cebula TA and Eisenstadt E (1991) Induction and cleavage of Salmonella typhimurium UmuD protein. Molecular and General Genetics 229 81-85
98. Yoshimura Y, Morita T, Yamamoto A and Matsushiro A (1993) Cloning and sequence of the human RecA-like gene cDNA. Nucleic Adds Research 21 1665