Interactions between adenovirus proteins and the p53 pathway: The development of ONYX-015

Seminars in Cancer Biology

Volumn 10, Issue 6, 2000, Pages 453-459

  McCormick, Frank ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Oncolytic virus; ONYX 015; p53

Indexed keywords

PROTEIN P53; VIRUS PROTEIN;

ADENOVIRUS; CANCER INHIBITION; CANCER RESEARCH; DRUG RESEARCH; HUMAN; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PROTEIN PROTEIN INTERACTION; REVIEW; VIRUS MUTANT; VIRUS REPLICATION;

EID: 0034472619     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.2000.0336     Document Type: Article

References (51)

1. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins
2. Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor
3. Distinct modulation of p53 activity in transcription and cell-cycle regulation by the large (54 kDa) and small (21 kDa) adenovirus E1B proteins
4. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein
5. Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence
6. Accumulation of p53 induced by the adenovirus E1A protein requires regions involved in the stimulation of DNA synthesis
7. The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells
8. E1B 55-kilodalton oncoproteins of adenovirus types 5 and 12 inactivate and relocalize p53, but not p51 or p73, and cooperate with e4orf6 proteins to destabilize p53
9. Control of p53-dependent apoptosis by E1B, Bcl-2, and Ha-ras proteins
10. T antigen is bound to a host protein in SV40-transformed cells
11. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
12. Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells
13. SV40 T antigen binds specifically to a cellular 53 K protein in vitro
14. Molecular mechanisms of transformation by the human papillomaviruses
15. Binding of polyomavirus small T antigen to protein phosphatase 2A is required for elimination of p27 and support of S-phase induction in concert with large T antigen
16. Cancer cell cycles
17. Tumor surveillance via the ARF-p53 pathway
18. Akt phosphorylation of BAD couples survival signals to the cel-intrinsic death machinery
19. Bcl-2 blocks p53-dependent apoptosis
20. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
21. A monoclonal antibody detecting the adenovirus type 5-E1b-58Kd tumor antigen: Characterization of the E1b-58Kd tumor antigen in adenovirus-infected and -transformed cells
22. Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection
23. Control of p53 expression by adenovirus 12 early region 1A and early region 1B 54K proteins
24. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
25. Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression
26. Adenovirus E1B 55K represses p53 activation in vitro
27. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
28. Biochemical properties and biological effects of p53
29. p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection
30. The adenovirus-inducible factor E2F stimulates transcription after specific DNA binding
31. Introduction to the E2F family: Protein structure and gene regulation
32. cyt gene of adenoviruses 2 and 5 is an oncogene for transforming function in early region E1B and encodes the E1B 19,000-molecular-weight polypeptide
33. p53-dependent cell death/apoptosis is required for a productive adenovirus infection
34. p53-independent and -dependent requirements for E1B-55K in adenovirus type 5 replication
35. Loss of p14ARF facilitates replication of the adenovirus mutant d11520 (ONYX-015) in tumor cells
36. Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells
37. Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport
38. E3 transcription unit of adenovirus
39. Adenovirus proteins that subvert host defenses
40. The replicative capacities of large E1B-null group A and group C adenoviruses are independent of host cell p53 status
41. Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
42. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
43. p14ARF links the tumour suppressors RB and p53
44. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
45. E1A signaling to p53 involves the p19(ARF) tumor suppressor
46. mdm2 expression is induced by wild type p53 activity
47. Regulation of the p53 tumor suppressor protein
48. A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer
49. Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: Intratumoral spread and distribution effects
50. Adenoviral vectors capable of replication improve the efficacy of HSVtk/GCV suicide gene therapy of cancer
51. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses