Programmed cell death

Drug News and Perspectives

Volumn 13, Issue 8, 2000, Pages 471-476

  Gottlieb, R A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE; CASPASE 3; CYTOCHROME C; DNA FRAGMENT; PROTEIN CED 3; PROTEIN KINASE; PROTEINASE; UNCLASSIFIED DRUG;

APOPTOSIS; CAENORHABDITIS ELEGANS; CELL DESTRUCTION; CELL MEMBRANE POTENTIAL; CELL PH; CELL STRUCTURE; CELL VOLUME; DNA CLEAVAGE; ENZYME ACTIVATION; ENZYME DEGRADATION; ION TRANSPORT; MITOCHONDRIAL ENERGY TRANSFER; PHAGOCYTOSIS; PROTEIN FAMILY; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVIEW;

EID: 0034510549     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (54)

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3. Activation of the c-Jun N-terminal kinase/stress-activated protein kinase pathway by overexpression of caspase-8 and its homologs
4. BID: A novel BH3 domain-only death agonist
5. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-RI/Fas death
6. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
7. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
8. Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c
9. Cif (Cytochrome c efflux-inducing factor) activity is regulated by bcl-2 and caspases and correlates with the activation of Bid
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12. Mechanisms of CD95 (APO-I/Fas)-mediated apoptosis
13. BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins
14. Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-I-mediated caspase pathway
15. Cytochrome c and dATP-dependent formation of Apaf-I/caspase-9 complex initiates an apoptotic protease cascade
16. Caspase-9 can be activated without proteolytic processing
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18. Apaf-I oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes
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20. Cleavage of Bax enhances its cell death function
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40. Niacin protects the isolated heart from ischemia-reperfusion injury
41. Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria
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45. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
46. Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis
47. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
48. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis
49. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
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51. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
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53. Cleavage of lamin A by Mch2 alpha but not CPP32: Multiple interleukin I beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis
54. Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution