Survival in small cell lung carcinoma is independent of bcl-2 expression

Human Pathology

Volumn 30, Issue 6, 1999, Pages 712-717

  Maitra, Anirban ^b   Amirkhan, Robin H ^b   Saboorian, M Hossein ^b   Frawley, William H ^b   Ashfaq, Raheela ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NONE

Author keywords

Bcl 2; Lung cancer; Small cell; Survival

Indexed keywords

MONOCLONAL ANTIBODY; ONCOPROTEIN; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CANCER RESISTANCE; CANCER SURVIVAL; CLINICAL ARTICLE; DISEASE SEVERITY; FOLLOW UP; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG CARCINOGENESIS; LUNG SMALL CELL CANCER; PROGNOSIS; PROTEIN EXPRESSION;

EID: 0033025610     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(99)90099-0     Document Type: Article

References (32)

1. American Cancer Society Cancer Information Database: Lung Cancer Information. Available at http://www.cancer.org. Accessed 1998
2. Ginsberg RJ, Vokes EE, Raben A: Non-small cell lung cancer, in DeVita VT, Hellman S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology (ed 5). Philadelphia, PA, Lippincott-Raven, 1997, pp 858-910
3. Ihde DC: Drug therapy: Chemotherapy of lung cancer. N Engl J Med 327:1434-1441, 1992
4. Ihde DC, Cohen MH, Bernath A, et al: Serial fiberoptic bronchoscopy during chemotherapy for small cell carcinoma of lung. Chest 74:531-536, 1978
5. Skarin A: Analysis of long term survivors with small cell carcinoma. Chest 103:440S-444S, 1993
6. Rowinsky E, Ettinger D: Drug development and new drugs for lung cancer, in Pass HI, Mitchell JB, Johnson DH, Turrisi A (eds): Lung Cancer: Principles and Practice. Philadelphia, PA, Lippincott-Raven, 1996, pp 793-810
7. Tsujimoto Y, Finger LR, Yunis J, et al: Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226:1097-1099, 1984
8. Hockenbery D, Nunez G, Milliman C, et al: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336, 1990
9. Korsmeyer S: Regulators of cell death. Trends Genet 11:101-105, 1995
10. LeBrun DP, Warnke RA, Cleary ML: Expression of bcl-2 in fetal tissues suggests a role in morphogenesis. Am J Pathol 142:743-753, 1993
11. Lu QL, Poulsom R, Wong L, et al: Bcl-2 expression in adult and embryonic non-hematopoietic tissues. J Pathol 169:431-437, 1993
12. Hockenbery DM, Zutter M, Hickey W, et al: Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci U S A 88:6961-6965, 1991
13. Lu QL, Abel P, Foster CS, et al: Bcl-2: Role in epithelial differentiation and oncogenesis. HUM PATHOL 27:102-110, 1996
14. Lauwers GY, Scott GV, Hendricks J: Immunohistochemical evidence of aberrant bcl-2 protein expression in gastric epithelial dysplasia. Cancer 73:2900-2904, 1994
15. Bronner MP, Culin C, Reed JC, et al: The bcl-2 protooncogene and the gastrointestinal epithelial tumor progression model. Am J Pathol 146:20-26, 1995
16. Pezzella F, Turley H, Kuzu I, et al: Bcl-2 protein in non-small cell lung carcinoma. N Engl J Med 329:690-694, 1993
17. Ritter JH, Dresler CM, Wick MR: Expression of bcl-2 protein in stage T1N0M0 non-small cell lung carcinoma. HUM PATHOL 26:1227-1232, 1995
18. Fontanini G, Vignati S, Bigini D, et al: Bcl-2 protein: A prognostic factor inversely correlated to p53 expression in non-small cell lung cancer. Br J Cancer 71:1003-1007, 1995
19. Higashiyama M, Doi O, Kodama K, et al: Bcl-2 oncoprotein in surgically resected nonsmall cell lung cancer: Possibly favorable prognostic factor in association with low incidence of distant metastasis. J Surg Oncol 64:48-54, 1997
20. Fleming MV, Guinee DG, Chu WS, et al: Bcl-2 immunohistochemistry in a surgical series of non-small cell lung cancer patients. HUM PATHOL 29:60-64, 1998
21. Anton RC, Brown RW, Younes M, et al: Absence of prognostic significance of bcl-2 immunopositivity in non-small cell lung cancer: analysis of 427 cases. HUM PATHOL 28:1079-1082, 1997
22. Jiang SX, Sato Y, Kuwao S, et al: Expression of bcl-2 oncogene protein is prevalent in small cell lung carcinomas. J Pathol 177:135-138, 1995
23. Higashiyama M, Doi Osamu, Kodama K, et al: High prevalence of bcl-2 oncoprotein expression in small cell lung cancer. Anticancer Res 15:503-505, 1995
24. Jiang SX, Kameya T, Sato Y, et al: Bcl-2 protein expression in lung cancer and close correlation with neuroendocrine differentiation. Am J Pathol 148:837-846, 1996
25. Kaiser U, Schilli M, Haag U, et al: Expression of bcl-2 protein in small cell lung cancer. Lung Cancer 15:31-40, 1996
26. Hirsch FR, Matthews MJ, Aisner S, et al: Histopathologic classification of small cell lung cancer: Changing concepts and terminology. Cancer 62:973-977, 1988
27. Shi S-R, Key ME, Kalra KL: Antigen retrieval in formalin-fixed, paraffin embedded tissues: An enhancement method for immunohistochemical staining based on microwave heating of tissue sections. J Histochem Cytochem 39:741-748, 1991
28. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-485, 1958
29. Cox DR: Regression models and life tables. J R Stat Soc B34:187-220, 1972
30. Ikegaki N, Katsumata M, Minna J, et al: Expression of bcl-2 in small cell lung carcinoma cells. Cancer Res 54:6-8, 1994
31. Ben-Ezra JM, Kornstein MJ, Grimes MM, et al: Small cell carcinomas of the lung express the bcl-2 protein. Am J Pathol 145:1036-1040, 1994
32. Yan JJ, Chen KF, Tsai YC, et al: Immunohistochemical detection of bcl-2 protein in small cell carcinomas. Oncology 53:6-11, 1996